ATE548027T1 - Sprühtrocknungsverfahren zur bildung von festen amorphen dispersionen von arzneimitteln und polymere - Google Patents
Sprühtrocknungsverfahren zur bildung von festen amorphen dispersionen von arzneimitteln und polymereInfo
- Publication number
- ATE548027T1 ATE548027T1 AT04744168T AT04744168T ATE548027T1 AT E548027 T1 ATE548027 T1 AT E548027T1 AT 04744168 T AT04744168 T AT 04744168T AT 04744168 T AT04744168 T AT 04744168T AT E548027 T1 ATE548027 T1 AT E548027T1
- Authority
- AT
- Austria
- Prior art keywords
- amorphic
- dispersions
- polymers
- drying process
- spray drying
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Glanulating (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49240703P | 2003-08-04 | 2003-08-04 | |
US56898904P | 2004-05-07 | 2004-05-07 | |
PCT/IB2004/002519 WO2005011636A2 (en) | 2003-08-04 | 2004-07-27 | Spray drying processes for forming solid amorphous dispersions of drugs and polymers |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE548027T1 true ATE548027T1 (de) | 2012-03-15 |
Family
ID=34118937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04744168T ATE548027T1 (de) | 2003-08-04 | 2004-07-27 | Sprühtrocknungsverfahren zur bildung von festen amorphen dispersionen von arzneimitteln und polymere |
Country Status (18)
Country | Link |
---|---|
US (1) | US10383941B2 (de) |
EP (2) | EP1653928B1 (de) |
JP (2) | JP2007501219A (de) |
KR (1) | KR20060087501A (de) |
AR (1) | AR045188A1 (de) |
AT (1) | ATE548027T1 (de) |
AU (1) | AU2004261061A1 (de) |
BR (1) | BRPI0413313A (de) |
CA (1) | CA2534129A1 (de) |
CL (1) | CL2004001884A1 (de) |
IL (1) | IL173130A0 (de) |
MX (1) | MXPA06001418A (de) |
NO (1) | NO20060305L (de) |
NZ (1) | NZ544892A (de) |
PT (1) | PT1653928E (de) |
RU (1) | RU2318495C2 (de) |
TW (1) | TWI290852B (de) |
WO (1) | WO2005011636A2 (de) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
EP1904510A1 (de) * | 2005-07-14 | 2008-04-02 | Pfizer Products Incorporated | Verfahren zur bildung amorpher azithromycinpartikel |
EP1909762A2 (de) * | 2005-07-28 | 2008-04-16 | Isp Investments Inc. | Amorphes efavirenz und seine herstellung |
ES2414434T3 (es) * | 2005-08-29 | 2013-07-19 | Sanofi-Aventis U.S. Llc | Dispersiones sólidas amorfas de 7-cloro-N,N,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4H-piridazino[4,5-b]indol-1-acetamida |
GB0518769D0 (en) * | 2005-09-14 | 2005-10-19 | Medpharm Ltd | Topical formulations |
US7524442B2 (en) * | 2006-01-10 | 2009-04-28 | Nanomist Systems, Llc | Method and device for manufacturing extremely fine particles and porous materials by controlled low temperature drying |
GB0613925D0 (en) * | 2006-07-13 | 2006-08-23 | Unilever Plc | Improvements relating to nanodispersions |
AR063704A1 (es) | 2006-09-14 | 2009-02-11 | Makhteshim Chem Works Ltd | Nanoparticulas de pesticida obtenida obtenidas a partir de microemulsiones y nanoemulsiones |
US20110021592A1 (en) * | 2006-09-14 | 2011-01-27 | Shlomo Magdassi | Organic nanoparticles obtained from microemulsions by solvent evaporation |
US20080085315A1 (en) * | 2006-10-10 | 2008-04-10 | John Alfred Doney | Amorphous ezetimibe and the production thereof |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
US20080152717A1 (en) * | 2006-12-14 | 2008-06-26 | Isp Investments, Inc. | Amorphous valsartan and the production thereof |
