SI1761541T1 - Derivati pirazolo-pirimidina - Google Patents

Derivati pirazolo-pirimidina

Info

Publication number
SI1761541T1
SI1761541T1 SI200530203T SI200530203T SI1761541T1 SI 1761541 T1 SI1761541 T1 SI 1761541T1 SI 200530203 T SI200530203 T SI 200530203T SI 200530203 T SI200530203 T SI 200530203T SI 1761541 T1 SI1761541 T1 SI 1761541T1
Authority
SI
Slovenia
Prior art keywords
pyrrazolo
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
SI200530203T
Other languages
English (en)
Inventor
Erwin Goetschi
Juergen Wichmann
Thomas Johannes Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SI1761541T1 publication Critical patent/SI1761541T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI200530203T 2004-06-21 2005-06-13 Derivati pirazolo-pirimidina SI1761541T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04102837 2004-06-21
EP05754665A EP1761541B1 (en) 2004-06-21 2005-06-13 Pyrrazolo-pyrimidine derivatives

Publications (1)

Publication Number Publication Date
SI1761541T1 true SI1761541T1 (sl) 2008-06-30

Family

ID=34971089

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200530203T SI1761541T1 (sl) 2004-06-21 2005-06-13 Derivati pirazolo-pirimidina

Country Status (26)

Country Link
US (1) US7378417B2 (sl)
EP (1) EP1761541B1 (sl)
JP (1) JP4608542B2 (sl)
CN (1) CN100528876C (sl)
AR (1) AR049521A1 (sl)
AT (1) ATE383361T1 (sl)
AU (1) AU2005254657B2 (sl)
BR (1) BRPI0512330A (sl)
CA (1) CA2571487C (sl)
DE (1) DE602005004287T2 (sl)
DK (1) DK1761541T3 (sl)
ES (1) ES2299044T3 (sl)
HK (1) HK1105971A1 (sl)
HR (1) HRP20080070T3 (sl)
IL (1) IL179736A (sl)
MX (1) MXPA06014809A (sl)
MY (1) MY143368A (sl)
NO (1) NO20070249L (sl)
NZ (1) NZ551660A (sl)
PL (1) PL1761541T3 (sl)
PT (1) PT1761541E (sl)
RU (1) RU2378277C2 (sl)
SI (1) SI1761541T1 (sl)
TW (1) TWI301835B (sl)
WO (1) WO2005123738A1 (sl)
ZA (1) ZA200610102B (sl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4708438B2 (ja) * 2005-02-11 2011-06-22 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ２アンタゴニストとしてのピラゾロピリミジン誘導体
RU2412943C2 (ru) 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
ATE463495T1 (de) 2005-09-27 2010-04-15 Hoffmann La Roche Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten
CA2626789A1 (en) * 2005-10-21 2007-04-26 Exelixis, Inc. Pyrimidinones as casein kinase ii (ck2) modulators
AU2008279759A1 (en) * 2007-07-20 2009-01-29 Merck & Co., Inc. Pyrazolo[1,5-a]pyrimidine derivatives
PE20131197A1 (es) * 2008-10-31 2013-11-06 Genentech Inc Compuestos de pirazolopirimidina como inhibidores de jak y composiciones farmaceuticas que los contienen
AR078171A1 (es) * 2009-09-15 2011-10-19 Sanofi Aventis Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas
WO2012075393A2 (en) * 2010-12-02 2012-06-07 President And Fellows Of Harvard College Activators of proteasomal degradation and uses thereof
DK2649075T3 (en) 2010-12-08 2018-07-30 Us Health SUBSTITUTED PYRAZOLOPYRIMIDINES AS GLUCOCEREBROSIDASE ACTIVATORS
WO2012149157A2 (en) 2011-04-26 2012-11-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
WO2013148333A1 (en) 2012-03-28 2013-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Salicylic acid derivatives useful as glucocerebrosidase activators
JP2015534993A (ja) 2012-10-23 2015-12-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａ 自閉症性障害の処置のためのｍＧｌｕ２／３アンタゴニスト
US9278973B2 (en) 2012-10-25 2016-03-08 Bioenergenix Llc Heterocyclic compounds for the inhibition of PASK
US10392389B2 (en) 2012-10-25 2019-08-27 Bioenergenix Llc Heterocyclic compounds for the inhibition of PASK
EP3134089A2 (en) 2014-04-23 2017-03-01 F. Hoffmann-La Roche AG Mglu2/3 antagonists for the treatment of intellectual disabilities
JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
AU2015342883B2 (en) 2014-11-06 2020-07-02 Bial - R&D Investments, S.A. Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders
AU2015342887B2 (en) 2014-11-06 2020-09-10 Bial - R&D Investments, S.A. Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders
US20170333435A1 (en) 2014-11-06 2017-11-23 Lysosomal Therapeutics Inc. Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
AU2015357169B2 (en) 2014-12-03 2021-03-04 Janssen Pharmaceutica Nv Radiolabelled mGluR2 PET ligands
WO2017066428A1 (en) 2015-10-13 2017-04-20 H. Lee Moffitt Cancer Center & Research Institute, Inc. Brd4-kinase inhibitors as cancer therapeutics
EP3389727B1 (en) 2015-12-18 2020-08-12 Janssen Pharmaceutica NV Radiolabelled mglur2/3 pet ligands
CA3003962A1 (en) 2015-12-18 2017-06-22 Janssen Pharmaceutica Nv Radiolabelled mglur2/3 pet ligands
WO2017176961A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
JP7034935B2 (ja) 2016-04-06 2022-03-14 リソソーマル・セラピューティクス・インコーポレイテッド ピロロ［１，２－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
MX2018012211A (es) * 2016-04-06 2019-03-28 Lysosomal Therapeutics Inc Compuestos de pirazol[1,5-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos.
CN109311902B (zh) 2016-05-05 2022-07-15 Bial研发投资股份有限公司 取代的咪唑并[1,2-b]哒嗪、咪唑并[1,5-b]哒嗪、相关化合物及其用途
EP3452455A4 (en) 2016-05-05 2019-11-13 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES
AU2019360941A1 (en) * 2018-10-15 2021-04-29 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017212A (en) * 1986-03-20 1991-05-21 Takeda Chemical Industries, Ltd. Sulfonylurea compounds and herbicidal use
SI0891978T1 (sl) * 1997-07-18 2002-06-30 F. Hoffmann-La Roche Ag Derivati 5H-tiazolo (3,2a) pirimidina
YU23802A (sh) * 1999-09-30 2004-09-03 Neurogen Corporation Određeni alkilen diamin-supstituisani pirazolo/1,5-a/-1,5- piramidini i pirazolo/1,5-a/1,3,5-triazini
JP2005534618A (ja) * 2002-03-28 2005-11-17 エーザイ株式会社 神経変性疾患用の、ｃ−ｊｕｎｎ−末端キナーゼ阻害剤としての７−アザインドール
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine

