ATE520678T1 - Asymmetrische hydrierung von alkenen mit chiralem iridiumkomplex - Google Patents

Asymmetrische hydrierung von alkenen mit chiralem iridiumkomplex

Info

Publication number
ATE520678T1
ATE520678T1 AT05820633T AT05820633T ATE520678T1 AT E520678 T1 ATE520678 T1 AT E520678T1 AT 05820633 T AT05820633 T AT 05820633T AT 05820633 T AT05820633 T AT 05820633T AT E520678 T1 ATE520678 T1 AT E520678T1
Authority
AT
Austria
Prior art keywords
alkenes
iridium complex
asymmetric hydrogenation
chiral iridium
hydrogenation
Prior art date
Application number
AT05820633T
Other languages
English (en)
Inventor
Werner Bonrath
Frederik Menges
Thomas Netscher
Andreas Pfaltz
Bettina Wuestenberg
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE520678T1 publication Critical patent/ATE520678T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C07C29/172—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds with the obtention of a fully saturated alcohol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Catalysts (AREA)
AT05820633T 2004-12-22 2005-12-20 Asymmetrische hydrierung von alkenen mit chiralem iridiumkomplex ATE520678T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04030432 2004-12-22
PCT/EP2005/013694 WO2006066863A1 (en) 2004-12-22 2005-12-20 Asymmetric hydrogenation of alkennes using chiral iridium complexes

Publications (1)

Publication Number Publication Date
ATE520678T1 true ATE520678T1 (de) 2011-09-15

Family

ID=35994658

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05820633T ATE520678T1 (de) 2004-12-22 2005-12-20 Asymmetrische hydrierung von alkenen mit chiralem iridiumkomplex

Country Status (8)

