AU2002323452C1 - Pulsed-multiline excitation for color-blind fluorescence detection - Google Patents

Pulsed-multiline excitation for color-blind fluorescence detection Download PDF

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Publication number
AU2002323452C1
AU2002323452C1 AU2002323452A AU2002323452A AU2002323452C1 AU 2002323452 C1 AU2002323452 C1 AU 2002323452C1 AU 2002323452 A AU2002323452 A AU 2002323452A AU 2002323452 A AU2002323452 A AU 2002323452A AU 2002323452 C1 AU2002323452 C1 AU 2002323452C1
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AU
Australia
Prior art keywords
excitation
laser
sample
lasers
dye
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Ceased
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AU2002323452A
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English (en)
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AU2002323452A1 (en
AU2002323452B2 (en
Inventor
Robert F Curl
Carter Kittrell
Michael L Metzker
Graham B I Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
William Marsh Rice University
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Baylor College of Medicine
William Marsh Rice University
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Application filed by Baylor College of Medicine, William Marsh Rice University filed Critical Baylor College of Medicine
Publication of AU2002323452A1 publication Critical patent/AU2002323452A1/en
Publication of AU2002323452B2 publication Critical patent/AU2002323452B2/en
Application granted granted Critical
Publication of AU2002323452C1 publication Critical patent/AU2002323452C1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/021—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using plane or convex mirrors, parallel phase plates, or particular reflectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2002323452A 2001-08-28 2002-08-28 Pulsed-multiline excitation for color-blind fluorescence detection Ceased AU2002323452C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/941,165 2001-08-28
US09/941,165 US6995841B2 (en) 2001-08-28 2001-08-28 Pulsed-multiline excitation for color-blind fluorescence detection
PCT/US2002/027406 WO2003021212A1 (en) 2001-08-28 2002-08-28 Pulsed-multiline excitation for color-blind fluorescence detection

Publications (3)

Publication Number Publication Date
AU2002323452A1 AU2002323452A1 (en) 2003-06-05
AU2002323452B2 AU2002323452B2 (en) 2008-01-10
AU2002323452C1 true AU2002323452C1 (en) 2008-06-26

Family

ID=25476036

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002323452A Ceased AU2002323452C1 (en) 2001-08-28 2002-08-28 Pulsed-multiline excitation for color-blind fluorescence detection

Country Status (6)

Country Link
US (4) US6995841B2 (https=)
EP (1) EP1432966A4 (https=)
JP (3) JP2005524051A (https=)
AU (1) AU2002323452C1 (https=)
CA (2) CA2774152A1 (https=)
WO (1) WO2003021212A1 (https=)

Families Citing this family (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) * 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
DE19829981C2 (de) * 1998-07-04 2002-10-17 Zeiss Carl Jena Gmbh Verfahren und Anordnung zur konfokalen Mikroskopie
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US7501245B2 (en) * 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US8217304B2 (en) 2001-03-29 2012-07-10 Gsi Group Corporation Methods and systems for thermal-based laser processing a multi-material device
US6281471B1 (en) * 1999-12-28 2001-08-28 Gsi Lumonics, Inc. Energy-efficient, laser-based method and system for processing target material
US7723642B2 (en) * 1999-12-28 2010-05-25 Gsi Group Corporation Laser-based system for memory link processing with picosecond lasers
US20040134894A1 (en) * 1999-12-28 2004-07-15 Bo Gu Laser-based system for memory link processing with picosecond lasers
US7838794B2 (en) * 1999-12-28 2010-11-23 Gsi Group Corporation Laser-based method and system for removing one or more target link structures
US20030222324A1 (en) * 2000-01-10 2003-12-04 Yunlong Sun Laser systems for passivation or link processing with a set of laser pulses
