IL158914A0 - Synthesis of 4-phenylbutyric acid - Google Patents

Synthesis of 4-phenylbutyric acid

Info

Publication number
IL158914A0
IL158914A0 IL15891402A IL15891402A IL158914A0 IL 158914 A0 IL158914 A0 IL 158914A0 IL 15891402 A IL15891402 A IL 15891402A IL 15891402 A IL15891402 A IL 15891402A IL 158914 A0 IL158914 A0 IL 158914A0
Authority
IL
Israel
Prior art keywords
phenylbutyric acid
synthesis
butyrolactone
neutralization
followed
Prior art date
Application number
IL15891402A
Other languages
English (en)
Original Assignee
Burzynski Stanislaw R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burzynski Stanislaw R filed Critical Burzynski Stanislaw R
Publication of IL158914A0 publication Critical patent/IL158914A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
IL15891402A 2001-05-21 2002-05-02 Synthesis of 4-phenylbutyric acid IL158914A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/862,074 US6372938B1 (en) 2001-05-21 2001-05-21 Synthesis of 4-phenylbutyric acid
PCT/US2002/013946 WO2002094756A1 (en) 2001-05-21 2002-05-02 Synthesis of 4-phenylbutyric acid

Publications (1)

Publication Number Publication Date
IL158914A0 true IL158914A0 (en) 2004-05-12

Family

ID=25337569

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15891402A IL158914A0 (en) 2001-05-21 2002-05-02 Synthesis of 4-phenylbutyric acid
IL158914A IL158914A (en) 2001-05-21 2003-11-17 Synthesis of 4-phenylbutyric acid and its derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL158914A IL158914A (en) 2001-05-21 2003-11-17 Synthesis of 4-phenylbutyric acid and its derivatives

Country Status (13)

Country Link
US (1) US6372938B1 (xx)
EP (1) EP1404638B1 (xx)
JP (1) JP4338401B2 (xx)
KR (1) KR100905139B1 (xx)
CN (1) CN1266105C (xx)
AT (1) ATE517857T1 (xx)
CA (1) CA2447803C (xx)
HK (1) HK1065996A1 (xx)
HU (1) HU229996B1 (xx)
IL (2) IL158914A0 (xx)
PL (1) PL201802B1 (xx)
RU (1) RU2297998C2 (xx)
WO (1) WO2002094756A1 (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1291015A1 (en) * 2001-09-10 2003-03-12 Lunamed AG Dosage forms having prolonged active ingredient release
CN1659126A (zh) * 2002-06-03 2005-08-24 昭和电工株式会社 通过弗瑞德－克来福特反应制备芳族化合物的方法
CA2582255A1 (en) * 2004-08-30 2006-08-08 Lunamed, Inc. 4-phenylbutyric acid controlled-release formulations for therapeutic use
US20070004805A1 (en) * 2005-07-01 2007-01-04 Navinta Llc Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
JP5163986B2 (ja) * 2005-09-23 2013-03-13 エスケー バイオファーマスティカルズ カンパニー リミテッド フェニル酪酸ナトリウムを使用する、薬物依存症又はアルコール依存症或いは躁うつ病の予防又は治療のための医薬組成物
WO2011124554A2 (de) * 2010-04-06 2011-10-13 Bayer Cropscience Ag Verwendung der 4-phenylbuttersäure und/oder ihrer salze zur steigerung der stresstoleranz in pflanzen
KR101374241B1 (ko) * 2010-11-17 2014-03-14 전북대학교병원 페닐부틸산（４－ｐｈｅｎｙｌｂｕｔｙｒｉｃ ａｃｉｄ）또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는, 천식 치료용 약학적 조성물
EP2599477A1 (en) 2011-11-30 2013-06-05 Lunamed AG 4-Phenylbutyric acid sustained release formulation
FR2993141B1 (fr) 2012-07-11 2014-11-28 Inst Rech Developpement Ird Utilisation de l'acide 4-phenylbutyrique pour ameliorer la tolerance des plantes aux bioagresseurs
CN103304402B (zh) * 2013-05-24 2015-04-22 苏州诚和医药化学有限公司 一种制备4-苯-1-丁酸的方法
CN103304403B (zh) * 2013-05-24 2015-04-22 苏州诚和医药化学有限公司 一种4-苯-1-丁酸的合成方法
US9914692B2 (en) * 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
CN106117045A (zh) * 2016-06-22 2016-11-16 北京阳光诺和药物研究有限公司 一种苯基丁酸的纯化方法
CN108530290A (zh) * 2018-06-04 2018-09-14 福州华博立乐新材料科技有限公司 一种4-苯基-1-丁酸的合成方法
CN110317132B (zh) * 2019-07-26 2021-09-10 南京工业大学 一种苯丁酸钠的制备方法
FR3110336B1 (fr) 2020-05-20 2022-12-23 Inst Des Sciences Et Industries Du Vivant Et De Lenvir Utilisation de l’Acide 4-phénylbutyrique et/ou de l’Acide 3-phénylbutyrique et/ou de l’Acide 2-phénylbutyrique pour la Prévention et le Traitement des Maladies Cryptogamiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037376A (en) 1991-10-21 2000-03-14 The United States Of America As Represented By The Department Of Health And Human Services Methods for therapy of cancer

Also Published As

Publication number Publication date
RU2297998C2 (ru) 2007-04-27
PL364646A1 (en) 2004-12-13
CA2447803C (en) 2009-04-07
CA2447803A1 (en) 2002-11-28
RU2003136765A (ru) 2005-04-10
US6372938B1 (en) 2002-04-16
PL201802B1 (pl) 2009-05-29
KR20040025679A (ko) 2004-03-24
WO2002094756A1 (en) 2002-11-28
IL158914A (en) 2010-04-29
CN1511133A (zh) 2004-07-07
CN1266105C (zh) 2006-07-26
JP4338401B2 (ja) 2009-10-07
HU229996B1 (hu) 2015-04-28
EP1404638B1 (en) 2011-07-27
HUP0400053A2 (hu) 2004-04-28
JP2004527577A (ja) 2004-09-09
EP1404638A1 (en) 2004-04-07
HK1065996A1 (en) 2005-03-11
KR100905139B1 (ko) 2009-06-29
HUP0400053A3 (en) 2006-01-30
ATE517857T1 (de) 2011-08-15

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