AU2008279778B2 - Method for Determining Insulin Sensitivity with Biomarkers - Google Patents

Method for Determining Insulin Sensitivity with Biomarkers Download PDF

Info

Publication number
AU2008279778B2
AU2008279778B2 AU2008279778A AU2008279778A AU2008279778B2 AU 2008279778 B2 AU2008279778 B2 AU 2008279778B2 AU 2008279778 A AU2008279778 A AU 2008279778A AU 2008279778 A AU2008279778 A AU 2008279778A AU 2008279778 B2 AU2008279778 B2 AU 2008279778B2
Authority
AU
Australia
Prior art keywords
metabolite
biomarkers
subject
hydroxybutyrate
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2008279778A
Other languages
English (en)
Other versions
AU2008279778A1 (en
Inventor
Danny Alexander
Costel Chirila
Walter Gall
Yun Fu Hu
Kay Lawton
Michael Milburn
Matthew W. Mitchell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabolon Inc
Original Assignee
Metabolon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolon Inc filed Critical Metabolon Inc
Publication of AU2008279778A1 publication Critical patent/AU2008279778A1/en
Priority to AU2014216035A priority Critical patent/AU2014216035B2/en
Application granted granted Critical
Publication of AU2008279778B2 publication Critical patent/AU2008279778B2/en
Priority to AU2016206265A priority patent/AU2016206265B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
AU2008279778A 2007-07-17 2008-07-17 Method for Determining Insulin Sensitivity with Biomarkers Active AU2008279778B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2014216035A AU2014216035B2 (en) 2007-07-17 2014-08-22 Method for Determining Insulin Sensitivity with Biomarkers
AU2016206265A AU2016206265B2 (en) 2007-07-17 2016-07-19 Method for Determining Insulin Sensitivity with Biomarkers

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95028607P 2007-07-17 2007-07-17
US60/950,286 2007-07-17
US3762808P 2008-03-18 2008-03-18
US61/037,628 2008-03-18
PCT/US2008/008756 WO2009014639A2 (en) 2007-07-17 2008-07-17 Biomarkers for pre-diabetes, cardiovascular diseases, and other metabolic-syndrome related disorders and methods using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014216035A Division AU2014216035B2 (en) 2007-07-17 2014-08-22 Method for Determining Insulin Sensitivity with Biomarkers

Publications (2)

Publication Number Publication Date
AU2008279778A1 AU2008279778A1 (en) 2009-01-29
AU2008279778B2 true AU2008279778B2 (en) 2014-09-18

Family

ID=40282019

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008279778A Active AU2008279778B2 (en) 2007-07-17 2008-07-17 Method for Determining Insulin Sensitivity with Biomarkers

Country Status (9)