US20060141681A1 (en) * 2000-01-10 2006-06-29 Yunlong Sun Processing a memory link with a set of at least two laser pulses
US7671295B2 (en) * 2000-01-10 2010-03-02 Electro Scientific Industries, Inc. Processing a memory link with a set of at least two laser pulses
EP1368497A4 (en) 2001-03-12 2007-08-15 California Inst Of Techn METHODS AND APPARATUS FOR ANALYZING ASYNCHRONOUS BASE EXTENSION POLYNUCLEOTIDE SEQUENCES
DE10112798A1 (de) * 2001-03-16 2002-10-02 Elegene Gmbh Vorrichtung und Verfahren zur automatischen Erzeugung einer Wärmevermeidungsreaktion von Nematoden oder ähnlichen Lebewesen
WO2003074740A1 (en) * 2002-03-01 2003-09-12 Ravgen, Inc. Rapid analysis of variations in a genome
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20030175821A1 (en) * 2002-03-14 2003-09-18 Hoover Rex A. Apparatus and method for microscopic comet assay
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
EP2775291B1 (en) 2002-05-17 2016-01-13 Life Technologies Corporation Apparatus for differentiating multiple fluorescence signals by excitation wavelength
WO2004029690A1 (en) * 2002-09-27 2004-04-08 Saloma Caesar A Two-color (two-photon) excitation with focused excitation beams and a raman shifter
US20040188594A1 (en) * 2003-05-01 2004-09-30 Brown Steven W. Spectrally tunable solid-state light source
US20050170367A1 (en) * 2003-06-10 2005-08-04 Quake Stephen R. Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
US20050006594A1 (en) * 2003-07-07 2005-01-13 Anthony Calderoni Simple systems for accurately detecting and measuring only fluorescent radiation from a sample in a plastic test tube
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20060172408A1 (en) * 2003-12-01 2006-08-03 Quake Steven R Device for immobilizing chemical and biochemical species and methods of using same
WO2005080605A2 (en) 2004-02-19 2005-09-01 Helicos Biosciences Corporation Methods and kits for analyzing polynucleotide sequences
JP4224640B2 (ja) * 2004-03-29 2009-02-18 オリンパス株式会社 蛍光分光分析装置
US20050239085A1 (en) * 2004-04-23 2005-10-27 Buzby Philip R Methods for nucleic acid sequence determination
US20050260609A1 (en) * 2004-05-24 2005-11-24 Lapidus Stanley N Methods and devices for sequencing nucleic acids
US20070117103A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US20070117104A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US7476734B2 (en) * 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
DE602005027700D1 (de) * 2004-05-25 2011-06-09 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
FR2871358B1 (fr) * 2004-06-14 2007-02-09 Mauna Kea Technologies Soc Par Procede et systeme d'imagerie microscopique de fluorescence fibree multimarquage
JP2006003167A (ja) * 2004-06-16 2006-01-05 Shimadzu Corp 生体試料分析用質量分析装置
WO2006010252A1 (en) * 2004-07-27 2006-02-02 National Research Council Of Canada Multi-wavelength fluorometric system for on-line monitoring of bioprocesses
US20060024678A1 (en) * 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
WO2006017811A2 (en) * 2004-08-06 2006-02-16 Compucyte Corporation Multiple-color monochromatic light absorption and quantification of light absorption in a stained sample
US7351538B2 (en) * 2004-08-23 2008-04-01 U.S. Genomics Systems and methods for detecting and analyzing polymers
US7209223B1 (en) * 2004-11-15 2007-04-24 Luna Innovations Incorporated Optical device for measuring optical properties of a sample and method relating thereto
WO2006055395A2 (en) * 2004-11-15 2006-05-26 Luna Innovations Incorporated Optical device for measuring optical properties of a sample and method relating thereto
US20060118754A1 (en) * 2004-12-08 2006-06-08 Lapen Daniel C Stabilizing a polyelectrolyte multilayer
US7286224B2 (en) * 2004-12-21 2007-10-23 Palo Alto Research Center Incorporated Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US20060172328A1 (en) * 2005-01-05 2006-08-03 Buzby Philip R Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
US20060191884A1 (en) * 2005-01-21 2006-08-31 Johnson Shepard D High-speed, precise, laser-based material processing method and system
