AU2004268621C1 - c-Kit modulators and methods of use - Google Patents

c-Kit modulators and methods of use Download PDF

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Publication number
AU2004268621C1
AU2004268621C1 AU2004268621A AU2004268621A AU2004268621C1 AU 2004268621 C1 AU2004268621 C1 AU 2004268621C1 AU 2004268621 A AU2004268621 A AU 2004268621A AU 2004268621 A AU2004268621 A AU 2004268621A AU 2004268621 C1 AU2004268621 C1 AU 2004268621C1
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Prior art keywords
phenyl
tetrazol
acetamide
oxy
chloro
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AU2004268621A
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AU2004268621A1 (en
AU2004268621B2 (en
Inventor
William Bajjalieh
Wei Cheng
Erick Wang Co
Moon Hwan Kim
Rhett Ronald Klein
Donna T. Le
Amy Lew
John M. Nuss
Wei Xu
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Exelixis Inc
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Exelixis Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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AU2004268621A 2003-08-29 2004-08-27 c-Kit modulators and methods of use Ceased AU2004268621C1 (en)

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US49922403P 2003-08-29 2003-08-29
US60/499,224 2003-08-29
PCT/US2004/028001 WO2005020921A2 (en) 2003-08-29 2004-08-27 C-kit modulators and methods of use

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AU2004268621A1 AU2004268621A1 (en) 2005-03-10
AU2004268621B2 AU2004268621B2 (en) 2010-12-16
AU2004268621C1 true AU2004268621C1 (en) 2011-08-18

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US (1) US8362017B2 (ja)
EP (1) EP1663204B1 (ja)
JP (2) JP5010917B2 (ja)
AU (1) AU2004268621C1 (ja)
CA (1) CA2536954C (ja)
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JP5010917B2 (ja) 2012-08-29
WO2005020921A3 (en) 2005-10-06
EP1663204A4 (en) 2008-08-13
JP2011190284A (ja) 2011-09-29
AU2004268621B2 (en) 2010-12-16

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