AU2008298948B2 - Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use - Google Patents

Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use Download PDF

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Publication number
AU2008298948B2
AU2008298948B2 AU2008298948A AU2008298948A AU2008298948B2 AU 2008298948 B2 AU2008298948 B2 AU 2008298948B2 AU 2008298948 A AU2008298948 A AU 2008298948A AU 2008298948 A AU2008298948 A AU 2008298948A AU 2008298948 B2 AU2008298948 B2 AU 2008298948B2
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Prior art keywords
formula
acid
compound
chemotherapeutic agent
days
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AU2008298948A
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AU2008298948A1 (en
Inventor
Marcia Belvin
Lori Friedman
Klaus Hoeflich
Leisa Johnson
Sonal Patel
Deepak Sampath
Mallika Singh
Ulka Vijapurkar
Jeffrey Wallin
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F Hoffmann La Roche AG
Genentech Inc
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F Hoffmann La Roche AG
Genentech Inc
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Application filed by F Hoffmann La Roche AG, Genentech Inc filed Critical F Hoffmann La Roche AG
Publication of AU2008298948A1 publication Critical patent/AU2008298948A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008298948A 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use Ceased AU2008298948B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97177307P 2007-09-12 2007-09-12
US60/971,773 2007-09-12
PCT/US2008/075883 WO2009036082A2 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use

Publications (2)

Publication Number Publication Date
AU2008298948A1 AU2008298948A1 (en) 2009-03-19
AU2008298948B2 true AU2008298948B2 (en) 2014-09-04

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AU2008298948A Ceased AU2008298948B2 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use

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US (3) US8247397B2 (https=)
EP (1) EP2205242B1 (https=)
JP (1) JP5658565B2 (https=)
KR (1) KR101584823B1 (https=)
CN (1) CN101939006B (https=)
AR (1) AR068402A1 (https=)
AU (1) AU2008298948B2 (https=)
BR (1) BRPI0816769A2 (https=)
CA (1) CA2699202C (https=)
CL (1) CL2008002687A1 (https=)
ES (1) ES2537352T3 (https=)
IL (1) IL204333A (https=)
MX (1) MX338504B (https=)
PE (2) PE20090678A1 (https=)
RU (1) RU2523890C2 (https=)
TW (1) TWI471134B (https=)
WO (1) WO2009036082A2 (https=)
ZA (1) ZA201002475B (https=)

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