US7482120B2 (en) * 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US7277169B2 (en) * 2005-02-18 2007-10-02 The Regents Of The University Of Michigan Whole spectrum fluorescence detection with ultrafast white light excitation
EP2348320B1 (en) * 2005-03-10 2024-05-01 Gen-Probe Incorporated Methods and systems for detecting multiple fluorescent emission signals
US7964413B2 (en) * 2005-03-10 2011-06-21 Gen-Probe Incorporated Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay
CA2539679A1 (en) * 2005-03-15 2006-09-15 Electronic Design To Market, Inc. System of measuring light transmission and/or reflection
EP1886145A2 (en) * 2005-05-03 2008-02-13 Applera Corporation Fluorescent detection system and dye set for use therewith
US20060263790A1 (en) * 2005-05-20 2006-11-23 Timothy Harris Methods for improving fidelity in a nucleic acid synthesis reaction
JP5238494B2 (ja) * 2005-05-30 2013-07-17 イェーカー・ヴィデングレン 分光計測および分析のための装置、ならびに、方法
JP4756948B2 (ja) * 2005-08-08 2011-08-24 ベイバイオサイエンス株式会社 フローサイトメータおよびフローサイトメトリ方法
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7728295B2 (en) * 2005-09-29 2010-06-01 The Trustees Of Princeton University Method and apparatus for detecting surface and subsurface properties of materials
US7560869B2 (en) * 2005-09-29 2009-07-14 The Trustees Of Princeton University Method and apparatus for remotely monitoring properties of gases and plasmas
TWI364889B (en) * 2005-11-11 2012-05-21 Hon Hai Prec Ind Co Ltd Laser device and laser system using the same
DE102005054184B4 (de) * 2005-11-14 2020-10-29 Carl Zeiss Microscopy Gmbh Multispektrale Beleuchtungsvorrichtung und Messverfahren
US20070117102A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
WO2007070869A2 (en) * 2005-12-16 2007-06-21 Applera Corporation Method and system for phase-locked sequencing
US7449667B2 (en) * 2005-12-19 2008-11-11 Motorola, Inc. Illumination method and apparatus having a plurality of feedback control circuit for controlling intensities of multiple light sources
US7405384B2 (en) * 2005-12-19 2008-07-29 Motorola, Inc. Method and apparatus for intensity control of multiple light sources using source timing
DE102006009053A1 (de) * 2006-02-27 2007-08-30 Carl Zeiss Jena Gmbh Multispektrale Beleuchtungsvorrichtung
US7397546B2 (en) * 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US20080309926A1 (en) * 2006-03-08 2008-12-18 Aaron Weber Systems and methods for reducing detected intensity non uniformity in a laser beam
JP4899648B2 (ja) * 2006-06-05 2012-03-21 株式会社ニコン スペクトル観察方法及びスペクトル観察システム
US8553221B2 (en) * 2006-10-24 2013-10-08 Pd-Ld, Inc. Compact, low cost Raman monitor for single substances
US20100144053A1 (en) * 2006-12-04 2010-06-10 Parallel Synthesis Technologies Multiplex assay reader system
US7893227B2 (en) * 2006-12-05 2011-02-22 Lasergen, Inc. 3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing
US7897737B2 (en) * 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
WO2008085991A2 (en) * 2007-01-08 2008-07-17 U.S. Genomics, Inc. Reaction chamber
WO2008092129A2 (en) * 2007-01-25 2008-07-31 The Trustees Of Princeton University Method and apparatus for detecting surface and subsurface properties of materials
JP4964647B2 (ja) * 2007-03-30 2012-07-04 ジーエルサイエンス株式会社 蛍光検出装置
CA2984820C (en) * 2007-04-04 2021-12-07 Ande Corporation Plastic microfluidic separation and detection platforms
WO2009009127A2 (en) * 2007-07-12 2009-01-15 U.S. Genomics, Inc. Method and system for transferring and/or concentrating a sample
TWI684644B (zh) * 2007-08-13 2020-02-11 美商網路生物有限公司 利用電泳偵測核酸及生物分子之整合微流體系統、生物晶片及方法
US8582098B2 (en) * 2007-10-25 2013-11-12 The Research Foundation Of State University Of New York Single photon spectrometer
JP4389991B2 (ja) * 2007-10-26 2009-12-24 ソニー株式会社 微小粒子の光学的測定方法及び光学的測定装置
US8059274B2 (en) * 2007-12-07 2011-11-15 The Spectranetics Corporation Low-loss polarized light diversion
AU2009204461A1 (en) 2008-01-10 2009-07-16 Pacific Biosciences Of California, Inc. Methods and systems for analysis of fluorescent reactions with modulated excitation
DE102008012635A1 (de) * 2008-03-05 2009-09-10 Carl Zeiss Microlmaging Gmbh Verfahren und Anordnung zur zeitaufgelösten Spektroskopie