Country Link
US (5) US8187830B2 (cg-RX-API-DMAC7.html)
EP (1) EP2164977B1 (cg-RX-API-DMAC7.html)
JP (3) JP5701601B2 (cg-RX-API-DMAC7.html)
AU (1) AU2008279778B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0815095B1 (cg-RX-API-DMAC7.html)
CA (1) CA2690541A1 (cg-RX-API-DMAC7.html)
ES (1) ES2443540T3 (cg-RX-API-DMAC7.html)
MX (3) MX341954B (cg-RX-API-DMAC7.html)
WO (1) WO2009014639A2 (cg-RX-API-DMAC7.html)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8216848B2 (en) * 2006-03-24 2012-07-10 Metanomics Gmbh Means and method for diagnosing diabetes
JPWO2008015929A1 (ja) * 2006-08-04 2009-12-24 味の素株式会社 メタボリック・シンドロームの評価方法、メタボリック・シンドローム評価装置、メタボリック・シンドローム評価方法、メタボリック・シンドローム評価システム、メタボリック・シンドローム評価プログラムおよび記録媒体、ならびにメタボリック・シンドロームの予防・改善物質の探索方法
US9867530B2 (en) 2006-08-14 2018-01-16 Volcano Corporation Telescopic side port catheter device with imaging system and method for accessing side branch occlusions
EP2172775A4 (en) * 2007-06-25 2010-12-01 Ajinomoto Kk METHOD OF EVALUATING VISCERAL GREASE ACCUMULATION
US9596993B2 (en) 2007-07-12 2017-03-21 Volcano Corporation Automatic calibration systems and methods of use
JP5524835B2 (ja) 2007-07-12 2014-06-18 ヴォルカノ コーポレイション 生体内撮像用カテーテル
WO2009009802A1 (en) 2007-07-12 2009-01-15 Volcano Corporation Oct-ivus catheter for concurrent luminal imaging
MX341954B (es) 2007-07-17 2016-09-08 Metabolon Inc Biomarcadores para prediabetes, enfermedades cardiovasculares y otros transtornos relacionados con sindrome metabolico, y metodos de uso de los mismos.
WO2009054350A1 (ja) * 2007-10-25 2009-04-30 Ajinomoto Co., Inc. 耐糖能異常の評価方法
EP2546649B1 (en) * 2007-11-02 2015-02-25 Metabolon Inc. Biomarkers for fatty liver disease and methods using the same
EA201400710A1 (ru) 2008-01-18 2015-03-31 Президент Энд Феллоуз Оф Гарвард Колледж Способы детекции признаков заболеваний или состояний в жидкостях организма
US20110111526A1 (en) * 2008-04-09 2011-05-12 B.R.A.H.M.S Gmbh Pro-endothelin-1 for the prediction of impaired peak oxygen consumption
US20100222315A1 (en) * 2008-09-24 2010-09-02 Harbor BioSciencs, Inc. Patient populations and treatment methods
CA2741034C (en) * 2008-10-20 2021-06-22 Liposcience, Inc. Lipoprotein insulin resistance indexes and related methods, systems and computer programs for generating same
JP5866206B2 (ja) 2009-03-10 2016-02-17 デューク ユニバーシティ 冠動脈疾患および心血管イベントのリスクの予測
JP2012522989A (ja) * 2009-03-31 2012-09-27 メタボロン インコーポレイテッド インスリン抵抗性に関連するバイオマーカー、及びそれを使用する方法
EA034552B1 (ru) 2009-05-11 2020-02-19 БЕРГ ЭлЭлСи Способ лечения или предотвращения прогрессирования онкологических заболеваний
WO2011031803A1 (en) * 2009-09-08 2011-03-17 Nodality, Inc. Analysis of cell networks
JP5787339B2 (ja) * 2009-12-28 2015-09-30 学校法人福岡大学 糖尿病前症の検査方法
EP2550533A4 (en) * 2010-03-23 2014-01-08 Purdue Research Foundation EARLY RECOGNITION OF RECYCLING BREAST CANCER BY METABOLIT PROFILING
CN103037878B (zh) 2010-06-08 2015-06-24 可尔必思株式会社 脂质代谢改善剂
CN103124795A (zh) 2010-07-23 2013-05-29 哈佛大学校长及研究员协会 利用吞噬细胞检测疾病或病症的方法
WO2012012717A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
MX361944B (es) 2010-07-23 2018-12-19 President And Fellows Of Harvard College Star Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales.
US20130210647A1 (en) 2010-07-23 2013-08-15 President And Fellows Of Harvard College Methods of Detecting Cardiovascular Diseases or Conditions
WO2012012694A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
WO2012013667A1 (en) * 2010-07-30 2012-02-02 Technische Universität Graz Analyses of analytes by mass spectrometry with values in at least 3 dimensions
WO2012058298A1 (en) * 2010-10-26 2012-05-03 Mayo Foundation For Medical Education And Research Biomarkers of reduced insulin action
