AU2004297533B2 - Methods and compositions for delivering polynucleotides - Google Patents

Methods and compositions for delivering polynucleotides Download PDF

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Publication number
AU2004297533B2
AU2004297533B2 AU2004297533A AU2004297533A AU2004297533B2 AU 2004297533 B2 AU2004297533 B2 AU 2004297533B2 AU 2004297533 A AU2004297533 A AU 2004297533A AU 2004297533 A AU2004297533 A AU 2004297533A AU 2004297533 B2 AU2004297533 B2 AU 2004297533B2
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Australia
Prior art keywords
polypeptide
polynucleotide
mitochondrial
protein
organelle
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Ceased
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AU2004297533A
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AU2004297533A1 (en
Inventor
Shaharyar Khan
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Gencia Corp
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Gencia Corp
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Publication of AU2004297533B2 publication Critical patent/AU2004297533B2/en
Priority to AU2010206037A priority Critical patent/AU2010206037A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

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  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Urology & Nephrology (AREA)
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AU2004297533A 2003-10-24 2004-10-25 Methods and compositions for delivering polynucleotides Ceased AU2004297533B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2010206037A AU2010206037A1 (en) 2003-10-24 2010-07-29 Methods and Compositions for Delivering Polynucleotides

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US51398303P 2003-10-24 2003-10-24
US60/513,983 2003-10-24
US56843604P 2004-05-05 2004-05-05
US60/568,436 2004-05-05
PCT/US2004/035137 WO2005056752A2 (en) 2003-10-24 2004-10-25 Methods and compositions for delivering polynucleotides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2010206037A Division AU2010206037A1 (en) 2003-10-24 2010-07-29 Methods and Compositions for Delivering Polynucleotides

Publications (2)

Publication Number Publication Date
AU2004297533A1 AU2004297533A1 (en) 2005-06-23
AU2004297533B2 true AU2004297533B2 (en) 2010-04-29

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ID=34681406

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Application Number Title Priority Date Filing Date
AU2004297533A Ceased AU2004297533B2 (en) 2003-10-24 2004-10-25 Methods and compositions for delivering polynucleotides
AU2010206037A Abandoned AU2010206037A1 (en) 2003-10-24 2010-07-29 Methods and Compositions for Delivering Polynucleotides

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AU2010206037A Abandoned AU2010206037A1 (en) 2003-10-24 2010-07-29 Methods and Compositions for Delivering Polynucleotides

Country Status (7)

Country Link
US (2) US8039587B2 (https=)
EP (2) EP2418281B1 (https=)
JP (2) JP4838722B2 (https=)
AU (2) AU2004297533B2 (https=)
CA (1) CA2543257C (https=)
ES (1) ES2411962T3 (https=)
WO (1) WO2005056752A2 (https=)

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US8273867B2 (en) * 2006-02-10 2012-09-25 The Regents Of The University Of California Transducible delivery of siRNA by dsRNA binding domain fusions to PTD/CPPS
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