ATE550325T1 - Verfahren zur herstellung von chinolincarboxaldehydderivaten und deren zwischenprodukte - Google Patents
Verfahren zur herstellung von chinolincarboxaldehydderivaten und deren zwischenprodukteInfo
- Publication number
- ATE550325T1 ATE550325T1 AT02712360T AT02712360T ATE550325T1 AT E550325 T1 ATE550325 T1 AT E550325T1 AT 02712360 T AT02712360 T AT 02712360T AT 02712360 T AT02712360 T AT 02712360T AT E550325 T1 ATE550325 T1 AT E550325T1
- Authority
- AT
- Austria
- Prior art keywords
- intermediate products
- quinolin
- producing
- carboxaldehyde derivatives
- carboxaldehyde
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- WPYJKGWLDJECQD-UHFFFAOYSA-N quinoline-2-carbaldehyde Chemical class C1=CC=CC2=NC(C=O)=CC=C21 WPYJKGWLDJECQD-UHFFFAOYSA-N 0.000 title 1
- FFFXIQFESQNINT-UHFFFAOYSA-N (2-aminophenyl)-(4-fluorophenyl)methanone Chemical compound NC1=CC=CC=C1C(=O)C1=CC=C(F)C=C1 FFFXIQFESQNINT-UHFFFAOYSA-N 0.000 abstract 1
- VFDAMMPNVZRZQG-UHFFFAOYSA-N 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbonitrile Chemical compound C1=CC(F)=CC=C1C1=C(C#N)C(C2CC2)=NC2=CC=CC=C12 VFDAMMPNVZRZQG-UHFFFAOYSA-N 0.000 abstract 1
- SDARMQNRQJBGQE-UHFFFAOYSA-N 3-cyclopropyl-3-oxopropanenitrile Chemical compound N#CCC(=O)C1CC1 SDARMQNRQJBGQE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001036357 | 2001-02-14 | ||
| PCT/JP2002/001261 WO2002064569A1 (en) | 2001-02-14 | 2002-02-14 | Process for producing quinoline carboxyaldehyde derivative and intermediate thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE550325T1 true ATE550325T1 (de) | 2012-04-15 |
Family
ID=18899637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02712360T ATE550325T1 (de) | 2001-02-14 | 2002-02-14 | Verfahren zur herstellung von chinolincarboxaldehydderivaten und deren zwischenprodukte |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6841681B2 (https=) |
| EP (1) | EP1361215B1 (https=) |
| JP (1) | JP4321065B2 (https=) |
| KR (1) | KR100714735B1 (https=) |
| CN (1) | CN1237053C (https=) |
| AT (1) | ATE550325T1 (https=) |
| AU (1) | AU2002232190B2 (https=) |
| CA (1) | CA2437954C (https=) |
| CY (1) | CY1112599T1 (https=) |
| CZ (1) | CZ305024B6 (https=) |
| DK (1) | DK1361215T3 (https=) |
| ES (1) | ES2383667T3 (https=) |
| HU (1) | HU230371B1 (https=) |
| IL (2) | IL157342A0 (https=) |
| MX (1) | MXPA03007233A (https=) |
| NO (1) | NO326000B1 (https=) |
| NZ (1) | NZ527552A (https=) |
| PT (1) | PT1361215E (https=) |
| RU (1) | RU2264391C2 (https=) |
| SI (1) | SI1361215T1 (https=) |
| SK (1) | SK287721B6 (https=) |
| TW (1) | TWI309644B (https=) |
| UA (1) | UA75113C2 (https=) |
| WO (1) | WO2002064569A1 (https=) |
| ZA (1) | ZA200306225B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4590749B2 (ja) * | 2001-02-14 | 2010-12-01 | 宇部興産株式会社 | キノリンカルボキシアルデヒド誘導体の製法 |