US11141063B2 (en) 2010-12-23 2021-10-12 Philips Image Guided Therapy Corporation Integrated system architectures and methods of use
AU2011346553A1 (en) * 2010-12-23 2013-07-11 Metanomics Health Gmbh Means and method for predicting diabetes
US11040140B2 (en) 2010-12-31 2021-06-22 Philips Image Guided Therapy Corporation Deep vein thrombosis therapeutic methods
WO2012116074A1 (en) * 2011-02-22 2012-08-30 Mayo Foundation For Medical Education And Research Biomarkers of insulin sensitivity
CN103608323B (zh) 2011-04-04 2016-08-17 博格有限责任公司 治疗中枢神经系统肿瘤的方法
WO2013002381A1 (ja) 2011-06-30 2013-01-03 味の素株式会社 脂肪性肝疾患の評価方法、脂肪性肝疾患評価装置、脂肪性肝疾患評価方法、脂肪性肝疾患評価プログラム、脂肪性肝疾患評価システム、情報通信端末装置、および脂肪性肝疾患の予防・改善物質の探索方法
EP3190418B1 (en) * 2011-07-28 2019-05-01 metanomics GmbH Use of sm_sphingomyelin (d18:1, c16:0) as a marker for heart failure
WO2013033489A1 (en) 2011-08-31 2013-03-07 Volcano Corporation Optical rotary joint and methods of use
EP2756095A4 (en) * 2011-09-14 2015-07-22 Metabolon Inc BIOMARKERS RELATED TO INSULIN RESISTANCE AND METHOD OF USE THEREOF
WO2013122469A2 (en) * 2012-02-17 2013-08-22 Rijksuniversiteit Groningen Prediction of the efficacy of a medicament on renal or cardiovascular clinical outcomes
EP2642296A1 (en) * 2012-03-22 2013-09-25 Nestec S.A. p-Cresol sulphate as biomarker for healthy ageing
EP2642294A1 (en) * 2012-03-22 2013-09-25 Nestec S.A. Phenylacetylglutamine as biomarker for healthy ageing
EP2642293A1 (en) * 2012-03-22 2013-09-25 Nestec S.A. 9-oxo-octadecadienoic acid (9-oxo-HODE)as as biomarker for healthy ageing
EP2642297A1 (en) * 2012-03-22 2013-09-25 Nestec S.A. Hydroxy-sphingomyelin 22:1 as biomarker for healthy ageing
EP2642295A1 (en) 2012-03-22 2013-09-25 Nestec S.A. 1-O-alkyl-2-acylglycerophosphocholine (PC-O) 40:1 as biomarker for healthy ageing
CN104364658B (zh) * 2012-06-05 2017-06-30 雀巢产品技术援助有限公司 用于诊断慢性瓣膜疾病的方法
US9928345B2 (en) 2012-06-08 2018-03-27 Liposciences, Inc. Multiple-marker risk parameters predictive of conversion to diabetes
US9361429B2 (en) 2012-06-08 2016-06-07 Liposcience, Inc. Multi-parameter diabetes risk evaluations
US20150141260A1 (en) 2012-06-15 2015-05-21 Harry Stylli Methods of detecting diseases or conditions using circulating diseased cells
US20140179805A1 (en) 2012-06-15 2014-06-26 Harry Stylli Methods of detecting diseases or conditions
EP2867669B1 (en) 2012-06-27 2016-12-21 Metanomics Health GmbH Methods for identifying diabetes drugs
EP2883058B1 (en) * 2012-08-13 2018-01-03 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Biomarkers for type 2 diabetes
US20140324460A1 (en) * 2012-09-26 2014-10-30 Health Diagnostic Laboratory, Inc. Method for determining and managing total cardiodiabetes risk
US9858668B2 (en) 2012-10-05 2018-01-02 Volcano Corporation Guidewire artifact removal in images
EP2904671B1 (en) 2012-10-05 2022-05-04 David Welford Systems and methods for amplifying light
US10070827B2 (en) 2012-10-05 2018-09-11 Volcano Corporation Automatic image playback
US9292918B2 (en) 2012-10-05 2016-03-22 Volcano Corporation Methods and systems for transforming luminal images
US9307926B2 (en) 2012-10-05 2016-04-12 Volcano Corporation Automatic stent detection
US9367965B2 (en) 2012-10-05 2016-06-14 Volcano Corporation Systems and methods for generating images of tissue
US10568586B2 (en) 2012-10-05 2020-02-25 Volcano Corporation Systems for indicating parameters in an imaging data set and methods of use
US20140100454A1 (en) 2012-10-05 2014-04-10 Volcano Corporation Methods and systems for establishing parameters for three-dimensional imaging
US9286673B2 (en) 2012-10-05 2016-03-15 Volcano Corporation Systems for correcting distortions in a medical image and methods of use thereof
US9324141B2 (en) 2012-10-05 2016-04-26 Volcano Corporation Removal of A-scan streaking artifact