Also Published As

Publication number Publication date
PT1761541E (pt) 2008-03-13
DE602005004287T2 (de) 2008-12-24
AR049521A1 (es) 2006-08-09
EP1761541B1 (en) 2008-01-09
EP1761541A1 (en) 2007-03-14
CA2571487A1 (en) 2005-12-29
NZ551660A (en) 2009-08-28
DK1761541T3 (da) 2008-04-28
HK1105971A1 (en) 2008-02-29
IL179736A (en) 2010-12-30
AU2005254657A1 (en) 2005-12-29
ZA200610102B (en) 2008-08-27
CN100528876C (zh) 2009-08-19
MY143368A (en) 2011-04-29
ES2299044T3 (es) 2008-05-16
DE602005004287D1 (de) 2008-02-21
MXPA06014809A (es) 2007-02-12
RU2006143571A (ru) 2008-07-27
WO2005123738A1 (en) 2005-12-29
IL179736A0 (en) 2007-05-15
PL1761541T3 (pl) 2008-06-30
HRP20080070T3 (en) 2008-05-31
TW200626598A (en) 2006-08-01
JP2008503510A (ja) 2008-02-07
BRPI0512330A (pt) 2008-02-26
AU2005254657B2 (en) 2011-03-17
CN1964973A (zh) 2007-05-16
US7378417B2 (en) 2008-05-27
ATE383361T1 (de) 2008-01-15
CA2571487C (en) 2013-04-30
RU2378277C2 (ru) 2010-01-10
JP4608542B2 (ja) 2011-01-12
US20050282827A1 (en) 2005-12-22
TWI301835B (en) 2008-10-11
NO20070249L (no) 2007-02-15

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