US8613946B2 (en) * | 2006-12-21 | 2013-12-24 | Isp Investment Inc. | Carotenoids of enhanced bioavailability |
US10189957B2 (en) * | 2007-01-26 | 2019-01-29 | Isp Investments Llc | Formulation process method to produce spray dried products |
US20080181961A1 (en) * | 2007-01-26 | 2008-07-31 | Isp Investments, Inc. | Amorphous oxcarbazepine and the production thereof |
PT103661B (pt) * | 2007-02-23 | 2010-09-07 | Hovione Farmaciencia S A | Processo de preparação de minociclina base cristalina |
WO2009012283A1 (en) | 2007-07-17 | 2009-01-22 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
WO2009026540A1 (en) * | 2007-08-22 | 2009-02-26 | Colorado School Of Mines | Lanthanide nanoparticle conjugates and uses thereof |
US20100284912A1 (en) * | 2007-12-04 | 2010-11-11 | Bracco Diagnostics Inc. | Homogenization of a radiopharmaceutical using sonification and/or rotor-stator technology to produce a homogenous suspension, emulsion, mixture or solid suspension of immiscible ingredients |
US20090182053A1 (en) * | 2007-12-19 | 2009-07-16 | Tong Sun | Fenofibric acid amorphous dispersion; method of making; and method of use thereof |
EP2309996A2 (de) * | 2008-08-11 | 2011-04-20 | Ratiopharm GmbH | Amorphes ambrisentan |
US8968705B2 (en) | 2008-08-22 | 2015-03-03 | Colorado School Of Mines | Gold/lanthanide nanoparticle conjugates and uses thereof |
PT104350A (pt) * | 2009-01-23 | 2010-07-23 | Hovione Farmaci Ncia S A | Processo de isolamento de tigeciclina |
DE102009013611A1 (de) * | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Festes Retigabin in nicht-kristalliner Form |
CN101602764B (zh) * | 2009-03-27 | 2011-06-29 | 浙江车头制药有限公司 | 一种阿昔洛韦2/3水合物的制备方法 |
ES2873502T3 (es) | 2009-03-27 | 2021-11-03 | Bend Res Inc | Proceso de secado por pulverización |
US8968563B2 (en) * | 2009-03-31 | 2015-03-03 | Shimadzu Corporation | Fractionating and refining device |
ES2552386T3 (es) * | 2009-04-03 | 2015-11-27 | F. Hoffmann-La Roche Ag | Composiciones de {3-[5-(4-cloro-fenil)-1H-pirrol[2,3-b]piridin-3-carbonil]-2,4-difluoro-fenil}-amida del ácido propano-1-sulfónico y usos de las mismas |
US20120076838A1 (en) | 2009-05-27 | 2012-03-29 | Samyang Biopharmaceuticals Corporation | Poorly soluble drug containing microsphere with improved bioavailabilty and method of preparing the same |
DK2473161T3 (en) | 2009-08-31 | 2017-09-11 | Dr Reddys Laboratories Ltd | TOPICAL FORMULATIONS INCLUDING A STEROID |
JP2013510166A (ja) | 2009-11-06 | 2013-03-21 | プレキシコン インコーポレーテッド | キナーゼ調節のための化合物、方法およびその適用 |
WO2011061748A1 (en) * | 2009-11-19 | 2011-05-26 | Strides Arcolab Limited | Rifaximin premix |
US20110201076A1 (en) | 2010-01-22 | 2011-08-18 | Colorado School Of Mines | Harvesting micro algae |
GB201006038D0 (en) | 2010-04-12 | 2010-05-26 | Unilever Plc | Improvements relating to antiviral compositions |
AU2011264993B2 (en) | 2010-06-09 | 2014-02-06 | Abbvie Bahamas Ltd. | Solid dispersions containing kinase inhibitors |
WO2011154014A1 (en) * | 2010-06-11 | 2011-12-15 | Gea Process Engineering A/S | Controlled humidity drying |
US20130093111A1 (en) * | 2010-06-14 | 2013-04-18 | Xspray Microparticles Ab | Apparatus and Method for the Production of Particles |
JP5728174B2 (ja) * | 2010-06-29 | 2015-06-03 | 藤崎電機株式会社 | 循環式の噴霧乾燥装置 |
WO2012002547A1 (ja) * | 2010-07-02 | 2012-01-05 | 富士化学工業株式会社 | ボセンタン固体分散体 |