US11272845B2 (en) 2012-10-05 2022-03-15 Philips Image Guided Therapy Corporation System and method for instant and automatic border detection
US9840734B2 (en) 2012-10-22 2017-12-12 Raindance Technologies, Inc. Methods for analyzing DNA
EP2931132B1 (en) 2012-12-13 2023-07-05 Philips Image Guided Therapy Corporation System for targeted cannulation
CA2895989A1 (en) 2012-12-20 2014-07-10 Nathaniel J. Kemp Optical coherence tomography system that is reconfigurable between different imaging modes
US9730613B2 (en) 2012-12-20 2017-08-15 Volcano Corporation Locating intravascular images
US11406498B2 (en) 2012-12-20 2022-08-09 Philips Image Guided Therapy Corporation Implant delivery system and implants
US10939826B2 (en) 2012-12-20 2021-03-09 Philips Image Guided Therapy Corporation Aspirating and removing biological material
US10942022B2 (en) 2012-12-20 2021-03-09 Philips Image Guided Therapy Corporation Manual calibration of imaging system
CA2895502A1 (en) 2012-12-20 2014-06-26 Jeremy Stigall Smooth transition catheters
JP2016508233A (ja) 2012-12-21 2016-03-17 ナサニエル ジェイ． ケンプ， 光学スイッチを用いた電力効率のよい光学バッファリング
US10420530B2 (en) 2012-12-21 2019-09-24 Volcano Corporation System and method for multipath processing of image signals
US9612105B2 (en) 2012-12-21 2017-04-04 Volcano Corporation Polarization sensitive optical coherence tomography system
WO2014100530A1 (en) 2012-12-21 2014-06-26 Whiseant Chester System and method for catheter steering and operation
US9486143B2 (en) 2012-12-21 2016-11-08 Volcano Corporation Intravascular forward imaging device
US10332228B2 (en) 2012-12-21 2019-06-25 Volcano Corporation System and method for graphical processing of medical data
JP2016502884A (ja) 2012-12-21 2016-02-01 ダグラス メイヤー， 延在カテーテル本体テレスコープを有する回転可能超音波撮像カテーテル
US10058284B2 (en) 2012-12-21 2018-08-28 Volcano Corporation Simultaneous imaging, monitoring, and therapy
CA2895990A1 (en) 2012-12-21 2014-06-26 Jerome MAI Ultrasound imaging with variable line density
US9383263B2 (en) 2012-12-21 2016-07-05 Volcano Corporation Systems and methods for narrowing a wavelength emission of light
ES2669620T3 (es) 2013-01-31 2018-05-28 Metabolon, Inc. Biomarcadores relacionados con el avance de la resistencia a la insulina y métodos que lo utilizan
EP2951575A4 (en) * 2013-01-31 2016-11-02 Caprion Proteomics Inc BIOMARKERS OF TYPE 2 DIABETES AND USES THEREOF
CA2900031A1 (en) * 2013-02-14 2014-08-21 Metanomics Health Gmbh Means and methods for assessing the quality of a biological sample
US9770172B2 (en) 2013-03-07 2017-09-26 Volcano Corporation Multimodal segmentation in intravascular images
US10226597B2 (en) 2013-03-07 2019-03-12 Volcano Corporation Guidewire with centering mechanism
US10494675B2 (en) 2013-03-09 2019-12-03 Cell Mdx, Llc Methods of detecting cancer
HK1220253A1 (zh) 2013-03-09 2017-04-28 Harry Stylli 诊断前列腺癌症的方法
US11154313B2 (en) 2013-03-12 2021-10-26 The Volcano Corporation Vibrating guidewire torquer and methods of use
CN105228518B (zh) 2013-03-12 2018-10-09 火山公司 用于诊断冠状微脉管疾病的系统和方法
US9301687B2 (en) 2013-03-13 2016-04-05 Volcano Corporation System and method for OCT depth calibration
US20140278121A1 (en) * 2013-03-13 2014-09-18 Robust for Life, Inc. Systems and methods for network-based calculation and reporting of metabolic risk
US11026591B2 (en) 2013-03-13 2021-06-08 Philips Image Guided Therapy Corporation Intravascular pressure sensor calibration
US10758207B2 (en) 2013-03-13 2020-09-01 Philips Image Guided Therapy Corporation Systems and methods for producing an image from a rotational intravascular ultrasound device
US12343198B2 (en) 2013-03-14 2025-07-01 Philips Image Guided Therapy Corporation Delivery catheter having imaging capabilities
