CA2590294A1 - Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors - Google Patents
Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors Download PDFInfo
- Publication number
- CA2590294A1 CA2590294A1 CA002590294A CA2590294A CA2590294A1 CA 2590294 A1 CA2590294 A1 CA 2590294A1 CA 002590294 A CA002590294 A CA 002590294A CA 2590294 A CA2590294 A CA 2590294A CA 2590294 A1 CA2590294 A1 CA 2590294A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- compound
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010077182 raf Kinases Proteins 0.000 title claims description 17
- 102000009929 raf Kinases Human genes 0.000 title claims description 17
- 229940043355 kinase inhibitor Drugs 0.000 title description 4
- 239000003757 phosphotransferase inhibitor Substances 0.000 title description 4
- IAAQUOVTPAMQCR-UHFFFAOYSA-N 1h-pyrido[3,2-d]pyrimidin-2-one Chemical class C1=CC=C2NC(=O)N=CC2=N1 IAAQUOVTPAMQCR-UHFFFAOYSA-N 0.000 title description 3
- VWXIHLCLIOQWRA-UHFFFAOYSA-N 1h-pteridin-2-one Chemical class N1=CC=NC2=NC(O)=NC=C21 VWXIHLCLIOQWRA-UHFFFAOYSA-N 0.000 title 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 552
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- 230000001404 mediated effect Effects 0.000 claims abstract description 17
- 102000001253 Protein Kinase Human genes 0.000 claims abstract description 15
- 108060006633 protein kinase Proteins 0.000 claims abstract description 15
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- 125000003118 aryl group Chemical group 0.000 claims description 430
- 125000001072 heteroaryl group Chemical group 0.000 claims description 422
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- 238000000034 method Methods 0.000 claims description 35
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 35
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 35
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- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Landscapes
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63564404P | 2004-12-13 | 2004-12-13 | |
| US60/635,644 | 2004-12-13 | ||
| US63674004P | 2004-12-16 | 2004-12-16 | |
| US60/636,740 | 2004-12-16 | ||
| US11/301,311 US7767687B2 (en) | 2004-12-13 | 2005-12-12 | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors |
| US11/301,311 | 2005-12-12 | ||
| PCT/US2005/044804 WO2006065703A1 (en) | 2004-12-13 | 2005-12-12 | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
Publications (1)
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|---|---|
| CA2590294A1 true CA2590294A1 (en) | 2006-06-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002590294A Abandoned CA2590294A1 (en) | 2004-12-13 | 2005-12-12 | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
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| Country | Link |
|---|---|
| US (2) | US7767687B2 (enExample) |
| EP (1) | EP1828186A1 (enExample) |
| JP (1) | JP5111113B2 (enExample) |
| AU (1) | AU2005316668B2 (enExample) |
| CA (1) | CA2590294A1 (enExample) |
| WO (1) | WO2006065703A1 (enExample) |
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| UY29439A1 (es) * | 2005-03-25 | 2006-10-02 | Glaxo Group Ltd | Nuevos compuestos |
| WO2007038215A1 (en) | 2005-09-22 | 2007-04-05 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| BRPI0617159B8 (pt) | 2005-10-07 | 2021-05-25 | Exelixis Inc | compostos de piridopirimidinone inibidores de pi3ka, composições que os contem e processo para preparo |
| CN102746298A (zh) | 2005-10-07 | 2012-10-24 | 埃克塞里艾克西斯公司 | PI3Kα的吡啶并嘧啶酮抑制剂 |
