PT2612926T - Métodos para utilização de mirna para deteção de morte celular in vivo - Google Patents

Métodos para utilização de mirna para deteção de morte celular in vivo

Info

Publication number
PT2612926T
PT2612926T PT131619850T PT13161985T PT2612926T PT 2612926 T PT2612926 T PT 2612926T PT 131619850 T PT131619850 T PT 131619850T PT 13161985 T PT13161985 T PT 13161985T PT 2612926 T PT2612926 T PT 2612926T
Authority
PT
Portugal
Prior art keywords
mirna
detection
methods
cell death
vivo cell
Prior art date
Application number
PT131619850T
Other languages
English (en)
Inventor
M Shekhtman Eugene
S Melkonyan Hovsep
R Umansky Samuil
S Scheinker Vladimir
Original Assignee
Trovagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40378881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2612926(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Trovagene Inc filed Critical Trovagene Inc
Publication of PT2612926T publication Critical patent/PT2612926T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT131619850T 2007-08-22 2008-08-22 Métodos para utilização de mirna para deteção de morte celular in vivo PT2612926T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96587107P 2007-08-22 2007-08-22

Publications (1)

Publication Number Publication Date
PT2612926T true PT2612926T (pt) 2018-03-02

Family

ID=40378881

Family Applications (2)

Application Number Title Priority Date Filing Date
PT131619850T PT2612926T (pt) 2007-08-22 2008-08-22 Métodos para utilização de mirna para deteção de morte celular in vivo
PT87955233T PT2195450E (pt) 2007-08-22 2008-08-22 Métodos de utilização de miarn para detecção de morte celular in vivo

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT87955233T PT2195450E (pt) 2007-08-22 2008-08-22 Métodos de utilização de miarn para detecção de morte celular in vivo

Country Status (17)

Country Link
US (4) US8486626B2 (pt)
EP (2) EP2195450B2 (pt)
JP (1) JP5416110B2 (pt)
CN (2) CN101861399B (pt)
AU (2) AU2008289447B2 (pt)
CA (1) CA2696403C (pt)
CY (1) CY1114111T1 (pt)
DK (2) DK2612926T3 (pt)
ES (2) ES2415245T5 (pt)
HK (1) HK1218767A1 (pt)
HR (1) HRP20130618T1 (pt)
HU (1) HUE019019T5 (pt)
NO (1) NO2612926T3 (pt)
PL (2) PL2612926T3 (pt)
PT (2) PT2612926T (pt)
TR (1) TR201802758T4 (pt)
WO (1) WO2009025852A2 (pt)

