AU2008240153B2 - SMAC mimetic dimers and trimers useful as anti-cancer agents - Google Patents

SMAC mimetic dimers and trimers useful as anti-cancer agents Download PDF

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Publication number
AU2008240153B2
AU2008240153B2 AU2008240153A AU2008240153A AU2008240153B2 AU 2008240153 B2 AU2008240153 B2 AU 2008240153B2 AU 2008240153 A AU2008240153 A AU 2008240153A AU 2008240153 A AU2008240153 A AU 2008240153A AU 2008240153 B2 AU2008240153 B2 AU 2008240153B2
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Australia
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optionally substituted
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alkyl
independently
formula
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AU2008240153A
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AU2008240153A1 (en
Inventor
Gunnar Hanson
Haizhou Sun
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Joyant Pharmaceuticals Inc
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Joyant Pharmaceuticals Inc
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Ceased legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2008240153A 2007-04-12 2008-04-11 SMAC mimetic dimers and trimers useful as anti-cancer agents Ceased AU2008240153B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US91147207P 2007-04-12 2007-04-12
US60/911,472 2007-04-12
US95249307P 2007-07-27 2007-07-27
US60/952,493 2007-07-27
PCT/US2008/060140 WO2008128121A1 (en) 2007-04-12 2008-04-11 Smac mimetic dimers and trimers useful as anti-cancer agents

Publications (2)

Publication Number Publication Date
AU2008240153A1 AU2008240153A1 (en) 2008-10-23
AU2008240153B2 true AU2008240153B2 (en) 2013-01-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008240153A Ceased AU2008240153B2 (en) 2007-04-12 2008-04-11 SMAC mimetic dimers and trimers useful as anti-cancer agents

Country Status (10)

Country Link
US (2) US8642554B2 (cg-RX-API-DMAC7.html)
EP (1) EP2079309B1 (cg-RX-API-DMAC7.html)
JP (1) JP5454943B2 (cg-RX-API-DMAC7.html)
CN (1) CN101668426B (cg-RX-API-DMAC7.html)
AU (1) AU2008240153B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0810178A2 (cg-RX-API-DMAC7.html)
CA (1) CA2684169C (cg-RX-API-DMAC7.html)
MX (1) MX2009010667A (cg-RX-API-DMAC7.html)
NZ (1) NZ580313A (cg-RX-API-DMAC7.html)
WO (1) WO2008128121A1 (cg-RX-API-DMAC7.html)

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US7932277B2 (en) 2007-05-10 2011-04-26 Intermune, Inc. Peptide inhibitors of hepatitis C virus replication
WO2010031171A1 (en) * 2008-09-19 2010-03-25 Aegera Therapeutics, Inc. Iap bir domain binding compounds
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Also Published As

Publication number Publication date
US20140127155A1 (en) 2014-05-08
CA2684169C (en) 2012-06-19
MX2009010667A (es) 2010-02-24
WO2008128121A1 (en) 2008-10-23
AU2008240153A1 (en) 2008-10-23
US8642554B2 (en) 2014-02-04
EP2079309A4 (en) 2011-07-06
CN101668426A (zh) 2010-03-10
JP5454943B2 (ja) 2014-03-26
US20090104151A1 (en) 2009-04-23
JP2010523717A (ja) 2010-07-15
NZ580313A (en) 2011-11-25
BRPI0810178A2 (pt) 2014-09-23
EP2079309B1 (en) 2015-11-11
EP2079309A1 (en) 2009-07-22
CA2684169A1 (en) 2008-10-23
CN101668426B (zh) 2014-01-15

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