ATE517857T1 - Herstellung von 4-phenylbutansäure - Google Patents

Herstellung von 4-phenylbutansäure

Info

Publication number
ATE517857T1
ATE517857T1 AT02729112T AT02729112T ATE517857T1 AT E517857 T1 ATE517857 T1 AT E517857T1 AT 02729112 T AT02729112 T AT 02729112T AT 02729112 T AT02729112 T AT 02729112T AT E517857 T1 ATE517857 T1 AT E517857T1
Authority
AT
Austria
Prior art keywords
acid
phenylbutanic
production
butyrolactone
neutralization
Prior art date
Application number
AT02729112T
Other languages
German (de)
English (en)
Inventor
Stanislaw R Burzynski
Leszek Musial
Original Assignee
Stanislaw R Burzynski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanislaw R Burzynski filed Critical Stanislaw R Burzynski
Application granted granted Critical
Publication of ATE517857T1 publication Critical patent/ATE517857T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
AT02729112T 2001-05-21 2002-05-02 Herstellung von 4-phenylbutansäure ATE517857T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/862,074 US6372938B1 (en) 2001-05-21 2001-05-21 Synthesis of 4-phenylbutyric acid
PCT/US2002/013946 WO2002094756A1 (en) 2001-05-21 2002-05-02 Synthesis of 4-phenylbutyric acid

Publications (1)

Publication Number Publication Date
ATE517857T1 true ATE517857T1 (de) 2011-08-15

Family

ID=25337569

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02729112T ATE517857T1 (de) 2001-05-21 2002-05-02 Herstellung von 4-phenylbutansäure

Country Status (12)

Country Link
US (1) US6372938B1 (enExample)
EP (1) EP1404638B1 (enExample)
JP (1) JP4338401B2 (enExample)
KR (1) KR100905139B1 (enExample)
CN (1) CN1266105C (enExample)
AT (1) ATE517857T1 (enExample)
CA (1) CA2447803C (enExample)
HU (1) HU229996B1 (enExample)
IL (2) IL158914A0 (enExample)
PL (1) PL201802B1 (enExample)
RU (1) RU2297998C2 (enExample)
WO (1) WO2002094756A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1291015A1 (en) * 2001-09-10 2003-03-12 Lunamed AG Dosage forms having prolonged active ingredient release
US7115782B2 (en) * 2002-06-03 2006-10-03 Showa Denko K.K. Process for producing aromatic compounds by Friedel-Crafts reaction
US20060045912A1 (en) * 2004-08-30 2006-03-02 Peter Truog 4-phenylbutyric acid controlled-release formulations for therapeutic use
US20070004805A1 (en) * 2005-07-01 2007-01-04 Navinta Llc Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
WO2007035029A1 (en) * 2005-09-23 2007-03-29 Sk Holdings Co., Ltd. Pharmaceutical composition for prevention and treatment of drug or alcohol addiction or bipolar disorder using sodium phenylbutyrate
BR112012025714A2 (pt) * 2010-04-06 2015-09-08 Bayer Ip Gmbh uso de ácido 4-fenilbutírico e/ou sais do mesmo para aumentar a tolerância a estresse de plantas
KR101374241B1 (ko) * 2010-11-17 2014-03-14 전북대학교병원 페닐부틸산（４－ｐｈｅｎｙｌｂｕｔｙｒｉｃ ａｃｉｄ）또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는, 천식 치료용 약학적 조성물
EP2599477A1 (en) 2011-11-30 2013-06-05 Lunamed AG 4-Phenylbutyric acid sustained release formulation
FR2993141B1 (fr) 2012-07-11 2014-11-28 Inst Rech Developpement Ird Utilisation de l'acide 4-phenylbutyrique pour ameliorer la tolerance des plantes aux bioagresseurs
CN103304402B (zh) * 2013-05-24 2015-04-22 苏州诚和医药化学有限公司 一种制备4-苯-1-丁酸的方法
CN103304403B (zh) * 2013-05-24 2015-04-22 苏州诚和医药化学有限公司 一种4-苯-1-丁酸的合成方法
US9914692B2 (en) * 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
CN106117045A (zh) * 2016-06-22 2016-11-16 北京阳光诺和药物研究有限公司 一种苯基丁酸的纯化方法
CN108530290A (zh) * 2018-06-04 2018-09-14 福州华博立乐新材料科技有限公司 一种4-苯基-1-丁酸的合成方法
CN110317132B (zh) * 2019-07-26 2021-09-10 南京工业大学 一种苯丁酸钠的制备方法
FR3110336B1 (fr) 2020-05-20 2022-12-23 Inst Des Sciences Et Industries Du Vivant Et De Lenvir Utilisation de l’Acide 4-phénylbutyrique et/ou de l’Acide 3-phénylbutyrique et/ou de l’Acide 2-phénylbutyrique pour la Prévention et le Traitement des Maladies Cryptogamiques
WO2024200617A1 (en) * 2023-03-28 2024-10-03 Dipharma Francis S.R.L. Process and intermediates for preparing a drug for the treatment of urea cycle disorders
IT202300019125A1 (it) * 2023-09-18 2025-03-18 Dipharma Francis Srl Metodo di purificazione di un farmaco usato per il trattamento di disturbi del ciclo dell’urea

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037376A (en) 1991-10-21 2000-03-14 The United States Of America As Represented By The Department Of Health And Human Services Methods for therapy of cancer

Also Published As

Publication number Publication date
JP4338401B2 (ja) 2009-10-07
WO2002094756A1 (en) 2002-11-28
HUP0400053A3 (en) 2006-01-30
CA2447803C (en) 2009-04-07
PL201802B1 (pl) 2009-05-29
IL158914A0 (en) 2004-05-12
RU2003136765A (ru) 2005-04-10
PL364646A1 (en) 2004-12-13
EP1404638B1 (en) 2011-07-27
EP1404638A1 (en) 2004-04-07
KR20040025679A (ko) 2004-03-24
CN1511133A (zh) 2004-07-07
HK1065996A1 (en) 2005-03-11
KR100905139B1 (ko) 2009-06-29
CN1266105C (zh) 2006-07-26
HUP0400053A2 (hu) 2004-04-28
JP2004527577A (ja) 2004-09-09
US6372938B1 (en) 2002-04-16
RU2297998C2 (ru) 2007-04-27
CA2447803A1 (en) 2002-11-28
IL158914A (en) 2010-04-29
HU229996B1 (hu) 2015-04-28

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