AU2008289447B2 - Methods of using miRNA for detection of in vivo cell death - Google Patents

Methods of using miRNA for detection of in vivo cell death Download PDF

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Publication number
AU2008289447B2
AU2008289447B2 AU2008289447A AU2008289447A AU2008289447B2 AU 2008289447 B2 AU2008289447 B2 AU 2008289447B2 AU 2008289447 A AU2008289447 A AU 2008289447A AU 2008289447 A AU2008289447 A AU 2008289447A AU 2008289447 B2 AU2008289447 B2 AU 2008289447B2
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mirna
urine
specific
sample
urine sample
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Ceased
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AU2008289447A
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AU2008289447A1 (en
Inventor
Hovsep S. Melkonyan
Vladimir S. Scheinker
Samuil R. Umansky
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Cardiff Oncology Inc
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Trovagene Inc
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Publication of AU2008289447A1 publication Critical patent/AU2008289447A1/en
Assigned to TROVAGENE, INC. reassignment TROVAGENE, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: XENOMICS, INC.
Priority to AU2014210676A priority Critical patent/AU2014210676B2/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2008289447A 2007-08-22 2008-08-22 Methods of using miRNA for detection of in vivo cell death Ceased AU2008289447B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014210676A AU2014210676B2 (en) 2007-08-22 2014-08-11 Methods of Using miRNA for Detection of In Vivo Cell Death

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96587107P 2007-08-22 2007-08-22
US60/965,871 2007-08-22
PCT/US2008/009991 WO2009025852A2 (en) 2007-08-22 2008-08-22 Methods of using mirna for detection of in vivo cell death

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014210676A Division AU2014210676B2 (en) 2007-08-22 2014-08-11 Methods of Using miRNA for Detection of In Vivo Cell Death

Publications (2)

Publication Number Publication Date
AU2008289447A1 AU2008289447A1 (en) 2009-02-26
AU2008289447B2 true AU2008289447B2 (en) 2014-09-04

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AU2008289447A Ceased AU2008289447B2 (en) 2007-08-22 2008-08-22 Methods of using miRNA for detection of in vivo cell death
AU2014210676A Ceased AU2014210676B2 (en) 2007-08-22 2014-08-11 Methods of Using miRNA for Detection of In Vivo Cell Death

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AU2014210676A Ceased AU2014210676B2 (en) 2007-08-22 2014-08-11 Methods of Using miRNA for Detection of In Vivo Cell Death

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US (4) US8486626B2 (enExample)
EP (2) EP2612926B1 (enExample)
JP (1) JP5416110B2 (enExample)
CN (2) CN101861399B (enExample)
AU (2) AU2008289447B2 (enExample)
CA (1) CA2696403C (enExample)
CY (1) CY1114111T1 (enExample)
DK (2) DK2195450T4 (enExample)
ES (2) ES2660785T3 (enExample)
HR (1) HRP20130618T1 (enExample)
HU (1) HUE019019T5 (enExample)
NO (1) NO2612926T3 (enExample)
PL (2) PL2195450T3 (enExample)
PT (2) PT2195450E (enExample)
TR (1) TR201802758T4 (enExample)
WO (1) WO2009025852A2 (enExample)