KR101677772B1 (ko) 2008-06-11 2016-11-18 레이저젠, 인코퍼레이티드 뉴클레오타이드 및 뉴클레오사이드 그리고 시퀀싱에서의 이들의 이용 방법
CN102150040B (zh) * 2008-08-07 2014-12-31 安捷伦科技有限公司 多波长光源
JP5208650B2 (ja) * 2008-09-29 2013-06-12 オリンパス株式会社 顕微鏡システム
US8361716B2 (en) * 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
US8860938B2 (en) 2008-10-21 2014-10-14 Chemometec A/S Apparatus and methods for analysing fluorescent particles
WO2010091046A2 (en) * 2009-02-03 2010-08-12 President & Fellows Of Harvard College Systems and methods for high throughput, high fidelity, single molecule nucleic acid sequencing using time multiplexed excitation
BRPI1006740A2 (pt) * 2009-04-15 2017-07-11 Koninklijke Philips Electronics Nv Dispositivo para detecção de fluorescência com tempo controlado para aplicações de sequenciamento de dna e estrutura de dados
EP2443254A2 (en) 2009-06-15 2012-04-25 NetBio, Inc. Improved methods for forensic dna quantitation
DE102009029831A1 (de) * 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Vorrichtung und Verfahren für die Mehr-Photonen-Fluoreszenzmikroskopie zur Gewinnung von Informationen aus biologischem Gewebe
FI20096067A0 (fi) 2009-10-15 2009-10-15 Valtion Teknillinen Raman-säteilyn mittaus
CN102985803A (zh) * 2010-02-19 2013-03-20 加利福尼亚太平洋生物科学股份有限公司 集成的分析系统和方法
JP5701618B2 (ja) * 2010-03-04 2015-04-15 ギガフォトン株式会社 極端紫外光生成装置
DE102010015915A1 (de) * 2010-03-11 2011-09-15 Leica Microsystems Cms Gmbh Verfahren für einen beschleunigten Anregungswellenlängen-Scan bei einem Fluoreszenzmikroskop
KR20130030256A (ko) 2010-03-12 2013-03-26 소시에테 디 코머셜리제이션 데스 프로듀이츠 데 라 레쳐쉐 아프리퀘 - 소크프라-사이언스 쌍뜨에 에트 휴마이네스 에스.이.씨. 생물과학, 방사화학, 및 중합체 화학 및 방사선 치료의 물리학에 적용되는 저-에너지 2차 전자의 생성 방법
US20110312554A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Microfluidic device with dialysis device, loc and interconnecting cap
CN103097878B (zh) * 2010-09-10 2015-07-22 奥林巴斯株式会社 使用单个发光颗粒的光强度的光学分析方法
JP5893564B2 (ja) * 2010-09-10 2016-03-23 オリンパス株式会社 複数の波長帯域の光計測を用いた光分析方法
US8729502B1 (en) 2010-10-28 2014-05-20 The Research Foundation For The State University Of New York Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection
GB2490857A (en) 2010-11-05 2012-11-21 Kratos Analytical Ltd Timing device and method
EP2631631B1 (en) 2010-11-25 2016-01-20 Olympus Corporation Photometric analysis device and photometric analysis method using wavelength characteristic of light emitted from single illuminant particle
DE102011009075B4 (de) * 2011-01-21 2021-07-22 Kostal Automobil Elektrik Gmbh & Co. Kg Kameraanordnung für ein Kraftfahrzeug
EP2678664B1 (en) 2011-02-24 2019-08-07 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
DE102011005432A1 (de) 2011-03-11 2012-09-13 Hellma Gmbh & Co. Kg Vorrichtung für die Analyse einer kleinen Flüssigkeitsmenge
KR101982627B1 (ko) 2011-05-12 2019-05-27 에이엔디이 코포레이션 Ｓｔｒ 유전자좌의 신속한 다중 증폭 방법 및 조성법
DE112012002055T5 (de) * 2011-05-12 2014-02-06 Lumen Dynamics Group Inc. Lichtquelle, LED-Impulssteuerung und Verfahren zur programmierbaren Impulssteurung und Synchronisierung von Leuchtvorrichtungen
JP5323130B2 (ja) * 2011-05-26 2013-10-23 富士フイルム株式会社 蛍光分析装置および蛍光分析方法
DE102011107645A1 (de) * 2011-07-12 2013-01-17 Leica Microsystems Cms Gmbh Vorrichtung und Verfahren zum Detektieren von Licht
EP2755019B1 (en) * 2011-09-09 2018-01-03 Konica Minolta, Inc. Biological substance detection method
MX342195B (es) 2011-09-13 2016-09-20 Lasergen Inc Nucleótidos de terminación de rápida fotodescomposición 5-metoxi, 3' -oh no bloqueados y métodos para secuenciación de ácido nucleico.
CN103091211B (zh) * 2011-11-03 2017-05-17 深圳迈瑞生物医疗电子股份有限公司 荧光检测系统和细胞分析仪
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US20140049771A1 (en) * 2012-08-16 2014-02-20 Behrokh B. Sadri High-throughput multi laser wave mixing detection methods and apparatus
US20140049768A1 (en) * 2012-08-16 2014-02-20 Behrokh B. Sadri HIgh-throughput single laser wave mixing detection methods and apparatus
US20140065628A1 (en) * 2012-08-28 2014-03-06 Integenx Inc. Methods and Devices for Multi-Color, Out-of-Phase Detection in Electrophoresis