CN103037946B (zh) | 2010-07-29 | 2015-07-22 | 田边工业株式会社 | 减压喷雾干燥方法及减压喷雾干燥装置 |
PT2611530T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Aparelho de secagem por pulverização e métodos de utilização do mesmo |
PT2611529T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Método de secagem por pulverização |
WO2012040502A1 (en) | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
RU2456065C2 (ru) * | 2010-10-01 | 2012-07-20 | Государственное образовательное учреждение высшего профессионального образования "Тамбовский государственный технический университет" ГОУ ВПО ТГТУ | Способ микродозирования наноструктурных материалов |
AU2012214762B2 (en) | 2011-02-07 | 2015-08-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
JP5522577B2 (ja) | 2011-08-08 | 2014-06-18 | ヤマトミシン製造株式会社 | 縫目のほつれ止め装置付二重環縫いミシン |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
JP6235584B2 (ja) * | 2012-07-17 | 2017-11-22 | ダウ グローバル テクノロジーズ エルエルシー | 高置換ヒドロキシアルキルメチルセルロースを含む固体分散体 |
KR101986683B1 (ko) * | 2012-12-13 | 2019-06-10 | 한미약품 주식회사 | 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체 |
EP2950797B1 (de) | 2013-02-01 | 2019-09-11 | Glialogix, Inc. | Zusammensetzungen sowie verfahren zur behandlung von neurodegenerativen und anderen erkrankungen |
RU2523520C1 (ru) * | 2013-04-23 | 2014-07-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Тамбовский государственный технический университет" ФГБОУ ВПО ТГТУ | Способ энергосберегающей сушки гранулированных полимерных материалов |
JP6387094B2 (ja) * | 2013-11-22 | 2018-09-05 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 非ヌクレオシド逆転写酵素阻害剤の組成物 |
EP3116473B1 (de) * | 2014-03-11 | 2020-12-30 | Promius Pharma, LLC | Topische corticosteroidzusammensetzungen |
US20160184431A1 (en) | 2014-03-11 | 2016-06-30 | Promius Pharma Llc | Topical compositions comprising a corticosteroid |
CN106458989A (zh) * | 2014-05-09 | 2017-02-22 | 艾伯维公司 | 晶型 |
EP3212169B1 (de) | 2014-10-31 | 2021-01-13 | Bend Research, Inc. | Verfahren zur herstellung von in einer matrix dispergierten aktiven domänen |
WO2017186889A1 (en) * | 2016-04-29 | 2017-11-02 | Rousselot B.V. | Protein based excipient for active pharmaceutical ingredients |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
WO2018069777A1 (en) * | 2016-10-13 | 2018-04-19 | Capsugel Belgium Nv | Process for making spray dried compositions and spray drying apparatus |
WO2018075865A1 (en) | 2016-10-21 | 2018-04-26 | Glialogix, Inc. | Compositions for the treatment of neurodegenerative diseases |
JP6937016B2 (ja) * | 2017-09-06 | 2021-09-22 | 東京理化器械株式会社 | 噴霧乾燥装置 |
CN107381691A (zh) * | 2017-09-12 | 2017-11-24 | 哈尔滨锅炉厂环保工程技术有限公司 | 一种用于湿法烟气脱硫废水蒸发的蒸发炉 |
ZA201808115B (en) * | 2017-11-30 | 2019-08-28 | G2Gbio Inc | Sustained release injection formulation comprising donepezil and method for preparing the same |
CA3089566A1 (en) | 2018-01-31 | 2019-08-08 | Deciphera Pharmaceuticals, Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
PT110585B (pt) * | 2018-02-22 | 2021-04-22 | Hovione Farmaciencia Sa | Processo de produção contínua de partículas compreendendo secagem por atomização com preparação contínua da solução de atomização |
WO2020001713A1 (en) * | 2018-06-29 | 2020-01-02 | Gea Process Engineering A/S | Gas disperser for guiding gas into a chamber, spray drying apparatus comprising such a gas disperser, and method of aligning a stream of gas in a gas disperser |
