CN101861399B - 使用miRNA检测体内细胞死亡情况的方法 - Google Patents

使用miRNA检测体内细胞死亡情况的方法 Download PDF

Info

Publication number
CN101861399B
CN101861399B CN200880113585.0A CN200880113585A CN101861399B CN 101861399 B CN101861399 B CN 101861399B CN 200880113585 A CN200880113585 A CN 200880113585A CN 101861399 B CN101861399 B CN 101861399B
Authority
CN
China
Prior art keywords
purposes
mirna
urine
specific
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200880113585.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN101861399A (zh
Inventor
E·M·沙克特曼
H·S·梅尔科尼杨
S·R·乌曼斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiff Oncology Inc
Original Assignee
Trovagene Inc
Xenomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40378881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101861399(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Trovagene Inc, Xenomics Inc filed Critical Trovagene Inc
Priority to CN201510649676.8A priority Critical patent/CN105400868B/zh
Publication of CN101861399A publication Critical patent/CN101861399A/zh
Application granted granted Critical
Publication of CN101861399B publication Critical patent/CN101861399B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200880113585.0A 2007-08-22 2008-08-22 使用miRNA检测体内细胞死亡情况的方法 Expired - Fee Related CN101861399B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510649676.8A CN105400868B (zh) 2007-08-22 2008-08-22 使用miRNA检测体内细胞死亡情况的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96587107P 2007-08-22 2007-08-22
US60/965,871 2007-08-22
PCT/US2008/009991 WO2009025852A2 (en) 2007-08-22 2008-08-22 Methods of using mirna for detection of in vivo cell death

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510649676.8A Division CN105400868B (zh) 2007-08-22 2008-08-22 使用miRNA检测体内细胞死亡情况的方法

Publications (2)

Publication Number Publication Date
CN101861399A CN101861399A (zh) 2010-10-13
CN101861399B true CN101861399B (zh) 2015-11-25

Family

ID=40378881

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880113585.0A Expired - Fee Related CN101861399B (zh) 2007-08-22 2008-08-22 使用miRNA检测体内细胞死亡情况的方法
CN201510649676.8A Expired - Fee Related CN105400868B (zh) 2007-08-22 2008-08-22 使用miRNA检测体内细胞死亡情况的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510649676.8A Expired - Fee Related CN105400868B (zh) 2007-08-22 2008-08-22 使用miRNA检测体内细胞死亡情况的方法

Country Status (16)