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US20120034608A1 (en) * 2009-04-14 2012-02-09 Merck Sharp & Dohme Corp. Microrna as a biomarker of pancreatic islet beta-cell engagement
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CA2780222C (en) * 2009-11-04 2021-11-16 Diamir, Llc Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases
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EP2569453B1 (en) * 2010-05-14 2015-12-16 Fluidigm Corporation Nucleic acid isolation methods
RU2626540C2 (ru) 2011-04-18 2017-07-28 Диамир, Ллс Способы обнаружения патологических изменений в органе или системе органов
CN102188719B (zh) * 2011-05-12 2012-12-19 南方医科大学 EB病毒miR-BART3反义寡聚核苷酸在制备治疗鼻咽癌的药物中的应用
CA2840196C (en) 2011-06-27 2022-09-20 Eisai R&D Management Co., Ltd. Microrna biomarkers indicative of alzheimer's disease
US20130040303A1 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for Alzheimer's Disease and/or Mild Cognitive Impairment, and Use Thereof
CA3067612A1 (en) * 2011-09-22 2013-03-28 Lineage Biosciences, Inc. Compositions and methods for analyzing heterogeneous samples
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
AU2013211850B8 (en) 2012-01-27 2017-06-29 The Board Of Trustees Of The Leland Stanford Junior University Methods for profiling and quantitating cell-free RNA
US20140087964A1 (en) * 2012-09-24 2014-03-27 University Of Virginia Patent Foundation Compositions and methods for detecting aberrant regulation, expression, and levels of hgh
EP2733219B1 (en) 2012-11-16 2017-09-20 Siemens Aktiengesellschaft Diagnostic miRNA markers for Alzheimer
EP2733220B1 (en) * 2012-11-16 2017-10-18 Siemens Aktiengesellschaft Novel miRNA as a diagnostic marker for Alzheimer's Disease
WO2014075822A1 (en) 2012-11-16 2014-05-22 Siemens Aktiengesellschaft New diagnostic mirna markers for parkinson disease
CN103045596A (zh) * 2012-12-20 2013-04-17 徐勇 唐氏综合征21号染色体相关miRNA、基因、筛选方法和应用
CN103045736B (zh) * 2012-12-20 2014-09-17 徐勇 唐氏综合征21号染色体miRNA差异表达图谱模型、构建方法及应用
EP2759602A1 (en) 2013-01-25 2014-07-30 Charité - Universitätsmedizin Berlin Non-invasive prenatal genetic diagnostic methods
WO2014144713A2 (en) 2013-03-15 2014-09-18 Immumetrix, Inc. Methods of sequencing the immune repertoire
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
EP3169813B1 (en) 2014-07-18 2019-06-12 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
CA2986036C (en) 2015-05-18 2022-07-26 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
WO2017019751A1 (en) 2015-07-27 2017-02-02 The Johns Hopkins University Method to use viral and host methylation markers for cervical cancer screening and triage in liquid prep, serum/plasma, and urine: pcr and sequencing based process methods
EP3347490A1 (en) * 2015-09-11 2018-07-18 Corning Incorporated Compositions and methods for nucleic acid purification from blood samples
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
WO2017165458A1 (en) 2016-03-21 2017-09-28 Diamir, Llc Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases
WO2018045359A1 (en) * 2016-09-02 2018-03-08 Karius, Inc. Detection and treatment of infection during pregnancy
US11001891B2 (en) 2016-11-14 2021-05-11 Berg Llc Methods for treating Parkinson's disease
IL315032A (en) 2016-11-30 2024-10-01 The Chinese Univ Of Hong Kong Analysis of cell-free DNA in urine and other samples
US10907211B1 (en) 2017-02-16 2021-02-02 Quantgene Inc. Methods and compositions for detecting cancer biomarkers in bodily fluids
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
CA3126990A1 (en) 2019-02-14 2020-08-20 Maneesh Jain Methods and systems for determining a pregnancy-related state of a subject
JP7389437B2 (ja) * 2019-10-29 2023-11-30 国立研究開発法人国立循環器病研究センター 脳梗塞治療支援システム
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay

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Also Published As

Publication number Publication date
WO2009025852A2 (en) 2009-02-26
CA2696403A1 (en) 2009-02-26
US20180135126A1 (en) 2018-05-17
CY1114111T1 (el) 2016-07-27
ES2415245T5 (es) 2016-12-23
WO2009025852A3 (en) 2009-05-07
HK1218767A1 (zh) 2017-03-10
AU2014210676B2 (en) 2017-04-06
HRP20130618T1 (en) 2013-07-31
PT2195450E (pt) 2013-07-10
EP2195450B2 (en) 2016-07-20
HUE019019T5 (en) 2017-04-28
DK2195450T3 (da) 2013-06-24
EP2612926B1 (en) 2017-11-29
PL2195450T3 (pl) 2013-09-30
ES2660785T3 (es) 2018-03-26
US8486626B2 (en) 2013-07-16
CN105400868A (zh) 2016-03-16
CN101861399A (zh) 2010-10-13
US20200283851A1 (en) 2020-09-10
NO2612926T3 (pt) 2018-04-28
CN105400868B (zh) 2021-03-26
US20090081640A1 (en) 2009-03-26
CA2696403C (en) 2018-01-02
AU2014210676A1 (en) 2014-08-28
CN101861399B (zh) 2015-11-25
EP2195450A2 (en) 2010-06-16
TR201802758T4 (tr) 2018-03-21
PL2612926T3 (pl) 2018-07-31
DK2195450T4 (en) 2016-10-24
DK2612926T3 (en) 2018-03-12
JP5416110B2 (ja) 2014-02-12
EP2612926A1 (en) 2013-07-10
EP2195450B1 (en) 2013-04-03
US20150197805A1 (en) 2015-07-16
ES2415245T3 (es) 2013-07-24
AU2008289447A1 (en) 2009-02-26
JP2010536372A (ja) 2010-12-02
AU2008289447B2 (en) 2014-09-04

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