DE102012019471B4 (de) * 2012-09-28 2023-12-21 Carl Zeiss Microscopy Gmbh Vorrichtung und Verfahren zum Ermitteln von Stoffeigenschaften
DE102012110749B4 (de) * 2012-11-09 2023-03-02 Endress+Hauser Conducta Gmbh+Co. Kg Messvorrichtung zur Messung optischer Eigenschaften eines Mediums
EP2972227B1 (en) 2013-03-12 2020-05-06 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
BR112016007781B1 (pt) 2013-10-07 2021-12-28 Douglas Scientific, Llc. Dispositivo de teste portátil para analisar amostras biológicas
US9941103B2 (en) * 2013-10-19 2018-04-10 Kla-Tencor Corporation Bias-variant photomultiplier tube
KR102204111B1 (ko) 2014-04-17 2021-01-15 삼성전자주식회사 화합물, 유기 광전 소자 및 이미지 센서
KR102315741B1 (ko) * 2014-06-03 2021-10-21 더 리전츠 오브 더 유니버시티 오브 캘리포니아 나노 입자 분석기
CN104198388B (zh) * 2014-09-15 2017-05-10 中国科学院烟台海岸带研究所 一种基于复合光谱测量的在线水质监测装置
US10184892B2 (en) * 2014-10-29 2019-01-22 Horiba Instruments Incorporated Determination of water treatment parameters based on absorbance and fluorescence
JP6551723B2 (ja) * 2014-11-13 2019-07-31 株式会社リコー 光学センサ、光学検査装置、及び光学特性検出方法
US10746600B2 (en) * 2015-01-09 2020-08-18 California Institute Of Technology Dual wavelength context imaging Raman and fluorescence spectrometer
US11971354B2 (en) 2015-04-08 2024-04-30 Molecular Devices, Llc Methods and systems for fluorescence detection using infrared dyes
US10379046B2 (en) * 2015-04-08 2019-08-13 Molecular Devices, Llc Method and system for multiplexed time-resolved fluorescence detection
AU2016264737B2 (en) * 2015-05-20 2021-09-09 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
EP3344964A2 (en) * 2015-09-01 2018-07-11 Qiagen Instruments AG Systems and methods for color detection in high-throughput nucleic acid sequencing systems
US9720243B1 (en) * 2015-12-31 2017-08-01 X Development Llc Wavelength division monolithic optical device
DE102016200271A1 (de) * 2016-01-13 2017-07-13 Institut Dr. Foerster Gmbh & Co. Kg Vorrichtung zur Erzeugung und Messung einer Emission
WO2017139008A1 (en) * 2016-02-11 2017-08-17 Stratio Broadband visible-shortwave infrared spectrometer
US10281327B2 (en) 2016-02-11 2019-05-07 Stratio Spectrometers with self-compensation of rotational misalignment
FI20165148A7 (fi) * 2016-02-25 2017-08-26 Arcdia Int Oy Ltd Kaksoisfotoniviritteistä fluoresenssia hyödyntävä bioaffiniteettimääritysmenetelmä
GB2549298B (en) * 2016-04-12 2022-02-02 Univ I Tromsoe Norges Arktiske Univ Super-resolution imaging
CN108603839A (zh) * 2016-04-18 2018-09-28 惠普发展公司，有限责任合伙企业 散射辐射的多重光谱的同时检测
US10338354B2 (en) * 2016-07-18 2019-07-02 Coherent, Inc. Achromatic anastigmatic anamorphic objective
CN106404723B (zh) * 2016-08-22 2022-01-11 深圳大学 一种二次谐波高分辨率成像方法及系统
DE102016123258B4 (de) * 2016-12-01 2018-07-19 Leica Microsystems Cms Gmbh Lumineszenzdetektoranordnung, Fluoreszenzmikroskop und Verfahren zum Detektieren eines Lumineszenzsignals
AU2017375481A1 (en) 2016-12-16 2019-06-20 Quantum-Si Incorporated Compact mode-locked laser module
CN116466494A (zh) 2016-12-16 2023-07-21 宽腾矽公司 紧密的光束整形及操纵总成
JP7042457B2 (ja) * 2017-06-06 2022-03-28 パナソニックＩｐマネジメント株式会社 蛍光体および発光装置
WO2019240801A1 (en) * 2017-06-14 2019-12-19 Chen Jinghong High sensitivity optical detection system
WO2019078230A1 (ja) * 2017-10-19 2019-04-25 コニカミノルタ株式会社 生体物質定量方法、画像処理装置、病理診断支援システム及びプログラム
BR112020012708A2 (pt) 2017-12-27 2020-11-24 Ethicon Llc imageamento por fluorescência em um ambiente de-ficiente de luz
IL277170B2 (en) * 2018-03-23 2025-09-01 Nippon Sheet Glass Co Ltd Reaction processing facility
JP6571303B1 (ja) 2018-03-23 2019-09-04 日本板硝子株式会社 反応処理装置
US11222779B2 (en) * 2018-05-17 2022-01-11 GMJ Technologies, Inc. Apparatuses for optical and mass spectrometry detection
US11808700B2 (en) 2018-06-15 2023-11-07 Quantum-Si Incorporated Data acquisition control for advanced analytic instruments having pulsed optical sources
CN112262308B (zh) 2018-06-22 2024-10-29 株式会社日立高新技术 电泳装置
JP7228060B2 (ja) * 2018-06-22 2023-02-22 株式会社日立ハイテク 電気泳動装置
JP6688342B2 (ja) 2018-07-06 2020-04-28 日本板硝子株式会社 反応処理装置
DE102018008980B4 (de) * 2018-11-14 2023-08-24 Particle Metrix Gmbh Vorrichtung und Verfahren zur Bestimmung der Fluoreszenz und der Anzahl von Antikörpern auf Exosomen.
