MXPA05007146A - Copolimeros en bloque de polipeptido-poli(etilenglicol) de ramificaciones multiples como vehiculos para suministro de farmacos. - Google Patents
Copolimeros en bloque de polipeptido-poli(etilenglicol) de ramificaciones multiples como vehiculos para suministro de farmacos.Info
- Publication number
- MXPA05007146A MXPA05007146A MXPA05007146A MXPA05007146A MXPA05007146A MX PA05007146 A MXPA05007146 A MX PA05007146A MX PA05007146 A MXPA05007146 A MX PA05007146A MX PA05007146 A MXPA05007146 A MX PA05007146A MX PA05007146 A MXPA05007146 A MX PA05007146A
- Authority
- MX
- Mexico
- Prior art keywords
- copolymer
- arm
- poly
- ethylene glycol
- drug delivery
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
- C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Electrophonic Musical Instruments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invencion proporciona un copolimero en bloque de ramificaciones multiples para utilizarse en el suministro de una variedad de agentes bioactivos. El copolimero de la invencion contiene un nucleo central a partir del cual se extienden multiples (3 o mas) ramificaciones copolimericas. Cada ramificacion copolimerica posee un segmento polipeptidico interno y un segmento polimerico hidrofilico externo. De esta forma, la estructura total del copolimero comprende una region nucleo interna que incluye el nucleo central y el segmento polipeptidico interno, mientras que la region nucleo externa es hidrofilica por naturaliza. El copolimero de ramificaciones multiples de la invencion es particularmente util para el suministro de agentes biologicamente activos que se pueden atrapar dentro de la region nucleo interna.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43737202P | 2002-12-30 | 2002-12-30 | |
PCT/US2003/041332 WO2004060977A1 (en) | 2002-12-30 | 2003-12-24 | Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05007146A true MXPA05007146A (es) | 2005-09-21 |
Family
ID=32713174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05007146A MXPA05007146A (es) | 2002-12-30 | 2003-12-24 | Copolimeros en bloque de polipeptido-poli(etilenglicol) de ramificaciones multiples como vehiculos para suministro de farmacos. |
Country Status (11)
Country | Link |
---|---|
US (3) | US7316811B2 (es) |
EP (1) | EP1581583B1 (es) |
JP (1) | JP4490291B2 (es) |
KR (1) | KR101045504B1 (es) |
CN (1) | CN100349963C (es) |
AT (1) | ATE461961T1 (es) |
AU (1) | AU2003300380B2 (es) |
CA (1) | CA2508015C (es) |
DE (1) | DE60331860D1 (es) |
MX (1) | MXPA05007146A (es) |
WO (1) | WO2004060977A1 (es) |
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US6225945B1 (en) * | 1999-09-22 | 2001-05-01 | Trimble Navigation Limited | GPS receiver using coarse orbital parameters for achieving a fast time to first fix |
US6228945B1 (en) | 1999-12-20 | 2001-05-08 | The University Of Akron | Three arm star compositions of matter having diblock arms based on polyisobutylene and methods of preparation |
US20020041898A1 (en) * | 2000-01-05 | 2002-04-11 | Unger Evan C. | Novel targeted delivery systems for bioactive agents |
JP2003520210A (ja) | 2000-01-05 | 2003-07-02 | イマレックス セラピューティクス, インコーポレイテッド | 低い水溶性を有する薬物の送達のための薬学的処方物 |
US7261875B2 (en) * | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
CA2508015C (en) | 2002-12-30 | 2012-04-03 | Nektar Therapeutics Al, Corporation | Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles |
-
2003
- 2003-12-24 CA CA2508015A patent/CA2508015C/en not_active Expired - Lifetime
- 2003-12-24 AU AU2003300380A patent/AU2003300380B2/en not_active Ceased
- 2003-12-24 AT AT03814969T patent/ATE461961T1/de not_active IP Right Cessation
- 2003-12-24 DE DE60331860T patent/DE60331860D1/de not_active Expired - Lifetime
- 2003-12-24 US US10/746,567 patent/US7316811B2/en active Active
- 2003-12-24 CN CNB2003801079843A patent/CN100349963C/zh not_active Expired - Fee Related
- 2003-12-24 JP JP2004565733A patent/JP4490291B2/ja not_active Expired - Fee Related
- 2003-12-24 WO PCT/US2003/041332 patent/WO2004060977A1/en active Application Filing
- 2003-12-24 EP EP03814969A patent/EP1581583B1/en not_active Expired - Lifetime
- 2003-12-24 MX MXPA05007146A patent/MXPA05007146A/es active IP Right Grant
- 2003-12-24 KR KR1020057012445A patent/KR101045504B1/ko active IP Right Grant
-
2007
- 2007-11-14 US US11/985,443 patent/US7976834B2/en not_active Expired - Fee Related
-
2011
- 2011-06-02 US US13/152,144 patent/US8323632B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU2003300380B2 (en) | 2008-11-06 |
US20040161403A1 (en) | 2004-08-19 |
JP4490291B2 (ja) | 2010-06-23 |
KR20050091050A (ko) | 2005-09-14 |
DE60331860D1 (en) | 2010-05-06 |
US7316811B2 (en) | 2008-01-08 |
AU2003300380A1 (en) | 2004-07-29 |
US8323632B2 (en) | 2012-12-04 |
CA2508015A1 (en) | 2004-07-22 |
CA2508015C (en) | 2012-04-03 |
JP2006512462A (ja) | 2006-04-13 |
US20110237747A1 (en) | 2011-09-29 |
EP1581583A1 (en) | 2005-10-05 |
EP1581583B1 (en) | 2010-03-24 |
WO2004060977A1 (en) | 2004-07-22 |
US7976834B2 (en) | 2011-07-12 |
CN1732212A (zh) | 2006-02-08 |
ATE461961T1 (de) | 2010-04-15 |
CN100349963C (zh) | 2007-11-21 |
KR101045504B1 (ko) | 2011-06-30 |
US20080069902A1 (en) | 2008-03-20 |
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