AU2005316668B2 - Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors - Google Patents

Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors Download PDF

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Publication number
AU2005316668B2
AU2005316668B2 AU2005316668A AU2005316668A AU2005316668B2 AU 2005316668 B2 AU2005316668 B2 AU 2005316668B2 AU 2005316668 A AU2005316668 A AU 2005316668A AU 2005316668 A AU2005316668 A AU 2005316668A AU 2005316668 B2 AU2005316668 B2 AU 2005316668B2
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Prior art keywords
alkyl
heteroaryl
aryl
compound
compound according
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Ceased
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AU2005316668A
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AU2005316668A1 (en
Inventor
Kenneth Barr
Jennifer Crossrow
Johan D. Oslob
Brian Raimundo
Hiroko Tanaka
Jiang Zhu
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Millennium Pharmaceuticals Inc
Viracta Therapeutics Inc
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Millennium Pharmaceuticals Inc
Sunesis Pharmaceuticals Inc
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Assigned to MILLENNIUM PHARMACEUTICALS, INC. reassignment MILLENNIUM PHARMACEUTICALS, INC. Request for Assignment Assignors: SUNESIS PHARMACEUTICALS, INC.
Assigned to MILLENNIUM PHARMACEUTICALS, INC., SUNESIS PHARMACEUTICALS, INC. reassignment MILLENNIUM PHARMACEUTICALS, INC. Request for Assignment Assignors: MILLENNIUM PHARMACEUTICALS, INC.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Rheumatology (AREA)
  • Neurosurgery (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
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  • Obesity (AREA)
  • Urology & Nephrology (AREA)
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AU2005316668A 2004-12-13 2005-12-12 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors Ceased AU2005316668B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US63564404P 2004-12-13 2004-12-13
US60/635,644 2004-12-13
US63674004P 2004-12-16 2004-12-16
US60/636,740 2004-12-16
PCT/US2005/044804 WO2006065703A1 (en) 2004-12-13 2005-12-12 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors
US11/301,311 2005-12-12
US11/301,311 US7767687B2 (en) 2004-12-13 2005-12-12 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors

Publications (2)

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AU2005316668A1 AU2005316668A1 (en) 2006-06-22
AU2005316668B2 true AU2005316668B2 (en) 2012-09-06

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AU2005316668A Ceased AU2005316668B2 (en) 2004-12-13 2005-12-12 Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors

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US (2) US7767687B2 (enExample)
EP (1) EP1828186A1 (enExample)
JP (1) JP5111113B2 (enExample)
AU (1) AU2005316668B2 (enExample)
CA (1) CA2590294A1 (enExample)
WO (1) WO2006065703A1 (enExample)

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