NL2023327B1 (en) * 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
CN109873878B (zh) * 2019-04-01 2021-08-24 宁波奥克斯电气股份有限公司 电子终端的通信连接方法与装置及电子终端、存储介质
CN111796475B (zh) * 2019-04-09 2022-03-08 成都理想境界科技有限公司 一种光源合束模组、投影显示装置及投影显示设备
CN110018159A (zh) * 2019-05-08 2019-07-16 衢州超越环保科技有限公司 一种城市雨水ph检测及管理利用系统
GB2619178B (en) * 2019-05-22 2024-05-01 Hitachi High Tech Corp Analysis device and analysis method
EP3980754A1 (en) * 2019-06-07 2022-04-13 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) System and method for real-time multicolor shortwave infrared fluorescence imaging
CA3142922A1 (en) 2019-06-14 2020-12-17 Quantum-Si Incorporated Sliced grating coupler with increased beam alignment sensitivity
US11674848B2 (en) 2019-06-20 2023-06-13 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for hyperspectral imaging
US11533417B2 (en) 2019-06-20 2022-12-20 Cilag Gmbh International Laser scanning and tool tracking imaging in a light deficient environment
US11516387B2 (en) 2019-06-20 2022-11-29 Cilag Gmbh International Image synchronization without input clock and data transmission clock in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11389066B2 (en) 2019-06-20 2022-07-19 Cilag Gmbh International Noise aware edge enhancement in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11925328B2 (en) 2019-06-20 2024-03-12 Cilag Gmbh International Noise aware edge enhancement in a pulsed hyperspectral imaging system
US11284785B2 (en) 2019-06-20 2022-03-29 Cilag Gmbh International Controlling integral energy of a laser pulse in a hyperspectral, fluorescence, and laser mapping imaging system
US11432706B2 (en) 2019-06-20 2022-09-06 Cilag Gmbh International Hyperspectral imaging with minimal area monolithic image sensor
US11102400B2 (en) 2019-06-20 2021-08-24 Cilag Gmbh International Pulsed illumination in a fluorescence imaging system
US11412152B2 (en) 2019-06-20 2022-08-09 Cilag Gmbh International Speckle removal in a pulsed hyperspectral imaging system
US11633089B2 (en) 2019-06-20 2023-04-25 Cilag Gmbh International Fluorescence imaging with minimal area monolithic image sensor
US12013496B2 (en) 2019-06-20 2024-06-18 Cilag Gmbh International Noise aware edge enhancement in a pulsed laser mapping imaging system
US11931009B2 (en) 2019-06-20 2024-03-19 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a hyperspectral imaging system
US10952619B2 (en) 2019-06-20 2021-03-23 Ethicon Llc Hyperspectral and fluorescence imaging and topology laser mapping with minimal area monolithic image sensor
US11550057B2 (en) 2019-06-20 2023-01-10 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a fluorescence imaging system
US11237270B2 (en) 2019-06-20 2022-02-01 Cilag Gmbh International Hyperspectral, fluorescence, and laser mapping imaging with fixed pattern noise cancellation
US11944273B2 (en) 2019-06-20 2024-04-02 Cilag Gmbh International Fluorescence videostroboscopy of vocal cords
US11898909B2 (en) 2019-06-20 2024-02-13 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US11412920B2 (en) 2019-06-20 2022-08-16 Cilag Gmbh International Speckle removal in a pulsed fluorescence imaging system
US11617541B2 (en) 2019-06-20 2023-04-04 Cilag Gmbh International Optical fiber waveguide in an endoscopic system for fluorescence imaging
US10841504B1 (en) 2019-06-20 2020-11-17 Ethicon Llc Fluorescence imaging with minimal area monolithic image sensor
US11266304B2 (en) 2019-06-20 2022-03-08 Cilag Gmbh International Minimizing image sensor input/output in a pulsed hyperspectral imaging system
US11187658B2 (en) 2019-06-20 2021-11-30 Cilag Gmbh International Fluorescence imaging with fixed pattern noise cancellation
US11589819B2 (en) 2019-06-20 2023-02-28 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a laser mapping imaging system
US11134832B2 (en) 2019-06-20 2021-10-05 Cilag Gmbh International Image rotation in an endoscopic hyperspectral, fluorescence, and laser mapping imaging system
US11716543B2 (en) 2019-06-20 2023-08-01 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for fluorescence imaging
US12007550B2 (en) 2019-06-20 2024-06-11 Cilag Gmbh International Driving light emissions according to a jitter specification in a spectral imaging system
US11012599B2 (en) 2019-06-20 2021-05-18 Ethicon Llc Hyperspectral imaging in a light deficient environment
US11903563B2 (en) 2019-06-20 2024-02-20 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a fluorescence imaging system
US12126887B2 (en) 2019-06-20 2024-10-22 Cilag Gmbh International Hyperspectral and fluorescence imaging with topology laser scanning in a light deficient environment
US11540696B2 (en) 2019-06-20 2023-01-03 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US11700995B2 (en) 2019-06-20 2023-07-18 Cilag Gmbh International Speckle removal in a pulsed fluorescence imaging system