WO2020187712A1 (en) * | 2019-03-15 | 2020-09-24 | Novo Nordisk A/S | Process for spray drying a glp-1 peptide |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
CN114615982A (zh) | 2019-08-12 | 2022-06-10 | 德西费拉制药有限责任公司 | 用于治疗胃肠道间质瘤的瑞普替尼 |
LT4084778T (lt) | 2019-12-30 | 2024-01-25 | Deciphera Pharmaceuticals, Llc | Amorfinės kinazės inhibitoriaus vaistinės formos ir jų panaudojimo būdai |
CN115243681A (zh) | 2019-12-30 | 2022-10-25 | 德西费拉制药有限责任公司 | 1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物 |
US20240000663A1 (en) * | 2020-12-11 | 2024-01-04 | Merck Sharp & Dohme Llc | Compact containment system for isolating, processing and packaging pharmaceutical products |
CN117015373A (zh) | 2021-02-02 | 2023-11-07 | 杜邦营养美国公司 | 包含乙基纤维素的水性凝胶组合物 |
KR102631642B1 (ko) * | 2021-04-19 | 2024-02-01 | 주식회사 그랩실 | 스프레이 건조 시스템 및 스프레이 건조 방법 |
WO2023158616A1 (en) * | 2022-02-18 | 2023-08-24 | Viking Therapeutics, Inc. | ORAL DOSAGE FORMS OF TRβ AGONIST VK2809 FOR THE TREATMENT OF LIVER DISORDERS AND METHODS OF PREPARING THE SAME |
US20240009128A1 (en) * | 2022-07-07 | 2024-01-11 | Serán BioScience, LLC | Methods and systems for use of low-volatility solvents for spray drying |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL46210C (de) * | 1936-06-19 | |||
DE818197C (de) | 1950-02-14 | 1951-10-22 | Otto H Dr-Ing E H Hartmann | Zweidruckkesselanlage fuer Hochdrucklokomotiven |
GB1131242A (en) | 1965-02-18 | 1968-10-23 | Gen Foods Ltd | Improvements in or relating to spray-drying apparatus |
DE2201111A1 (de) | 1971-01-19 | 1972-07-27 | Niro Atomizer As | Zerstaeubungstrocknungsvorrichtung zur Herstellung von Pulver,z.B. Milchpulver |
IT1025765B (it) * | 1974-11-18 | 1978-08-30 | Gastaldi Francesco | Essiccatore perfezionato a spruzzo |
US4056599A (en) * | 1975-10-20 | 1977-11-01 | Bechtel International Corporation | Process for the recovery of magnesium chloride hydrate and potassium chloride from carnallite and bischofite |
US4187617A (en) * | 1978-12-18 | 1980-02-12 | Becker James J Jr | Spray dryer |
US4702799A (en) | 1985-09-03 | 1987-10-27 | Nestec S.A. | Dryer and drying method |
IT1230095B (it) | 1989-04-27 | 1991-10-05 | Parenta Srl | Procedimento per la preparazione di forme sterili di polveri iniettabili di antibiotici. |
US5000947A (en) | 1989-05-30 | 1991-03-19 | Moleculon, Inc. | Shaped articles containing liquefiable powders for delivery of cosmetic and other personal care agents |
PT96229B (pt) | 1989-12-22 | 1998-06-30 | Syntex Pharma Int | Processo para a preparacao de composicoes farmaceuticas em po, secas por pulverizacao, directamente compressiveis em comprimidos, contendo naproxeno ou naproxeno sodico |
ATE118178T1 (de) | 1990-11-29 | 1995-02-15 | Faulding F H & Co Ltd | Verfahren zur herstellung von flüssigkeiten enthaltenden pulvern. |
KR0159947B1 (ko) * | 1991-03-12 | 1998-11-16 | 마사아키 오카와라 | 분수형 가압 2류체 노즐 장치와 그것을 편입하여 이루어지는 스프레이 드라이어 장치, 및 가압 2류체에 있어서의 액적 경 제어법 |
DE4244466C2 (de) * | 1992-12-24 | 1995-02-23 | Pharmatech Gmbh | Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten |
ES2163504T5 (es) * | 1994-05-06 | 2008-05-16 | Pfizer Inc. | Formas de dosificacion de liberacion controlada de azitromicina. |
AUPN605795A0 (en) | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