US10219887B2 (en) 2013-03-14 2019-03-05 Volcano Corporation Filters with echogenic characteristics
US10292677B2 (en) 2013-03-14 2019-05-21 Volcano Corporation Endoluminal filter having enhanced echogenic properties
CN105208947B (zh) 2013-03-14 2018-10-12 火山公司 具有回声特性的过滤器
KR102279451B1 (ko) 2013-04-08 2021-07-19 버그 엘엘씨 코엔자임 q10 병용 요법을 이용한 암 치료
WO2015010042A2 (en) * 2013-07-18 2015-01-22 Health Diagnostic Laboratory, Inc. Method of determination of risk of 2 hour blood glucose equal to or greater than 140 mg/di
KR102370843B1 (ko) 2013-09-04 2022-03-04 버그 엘엘씨 코엔자임 q10의 연속주입에 의한 암치료 방법
GB2524230A (en) * 2014-02-14 2015-09-23 Asda Stores Ltd Transaction processing system and transaction processing method
EP3693742B1 (en) 2014-09-11 2022-04-06 Harry Stylli Methods of detecting prostate cancer
WO2016103390A1 (ja) * 2014-12-25 2016-06-30 株式会社日立製作所 インスリン分泌能分析装置、当該装置を備えるインスリン分泌能分析システム及びインスリン分泌能分析方法
HUE056203T2 (hu) * 2015-01-09 2022-01-28 Global Genomics Group Llc Vér alapú biomarkerek atheroszklerotikus koszorúsér betegség diagnosztizálására
US10451641B2 (en) 2015-03-13 2019-10-22 Duke University Compositions and methods for metabolic profiling in subjects with heart failure with preserved ejection fraction
JP6051258B2 (ja) * 2015-04-15 2016-12-27 ライオン株式会社 脂質異常症への罹患しやすさを試験する方法
KR101795689B1 (ko) * 2015-04-30 2017-11-30 경희대학교 산학협력단 혈관 협착 질환 진단용 마커 및 이의 용도
WO2017087576A1 (en) 2015-11-16 2017-05-26 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
WO2018094204A1 (en) * 2016-11-17 2018-05-24 Arivale, Inc. Determining relationships between risks for biological conditions and dynamic analytes
US11881311B1 (en) 2017-02-17 2024-01-23 BioAge Labs, Inc. Survival prediction using metabolomic profiles
JP2018141728A (ja) * 2017-02-28 2018-09-13 トヨタ自動車株式会社 生活習慣病の診断方法
US11740247B2 (en) * 2017-11-22 2023-08-29 Mayo Foundation For Medical Education And Research Methods and materials for assessing and treating obesity
US20200041496A1 (en) * 2018-08-01 2020-02-06 Joshua Health Care LLC Methods for Identifying and Treating Mammalian Subjects with Insulin Resistance
JP7189537B2 (ja) * 2019-06-27 2022-12-14 サンスター株式会社 血液試料の酸化ｈｄｌ量の反映値を測定する工程を含む、測定方法
US20220291225A1 (en) * 2019-07-08 2022-09-15 Shimadzu Corporation Method of evaluating function of organ for transplantation, program for evaluating function of organ for transplantation, and apparatus that evaluates function of organ for transplantation
WO2021072222A1 (en) * 2019-10-11 2021-04-15 The Regents Of The University Of California Metabolic profile screening for gestational diabetes
US20230091848A1 (en) * 2020-02-05 2023-03-23 The Cleveland Clinic Foundation Disease detection and treatment based on phenylacetyl glutamine levels
CN113866284B (zh) * 2020-06-30 2023-09-05 上海脉示生物技术有限公司 一组用于心力衰竭诊断的肠道微生物代谢标志物及其应用
CN112684064B (zh) * 2020-12-08 2022-05-17 安徽农业大学 用于筛选抗应激胁迫肉羊的血清代谢标志物及其应用
WO2022133034A1 (en) * 2020-12-16 2022-06-23 St. Jude Children's Research Hospital, Inc. Methods of treating disorders associated with castor
CN113325117B (zh) * 2021-06-25 2022-07-15 中国医学科学院北京协和医院 一组生物标记物在制备预测静脉内平滑肌瘤病进展的试剂盒中的应用
CN117741023A (zh) * 2021-11-30 2024-03-22 江苏品生医疗科技集团有限公司 预测受试者患有糖尿病的可能性的标记物及其应用
JP2025504961A (ja) * 2022-01-28 2025-02-19 ジーエーティーシー ヘルス コーポレーション 糖尿病の早期発見のためのバイオマーカー
CN114965733B (zh) * 2022-04-07 2023-12-01 中国人民解放军总医院第一医学中心 结直肠进展期腺瘤诊断代谢标志物组合及其应用
WO2025019706A1 (en) * 2023-07-19 2025-01-23 Ahara Corporation Systems and methods for generating a nutrition program
CN119846232B (zh) * 2025-01-21 2025-10-03 宁夏农林科学院动物科学研究所(宁夏草畜工程技术研究中心) 一种早期诊断奶牛隐性乳房炎的生物标志物组合及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070026458A1 (en) * 2004-12-17 2007-02-01 Entelos, Inc. Assessing insulin resistance using biomarkers