US11671691B2 (en) 2019-06-20 2023-06-06 Cilag Gmbh International Image rotation in an endoscopic laser mapping imaging system
US12440085B2 (en) 2019-06-20 2025-10-14 Cilag Gmbh International Image synchronization without input clock and data transmission clock in a pulsed laser mapping imaging system
US11147436B2 (en) 2019-06-20 2021-10-19 Cilag Gmbh International Image rotation in an endoscopic fluorescence imaging system
US11471055B2 (en) 2019-06-20 2022-10-18 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US11457154B2 (en) 2019-06-20 2022-09-27 Cilag Gmbh International Speckle removal in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11937784B2 (en) 2019-06-20 2024-03-26 Cilag Gmbh International Fluorescence imaging in a light deficient environment
US11758256B2 (en) 2019-06-20 2023-09-12 Cilag Gmbh International Fluorescence imaging in a light deficient environment
US11624830B2 (en) 2019-06-20 2023-04-11 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for laser mapping imaging
US11622094B2 (en) 2019-06-20 2023-04-04 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for fluorescence imaging
JP2022545093A (ja) * 2019-08-23 2022-10-25 ミダイアグノスティクス・エヌブイ リアルタイムｐｃｒ検出のためのマルチカラーシステム
GB201912351D0 (en) * 2019-08-28 2019-10-09 Fluoretiq Ltd Spectrofluoromteric apparatus and methods for the detection of bacteria
DE102020126260A1 (de) * 2019-10-17 2021-04-22 Phoseon Technology, Inc. Verfahren und Systeme für ein Mehrwellenlängen-Beleuchtungssystem
CN110804679B (zh) * 2019-11-08 2021-02-12 宁波胤瑞生物医学仪器有限责任公司 一种核酸扩增仪调节方法
IL292993A (en) * 2019-11-17 2022-07-01 Berkeley Lights Inc Systems and methods for analyses of biological samples
US20210182531A1 (en) * 2019-12-17 2021-06-17 Applied Materials, Inc. Registration techniques for multiplexed fluorescence in-situ hybridization images
KR20220137027A (ko) 2020-01-14 2022-10-11 퀀텀-에스아이 인코포레이티드 진폭 변조 레이저
US20210215609A1 (en) * 2020-01-15 2021-07-15 Osram Opto Semiconductors Gmbh Apparatus, a Handheld Electronic Device, and a Method for Carrying Out Raman Spectroscopy
JP7233385B2 (ja) * 2020-01-20 2023-03-06 日本板硝子株式会社 反応処理装置
DE102020207587A1 (de) 2020-06-18 2021-12-23 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren und Steuergerät zum Auswerten eines Lumineszenzsignals in einem Analysegerät zum Analysieren einer Probe biologischen Materials und Analysegerät zum Analysieren einer Probe biologischen Materials
JP7605962B2 (ja) * 2020-08-05 2024-12-24 ライカ マイクロシステムズ シーエムエス ゲゼルシャフト ミット ベシュレンクテル ハフツング 蛍光顕微鏡における照明調整方法および対応する蛍光顕微鏡
WO2022126899A1 (zh) * 2020-12-14 2022-06-23 苏州先达基因科技有限公司 一种便携式荧光检测装置
US20220195516A1 (en) * 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
DE102021206879A1 (de) * 2021-06-30 2023-01-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Verfahren zur optischen Überwachung und/oder Bestimmung von Eigenschaften an Proben
KR102624004B1 (ko) * 2021-11-16 2024-01-11 한국광기술원 형광영상 및 컬러영상 획득을 위한 다중 형광영상장치 및 그 제어방법
CN119013547A (zh) * 2022-05-20 2024-11-22 株式会社日立高新技术 电泳数据处理装置以及电泳数据处理方法
US20240326151A1 (en) * 2023-03-30 2024-10-03 Illinois Tool Works Inc. Welding torch consumables cleaning systems
DE102023108783A1 (de) * 2023-04-05 2024-10-10 Ams-Osram International Gmbh Halbleiterlaservorrichtung und verfahren zur herstellung einer halbleiterlaservorrichtung

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
US5784157A (en) * 1995-11-21 1998-07-21 The Research Foundation Of State University Of New York Method and apparatus for identifying fluorophores
US6211955B1 (en) * 2000-01-24 2001-04-03 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3734631A (en) * 1971-05-28 1973-05-22 Hewlett Packard Co Nondispersive infrared gas analyzer employing solid state emitters and photodetectors
DE3137658C2 (de) * 1981-09-22 1985-06-05 H. Maihak Ag, 2000 Hamburg Vorrichtung zur Messung der Konzentration eines IR-, NIR-, VIS- oder UV-Strahlung absorbierenden Gases in einer Gasmatrix
US4582788A (en) 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
JPS60131428A (ja) 1983-12-21 1985-07-13 Komatsu Ltd カ−ス分光装置
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4744667A (en) * 1986-02-11 1988-05-17 University Of Massachusetts Microspectrofluorimeter
US5510894A (en) * 1988-12-22 1996-04-23 Renishaw Plc Spectroscopic apparatus and methods
US5760900A (en) * 1989-03-18 1998-06-02 Canon Kabushiki Kaisha Method and apparatus for optically measuring specimen
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US5504337A (en) * 1990-10-10 1996-04-02 Joseph R. Lakowicz Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
US5846710A (en) 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