Country Link
US (1) US8426617B2 (de)
EP (1) EP1828159B1 (de)
JP (1) JP5090926B2 (de)
KR (1) KR101342722B1 (de)
CN (1) CN101087774B (de)
AT (1) ATE520678T1 (de)
ES (1) ES2371653T3 (de)
WO (1) WO2006066863A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101565366B (zh) * 2008-04-25 2013-04-17 浙江九洲药业股份有限公司 铱络合物在不饱和羧酸不对称催化氢化中的应用
GB2466629B (en) 2008-12-29 2011-08-17 Schlumberger Holdings Catalytic hydrogenation
WO2010125035A1 (de) * 2009-04-30 2010-11-04 Basf Se Metallkomplex mit schwach koordinierendem gegenion als polymerisationskatalysator für isobuten oder ein isobuten-haltiges monomerengemisch
RU2573824C2 (ru) 2010-08-23 2016-01-27 Новартис Аг Новый способ получения промежуточных соединений, используемыхпри полученииингибиторов nep
EP2522647B1 (de) 2011-05-10 2014-04-30 DSM IP Assets B.V. Verfahren zum Trennen von chiralen Isomeren von Chromverbindungen und ihre Derivate und Vorläufer
EP2535323A1 (de) 2011-06-14 2012-12-19 DSM IP Assets B.V. Hydrierung von Ketonen mit mindestens einer Kohlenstoff-Doppelbindung in der gamma-,delta-Position
ES2606354T3 (es) 2012-08-10 2017-03-23 Dsm Ip Assets B.V. Tocoferoles con estabilidad cromática incrementada
CN104520284B (zh) 2012-08-10 2018-01-26 帝斯曼知识产权资产管理有限公司 具有含量降低的游离生育酚的经保护生育酚
US9573872B2 (en) 2012-12-18 2017-02-21 Dsm Ip Assets B.V. Using mixtures of E/Z isomers to obtain quantitatively specific products by combining asymmetric hydrogenation and isomerization
WO2014096067A1 (en) * 2012-12-18 2014-06-26 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from (r)-6,10,14-trimetylpentadec-5-en-2-one
US9561989B2 (en) 2012-12-18 2017-02-07 Dsm Ip Assets B.V. Process of asymmetric hydrogenation of ketals and acetals
WO2014097173A1 (en) * 2012-12-18 2014-06-26 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 6,10-dimetylundeca-3,5,9-trien-2-one
CN104854070B (zh) * 2012-12-18 2017-08-04 帝斯曼知识产权资产管理有限公司 由(r)‑3,7‑二甲基辛‑6‑烯醛制备的(6r,10r)‑6,10,14‑三甲基十五烷‑2‑酮
US9458076B2 (en) 2012-12-18 2016-10-04 Dsm Ip Assets B.V. Using mixtures of E/Z isomers to obtain quantitatively specific products by combined asymmetric hydrogenations
EP2935185B1 (de) 2012-12-18 2019-02-20 DSM IP Assets B.V. (6r,10r)-6,10,14-trimethylpentadecan-2-on, das aus 6,10,14-trimethylpentadeca-5,9,13-trien-2-on oder 6,10,14-trimethylpentadeca-5,9-dien-2-on hergestellt wurde
US10047019B2 (en) 2012-12-18 2018-08-14 Dsm Ip Assets B.V. Efficient process of asymmetric hydrogenation of unsaturated ketones using additives
WO2014096063A1 (en) * 2012-12-18 2014-06-26 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetylpentadecan-2-one prepared from 3,7-dimetyloct-2-enal or 3,7-dimetylocta-2,6-dienal
BR112015014335B1 (pt) * 2012-12-18 2020-12-08 Dsm Ip Assets B.V. (6r,10r)-6,10,14-trimetilpentadecan-2-ona preparada a partir de 6,10-dimetilundec-5-en-2-ona ou 6,10 dimetilundeca-5,9-dien-2-ona
US20160152588A1 (en) 2013-07-05 2016-06-02 Dsm Ip Assets B.V. Formation of chiral 4-chromanones using chiral pyrrolidines
BR112015033011B8 (pt) 2013-07-05 2022-01-18 Dsm Ip Assets Bv Processos para a fabricação de cromanonas ou cromanos usando pirrolidinas quirais na presença de ureias ou tioureias e composição compreendendo as mesmas
EP2842951A1 (de) 2013-08-30 2015-03-04 DSM IP Assets B.V. Bildung von Chromanen und Chromenen durch Verwendung von Silber(I)- oder Gold(I)-Salzen oder -Komplexen
US20180155311A1 (en) 2015-05-26 2018-06-07 Dsm Ip Assets B.V. Separation of chiral isomers by sfc
WO2018108606A1 (en) * 2016-12-12 2018-06-21 Dsm Ip Assets B.V. Process for the manufacture of 6,10-dimethylundecan-2-one, isophytol, alpha-tocopherol (acetate) and further intermediates thereof
KR20200038182A (ko) * 2018-10-02 2020-04-10 주식회사 글라세움 탄소 이중결합 함유 화합물의 비대칭 수소첨가 반응용 촉매
CN114790221B (zh) * 2022-05-25 2024-07-12 西安交通大学 一种基于吲哚骨架的pcp钳形配体的合成及应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63152337A (ja) * 1986-08-27 1988-06-24 Takasago Corp 光学活性アルコ−ルの製法
DE3781749T3 (de) * 1986-08-27 1997-02-06 Takasago Perfumery Co Ltd Herstellungsverfahren von optisch aktiven Alkoholen.
DE3813624A1 (de) * 1988-04-22 1989-11-02 Basf Ag Verfahren zur herstellung von d-(alpha)-tocopherol aus natuerlichen vorprodukten
DK0398132T3 (da) * 1989-05-18 1995-12-18 Hoffmann La Roche Phosphorforbindelser
JPH0474192A (ja) * 1990-07-12 1992-03-09 Takasago Internatl Corp ２，２′―ビス（ジシクロペンチルホスフィノ）―１，１′―ビナフチル及びこれれを配位子とする遷移金属錯体
DE59303616D1 (de) * 1992-04-16 1996-10-10 Hoffmann La Roche Verfahren zur Herstellung von Isoprenderivaten
DE19619013A1 (de) 1996-05-10 1997-11-13 Basf Ag Verfahren zur Herstellung von Hexahydrofarnesylaceton aus 6,7-Dihydro-geraniol sowie neue Zwischenprodukte für dieses Verfahren
JPH10114767A (ja) * 1996-10-09 1998-05-06 Sumitomo Chem Co Ltd トコフェロール誘導体の製造法
JPH10251248A (ja) 1997-01-08 1998-09-22 Sumitomo Chem Co Ltd クロマン誘導体の製造法
EP1095034A1 (de) * 1998-07-06 2001-05-02 Eastman Chemical Company Darstellung von tocoferolen
US6410755B1 (en) * 1998-07-06 2002-06-25 Dcv, Inc. Method of vitamin production
JP3771070B2 (ja) * 1998-12-24 2006-04-26 高砂香料工業株式会社 軸不斉化合物の製造方法、その製造中間体、新規な軸不斉化合物を配位子とする遷移金属錯体、不斉水素化触媒及び不斉炭素−炭素結合形成触媒
DE60110516T2 (de) * 2000-09-21 2005-10-13 Solvias Ag Phosphinite-oxazoline und Metallkomplexe
DE10160142A1 (de) * 2001-12-07 2003-06-18 Basf Ag Verfahren zur Herstellung von Tetrahydrogeraniol
DE102004049631A1 (de) * 2004-10-11 2006-04-20 Basf Ag Verfahren zur Herstellung optisch aktiver Carbonylverbindungen

Also Published As

Publication number Publication date
CN101087774B (zh) 2012-02-08
WO2006066863A1 (en) 2006-06-29
CN101087774A (zh) 2007-12-12
EP1828159B1 (de) 2011-08-17
KR101342722B1 (ko) 2013-12-19
KR20070089874A (ko) 2007-09-03
ES2371653T3 (es) 2012-01-05
EP1828159A1 (de) 2007-09-05
US20080039638A1 (en) 2008-02-14
JP5090926B2 (ja) 2012-12-05
JP2008524288A (ja) 2008-07-10
US8426617B2 (en) 2013-04-23

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