AU2001245988A1 - Microspheres for active embolization - Google Patents

Microspheres for active embolization

Info

Publication number
AU2001245988A1
AU2001245988A1 AU2001245988A AU4598801A AU2001245988A1 AU 2001245988 A1 AU2001245988 A1 AU 2001245988A1 AU 2001245988 A AU2001245988 A AU 2001245988A AU 4598801 A AU4598801 A AU 4598801A AU 2001245988 A1 AU2001245988 A1 AU 2001245988A1
Authority
AU
Australia
Prior art keywords
embolization
microspheres
angiogenic
present
injectable compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001245988A
Other languages
English (en)
Inventor
Egisto Boschetti
Jean-Marie Vogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosphere Medical Inc
Original Assignee
Biosphere Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22707362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2001245988(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biosphere Medical Inc filed Critical Biosphere Medical Inc
Publication of AU2001245988A1 publication Critical patent/AU2001245988A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
AU2001245988A 2000-03-24 2001-03-23 Microspheres for active embolization Abandoned AU2001245988A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19189900P 2000-03-24 2000-03-24
US60191899 2000-03-24
PCT/US2001/009619 WO2001072281A2 (en) 2000-03-24 2001-03-23 Microspheres for active embolization

Publications (1)

Publication Number Publication Date
AU2001245988A1 true AU2001245988A1 (en) 2001-10-08

Family

ID=22707362

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001245988A Abandoned AU2001245988A1 (en) 2000-03-24 2001-03-23 Microspheres for active embolization

Country Status (10)