US5252834A (en) * 1990-11-13 1993-10-12 Union Oil Company Of California Pulsed and gated multi-mode microspectrophotometry device and method
US5489777A (en) * 1990-12-26 1996-02-06 Denver Seminary Apparatus for remote analysis of vehicle emissions using reflective thermography
WO1992013265A1 (en) * 1991-01-24 1992-08-06 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5888819A (en) 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
US5196709A (en) * 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5233197A (en) * 1991-07-15 1993-08-03 University Of Massachusetts Medical Center High speed digital imaging microscope
DE69221423T2 (de) * 1991-09-30 1998-03-19 Beckman Instruments Inc Verbesserte Fluoreszenz-Erfassung von Proben in einem Kapillarrohr
US5484571A (en) * 1991-10-08 1996-01-16 Beckman Instruments, Inc. Enhanced fluorescence detection of samples in capillary column
JP2815506B2 (ja) * 1992-04-14 1998-10-27 株式会社日立製作所 光検出型電気泳動装置
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US6159686A (en) * 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US6153379A (en) 1993-06-22 2000-11-28 Baylor College Of Medicine Parallel primer extension approach to nucleic acid sequence analysis
DE4338531A1 (de) * 1993-11-11 1995-05-18 Leica Lasertechnik Vorrichtung zur Mehrfarbbeleuchtung von Präparaten
US5491344A (en) * 1993-12-01 1996-02-13 Tufts University Method and system for examining the composition of a fluid or solid sample using fluorescence and/or absorption spectroscopy
FI95322C (fi) * 1994-03-02 1996-01-10 Instrumentarium Oy Spektroskooppinen mittausanturi väliaineiden analysointiin
US6903347B2 (en) * 1994-07-15 2005-06-07 Stephen C. Baer Superresolution in microlithography and fluorescence microscopy
US5599717A (en) * 1994-09-02 1997-02-04 Martin Marietta Energy Systems, Inc. Advanced synchronous luminescence system
US5556790A (en) * 1994-12-05 1996-09-17 Pettit; John W. Method for Automated DNA sequencing
WO1996023213A1 (en) * 1995-01-23 1996-08-01 Murray Anthony J Analysis of biological molecules
US5675155A (en) * 1995-04-26 1997-10-07 Beckman Instruments, Inc. Multicapillary fluorescent detection system
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JPH09288203A (ja) 1996-02-22 1997-11-04 Nikon Corp 多重焦線レンズ
JPH09329548A (ja) * 1996-06-11 1997-12-22 Bunshi Bio Photonics Kenkyusho:Kk 蛍光寿命測定装置
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
JPH10267844A (ja) * 1997-03-25 1998-10-09 Jasco Corp 時間分解蛍光検出器およびそれを用いた蛍光分析装置、方法
AU8148898A (en) * 1997-06-23 1999-01-04 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
GB9717021D0 (en) * 1997-08-12 1997-10-15 Kalibrant Limited A detector
US6043506A (en) * 1997-08-13 2000-03-28 Bio-Rad Laboratories, Inc. Multi parameter scanner
JPH11119106A (ja) * 1997-10-16 1999-04-30 Olympus Optical Co Ltd レーザ走査型顕微鏡
US6369893B1 (en) * 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
US6038023A (en) 1998-07-31 2000-03-14 The Research Foundation Of State University Of New York Sensors for detection and spectroscopy
US6215598B1 (en) 1998-10-05 2001-04-10 Ruey Jennifer Hwu Apparatus and method for concentrating beams from broad area diode lasers, diode laser bars and/ or diode laser arrays
US6134050A (en) 1998-11-25 2000-10-17 Advanced Laser Technologies, Inc. Laser beam mixer
JP2000266666A (ja) * 1999-03-19 2000-09-29 Hitachi Koki Co Ltd エリプソメータ
JP2001116696A (ja) * 1999-10-21 2001-04-27 Olympus Optical Co Ltd 走査型光学装置
JP2001124627A (ja) * 1999-10-28 2001-05-11 Horiba Ltd 分光分析装置
JP2001133405A (ja) * 1999-11-04 2001-05-18 Hitachi Kokusai Electric Inc 蛍光読取り装置
US6630680B2 (en) * 2000-12-25 2003-10-07 Fuji Photo Film Co., Ltd. Scanner having confocal optical system, method for producing focus position data of confocal optical system of scanner having confocal optical system and method for producing digital data of scanner having confocal optical system
EP1354193B1 (en) * 2001-01-26 2007-06-06 Biocal Technology, Inc. Optical detection in a multi-channel bio-separation system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
US5784157A (en) * 1995-11-21 1998-07-21 The Research Foundation Of State University Of New York Method and apparatus for identifying fluorophores
US6211955B1 (en) * 2000-01-24 2001-04-03 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells

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CA2774152A1 (en) 2003-03-13
AU2002323452B2 (en) 2008-01-10
JP2005524051A (ja) 2005-08-11
WO2003021212A1 (en) 2003-03-13
US20060139634A1 (en) 2006-06-29
US20090156429A1 (en) 2009-06-18
US7511811B2 (en) 2009-03-31
US8089628B2 (en) 2012-01-03
JP2009098151A (ja) 2009-05-07
JP2011027748A (ja) 2011-02-10
EP1432966A1 (en) 2004-06-30
EP1432966A4 (en) 2011-05-04

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