Country Link
US (4) US8486626B2 (enExample)
EP (2) EP2612926B1 (enExample)
JP (1) JP5416110B2 (enExample)
CN (2) CN101861399B (enExample)
AU (2) AU2008289447B2 (enExample)
CA (1) CA2696403C (enExample)
CY (1) CY1114111T1 (enExample)
DK (2) DK2612926T3 (enExample)
ES (2) ES2660785T3 (enExample)
HR (1) HRP20130618T1 (enExample)
HU (1) HUE019019T5 (enExample)
NO (1) NO2612926T3 (enExample)
PL (2) PL2612926T3 (enExample)
PT (2) PT2612926T (enExample)
TR (1) TR201802758T4 (enExample)
WO (1) WO2009025852A2 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009132273A2 (en) * 2008-04-25 2009-10-29 Merck & Co., Inc. Microrna biomarkers of tissue injury
WO2010004562A2 (en) * 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer
ES2532153T3 (es) * 2008-07-18 2015-03-24 Trovagene, Inc. Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR
CA2757711A1 (en) * 2009-04-14 2010-10-21 Merck Sharp & Dohme Corp. Microrna as a biomarker of pancreatic islet beta-cell engagement
CA2767616A1 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
EP3118334A1 (en) * 2009-11-04 2017-01-18 DiamiR, LLC Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases
JP2013509883A (ja) 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
WO2011143659A2 (en) * 2010-05-14 2011-11-17 Fluidigm Corporation Nucleic acid isolation methods
JP6211511B2 (ja) * 2011-04-18 2017-10-11 ディアミール, エルエルシーDiamir, Llc ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ）
CN102188719B (zh) * 2011-05-12 2012-12-19 南方医科大学 EB病毒miR-BART3反义寡聚核苷酸在制备治疗鼻咽癌的药物中的应用
US9771617B2 (en) * 2011-06-27 2017-09-26 Eisai R&D Management Co., Ltd. Microrna biomarkers indicative of alzheimer's disease
WO2013022953A2 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof
CA3067612A1 (en) * 2011-09-22 2013-03-28 Lineage Biosciences, Inc. Compositions and methods for analyzing heterogeneous samples
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
HK1211624A1 (en) * 2012-01-27 2016-05-27 The Board Of Trustees Of The University Of The Leland Stanford Junior University Methods for profiling and quantitating cell-free rna
US20140087964A1 (en) * 2012-09-24 2014-03-27 University Of Virginia Patent Foundation Compositions and methods for detecting aberrant regulation, expression, and levels of hgh
CN104903468B (zh) * 2012-11-16 2019-04-23 萨尔大学 用于帕金森氏病的新诊断MiRNA标志物
EP2733219B1 (en) 2012-11-16 2017-09-20 Siemens Aktiengesellschaft Diagnostic miRNA markers for Alzheimer
EP2733220B1 (en) 2012-11-16 2017-10-18 Siemens Aktiengesellschaft Novel miRNA as a diagnostic marker for Alzheimer's Disease
CN103045596A (zh) * 2012-12-20 2013-04-17 徐勇 唐氏综合征21号染色体相关miRNA、基因、筛选方法和应用
CN103045736B (zh) * 2012-12-20 2014-09-17 徐勇 唐氏综合征21号染色体miRNA差异表达图谱模型、构建方法及应用
EP2759602A1 (en) 2013-01-25 2014-07-30 Charité - Universitätsmedizin Berlin Non-invasive prenatal genetic diagnostic methods
DK2970958T3 (en) 2013-03-15 2018-02-19 Lineage Biosciences Inc METHODS FOR SEQUENCING THE IMMUN REPERTOIR
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11062789B2 (en) 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
EP4450636A3 (en) 2015-05-18 2025-01-01 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
US10428391B2 (en) 2015-07-27 2019-10-01 The Johns Hopkins University Method to use viral and host methylation markers for cervical cancer screening and triage in liquid prep, serum/plasma, and urine: PCR and sequencing based process methods
CN108026570A (zh) * 2015-09-11 2018-05-11 康宁股份有限公司 从血液样品中纯化核酸的组合物和方法
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
WO2018045359A1 (en) * 2016-09-02 2018-03-08 Karius, Inc. Detection and treatment of infection during pregnancy
CA3043709A1 (en) 2016-11-14 2018-05-17 Berg Llc Methods for treating parkinson's disease
WO2018099418A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
US10907211B1 (en) 2017-02-16 2021-02-02 Quantgene Inc. Methods and compositions for detecting cancer biomarkers in bodily fluids
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
GB2612911B (en) 2019-02-14 2023-11-22 Mirvie Inc Methods and systems for determining a pregnancy-related state of a subject
CN114449954B (zh) * 2019-10-29 2025-05-02 国立研究开发法人国立循环器病研究中心 脑梗塞治疗辅助系统
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856088A (en) 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5168039A (en) 1990-09-28 1992-12-01 The Board Of Trustees Of The University Of Arkansas Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
US5770366A (en) 1993-07-20 1998-06-23 Boehringer Mannheim Gmbh Melanoma-inhibiting protein
WO1995004140A1 (en) 1993-07-28 1995-02-09 Akzo Nobel N.V. Process for isolating nucleic acid from gram positive microorganisms
AU689815B2 (en) 1993-08-30 1998-04-09 Promega Corporation Nucleic acid purification compositions and methods
US5631130A (en) 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
RU2204608C2 (ru) 1994-06-09 2003-05-20 Инноженетик Н.В. Способ выявления устойчивости микобактерий к рифампицину с возможной их идентификацией, способ гибридизации, зонд и композиция для его осуществления, набор праймеров (варианты)
US5731150A (en) 1995-11-01 1998-03-24 Chiron Diagnostic Corporation IS6110 based molecular detection of mycobacterium tuberculosis
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US20020119478A1 (en) 1997-05-30 2002-08-29 Diagen Corporation Methods for detection of nucleic acid sequences in urine
DE69841989D1 (de) 1997-05-30 2010-12-16 Trovagene Inc Verfahren zur Bestimmung von Nukleinsäuresequenzen in Urin
US6492144B1 (en) 1997-05-30 2002-12-10 Diagen Corporation Methods for detection of nucleic acid sequences in urine
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
US20060204989A1 (en) * 1998-09-22 2006-09-14 Kopreski Michael S Comparative analysis of extracellular RNA species
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US20040053264A1 (en) 2002-02-01 2004-03-18 Park Sung Sup Clinical panel assay using DNA chips
EP2290071B1 (en) * 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
ITRM20050067A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
AU2006214444B8 (en) 2005-02-17 2012-04-05 Trovagene, Inc. Compositions and methods for detecting pathogen specific nucleic acids in urine
EP1856295B1 (en) 2005-02-17 2013-04-03 TrovaGene, Inc. Compositions and methods for detecting viral specific nucleic acids in urine
US7914982B2 (en) 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
US20060292616A1 (en) * 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
DE102005059315A1 (de) * 2005-12-09 2007-06-14 Qiagen Gmbh Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren
US20070202511A1 (en) * 2006-02-28 2007-08-30 Sigma-Aldrich Co. Methods and compositions for the rapid isolation of small RNA molecules
ES2532153T3 (es) 2008-07-18 2015-03-24 Trovagene, Inc. Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YING-HISU SU.TRANSRENAL DNA AS A DIAGNOSTIC TOOL IMPORTANT TECHNICAL NOTES.《ANNALS NEW YORK ACADEMY OF SCIENCES》.2004,第1022卷第81－89页. *