DE19542442A1 (de) * | 1995-11-14 | 1997-05-15 | Wacker Chemie Gmbh | Verfahren zur Herstellung von in Wasser redispergierbaren, Organosiliciumverbindungen enthaltenden Pulverzusammensetzungen |
DE19610932A1 (de) | 1996-03-20 | 1997-09-25 | Bayer Ag | 2-Aryl-substituierte Pyridine |
US5858409A (en) | 1996-04-17 | 1999-01-12 | Fmc Corporation | Hydrolyzed cellulose granulations for pharmaceuticals |
US20030064108A1 (en) * | 1996-04-23 | 2003-04-03 | Stefan Lukas | Taste masked pharmaceutical compositions |
AUPN969796A0 (en) * | 1996-05-07 | 1996-05-30 | F.H. Faulding & Co. Limited | Taste masked liquid suspensions |
DE19627430A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Bicyclisch kondensierte Pyridine |
DE19627431A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
DE19627419A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Cycloalkano-pyridine |
HRP970330B1 (en) | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
AR008789A1 (es) | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
DE19704244A1 (de) | 1997-02-05 | 1998-08-06 | Bayer Ag | 5-Hydroxy-alkyl substituierte Phenyle |
DE19704243A1 (de) | 1997-02-05 | 1998-08-06 | Bayer Ag | Neue 2-Amino-substituierte Pyridine |
JP2894445B2 (ja) | 1997-02-12 | 1999-05-24 | 日本たばこ産業株式会社 | Cetp活性阻害剤として有効な化合物 |
DE19709125A1 (de) | 1997-03-06 | 1998-09-10 | Bayer Ag | Substituierte Chinoline |
ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
AU9297798A (en) | 1997-09-16 | 1999-04-05 | G.D. Searle & Co. | Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity |
DE19832159A1 (de) | 1997-09-18 | 1999-03-25 | Bayer Ag | Substituierte Tetrahydro-naphthaline |
MA24643A1 (fr) | 1997-09-18 | 1999-04-01 | Bayer Ag | Tetrahydro-naphtalenes substitues et composes analogues |
DE19741051A1 (de) | 1997-09-18 | 1999-03-25 | Bayer Ag | Hetero-Tetrahydrochinoline |
DE19741400A1 (de) | 1997-09-19 | 1999-03-25 | Bayer Ag | Benzyl-biphenyle |
DE19741399A1 (de) | 1997-09-19 | 1999-03-25 | Bayer Ag | Tetrahydrochinoline |
WO1999041237A1 (en) | 1998-02-13 | 1999-08-19 | G.D. Searle & Co. | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity |
US6609102B2 (en) | 1998-07-20 | 2003-08-19 | Usa Technologies, Inc. | Universal interactive advertizing and payment system for public access electronic commerce and business related products and services |
US6147090A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
US6140342A (en) | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
US6147089A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
EP1115694A1 (de) | 1998-09-25 | 2001-07-18 | Monsanto Company | Substituierte n-aliphatisch- n-aromatisch tertiäre heteroalkylamine für die hemmung der aktivität des cholesteryl-ester-transfer-proteins |
PT1115693E (pt) | 1998-09-25 | 2007-08-02 | Monsanto Co | Arial- e heteroaril - heteroalquilaminas terciárias policíclicas substituídas úteis para inibir a actividade da proteína de transferência de éster de colesterilo. |
ES2310164T3 (es) | 1999-02-10 | 2009-01-01 | Pfizer Products Inc. | Dispositivo de liberacion controlada por la matriz. |
DE60042352D1 (de) | 1999-02-10 | 2009-07-23 | Pfizer Prod Inc | Osmotisches System zur Verabreichung von Wirkstoffen, die feste amorphe Dispersionen enthalten |
ATE400252T1 (de) | 1999-02-10 | 2008-07-15 | Pfizer Prod Inc | Pharmazeutische feste dispersionen |
US6253463B1 (en) * | 1999-04-26 | 2001-07-03 | Niro A/S | Method of spray drying |