Country Link
US (4) US8697137B2 (ja)
EP (3) EP1820495B1 (ja)
JP (4) JP2003528130A (ja)
KR (2) KR20080046750A (ja)
CN (2) CN1430505A (ja)
AT (1) ATE374597T1 (ja)
AU (1) AU2001245988A1 (ja)
DE (2) DE60130743T2 (ja)
ES (2) ES2254042T3 (ja)
WO (1) WO2001072281A2 (ja)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
DE60130544T2 (de) 2000-03-13 2008-06-26 Biocure, Inc. Embolische zusammensetzungen
JP5460939B2 (ja) 2000-03-13 2014-04-02 バイオコンパティブルズ ユーケー リミテッド ヒドロゲル生物医学用製品
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
WO2001070289A2 (en) 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
DE60130743T2 (de) * 2000-03-24 2008-07-17 Biosphere Medical, Inc., Rockland Mikrokugeln zur aktiven embolisierung
US20040266983A1 (en) * 2000-08-17 2004-12-30 Reeve Lorraine E Purified polyoxyalkylene block copolymers
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
WO2003090604A2 (en) * 2002-04-24 2003-11-06 University Of Florida Method of endovascular brain mapping
US7332160B2 (en) 2002-07-12 2008-02-19 Boston Scientific Scimed, Inc. Medical device and method for tissue removal and repair
US7588825B2 (en) * 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US20050008610A1 (en) * 2003-03-24 2005-01-13 Alexander Schwarz Temporary embolization using inverse thermosensitive polymers
CA2531894C (en) * 2003-09-25 2014-02-11 Rutgers, The State University Inherently radiopaque polymeric products for embolotherapy
US7901770B2 (en) * 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7700086B2 (en) * 2003-11-06 2010-04-20 Pluromed, Inc. Internal clamp for surgical procedures
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
CA2565721C (en) * 2004-05-06 2015-10-06 Bioresponse, L.L.C. Diindolymethane formulations for the treatment of leiomyomas
US8821859B2 (en) * 2004-05-19 2014-09-02 Agency For Science, Technology And Research Methods and articles for the delivery of therapeutic agents
EP1600456A1 (en) * 2004-05-28 2005-11-30 Deutsches Krebsforschungszentrum Method for the purification of polymers carrying a lipophilic group
WO2006013309A1 (en) * 2004-08-03 2006-02-09 Biocompatibles Uk Limited Drug delivery from embolic agents
US20070281028A1 (en) * 2004-08-04 2007-12-06 Biocompatibles Uk Limited Drug Delivery of a Cox Inhibitor from Embolic Agents
US20210299056A9 (en) * 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
JP4885866B2 (ja) 2004-10-25 2012-02-29 セロノヴァ バイオサイエンスィズ ジャーマニー ゲーエムベーハー 治療適用および／または診断適用のための充填可能なポリホスファゼン含有粒子、ならびにその調製方法および使用方法
US11426355B2 (en) 2004-10-25 2022-08-30 Varian Medical Systems, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
ATE497762T1 (de) 2004-12-30 2011-02-15 Bioresponse Llc Verwendung von diindolylmethan-verwandten indolen zur behandlung und prävention von erkrankungen im zusammenhang mit dem respiratory syncytial virus
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
WO2006119968A2 (en) 2005-05-09 2006-11-16 Biosphere Medical S.A. Compositions and methods using microspheres and non-ionic contrast agents
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
FR2892927B1 (fr) * 2005-11-04 2008-01-11 Oreal Utilisation d'une composition cosmetique comprenant des particules spheriques flexibles pour la mise en forme des cheveux
EP1978938B1 (en) * 2006-01-24 2015-09-09 Biocompatibles UK Limited Process for loading polymer particles with drug
US20080033366A1 (en) * 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
EP1986706B1 (en) * 2006-01-30 2011-08-17 Biosphere Medical, Inc. Porous intravascular embolization particles and methods of making them
US7794755B2 (en) 2006-04-11 2010-09-14 E.I. Du Pont De Nemours And Company Process for preparation of swellable and deformable microspheres
US8062673B2 (en) 2006-04-11 2011-11-22 E I Du Pont De Nemours And Company Process for embolization using swellable and deformable microspheres
US8252339B2 (en) 2006-04-11 2012-08-28 Massachusetts Institute Of Technology Medical treatment applications of swellable and deformable microspheres
US7838035B2 (en) * 2006-04-11 2010-11-23 E. I. Du Pont De Nemours And Company Microsphere powder of high density, swellable, deformable, durable occlusion-forming microspheres
CN100518719C (zh) * 2006-07-05 2009-07-29 中国科学院大连化学物理研究所 一种复合基质的多功能动脉栓塞剂的制备方法
WO2008057253A2 (en) 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
CN101677822A (zh) * 2006-12-11 2010-03-24 普拉罗美德公司 灌注器官止血法
KR20090114469A (ko) * 2007-02-22 2009-11-03 플루로메드, 인코포레이티드 수술후 생물학적 유체 흐름을 제어하기 위한 역 감열 폴리머의 용도
US9987221B2 (en) * 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
