TR201802758T4 - In vivo hücre ölümünün saptanmasına yönelik miRNA kullanmanın yöntemleri. - Google Patents

In vivo hücre ölümünün saptanmasına yönelik miRNA kullanmanın yöntemleri. Download PDF

Info

Publication number
TR201802758T4
TR201802758T4 TR2018/02758T TR201802758T TR201802758T4 TR 201802758 T4 TR201802758 T4 TR 201802758T4 TR 2018/02758 T TR2018/02758 T TR 2018/02758T TR 201802758 T TR201802758 T TR 201802758T TR 201802758 T4 TR201802758 T4 TR 201802758T4
Authority
TR
Turkey
Prior art keywords
mirna
urea
specific
disease
patient
Prior art date
Application number
TR2018/02758T
Other languages
English (en)
Turkish (tr)
Inventor
M Shekhtman Eugene
S Melkonyan Hovsep
R Umansky Samuil
S Scheinker Vladimir
Original Assignee
Trovagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40378881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201802758(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Trovagene Inc filed Critical Trovagene Inc
Publication of TR201802758T4 publication Critical patent/TR201802758T4/tr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/705Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TR2018/02758T 2007-08-22 2008-08-22 In vivo hücre ölümünün saptanmasına yönelik miRNA kullanmanın yöntemleri. TR201802758T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96587107P 2007-08-22 2007-08-22

Publications (1)

Publication Number Publication Date
TR201802758T4 true TR201802758T4 (tr) 2018-03-21

Family

ID=40378881

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/02758T TR201802758T4 (tr) 2007-08-22 2008-08-22 In vivo hücre ölümünün saptanmasına yönelik miRNA kullanmanın yöntemleri.

Country Status (16)