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5367052A (en) * 1987-04-27 1994-11-22 Amylin Pharmaceuticals, Inc. Amylin peptides
WO1997031103A1 (en) 1996-02-20 1997-08-28 Kyowa Hakko Kogyo Co., Ltd. Method for determining 1,5-anhydroglucitol
JP2938048B1 (ja) * 1998-06-30 1999-08-23 技術研究組合医療福祉機器研究所 代謝機能測定装置
US6140067A (en) * 1999-04-30 2000-10-31 Mitokor Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus
JP3975279B2 (ja) * 1999-11-01 2007-09-12 旭化成ファーマ株式会社 糖尿病予備群の検査方法
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
WO2001078652A2 (en) 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
SK2102003A3 (en) * 2000-08-07 2003-08-05 Ranbaxy Signature Llc Liquid formulation of metformin
WO2002098355A2 (en) * 2001-06-01 2002-12-12 Clingenix, Inc. Methods and reagents for diagnosis and treatment of insulin resistance and related conditions
US7425545B2 (en) 2001-07-25 2008-09-16 Isis Pharmaceuticals, Inc. Modulation of C-reactive protein expression
JP4100673B2 (ja) * 2001-12-07 2008-06-11 日本化薬株式会社 肝糖放出の検査方法
JP2003204800A (ja) * 2002-01-15 2003-07-22 Sumitomo Pharmaceut Co Ltd 糖代謝異常疾患マーカーおよびその利用
US20040101874A1 (en) 2002-04-12 2004-05-27 Mitokor Inc. Targets for therapeutic intervention identified in the mitochondrial proteome
US20060148690A1 (en) * 2002-07-08 2006-07-06 Lydie Bougueleret Secreted peptides
JP2005006645A (ja) * 2003-05-22 2005-01-13 Sumitomo Chemical Co Ltd インスリン応答性の評価方法
WO2005094200A2 (en) * 2003-06-20 2005-10-13 University Of Florida Biomarkers for differentiating between type 2 and type 2 diabetes
US7345142B2 (en) * 2004-01-27 2008-03-18 Compugen Ltd. Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease
JP4547173B2 (ja) * 2004-03-17 2010-09-22 シスメックス株式会社 糖尿病診療支援システム
JP4533042B2 (ja) * 2004-08-25 2010-08-25 裕 笹川 糖尿病および糖代謝異常を判断する方法
WO2006036476A2 (en) * 2004-09-07 2006-04-06 The General Hospital Corporation Methods of detecting myocardial ischemia and myocardial infarction
JP4522222B2 (ja) * 2004-10-22 2010-08-11 扶桑薬品工業株式会社 血中脂肪酸濃度測定による心疾患の早期診断方法
EP1828774A1 (en) * 2004-12-14 2007-09-05 F. Hoffmann-Roche AG Cd99 as target/marker for insulin resistance
JPWO2006073195A1 (ja) * 2005-01-07 2008-06-12 敏一 吉川 糖尿病の予知・診断方法および糖尿病予知・診断用キット
FR2890079B1 (fr) * 2005-08-26 2007-11-30 Alain Rambach Detection des salmonelles lactose +
EP1931805A2 (en) * 2005-09-30 2008-06-18 Perlegen Sciences, Inc. Methods and compositions for screening and treatment of disorders of blood glucose regulation
AU2006302031A1 (en) * 2005-10-11 2007-04-19 Tethys Bioscience, Inc. Diabetes-associated markers and methods of use thereof
JP2007127423A (ja) * 2005-10-31 2007-05-24 Toray Ind Inc ３−ヒドロキシ酪酸の測定方法およびキット
US8216848B2 (en) * 2006-03-24 2012-07-10 Metanomics Gmbh Means and method for diagnosing diabetes
US8321154B2 (en) * 2007-03-26 2012-11-27 Bg Medicine, Inc. Methods for detecting coronary artery disease
MX341954B (es) * 2007-07-17 2016-09-08 Metabolon Inc Biomarcadores para prediabetes, enfermedades cardiovasculares y otros transtornos relacionados con sindrome metabolico, y metodos de uso de los mismos.
JP2012522989A (ja) * 2009-03-31 2012-09-27 メタボロン インコーポレイテッド インスリン抵抗性に関連するバイオマーカー、及びそれを使用する方法
AU2011346553A1 (en) * 2010-12-23 2013-07-11 Metanomics Health Gmbh Means and method for predicting diabetes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070026458A1 (en) * 2004-12-17 2007-02-01 Entelos, Inc. Assessing insulin resistance using biomarkers