EP2229147A2 (en) * 2007-12-03 2010-09-22 The Johns Hopkins University Methods of synthesis and use of chemospheres
EP2123256A1 (en) 2008-05-19 2009-11-25 Ruhr-Universität Bochum Perfluorcarbon nanoemulsions with endocytosis enhancing surface for gene-transfer
US20110212179A1 (en) * 2008-10-30 2011-09-01 David Liu Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same
EP2403483B1 (en) * 2009-03-02 2017-05-10 Assistance Publique Hôpitaux De Paris Injectable biomaterial
WO2010143708A1 (ja) * 2009-06-12 2010-12-16 富士フイルム株式会社 新生血管に対する標的化剤
CN102905733B (zh) 2009-10-06 2014-10-15 明尼苏达大学董事会 生物可吸收栓塞微球
US9089512B2 (en) * 2009-12-18 2015-07-28 President And Fellows Of Harvard College Active scaffolds for on-demand drug and cell delivery
EP2351779B1 (en) * 2010-01-27 2019-04-24 Biosphere Medical, Inc. Microspheres and method of making the microspheres
KR101151688B1 (ko) * 2010-05-18 2012-06-14 중앙대학교 산학협력단 색전 미세구 제조 시스템
US9192746B2 (en) * 2010-06-07 2015-11-24 Cook Medical Technologies Llc Reperfusion catheter system
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
CN107043339B (zh) * 2011-07-19 2019-09-06 希默赛生物技术有限责任公司 新交联试剂、大分子、治疗用偶联物及其合成方法
JP6208749B2 (ja) * 2012-05-24 2017-10-04 バイオスフィア メディカル，インコーポレイテッド 薬剤溶出性で磁気共鳴画像法で検出可能な血管閉塞用インプラントとしての使用に適した生体材料
CN103142491B (zh) * 2013-02-06 2015-07-15 广东先强药业有限公司 一种单磷酸阿糖腺苷微球给药系统及其制备方法
CN103536974B (zh) * 2013-07-05 2015-07-15 北京大学 磁共振成像可检测的原位液晶前体栓塞组合物及其制备和应用
CN103536972B (zh) * 2013-07-05 2016-01-13 北京大学 磁共振成像可检测的液体栓塞组合物及其制备和应用
US20150080940A1 (en) * 2013-09-13 2015-03-19 Cook Medical Technologies Llc Anti-tumor macrophage m1 morphology inducer
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
AU2014321278B2 (en) 2013-09-19 2016-11-10 Microvention, Inc. Polymer films
US9546236B2 (en) 2013-09-19 2017-01-17 Terumo Corporation Polymer particles
CN103550834B (zh) * 2013-10-25 2015-07-15 北京大学 一种栓塞材料组合物及其制备方法和用途
EP3065719A4 (en) 2013-11-08 2017-08-09 Terumo Corporation Polymer particles
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
CN104865333B (zh) * 2015-05-14 2016-08-24 武汉轻工大学 一种龙眼肉蛋白多糖的检测方法
AU2016313969B2 (en) * 2015-06-19 2021-12-23 Sillajen, Inc. Compositions and methods for viral embolization
GB201515602D0 (en) * 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
KR20180066075A (ko) * 2015-09-08 2018-06-18 신라젠(주) 사이토카인 및 카르복실에스테라제를 발현하는 변형된 종양용해성 백시니아 바이러스 및 이의 사용 방법
US10053693B2 (en) 2016-01-19 2018-08-21 Mubin I. Syed Method for controlling obesity using minimally invasive means
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
TWI604819B (zh) * 2016-04-13 2017-11-11 Bioabsorbable bone nail capable of developing under x-ray and its making method
AU2017300629B2 (en) * 2016-07-21 2019-11-07 Boston Scientific Scimed, Inc. Injectable compositions
CN109789222B (zh) 2016-09-28 2022-02-25 泰尔茂株式会社 聚合物颗粒
EA038657B1 (ru) * 2016-10-12 2021-09-29 Общество С Ограниченной Ответственностью "Технология Лекарств" Химиоэмболизирующие частицы для лечения солидных опухолей
CN110831526A (zh) 2017-05-19 2020-02-21 波士顿科学国际有限公司 用于粘膜下组织分离的系统和方法
MX2019014038A (es) 2017-05-26 2022-04-20 Bruin Biosciences Inc Agentes de quimioembolizacion.
US20200281960A1 (en) * 2017-10-25 2020-09-10 Medigear International Corporation Biodegradable and biometabolic tumor sealant
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
WO2019126169A1 (en) 2017-12-18 2019-06-27 C. R. Bard, Inc. Drug-loaded microbead compositions, embolization compositions and associated methods
CN109010902A (zh) * 2018-05-04 2018-12-18 南京大学 一种具有抗肿瘤作用的肝素淀粉微球血管栓塞剂及制备方法
US20210228766A1 (en) * 2018-05-31 2021-07-29 T-ACE Medical Co., Ltd. Microsphere for embolization, preparation method thereof, and method for embolizing tumor using the same
CN108992431B (zh) * 2018-09-30 2020-10-09 重庆医科大学附属永川医院 一种多柔比星栓塞微球及其制备方法
CN112646082B (zh) * 2019-10-10 2023-06-23 陈忠 丙烯酸酯聚合物微球聚集体及其制备方法
CN112791228A (zh) * 2019-11-13 2021-05-14 太阳雨林（厦门）生物医药有限公司 一种用于肺结核咯血的缓释栓塞微球
CN112972753A (zh) * 2019-12-02 2021-06-18 太阳雨林（厦门）生物医药有限公司 一种用于治疗慢性炎症引起的支气管扩张性咯血的缓释栓塞微球
WO2022060993A1 (en) * 2020-09-16 2022-03-24 Said Farha System and method for integrated blood vessel embolization and localized drug delivery
CN112305123B (zh) * 2020-10-30 2021-12-28 河北医科大学第二医院 小分子物质在动脉粥样硬化性脑梗死中的应用
CN113975453B (zh) * 2021-09-10 2023-03-07 苏州浩微生物医疗科技有限公司 水凝胶栓塞微球及其制备方法
CN113694248B (zh) * 2021-09-13 2023-03-17 中山大学 一种基于可溶性淀粉的栓塞微球及其制备和应用
WO2023200921A1 (en) * 2022-04-13 2023-10-19 Ned Medical, Inc. Radioembolic beads and methods for treatment of tumor cells

Family Cites Families (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3673125A (en) 1969-05-10 1972-06-27 Kanegafuchi Spinning Co Ltd Method of producing polyvinyl acetal porous articles
US3919411A (en) 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant
JPS49108168A (ja) 1973-02-16 1974-10-15
US4197846A (en) 1974-10-09 1980-04-15 Louis Bucalo Method for structure for situating in a living body agents for treating the body
JPS5350290A (en) 1976-10-18 1978-05-08 Sumitomo Chem Co Ltd Preparation f hydrogel
FR2378808A1 (fr) 1977-01-28 1978-08-25 Mar Pha Etu Expl Marques Nouveaux copolymeres hydrophiles a base de n-(tris(hydroxy-methyl)methyl)acrylamide ou de n-(tris (hydroxymethyl)methyl)methacrylamide, leur preparation et leur emploi dans les techniques de separation
CS204190B1 (en) 1978-02-22 1981-03-31 Jaroslav Drobnik Activation method for hydrxyl groups containing insoluble carriers
CA1134977A (en) 1978-09-07 1982-11-02 Sumitomo Chemical Co., Ltd. Method for preparing highly absorbent polymers
US4314032A (en) 1978-10-26 1982-02-02 Kureha Kagaku Kogyo Kabushiki Kaisha Crosslinked polyvinyl alcohol gel
US4268495A (en) 1979-01-08 1981-05-19 Ethicon, Inc. Injectable embolization and occlusion solution
US4306031A (en) 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
FR2482112B1 (fr) 1980-05-09 1985-06-07 Pharmindustrie Nouveaux copolymeres hydrophiles a base de n-(tris (hydroxymethyl) methyl) acrylamide, procedes pour leur preparation, gels aqueux desdits copolymeres et leur utilisation comme echangeurs d'ions
GB2088392B (en) 1980-12-03 1984-05-02 Sumitomo Chemical Co Production of hydrogels
JPS57128709A (en) 1981-02-03 1982-08-10 Sumitomo Chem Co Ltd Preparation of hydrogel
US4622362A (en) 1981-03-30 1986-11-11 California Institute Of Technology Polyacrolein microspheres
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
JPS5988418A (ja) * 1982-11-08 1984-05-22 Unitika Ltd 抗癌性物質徐放性塞栓剤
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4500658A (en) 1983-06-06 1985-02-19 Austenal International, Inc. Radiopaque acrylic resin
CA1225585A (en) 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
GB8418772D0 (en) 1984-07-24 1984-08-30 Geistlich Soehne Ag Chemical substances
FR2573436B1 (fr) 1984-11-20 1989-02-17 Pasteur Institut Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins
US4680171A (en) 1985-03-15 1987-07-14 William Shell Visualization of a bloodstream circulation with biodegradable microspheres
US5186922A (en) 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
DE3751873T2 (de) 1986-04-09 1997-02-13 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
JPS6317904A (ja) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd 多孔質架橋ポリビニルアルコ−ル粒子の製造法
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4803072A (en) * 1986-09-10 1989-02-07 Smithkline Beckman Corporation Immunomodulation
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4795741A (en) 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
CA1329800C (en) 1987-12-29 1994-05-24 Hiroaki Takayanagi Composite separating agent
AU3049489A (en) 1988-02-12 1989-09-06 Brigitte De Zaepffel Crosslinked hydrophilic copolymer for medical and paramedical use
JPH064713B2 (ja) 1988-07-22 1994-01-19 テルモ株式会社 生体適合性材料
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
JPH0286838A (ja) 1988-09-22 1990-03-27 Terumo Corp 水不溶性ヒドロゲルおよびその製造方法
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
DE3841401A1 (de) 1988-12-08 1990-06-13 Martin Lemperle Alloplastisches implantat
US5258028A (en) 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US5092883A (en) 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
JPH03503651A (ja) 1989-01-27 1991-08-15 メルク　パテント　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフトング ビフェニリルエタン化合物
FR2645866B1 (fr) 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
CA2017570C (en) 1989-05-31 2000-12-19 James R. Gross Porous structure of an absorbent polymer
US5007940A (en) 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5147937A (en) 1990-03-22 1992-09-15 Rohm And Haas Company Process for making controlled, uniform-sized particles in the 1 to 50 micrometer range
JP3120187B2 (ja) * 1990-08-08 2000-12-25 武田薬品工業株式会社 血管新生阻害物質を含む血管内塞栓剤
EP0470569B1 (en) 1990-08-08 1995-11-22 Takeda Chemical Industries, Ltd. Intravascular embolizing agent containing angiogenesis inhibiting substance
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5117577A (en) 1990-11-05 1992-06-02 Gary Burghoff Fish attractor device
US5312617A (en) 1991-05-23 1994-05-17 Unger Evan C Liposoluble compounds useful as magnetic resonance imaging agents
FR2676927B1 (fr) 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
US5554658A (en) 1991-08-06 1996-09-10 Rosenblatt; Solomon Injection molded PVA Sponge
DE69208976T2 (de) 1991-08-23 1997-04-17 Nippon Catalytic Chem Ind Biologisch abbaubares, hydrophiles, vernetztes Polymer, Verfahren zu seiner Herstellung und seine Verwendung
JPH082985B2 (ja) 1991-08-26 1996-01-17 東京シート株式会社 高密度表層付ウレタンフォーム成形品の製造方法
JP3356447B2 (ja) 1991-10-16 2002-12-16 テルモ株式会社 乾燥高分子ゲルからなる血管病変塞栓材料
NZ249770A (en) 1992-02-28 1996-09-25 Univ Texas Biodegradable, polymerisable, substantially water soluble macromer comprising at least one water soluble region, at least one degradable region and at least two free radical polymerisable regions separated by at least one degradable region
JPH05294839A (ja) * 1992-04-20 1993-11-09 Biomaterial Universe Kk シスプラチン含有生体内分解吸収性高分子の微小球お よびその製造法
JPH0656676A (ja) * 1992-08-05 1994-03-01 Hori Shinichi 血管塞栓用懸濁液
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5654006A (en) * 1993-02-12 1997-08-05 Mayo Foundation For Medical Education And Research Condensed-phase microparticle composition and method
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
DE69408527T2 (de) 1993-03-09 1998-06-04 Epic Therapeutics Inc Makromolekulare mikropartikel und verfahren zu ihrer herstellung
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
CA2158638C (en) 1993-03-19 1999-11-30 Bengt Agerup A composition and a method for tissue augmentation
FR2705361B1 (fr) 1993-05-18 1995-08-04 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
FR2707664B1 (fr) 1993-07-13 1995-09-29 Centre Nat Rech Scient Vecteurs viraux et utilisation en thérapie génique.
DE69435002T2 (de) * 1993-07-19 2008-03-20 Angiotech Pharmaceuticals, Inc., Vancouver Anti-angiogene Mittel enthaltend Taxol und einen nicht biodegradierbaren Träger und deren Verwendung
US20030203976A1 (en) * 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US5994341A (en) * 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US5639872A (en) * 1993-07-27 1997-06-17 Hybridon, Inc. Human VEGF-specific oligonucleotides
GB2281861B (en) 1993-09-21 1997-08-20 Johnson & Johnson Medical Bioabsorbable wound implant materials containing microspheres
WO1995013798A1 (en) 1993-11-18 1995-05-26 Cancer Research Institute Inc. Controlled release preparation
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
US5830686A (en) 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
US5583162A (en) 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
US5451406A (en) 1994-07-14 1995-09-19 Advanced Uroscience, Inc. Tissue injectable composition and method of use
UA10911C2 (uk) 1994-08-10 1996-12-25 Мале Впроваджувальне Підприємство "Іhтерфалл" Біосумісhий гідрогель
AU700903B2 (en) 1994-10-12 1999-01-14 Focal, Inc. Targeted delivery via biodegradable polymers
US6099864A (en) * 1994-12-02 2000-08-08 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration In situ activation of microcapsules
US5955108A (en) 1994-12-16 1999-09-21 Quadrant Healthcare (Uk) Limited Cross-linked microparticles and their use as therapeutic vehicles
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
EP0805656B1 (en) 1995-01-27 2004-05-06 SciMed Life Systems, Inc. Embolizing system
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US5888546A (en) * 1995-08-28 1999-03-30 The Regents Of The University Of California Embolic material for endovascular occlusion of abnormal vasculature and method for using the same
US5985177A (en) 1995-12-14 1999-11-16 Shiseido Co., Ltd. O/W/O type multiple emulsion and method of preparing the same
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
DE19601699A1 (de) 1996-01-18 1997-07-24 Wacker Chemie Gmbh Redispergierbare Polymerisatpulver und daraus erhältliche wäßrige Polymerisat-Dispersionen
US5785977A (en) 1996-02-07 1998-07-28 Breithbarth; Richard Non-metallic microparticle carrier materials
US5611344A (en) 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
BR9708355A (pt) 1996-03-27 1999-08-03 Novartis Ag Processo para produção de um polímero poroso através do uso de um porogénio
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
US6083484A (en) * 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US5925683A (en) 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
AU7068698A (en) 1997-04-24 1998-11-13 General Hospital Corporation, The Embolus therapy using insoluble microparticles or vesicles containing contrast agents
US5861149A (en) 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
US6048908A (en) 1997-06-27 2000-04-11 Biopore Corporation Hydrophilic polymeric material
WO1999011196A1 (en) 1997-09-04 1999-03-11 Point Biomedical Corporation Injectable tissue reconstruction material
AU8877098A (en) * 1997-09-05 1999-03-29 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization
US6548047B1 (en) * 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6015541A (en) 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
GB9727518D0 (en) * 1997-12-31 1998-02-25 Nycomed Imaging As Use
CN1714783A (zh) 1998-03-06 2006-01-04 生物领域医疗公司 用于组织膨胀和治疗的可植入颗粒
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US5891470A (en) 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol
US6224794B1 (en) * 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US6316011B1 (en) 1998-08-04 2001-11-13 Madash, Llc End modified thermal responsive hydrogels
US6315709B1 (en) 1998-08-07 2001-11-13 Stereotaxis, Inc. Magnetic vascular defect treatment system
CA2248592A1 (en) * 1998-08-31 2000-02-29 Christopher D. Batich Microspheres for use in the treatment of cancer
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US20040047804A1 (en) 1998-10-29 2004-03-11 The General Hospital Corporation, A Massachusetts Corporation Enhanced radiation therapy
US6955661B1 (en) * 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US6296604B1 (en) * 1999-03-17 2001-10-02 Stereotaxis, Inc. Methods of and compositions for treating vascular defects
US6710126B1 (en) * 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
KR100335866B1 (ko) 2000-01-06 2002-05-10 박호군 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법
DE60130544T2 (de) * 2000-03-13 2008-06-26 Biocure, Inc. Embolische zusammensetzungen
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
WO2001070289A2 (en) 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
DE60130743T2 (de) 2000-03-24 2008-07-17 Biosphere Medical, Inc., Rockland Mikrokugeln zur aktiven embolisierung
US20030212022A1 (en) 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
FR2808026B1 (fr) 2000-04-25 2002-06-14 Alexandre Laurent Biomateriau a base de polymere hydrophile presentant un signal specifique en imagerie par resonance magnetique et procede de preparation d'un tel biomateriau
US6537569B2 (en) 2001-02-14 2003-03-25 Microvention, Inc. Radiation cross-linked hydrogels
JP4094823B2 (ja) 2001-04-03 2008-06-04 日本碍子株式会社 ハニカム構造体及びそのアッセンブリ
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
US6488952B1 (en) 2001-08-28 2002-12-03 John P. Kennedy Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system
US6911219B2 (en) 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
EP1490120B1 (en) 2002-03-29 2009-11-11 Boston Scientific Limited Embolization
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7034004B2 (en) 2002-05-07 2006-04-25 University Of Florida Peptides and methods for the control of obesity
US7838699B2 (en) 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
WO2004035022A2 (en) 2002-10-15 2004-04-29 Microtherapeutics, Inc. Prepolymeric materials for site specific delivery to the body
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US20040091553A1 (en) 2002-11-12 2004-05-13 West Agro, Inc Composition and method for mammary disinfection during winter conditions
US20040161466A1 (en) 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
CN103908704B (zh) 2003-02-12 2017-09-01 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
US20060057198A1 (en) 2003-02-21 2006-03-16 Biocompatibles Uk Limited Drug delivery from embolic agents
US20050008610A1 (en) 2003-03-24 2005-01-13 Alexander Schwarz Temporary embolization using inverse thermosensitive polymers
US20050058603A1 (en) 2003-05-02 2005-03-17 Case Western Reserve University Drug delivery system based on polymer nanoshells
JP4342219B2 (ja) 2003-06-13 2009-10-14 株式会社ブリヂストン 無機物鋳型配合組成物およびこれを用いたタイヤ用モールドの製造方法
WO2005078124A2 (de) * 2004-02-16 2005-08-25 Proteosys Ag Diagnostische marker für krebs
WO2005087193A2 (en) 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
JP2005315107A (ja) * 2004-04-27 2005-11-10 Toyota Motor Corp ８気筒エンジン
US20070281028A1 (en) 2004-08-04 2007-12-06 Biocompatibles Uk Limited Drug Delivery of a Cox Inhibitor from Embolic Agents
EP1796644B1 (en) 2004-09-07 2011-04-13 Biocompatibles UK Limited Drug delivery from embolic agents
JP4885866B2 (ja) 2004-10-25 2012-02-29 セロノヴァ バイオサイエンスィズ ジャーマニー ゲーエムベーハー 治療適用および／または診断適用のための充填可能なポリホスファゼン含有粒子、ならびにその調製方法および使用方法
WO2006119968A2 (en) 2005-05-09 2006-11-16 Biosphere Medical S.A. Compositions and methods using microspheres and non-ionic contrast agents
JP4180582B2 (ja) 2005-05-16 2008-11-12 富士通株式会社 記憶装置
US7210338B2 (en) 2005-07-29 2007-05-01 Honda Motor Co., Ltd. Valve testing device having integrated purge circuit and method of valve testing
WO2007017839A2 (en) 2005-08-10 2007-02-15 Nxp B.V. Testing of an integrated circuit that contains secret information
EP2561881A3 (en) 2005-09-16 2013-04-17 Shiseido Company, Ltd. Novel vascular endothelial growth factor expression inhibitors
US7626626B2 (en) 2006-01-13 2009-12-01 Micron Technology, Inc. Method and apparatus providing pixel storage gate charge sensing for electronic stabilization in imagers
EP1978938B1 (en) 2006-01-24 2015-09-09 Biocompatibles UK Limited Process for loading polymer particles with drug
EP1986706B1 (en) 2006-01-30 2011-08-17 Biosphere Medical, Inc. Porous intravascular embolization particles and methods of making them
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
GB0619869D0 (en) 2006-10-07 2006-11-15 Regentec Ltd Porous particles
JP5000969B2 (ja) 2006-10-13 2012-08-15 株式会社リコー カラー画像形成装置及び色ずれ補正方法
US20110212179A1 (en) 2008-10-30 2011-09-01 David Liu Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same
EP2351779B1 (en) 2010-01-27 2019-04-24 Biosphere Medical, Inc. Microspheres and method of making the microspheres
US9872655B2 (en) * 2012-03-30 2018-01-23 Siemens Aktiengesellschaft PAE treatment for BPH
JP6056676B2 (ja) * 2013-06-21 2017-01-11 富士通株式会社 電子装置及びその製造方法

Also Published As

Publication number Publication date
US20080220077A1 (en) 2008-09-11
JP2013082743A (ja) 2013-05-09
CN101708165A (zh) 2010-05-19
EP1267839A2 (en) 2003-01-02
EP1820495A3 (en) 2008-04-02
ATE374597T1 (de) 2007-10-15
JP2016147885A (ja) 2016-08-18
US20030211165A1 (en) 2003-11-13
WO2001072281A2 (en) 2001-10-04
EP1820495B1 (en) 2017-03-01
EP1820495A2 (en) 2007-08-22
ES2254042T1 (es) 2006-06-16
US8697137B2 (en) 2014-04-15
JP2008214355A (ja) 2008-09-18
DE60130743T2 (de) 2008-07-17
ES2254042T3 (es) 2008-03-16
CN1430505A (zh) 2003-07-16
WO2001072281A3 (en) 2002-02-28
KR20080046750A (ko) 2008-05-27
EP1267839B1 (en) 2007-10-03
EP2286799B1 (en) 2015-07-29
ES2551164T3 (es) 2015-11-16
US20120213831A1 (en) 2012-08-23
KR100872884B1 (ko) 2008-12-10
EP2286799A2 (en) 2011-02-23
KR20030011803A (ko) 2003-02-11
US10265271B2 (en) 2019-04-23
US8741351B2 (en) 2014-06-03
US9308169B2 (en) 2016-04-12
JP2003528130A (ja) 2003-09-24
DE01918975T1 (de) 2006-04-13
US20120141379A1 (en) 2012-06-07
EP2286799A3 (en) 2012-03-07
DE60130743D1 (de) 2007-11-15

Similar Documents

Publication Publication Date Title
AU2001245988A1 (en) Microspheres for active embolization
WO2001072280A3 (en) Microspheres for gene therapy
WO2003082188A3 (en) Methods and drug delivery systems for the treatment of orofacial diseases
NO20005190D0 (no) Terapeutiske angiogene faktorer og metoder for deres anvendelse
EP1343492A4 (en) MUCOSITY TREATMENT
AU5056196A (en) Hydrogel-forming, self-solvating absorbable polyester copolymers and methods for use thereof
WO2006002366A3 (en) Biodegradable ocular devices, methods and systems
IL153665A0 (en) Topical pharmaceutical formulations and methods of treatment
WO2003044076A8 (en) Bioerodible poly(ortho esters) containing amine groups, and block copolymers containing them
CA2235919A1 (en) Non-polymeric sustained release delivery system
WO2003061578A3 (en) Compositions for treatment or prevention of bioterrorism
WO2005110436A3 (en) Macromolecule-containing sustained release intraocular implants and related methods
WO2003028622A3 (en) Method of delivering drugs to a tissue using drug-coated medical devices
MXPA05007146A (es) Copolimeros en bloque de polipeptido-poli(etilenglicol) de ramificaciones multiples como vehiculos para suministro de farmacos.
EP2407203A3 (en) Solid therapeutic agent for use in an implantable drug delivery device
EP3056229A3 (en) The local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque
MXPA03010085A (es) Composiciones y su uso en la hiperplasia.
ATE198979T1 (de) Zielgerichte verabreichung mittels biologisch abbaubarer polymere
ES2287660T3 (es) Composicion farmaceutica de los derivados peptidicos de trombina.
EP1982695A3 (en) Manufacture of long term drug delivery devices with polyurethane
WO2004034975A3 (en) Sustained release profile modification
WO2004087065A8 (en) Compositions for induction of a therapeutic response
EP1569664A4 (en) BIOERODABLE POLY (ORTHO ESTERS) PREPARED FROM DI (CETENE ACETALS) BASED ON DIOXANE AND COPOLYMER SEQUENCES CONTAINING THE SAME
WO2004012676A3 (en) Drug-loaded biological material chemically treated with genipin
WO2007042040A3 (en) TREATMENT OF RETINOPATHIES USING GFRα3 AGONISTS