| CN102442997B (zh) * | 2010-10-12 | 2015-04-08 | 上海医药工业研究院 | 一类喹啉衍生物、其制备方法、中间体及其应用 |
| CN103204807B (zh) * | 2013-04-08 | 2015-12-23 | 黄河三角洲京博化工研究院有限公司 | 一种2-环丙基-4-（4-氟-苯基）-3-喹啉甲醛的合成方法 |
| CN103508949B (zh) * | 2013-10-22 | 2015-12-09 | 黄河三角洲京博化工研究院有限公司 | 一种（e）-3-[2-环丙基-4-（4-氟-苯基）-3-喹啉基]丙烯醛的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2569746B2 (ja) | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
| CA1336714C (en) | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis |
| JPH0340632A (ja) * | 1989-07-07 | 1991-02-21 | Canon Inc | ターミナルアダプタ装置 |
| DE4105551A1 (de) * | 1991-02-22 | 1992-08-27 | Bayer Ag | 2-substituierte chinoline, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| JP3130342B2 (ja) * | 1991-10-04 | 2001-01-31 | 日産化学工業株式会社 | 動脈硬化性血管内膜肥厚抑制薬 |
| JP4281248B2 (ja) * | 1998-07-23 | 2009-06-17 | 日産化学工業株式会社 | キノリン誘導体の製造法及び中間体 |
-
2002
- 2002-02-08 TW TW091102496A patent/TWI309644B/zh not_active IP Right Cessation
- 2002-02-14 SK SK1113-2003A patent/SK287721B6/sk not_active IP Right Cessation
- 2002-02-14 DK DK02712360.3T patent/DK1361215T3/da active
- 2002-02-14 JP JP2002564502A patent/JP4321065B2/ja not_active Expired - Fee Related
- 2002-02-14 MX MXPA03007233A patent/MXPA03007233A/es active IP Right Grant
- 2002-02-14 RU RU2003127743/04A patent/RU2264391C2/ru not_active IP Right Cessation
- 2002-02-14 PT PT02712360T patent/PT1361215E/pt unknown
- 2002-02-14 CZ CZ2003-2251A patent/CZ305024B6/cs not_active IP Right Cessation
- 2002-02-14 IL IL15734202A patent/IL157342A0/xx unknown
- 2002-02-14 CA CA002437954A patent/CA2437954C/en not_active Expired - Fee Related
- 2002-02-14 AU AU2002232190A patent/AU2002232190B2/en not_active Ceased
- 2002-02-14 SI SI200230978T patent/SI1361215T1/sl unknown
- 2002-02-14 AT AT02712360T patent/ATE550325T1/de active
- 2002-02-14 CN CNB028048229A patent/CN1237053C/zh not_active Expired - Fee Related
- 2002-02-14 US US10/468,062 patent/US6841681B2/en not_active Expired - Fee Related
- 2002-02-14 UA UA2003087498A patent/UA75113C2/uk unknown
- 2002-02-14 ES ES02712360T patent/ES2383667T3/es not_active Expired - Lifetime
- 2002-02-14 HU HU0303846A patent/HU230371B1/hu not_active IP Right Cessation
- 2002-02-14 KR KR1020037010708A patent/KR100714735B1/ko not_active Expired - Fee Related
- 2002-02-14 WO PCT/JP2002/001261 patent/WO2002064569A1/ja not_active Ceased
- 2002-02-14 NZ NZ527552A patent/NZ527552A/en not_active IP Right Cessation
- 2002-02-14 EP EP02712360A patent/EP1361215B1/en not_active Expired - Lifetime
-
2003
- 2003-08-11 IL IL157342A patent/IL157342A/en not_active IP Right Cessation
- 2003-08-12 ZA ZA200306225A patent/ZA200306225B/en unknown
- 2003-08-13 NO NO20033592A patent/NO326000B1/no not_active IP Right Cessation
-
2012
- 2012-03-23 CY CY20121100304T patent/CY1112599T1/el unknown
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