Also Published As

Publication number Publication date
US20090155826A1 (en) 2009-06-18
US20120208215A1 (en) 2012-08-16
JP2015064362A (ja) 2015-04-09
CA2690541A1 (en) 2009-01-29
MX377928B (es) 2025-03-10
ES2443540T3 (es) 2014-02-19
BRPI0815095B1 (pt) 2021-04-13
JP5876918B2 (ja) 2016-03-02
AU2008279778A1 (en) 2009-01-29
MX341954B (es) 2016-09-08
EP2164977A4 (en) 2011-07-27
JP2010537157A (ja) 2010-12-02
US8809008B2 (en) 2014-08-19
WO2009014639A3 (en) 2009-03-19
JP2016102797A (ja) 2016-06-02
US8546098B2 (en) 2013-10-01
WO2009014639A2 (en) 2009-01-29
JP5701601B2 (ja) 2015-04-15
US20150005195A1 (en) 2015-01-01
US10175233B2 (en) 2019-01-08
MX2010000414A (es) 2010-04-01
US20130338031A1 (en) 2013-12-19
EP2164977B1 (en) 2013-10-30
HK1142636A1 (en) 2010-12-10
EP2164977A2 (en) 2010-03-24
US8187830B2 (en) 2012-05-29
US20160178620A1 (en) 2016-06-23
US9250225B2 (en) 2016-02-02
BRPI0815095A2 (pt) 2017-05-09

Similar Documents

Publication Publication Date Title
AU2008279778B2 (en) Method for Determining Insulin Sensitivity with Biomarkers
US9910047B2 (en) Biomarkers related to insulin resistance progression and methods using the same
US20190120855A1 (en) Biomarkers for Fatty Liver Disease and Methods Using the Same
US20120122981A1 (en) Biomarkers Related to Insulin Resistance and Methods using the Same
JP6158186B2 (ja) インスリン抵抗性に関連するバイオマーカーおよびそれを使用する方法
AU2016206265B2 (en) Method for Determining Insulin Sensitivity with Biomarkers
AU2014216035A1 (en) Method for Determining Insulin Sensitivity with Biomarkers
HK1142636B (en) Biomarkers for pre-diabetes and methods using the same
HK1217516B (en) Biomarkers related to insulin resistance progression and methods using the same

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)