AU4133899A (en) * | 1999-06-08 | 2000-12-28 | Niro A/S | A process and a plant for spray drying |
CA2396380C (en) * | 1999-12-23 | 2015-04-21 | David Hayes | Improved pharmaceutical compositions for poorly soluble drugs |
PE20011184A1 (es) | 2000-03-16 | 2001-11-15 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la glucogeno-fosforilasa |
US20010053791A1 (en) * | 2000-03-16 | 2001-12-20 | Babcock Walter C. | Glycogen phosphorylase inhibitor |
US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
EP1186347A1 (de) * | 2000-09-05 | 2002-03-13 | F. Hoffmann-La Roche Ag | Verfahren und Vorrichtung zum Zerstäuben von Flüssigkeiten |
US6848197B2 (en) * | 2001-04-18 | 2005-02-01 | Advanced Inhalation Research, Inc. | Control of process humidity to produce large, porous particles |
MXPA03011935A (es) * | 2001-06-22 | 2004-03-26 | Pfizer Prod Inc | Composiciones farmaceuticas que contienen conjuntos de polimero y farmaco. |
WO2003063868A1 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Controlled release pharmaceutical dosage forms of a cholesteryl ester transfer protein inhibitor |
CA2474838C (en) * | 2002-02-01 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
CA2474958A1 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles |
AR038375A1 (es) * | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
-
2004
- 2004-07-26 CL CL200401884A patent/CL2004001884A1/es unknown
- 2004-07-27 RU RU2006103256/15A patent/RU2318495C2/ru not_active IP Right Cessation
- 2004-07-27 EP EP04744168A patent/EP1653928B1/de active Active
- 2004-07-27 CA CA002534129A patent/CA2534129A1/en not_active Abandoned
- 2004-07-27 MX MXPA06001418A patent/MXPA06001418A/es unknown
- 2004-07-27 BR BRPI0413313-7A patent/BRPI0413313A/pt not_active IP Right Cessation
- 2004-07-27 JP JP2006522431A patent/JP2007501219A/ja not_active Withdrawn
- 2004-07-27 KR KR1020067002434A patent/KR20060087501A/ko not_active Application Discontinuation
- 2004-07-27 NZ NZ544892A patent/NZ544892A/en unknown
- 2004-07-27 EP EP10182036A patent/EP2283822A3/de not_active Withdrawn
- 2004-07-27 WO PCT/IB2004/002519 patent/WO2005011636A2/en active Application Filing
- 2004-07-27 AU AU2004261061A patent/AU2004261061A1/en not_active Abandoned
- 2004-07-27 PT PT04744168T patent/PT1653928E/pt unknown
- 2004-07-27 AT AT04744168T patent/ATE548027T1/de active
- 2004-08-02 AR ARP040102742A patent/AR045188A1/es unknown
- 2004-08-03 US US10/910,115 patent/US10383941B2/en active Active
- 2004-08-03 TW TW093123239A patent/TWI290852B/zh active
-
2006
- 2006-01-12 IL IL173130A patent/IL173130A0/en unknown
- 2006-01-20 NO NO20060305A patent/NO20060305L/no not_active Application Discontinuation
-
2010
- 2010-08-27 JP JP2010190789A patent/JP2011016821A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IL173130A0 (en) | 2006-06-11 |
AU2004261061A1 (en) | 2005-02-10 |
AR045188A1 (es) | 2005-10-19 |
EP2283822A2 (de) | 2011-02-16 |
EP2283822A3 (de) | 2012-06-13 |
JP2007501219A (ja) | 2007-01-25 |
US20050031692A1 (en) | 2005-02-10 |
NO20060305L (no) | 2006-05-03 |
JP2011016821A (ja) | 2011-01-27 |
US10383941B2 (en) | 2019-08-20 |
BRPI0413313A (pt) | 2006-10-10 |
KR20060087501A (ko) | 2006-08-02 |
NZ544892A (en) | 2008-09-26 |
CA2534129A1 (en) | 2005-02-10 |
RU2318495C2 (ru) | 2008-03-10 |
EP1653928A2 (de) | 2006-05-10 |
EP1653928B1 (de) | 2012-03-07 |
WO2005011636A2 (en) | 2005-02-10 |
RU2006103256A (ru) | 2006-06-27 |
MXPA06001418A (es) | 2006-05-15 |
TW200524675A (en) | 2005-08-01 |
PT1653928E (pt) | 2012-04-13 |
WO2005011636A3 (en) | 2005-03-31 |
TWI290852B (en) | 2007-12-11 |
CL2004001884A1 (es) | 2005-06-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE548027T1 (de) | Sprühtrocknungsverfahren zur bildung von festen amorphen dispersionen von arzneimitteln und polymere | |
ATE551100T1 (de) | Pharmazeutische zusammensetzung zur behandlung von kardiovaskulären und cerebrovasakulären erkrankungen | |
DE60301350D1 (de) | Verfahren zur herstellung von 7-substituierten -3-chinolin und 3-chinol-4-on carbonitrile | |
DE602004022036D1 (de) | Verfahren zur behandlung von atherosklerose, dyslipidämie und verwandten erkrankungen und pharmazeutische zusammensetzungen | |
IL230815A0 (en) | Dictopiperazine compounds and pharmaceutical preparations containing them for the treatment of T-cell mediated diseases | |
TR200500221T2 (tr) | Farmasötik Maddeler Olarak Bisiklik Amino Asitler | |
DE602004017173D1 (de) | Vorrichtung und vefahren zur herstellung von aromatischen carbonsäuren | |
DE602004027218D1 (de) | Neue cyanopyridine-derivate zur behandlung von krebs und anderer erkrankungen | |
DE60314865D1 (de) | Verfahren zur herstellung von modifiziertem polymer, danach erhaltenes modifiziertes polymer und kautschukzusammensetzung | |
GB2410620A8 (en) | Liquid cyrstalline polymer composites, method of manufacture thereof, and articles formed therefrom | |
DE602004021878D1 (de) | Masterbatch und Verfahren zur Herstellung von sauerstoffabsorbierenden Formkörpern | |
ATE466925T1 (de) | Duftverfahren und produkt | |
IL220682A0 (en) | 1h-quinazoline-2,4-diones, processes for their manufacture, and use thereof in the preparation of medicaments for treating conditions mediated by the ampa-receptor | |
DE60334747D1 (de) | Verfahren und Vorrichtung zur Herstellung von Microarrays | |
DE502004005547D1 (de) | Vorrichtung zur Wärmebehandlung von Substanzen, insbesondere Nahrungsmitteln | |
ATE424823T1 (de) | 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin- derivate als arzneimittel zur behandlung von unfruchtbarkeit | |
DE60328502D1 (de) | Verfahren zur herstellung von 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazolen aus cyclohexanen und cycylohexanonen als zwischenprodukte | |
DE60224986D1 (de) | Verfahren und vorrichtung zur kontinuierlichen herstellung von pellets zur herstellung von snackprodukten | |
ATE455091T1 (de) | Para-alkyl-substituierte n-(4-hydroxy-3-methoxy- benzyl)-zimtsäeureamide und deren verwendung zur herstellung von arzneimitteln | |
ATE406895T1 (de) | 4-phenyl-5-oxo-l,4,5,6,7,8-hexahydrochinolin- derivate als arzneimittel zur behandlung von unfruchtbarkeit | |
DE502005007695D1 (de) | Verfahren und Vorrichtung zur gleichzeittigen Herstellung von Süsswaren in mehreren Produktsorten | |
DE60307830D1 (de) | Neue multimerische moleküle, verfahren zu deren herstellung, und deren verwendung zur herstellung von arzneimitteln | |
DE60223326D1 (de) | Polymermaterial, geformtes Produkt und deren Herstellungsverfahren | |
DE60012666D1 (de) | Produkt auf basis von kautschuk, verfahren zu seiner herstellung, reifen und verfahren zur verringerung des rollwiderstandes von diesem reifen | |
DE60101848D1 (de) | Hochfunktionalisierte polymere und verfahren zur herstellung davon |