Country Link
US (4) US8486626B2 (enExample)
EP (2) EP2612926B1 (enExample)
JP (1) JP5416110B2 (enExample)
CN (2) CN101861399B (enExample)
AU (2) AU2008289447B2 (enExample)
CA (1) CA2696403C (enExample)
CY (1) CY1114111T1 (enExample)
DK (2) DK2612926T3 (enExample)
ES (2) ES2660785T3 (enExample)
HR (1) HRP20130618T1 (enExample)
HU (1) HUE019019T5 (enExample)
NO (1) NO2612926T3 (enExample)
PL (2) PL2612926T3 (enExample)
PT (2) PT2612926T (enExample)
TR (1) TR201802758T4 (enExample)
WO (1) WO2009025852A2 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009132273A2 (en) * 2008-04-25 2009-10-29 Merck & Co., Inc. Microrna biomarkers of tissue injury
WO2010004562A2 (en) * 2008-07-09 2010-01-14 Rosetta Genomics Ltd. Methods and compositions for detecting colorectal cancer
ES2532153T3 (es) * 2008-07-18 2015-03-24 Trovagene, Inc. Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR
CA2757711A1 (en) * 2009-04-14 2010-10-21 Merck Sharp & Dohme Corp. Microrna as a biomarker of pancreatic islet beta-cell engagement
CA2767616A1 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
EP3118334A1 (en) * 2009-11-04 2017-01-18 DiamiR, LLC Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases
JP2013509883A (ja) 2009-11-06 2013-03-21 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 臓器移植患者における移植片拒絶反応の非侵襲的診断方法
WO2011143659A2 (en) * 2010-05-14 2011-11-17 Fluidigm Corporation Nucleic acid isolation methods
JP6211511B2 (ja) * 2011-04-18 2017-10-11 ディアミール, エルエルシーDiamir, Llc miRNAに基づくユニバーサルスクリーニングテスト(UST)
CN102188719B (zh) * 2011-05-12 2012-12-19 南方医科大学 EB病毒miR-BART3反义寡聚核苷酸在制备治疗鼻咽癌的药物中的应用
US9771617B2 (en) * 2011-06-27 2017-09-26 Eisai R&D Management Co., Ltd. Microrna biomarkers indicative of alzheimer's disease
WO2013022953A2 (en) * 2011-08-08 2013-02-14 Eugenia Wang Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof
CA3067612A1 (en) * 2011-09-22 2013-03-28 Lineage Biosciences, Inc. Compositions and methods for analyzing heterogeneous samples
ITRM20110685A1 (it) 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
HK1211624A1 (en) * 2012-01-27 2016-05-27 The Board Of Trustees Of The University Of The Leland Stanford Junior University Methods for profiling and quantitating cell-free rna
US20140087964A1 (en) * 2012-09-24 2014-03-27 University Of Virginia Patent Foundation Compositions and methods for detecting aberrant regulation, expression, and levels of hgh
CN104903468B (zh) * 2012-11-16 2019-04-23 萨尔大学 用于帕金森氏病的新诊断MiRNA标志物
EP2733219B1 (en) 2012-11-16 2017-09-20 Siemens Aktiengesellschaft Diagnostic miRNA markers for Alzheimer
EP2733220B1 (en) 2012-11-16 2017-10-18 Siemens Aktiengesellschaft Novel miRNA as a diagnostic marker for Alzheimer's Disease
CN103045596A (zh) * 2012-12-20 2013-04-17 徐勇 唐氏综合征21号染色体相关miRNA、基因、筛选方法和应用
CN103045736B (zh) * 2012-12-20 2014-09-17 徐勇 唐氏综合征21号染色体miRNA差异表达图谱模型、构建方法及应用
EP2759602A1 (en) 2013-01-25 2014-07-30 Charité - Universitätsmedizin Berlin Non-invasive prenatal genetic diagnostic methods
DK2970958T3 (en) 2013-03-15 2018-02-19 Lineage Biosciences Inc METHODS FOR SEQUENCING THE IMMUN REPERTOIR
WO2015073972A1 (en) 2013-11-18 2015-05-21 Diamir, Llc METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD)
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11062789B2 (en) 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
EP4450636A3 (en) 2015-05-18 2025-01-01 Karius, Inc. Compositions and methods for enriching populations of nucleic acids
US10428391B2 (en) 2015-07-27 2019-10-01 The Johns Hopkins University Method to use viral and host methylation markers for cervical cancer screening and triage in liquid prep, serum/plasma, and urine: PCR and sequencing based process methods
CN108026570A (zh) * 2015-09-11 2018-05-11 康宁股份有限公司 从血液样品中纯化核酸的组合物和方法
US10975436B2 (en) 2016-01-05 2021-04-13 Diamir, Llc Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders
US11149313B2 (en) 2016-03-21 2021-10-19 Diamir, Llc Methods of using miRNAs from bodily fluids for detection and differentiation of neurodegenerative diseases
WO2018045359A1 (en) * 2016-09-02 2018-03-08 Karius, Inc. Detection and treatment of infection during pregnancy
CA3043709A1 (en) 2016-11-14 2018-05-17 Berg Llc Methods for treating parkinson's disease
WO2018099418A1 (en) 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
US10907211B1 (en) 2017-02-16 2021-02-02 Quantgene Inc. Methods and compositions for detecting cancer biomarkers in bodily fluids
US10781487B2 (en) 2017-07-24 2020-09-22 Diamir, Llc miRNA-based methods for detecting and monitoring aging
GB2612911B (en) 2019-02-14 2023-11-22 Mirvie Inc Methods and systems for determining a pregnancy-related state of a subject
CN114449954B (zh) * 2019-10-29 2025-05-02 国立研究开发法人国立循环器病研究中心 脑梗塞治疗辅助系统
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856088A (en) 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5168039A (en) 1990-09-28 1992-12-01 The Board Of Trustees Of The University Of Arkansas Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
US6020124A (en) 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
US5770366A (en) 1993-07-20 1998-06-23 Boehringer Mannheim Gmbh Melanoma-inhibiting protein
WO1995004140A1 (en) 1993-07-28 1995-02-09 Akzo Nobel N.V. Process for isolating nucleic acid from gram positive microorganisms
AU689815B2 (en) 1993-08-30 1998-04-09 Promega Corporation Nucleic acid purification compositions and methods
US5631130A (en) 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
RU2204608C2 (ru) 1994-06-09 2003-05-20 Инноженетик Н.В. Способ выявления устойчивости микобактерий к рифампицину с возможной их идентификацией, способ гибридизации, зонд и композиция для его осуществления, набор праймеров (варианты)
US5731150A (en) 1995-11-01 1998-03-24 Chiron Diagnostic Corporation IS6110 based molecular detection of mycobacterium tuberculosis
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US20020119478A1 (en) 1997-05-30 2002-08-29 Diagen Corporation Methods for detection of nucleic acid sequences in urine
DE69841989D1 (de) 1997-05-30 2010-12-16 Trovagene Inc Verfahren zur Bestimmung von Nukleinsäuresequenzen in Urin
US6492144B1 (en) 1997-05-30 2002-12-10 Diagen Corporation Methods for detection of nucleic acid sequences in urine
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
US20060204989A1 (en) * 1998-09-22 2006-09-14 Kopreski Michael S Comparative analysis of extracellular RNA species
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US20040053264A1 (en) 2002-02-01 2004-03-18 Park Sung Sup Clinical panel assay using DNA chips
EP2290071B1 (en) * 2004-05-28 2014-12-31 Asuragen, Inc. Methods and compositions involving microRNA
ITRM20050067A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
AU2006214444B8 (en) 2005-02-17 2012-04-05 Trovagene, Inc. Compositions and methods for detecting pathogen specific nucleic acids in urine
EP1856295B1 (en) 2005-02-17 2013-04-03 TrovaGene, Inc. Compositions and methods for detecting viral specific nucleic acids in urine
US7914982B2 (en) 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
US20060292616A1 (en) * 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
DE102005059315A1 (de) * 2005-12-09 2007-06-14 Qiagen Gmbh Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren
US20070202511A1 (en) * 2006-02-28 2007-08-30 Sigma-Aldrich Co. Methods and compositions for the rapid isolation of small RNA molecules
ES2532153T3 (es) 2008-07-18 2015-03-24 Trovagene, Inc. Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR

Also Published As

Publication number Publication date
ES2415245T3 (es) 2013-07-24
AU2014210676B2 (en) 2017-04-06
EP2195450A2 (en) 2010-06-16
NO2612926T3 (enExample) 2018-04-28
DK2195450T3 (da) 2013-06-24
AU2008289447A1 (en) 2009-02-26
CN105400868B (zh) 2021-03-26
CN101861399A (zh) 2010-10-13
WO2009025852A2 (en) 2009-02-26
EP2612926B1 (en) 2017-11-29
PL2195450T3 (pl) 2013-09-30
CN101861399B (zh) 2015-11-25
PT2612926T (pt) 2018-03-02
WO2009025852A3 (en) 2009-05-07
CN105400868A (zh) 2016-03-16
EP2612926A1 (en) 2013-07-10
US20200283851A1 (en) 2020-09-10
ES2415245T5 (es) 2016-12-23
DK2195450T4 (en) 2016-10-24
JP2010536372A (ja) 2010-12-02
DK2612926T3 (en) 2018-03-12
EP2195450B2 (en) 2016-07-20
EP2195450B1 (en) 2013-04-03
AU2014210676A1 (en) 2014-08-28
CA2696403C (en) 2018-01-02
PT2195450E (pt) 2013-07-10
AU2008289447B2 (en) 2014-09-04
ES2660785T3 (es) 2018-03-26
CY1114111T1 (el) 2016-07-27
US8486626B2 (en) 2013-07-16
JP5416110B2 (ja) 2014-02-12
HK1218767A1 (zh) 2017-03-10
US20090081640A1 (en) 2009-03-26
HUE019019T5 (en) 2017-04-28
HRP20130618T1 (en) 2013-07-31
US20180135126A1 (en) 2018-05-17
PL2612926T3 (pl) 2018-07-31
CA2696403A1 (en) 2009-02-26
US20150197805A1 (en) 2015-07-16

Similar Documents

Publication Publication Date Title
TR201802758T4 (tr) In vivo hücre ölümünün saptanmasına yönelik miRNA kullanmanın yöntemleri.
US12018334B2 (en) Controls for nucleic acid assays
EP2904118B1 (en) Urine exosome mrnas and methods of using same to detect diabetic nephropathy
CN109642229A (zh) 从生物液体分离细胞外囊泡和共分离无细胞dna的自动和手动方法
CN109402262A (zh) 辅助诊断神经母细胞瘤的PCR检测试剂盒及检测miR-199a-3p表达水平的方法
CN105063052A (zh) 急性髓系白血病miRNA标记物
CN107385101A (zh) 一种检测临床抑郁情绪及抑郁症的试剂盒及其应用
CN107312775B (zh) hsa_circRNA_103096在肝癌的诊断、治疗及预后中的应用
CN111349698A (zh) 与中枢神经系统感染疾病相关的外泌体内核酸标志物及其应用
CN109504760A (zh) 作为呼吸道合胞病毒感染诊断标志物的luc7l及其应用
WO2019038660A1 (en) EXOSOMAL PROFILING FOR THE DIAGNOSIS AND MONITORING OF VASCULITE AND VASCULOPATHIES, INCLUDING KAWASAKI'S DISEASE
CN120796529A (zh) 一种用于检测布鲁氏菌病的miRNA生物标志物组合物和试剂盒
CN117431309A (zh) circRNA_03628在制备动眼神经麻痹特异性辅助诊断试剂中的应用
CN118562951A (zh) hsa_circ_0002867标志物在制备肺结核诊断的产品中的应用
CN117448435A (zh) 基于steap4荧光定量pcr诊断活动性结核病的试剂盒及其应用
CN117821579A (zh) 一种用于突发性聋的5hmC分子标记物及其应用
CN116024328A (zh) 外泌体中miRNA在制备神经退行性疾病鉴别诊断及早筛试剂盒中的用途
CN118308531A (zh) 一种基于实时荧光定量pcr技术检测阿龙山病毒的引物探针组、试剂盒和应用
CN121023008A (zh) 一种检测miRNA unconservative_28_471730表达量的引物对和检测方法
CN114015763A (zh) miR-378-5p在系膜增生性肾小球肾炎中的应用
CN114107486A (zh) 一种超氧化物歧化酶1基因突变检测试剂盒及其应用
KR20210007180A (ko) 당뇨병성 신증 진단용 조성물
CN109536598A (zh) Tctn1基因及其表达产物的诊断用途