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EP2419536A4 (en) * 2009-04-14 2012-09-05 Merck Sharp & Dohme MICRO RNA AS A BIOMARKER FOR IMPROVING BETAZELLES IN THE PANCREAS ISLANDS
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WO2011057003A2 (en) 2009-11-04 2011-05-12 Samuil Umansky Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases
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SG185544A1 (en) * 2010-05-14 2012-12-28 Fluidigm Corp Nucleic acid isolation methods
JP6211511B2 (ja) 2011-04-18 2017-10-11 ディアミール, エルエルシーDiamir, Llc ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ）
CN102188719B (zh) * 2011-05-12 2012-12-19 南方医科大学 EB病毒miR-BART3反义寡聚核苷酸在制备治疗鼻咽癌的药物中的应用
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WO2013022953A2 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof
CA3069089A1 (en) * 2011-09-22 2013-03-28 Lineage Biosciences, Inc. Compositions and methods for analyzing heterogeneous samples
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
EP3584327A1 (en) * 2012-01-27 2019-12-25 The Board of Trustees of the Leland Stanford Junior University Methods for profiling and quantitating cell-free rna
US20160289762A1 (en) 2012-01-27 2016-10-06 The Board Of Trustees Of The Leland Stanford Junior University Methods for profiliing and quantitating cell-free rna
US20140087964A1 (en) * 2012-09-24 2014-03-27 University Of Virginia Patent Foundation Compositions and methods for detecting aberrant regulation, expression, and levels of hgh
EP2733219B1 (en) 2012-11-16 2017-09-20 Siemens Aktiengesellschaft Diagnostic miRNA markers for Alzheimer
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EP2733220B1 (en) 2012-11-16 2017-10-18 Siemens Aktiengesellschaft Novel miRNA as a diagnostic marker for Alzheimer's Disease
CN103045596A (zh) * 2012-12-20 2013-04-17 徐勇 唐氏综合征21号染色体相关miRNA、基因、筛选方法和应用
CN103045736B (zh) * 2012-12-20 2014-09-17 徐勇 唐氏综合征21号染色体miRNA差异表达图谱模型、构建方法及应用
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US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
TWI758011B (zh) 2014-07-18 2022-03-11 香港中文大學 Ｄｎａ混合物中之組織甲基化模式分析
EP3298169B1 (en) 2015-05-18 2024-10-02 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
US10428391B2 (en) 2015-07-27 2019-10-01 The Johns Hopkins University Method to use viral and host methylation markers for cervical cancer screening and triage in liquid prep, serum/plasma, and urine: PCR and sequencing based process methods
WO2017044710A1 (en) * 2015-09-11 2017-03-16 Corning Incorporated Compositions and methods for nucleic acid purification from blood samples
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WO2018045359A1 (en) * 2016-09-02 2018-03-08 Karius, Inc. Detection and treatment of infection during pregnancy
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IL266347B2 (en) 2016-11-30 2025-01-01 Univ Hong Kong Chinese Analysis of cell-free DNA in urine and other samples
US10907211B1 (en) 2017-02-16 2021-02-02 Quantgene Inc. Methods and compositions for detecting cancer biomarkers in bodily fluids
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
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Also Published As

Publication number Publication date
US20150197805A1 (en) 2015-07-16
EP2195450B2 (en) 2016-07-20
EP2195450B1 (en) 2013-04-03
JP2010536372A (ja) 2010-12-02
PT2612926T (pt) 2018-03-02
TR201802758T4 (tr) 2018-03-21
AU2014210676B2 (en) 2017-04-06
CN105400868A (zh) 2016-03-16
CN105400868B (zh) 2021-03-26
HK1218767A1 (zh) 2017-03-10
EP2195450A2 (en) 2010-06-16
EP2612926A1 (en) 2013-07-10
CN101861399A (zh) 2010-10-13
HRP20130618T1 (en) 2013-07-31
EP2612926B1 (en) 2017-11-29
AU2008289447A1 (en) 2009-02-26
DK2612926T3 (en) 2018-03-12
DK2195450T4 (en) 2016-10-24
US8486626B2 (en) 2013-07-16
US20180135126A1 (en) 2018-05-17
US20090081640A1 (en) 2009-03-26
CA2696403C (en) 2018-01-02
HUE019019T5 (en) 2017-04-28
DK2195450T3 (da) 2013-06-24
ES2660785T3 (es) 2018-03-26
ES2415245T5 (es) 2016-12-23
JP5416110B2 (ja) 2014-02-12
PT2195450E (pt) 2013-07-10
WO2009025852A2 (en) 2009-02-26
CA2696403A1 (en) 2009-02-26
NO2612926T3 (enExample) 2018-04-28
CN101861399B (zh) 2015-11-25
AU2014210676A1 (en) 2014-08-28
ES2415245T3 (es) 2013-07-24
CY1114111T1 (el) 2016-07-27
US20200283851A1 (en) 2020-09-10
WO2009025852A3 (en) 2009-05-07
PL2612926T3 (pl) 2018-07-31
PL2195450T3 (pl) 2013-09-30

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