| CA2632512A1 (en) | 2005-12-08 | 2007-06-14 | Millennium Pharmaceuticals, Inc. | Bicyclic compounds with kinase inhibitory activity |
| ATE514695T1 (de) | 2006-09-15 | 2011-07-15 | Pfizer Prod Inc | Pyrido(2,3-d)pyrimidinonverbindungen und ihre verwendung als pi3-inhibitoren |
| JP5513118B2 (ja) | 2006-10-19 | 2014-06-04 | シグナル ファーマシューティカルズ，エルエルシー | ヘテロアリール化合物、その組成物、及びプロテインキナーゼ阻害剤としてのそれらの使用 |
| TW200835497A (en) * | 2007-01-11 | 2008-09-01 | Astrazeneca Ab | Chemical compounds 636 |
| JP2010517989A (ja) * | 2007-02-01 | 2010-05-27 | アストラゼネカ アクチボラグ | Ｈｓｐ９０阻害剤としての５，６，７，８−テトラヒドロプテリジン誘導体 |
| JP5238172B2 (ja) * | 2007-03-22 | 2013-07-17 | 公益財団法人相模中央化学研究所 | パーフルオロアルキル基を有する含窒素六員環化合物およびその製造方法 |
| CL2008001933A1 (es) * | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| JP2010532381A (ja) * | 2007-06-29 | 2010-10-07 | サネシス ファーマシューティカルズ， インコーポレイテッド | Ｒａｆキナーゼ阻害剤として有用な複素環式化合物 |
| US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| UY32153A (es) | 2008-09-30 | 2011-04-29 | Exelixis Inc | Inhibidores de piridomidinona de pi13ka(alfa) y mtor |
| US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| CA2748274A1 (en) | 2008-12-30 | 2010-07-08 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as raf kinase inhibitors |
| CA2778291C (en) * | 2009-10-23 | 2014-02-11 | Eli Lilly And Company | Akt inhibitors |
| NZ599549A (en) | 2009-10-26 | 2013-11-29 | Signal Pharm Llc | Methods of synthesis and purification of heteroaryl compounds |
| AR080643A1 (es) * | 2010-02-03 | 2012-04-25 | Signal Pharm Llc | Identificacion de la mutacion de lkb1 como un biomarcador predictivo para la sensibilidad a inhibidores de la tor quinasa |
| AR080151A1 (es) | 2010-02-09 | 2012-03-14 | Exelixis Inc | Metodos para tratar cancer usando inhibidores de piridopirimidinona de pi 3k y mtor en combinacion con inhibidores de autofagia |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| ES2712803T3 (es) | 2011-02-28 | 2019-05-14 | Biomarin Pharm Inc | Inhibidores de histona desacetilasa |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| HK1199028A1 (en) * | 2011-09-30 | 2015-06-19 | Kineta, Inc. | Anti-viral compounds |
| EA034512B1 (ru) | 2011-10-19 | 2020-02-14 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Лечение злокачественной опухоли ингибиторами tor-киназы |
| PE20141696A1 (es) | 2011-12-02 | 2014-11-08 | Signal Pharm Llc | Composiciones farmaceuticas de 7-(6-(2-hidroxipropan-2-il) piridin-3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino[2,3-b] pirazin-2(1h)-ona, una forma solida del mismo y metodos de su uso |
| EP2797888B1 (en) * | 2011-12-31 | 2016-06-08 | BeiGene, Ltd. | Fused tricyclic compounds as raf kinase inhibitors |
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- 2005-12-12 WO PCT/US2005/044804 patent/WO2006065703A1/en not_active Ceased
- 2005-12-12 EP EP05853671A patent/EP1828186A1/en not_active Withdrawn
- 2005-12-12 JP JP2007545694A patent/JP5111113B2/ja not_active Expired - Fee Related
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2010
- 2010-07-26 US US12/843,105 patent/US20110059976A1/en not_active Abandoned
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| US20060211702A1 (en) | 2006-09-21 |
| JP2008523099A (ja) | 2008-07-03 |
| WO2006065703A1 (en) | 2006-06-22 |
| JP5111113B2 (ja) | 2012-12-26 |
| AU2005316668A1 (en) | 2006-06-22 |
| US20110059976A1 (en) | 2011-03-10 |
| US7767687B2 (en) | 2010-08-03 |
| EP1828186A1 (en) | 2007-09-05 |
| AU2005316668B2 (en) | 2012-09-06 |
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