ATE271025T1 - Zwischenprodukte für die herstellung von citalopram - Google Patents
Zwischenprodukte für die herstellung von citalopramInfo
- Publication number
- ATE271025T1 ATE271025T1 AT00119222T AT00119222T ATE271025T1 AT E271025 T1 ATE271025 T1 AT E271025T1 AT 00119222 T AT00119222 T AT 00119222T AT 00119222 T AT00119222 T AT 00119222T AT E271025 T1 ATE271025 T1 AT E271025T1
- Authority
- AT
- Austria
- Prior art keywords
- citalopram
- compound
- production
- following formula
- intermediate products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
- C07C51/255—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting
- C07C51/265—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting having alkyl side chains which are oxidised to carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000039936 | 2000-02-17 | ||
JP2000065527 | 2000-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE271025T1 true ATE271025T1 (de) | 2004-07-15 |
Family
ID=26585589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00119222T ATE271025T1 (de) | 2000-02-17 | 2000-09-06 | Zwischenprodukte für die herstellung von citalopram |
Country Status (10)
Country | Link |
---|---|
US (5) | US6433196B1 (de) |
EP (2) | EP1428813A1 (de) |
AT (1) | ATE271025T1 (de) |
AU (1) | AU777193B2 (de) |
CA (1) | CA2318701A1 (de) |
DE (1) | DE60012131T2 (de) |
DK (1) | DK1125907T3 (de) |
ES (1) | ES2220308T3 (de) |
PT (1) | PT1125907E (de) |
SI (1) | SI1125907T1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR200102957T2 (tr) | 1999-04-14 | 2004-12-21 | H. Lundbeck A/S | Sitalopram hazırlanması için metod. |
US6310222B1 (en) * | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
AR026063A1 (es) * | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
IES20010143A2 (en) * | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
NZ521201A (en) * | 2000-03-13 | 2004-02-27 | H | Method for the preparation of citalopram |
GB2357762B (en) * | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
CN1427835A (zh) * | 2000-03-13 | 2003-07-02 | H·隆德贝克有限公司 | 5-取代的1-(4-氟苯基)-1,3-二氢异苯并呋喃的分步烷基化 |
ATE257832T1 (de) | 2000-03-14 | 2004-01-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
WO2001068632A1 (en) | 2000-03-16 | 2001-09-20 | H. Lundbeck A/S | Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
EP1346989A1 (de) * | 2002-03-21 | 2003-09-24 | Jubilant Organosys Limited | Verbessertes Verfahren zur Herstellung von Citalopram und Citalopram Hydrobromid |
ITMI20030479A1 (it) * | 2003-03-13 | 2004-09-14 | Adorkem Technology S P A | Procedimento per la preparazione di un ciano-isobenzofurano. |
US20050154052A1 (en) * | 2003-03-24 | 2005-07-14 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
AU2003238676A1 (en) * | 2003-04-21 | 2004-11-19 | Podile Khadgapathi | An improved process for the preparation of citalopram hydrobromide |
EP1706394B1 (de) * | 2003-11-12 | 2014-12-17 | Dr. Reddy's Laboratories, Inc. | