WO2004012676A3 - Drug-loaded biological material chemically treated with genipin - Google Patents

Drug-loaded biological material chemically treated with genipin Download PDF

Info

Publication number
WO2004012676A3
WO2004012676A3 PCT/US2003/024445 US0324445W WO2004012676A3 WO 2004012676 A3 WO2004012676 A3 WO 2004012676A3 US 0324445 W US0324445 W US 0324445W WO 2004012676 A3 WO2004012676 A3 WO 2004012676A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
biological material
genipin
chemically treated
material chemically
Prior art date
Application number
PCT/US2003/024445
Other languages
French (fr)
Other versions
WO2004012676A2 (en
Inventor
Hsing-Wen Sung
Hosheng Tu
Original Assignee
Gp Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/211,656 external-priority patent/US6624138B1/en
Application filed by Gp Medical filed Critical Gp Medical
Priority to AU2003257179A priority Critical patent/AU2003257179A1/en
Priority to JP2004526437A priority patent/JP2006500975A/en
Priority to EP03767189A priority patent/EP1545505A4/en
Publication of WO2004012676A2 publication Critical patent/WO2004012676A2/en
Publication of WO2004012676A3 publication Critical patent/WO2004012676A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

Abstract

A method for treating a target tissue of a patient comprising, in combination, mixing a drug with a solidifiabile biological material, chemically treating the drug with the biological material with a crosslinking agent, loading the solidifiable drug-containing biological material onto a medical device, solidifying the drug-containing biological material; and delivering the medical device to the target tissue for treating the tissue.
PCT/US2003/024445 2002-08-02 2003-08-01 Drug-loaded biological material chemically treated with genipin WO2004012676A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003257179A AU2003257179A1 (en) 2002-08-02 2003-08-01 Drug-loaded biological material chemically treated with genipin
JP2004526437A JP2006500975A (en) 2002-08-02 2003-08-01 Drug-carrying biomaterials chemically treated with genipin
EP03767189A EP1545505A4 (en) 2002-08-02 2003-08-01 Drug-loaded biological material chemically treated with genipin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/211,656 2002-08-02
US10/211,656 US6624138B1 (en) 2001-09-27 2002-08-02 Drug-loaded biological material chemically treated with genipin

Publications (2)

Publication Number Publication Date
WO2004012676A2 WO2004012676A2 (en) 2004-02-12
WO2004012676A3 true WO2004012676A3 (en) 2004-09-16

Family

ID=31494298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/024445 WO2004012676A2 (en) 2002-08-02 2003-08-01 Drug-loaded biological material chemically treated with genipin

Country Status (4)

Country Link
EP (1) EP1545505A4 (en)
JP (1) JP2006500975A (en)
AU (1) AU2003257179A1 (en)
WO (1) WO2004012676A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1603485A4 (en) * 2003-02-26 2011-03-30 Medivas Llc Bioactive stents and methods for use thereof
WO2004089926A2 (en) 2003-03-31 2004-10-21 Beth Israel Deaconess Medical Center, Inc. Genipin derivatives and uses thereof
WO2004112863A1 (en) * 2003-06-20 2004-12-29 Mcgill University Biodegradable membrane-covered implant comprising chitosan
US7780974B2 (en) 2004-09-20 2010-08-24 Research Development Foundation Avicin coated stents
DE102005032691A1 (en) * 2005-07-06 2007-01-18 Biotronik Vi Patent Ag Medical implant (e.g. stent) has a peroxidase covalently attached to its surface
WO2007126411A2 (en) * 2005-07-28 2007-11-08 Carnegie Mellon University Biocompatible polymers and methods of use
US10029034B2 (en) * 2005-12-15 2018-07-24 CARDINAL HEALTH SWITZERLAND 515 GmbH Drug-eluting articles with improved drug release profiles
CN1986007B (en) * 2005-12-20 2011-09-14 广东冠昊生物科技股份有限公司 Biological surgical patch
CN1986001B (en) * 2005-12-20 2011-09-14 广东冠昊生物科技股份有限公司 Biological wound-protecting film
WO2007083797A1 (en) * 2006-01-23 2007-07-26 Terumo Kabushiki Kaisha Stent
EP1991111B1 (en) * 2006-02-27 2011-04-06 Edwards Lifesciences Corporation Hydrogel for an intravenous amperometric biosensor
NZ574597A (en) * 2006-07-03 2011-11-25 Hemoteq Ag Stent coated with a biodegradable polymer and rapamycin
JP2010522023A (en) * 2007-03-20 2010-07-01 ボストン サイエンティフィック サイムド，インコーポレイテッド Urological medical device for releasing beneficial therapeutics to the prostate
EP2136854A2 (en) * 2007-03-20 2009-12-30 Boston Scientific Scimed, Inc. Urological medical devices for release of therapeutic agents
FR2917293B1 (en) * 2007-06-13 2010-11-26 Olivier Paul Christian Schussler MODIFIED COLLAGENIC CARRIAGE BY COVALENT GRAFTING OF MEMBRANE MOLECULES: METHODS AND APPLICATIONS FOR CONTRACTIVELY TISSUE ENGINEERING, CELL THERAPY AND CARDIOVASCULAR THERAPY
EP3473260B1 (en) * 2007-07-10 2020-09-23 LifeCell Corporation Acellular tissue matrix compositions for tissue repair
US20100104608A1 (en) * 2008-09-26 2010-04-29 Tyco Healthcare Group Lp Reactive surgical implant
JP6003326B2 (en) * 2012-07-19 2016-10-05 凸版印刷株式会社 Acicular body and method for producing acicular body
TWI439288B (en) 2012-10-05 2014-06-01 Univ China Medical Medicinal carriers and preparation method and uses thereof
WO2014165023A1 (en) 2013-03-12 2014-10-09 Carnegie Mellon University Coated vaso-occclusive device for treatment of aneurysms
JP7007086B2 (en) 2016-11-17 2022-01-24 地方独立行政法人東京都立産業技術研究センター Collagen sol for submucosal injection
JP7012950B2 (en) 2016-11-17 2022-01-31 地方独立行政法人東京都立産業技術研究センター Sol for closing biological tissue holes, protecting ulcers and treating vascular embolism

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162826A (en) * 1996-10-18 2000-12-19 Choongwae Pharmaceutical Corporation Genipin derivative having anti hepatitis B virus activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69720243T2 (en) * 1996-11-05 2004-02-12 Challenge Bioproducts Co., Ltd. CHEMICAL MODIFICATION OF BIOMEDICAL MATERIALS WITH GENIPIN
US6545042B2 (en) * 1996-11-05 2003-04-08 Gp Medical Acellular biological material chemically treated with genipin
AU4907901A (en) * 2000-02-28 2001-11-26 Gel Del Technologies Inc Protein matrix materials, devices and methods of making and using thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162826A (en) * 1996-10-18 2000-12-19 Choongwae Pharmaceutical Corporation Genipin derivative having anti hepatitis B virus activity

Also Published As

Publication number Publication date
WO2004012676A2 (en) 2004-02-12
EP1545505A4 (en) 2008-01-02
JP2006500975A (en) 2006-01-12
AU2003257179A1 (en) 2004-02-23
EP1545505A2 (en) 2005-06-29
AU2003257179A8 (en) 2004-02-23

Similar Documents

Publication Publication Date Title
WO2004012676A3 (en) Drug-loaded biological material chemically treated with genipin
KR102341601B1 (en) Microarray for delivery of therapeutic agent and methods of use
WO2007030477A3 (en) Solid solution perforator containing drug particle and/or drug-adsorbed particles
WO2006080951A3 (en) Targeted and high density drug loaded polymeric materials
WO2006036983A3 (en) Pre-dried drug delivery coating for use with a stent
EP1586337A3 (en) The local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque
WO2004010975A3 (en) Controlled drug delivery
WO2006030431A3 (en) Biocompatible drug delivery apparatus and methods
WO2005110364A3 (en) Drug delivery systems and methods for treatment of an eye
EP1723976A3 (en) Intraluminal medical devices in combination with therapeutic agents
EP2289572A3 (en) Therapeutic agent delivery device with controlled therapeutic agent release rates
WO2001043749A3 (en) Pharmaceutical implant containing immediate-release and sustained-release components and method of administration
WO2005027994A3 (en) Application of a therapeutic substance to a tissue location using a porous medical device
CA2235919A1 (en) Non-polymeric sustained release delivery system
WO2003028622A3 (en) Method of delivering drugs to a tissue using drug-coated medical devices
WO2006023130A3 (en) Biodegradable controlled release bioactive agent delivery device
EP2042202A3 (en) Local vascular delivery of mTor inhibitors in combination with peroxisome proliferators-activated receptor stimulators
EP1591108A3 (en) Solution formulations of sirolimus and its analogs for CAD treatment
WO2002041837A3 (en) Treatment of mucositis
EP1582225A3 (en) Drug delivery device
WO2004006990A3 (en) Medical device and method for tissue removal and repair
WO2006036970A3 (en) Method of thickening a coating using a drug
DE602005011653D1 (en) MEDICINE PRODUCT WITH TISSUE-DEPENDENT MEDICAMENT LIQUID
PT774964E (en) CONTROLLED LOCAL DELIVERY OF CHEMOTHERAPEUTIC AGENTS FOR TREATMENT OF SOLID TUMORS
WO2001072281A3 (en) Microspheres for active embolization

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004526437

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2003767189

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003767189

Country of ref document: EP