Also Published As

Publication number Publication date
ES2415245T3 (es) 2013-07-24
AU2014210676B2 (en) 2017-04-06
EP2195450A2 (en) 2010-06-16
NO2612926T3 (enExample) 2018-04-28
DK2195450T3 (da) 2013-06-24
AU2008289447A1 (en) 2009-02-26
CN105400868B (zh) 2021-03-26
CN101861399A (zh) 2010-10-13
WO2009025852A2 (en) 2009-02-26
EP2612926B1 (en) 2017-11-29
PL2195450T3 (pl) 2013-09-30
PT2612926T (pt) 2018-03-02
WO2009025852A3 (en) 2009-05-07
CN105400868A (zh) 2016-03-16
EP2612926A1 (en) 2013-07-10
US20200283851A1 (en) 2020-09-10
ES2415245T5 (es) 2016-12-23
DK2195450T4 (en) 2016-10-24
JP2010536372A (ja) 2010-12-02
DK2612926T3 (en) 2018-03-12
EP2195450B2 (en) 2016-07-20
EP2195450B1 (en) 2013-04-03
AU2014210676A1 (en) 2014-08-28
CA2696403C (en) 2018-01-02
PT2195450E (pt) 2013-07-10
AU2008289447B2 (en) 2014-09-04
ES2660785T3 (es) 2018-03-26
CY1114111T1 (el) 2016-07-27
US8486626B2 (en) 2013-07-16
JP5416110B2 (ja) 2014-02-12
TR201802758T4 (tr) 2018-03-21
HK1218767A1 (zh) 2017-03-10
US20090081640A1 (en) 2009-03-26
HUE019019T5 (en) 2017-04-28
HRP20130618T1 (en) 2013-07-31
US20180135126A1 (en) 2018-05-17
PL2612926T3 (pl) 2018-07-31
CA2696403A1 (en) 2009-02-26
US20150197805A1 (en) 2015-07-16

Similar Documents

Publication Publication Date Title
CN101861399B (zh) 使用miRNA检测体内细胞死亡情况的方法
JP2010536372A5 (enExample)
CN106029900B (zh) 尿生物标志物群、基因表达特征及其使用方法
CN105861712B (zh) 使用来自体液的miRNA来早期检测和监控轻度认知障碍(MCI)和阿尔茨海默病(AD)的方法
CN111733227A (zh) 特发性视神经炎诊断分子标记物circRNA、试剂盒及应用
CN111893188A (zh) 生物标志物linc01356在宫颈癌诊断和治疗中的应用
CN111424096B (zh) 一种与胃腺癌发生发展相关的生物标志物
CN111471772B (zh) 一种用于癌症诊断的分子标志物
HK1218767B (zh) 使用mirna检测体内细胞死亡情况的方法
CN111363808B (zh) 一种与阿尔茨海默相关的生物标志物及其应用
CN111394464B (zh) 放射性损伤疾病的检测试剂及其应用
CN110079601B (zh) 放射性相关疾病诊疗标志物及其应用
Totonchi et al. Samaneh Alsadat Sadati1, 2, Zahra Chekini3, Faezeh Shekari4, Maryam Hafezi3, Azadeh Ghaheri5, Maryam Shahhoseini2, Ashraf Moini3, 6, Reza Aflatonian3
CN113322321A (zh) 一种乳腺癌基因检测试剂盒及其应用方法
CN110184354A (zh) 生物标志物在癌症诊断中的应用
CN108251519A (zh) 轴前多指病的致病基因及其用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20151125

Termination date: 20180822

CF01 Termination of patent right due to non-payment of annual fee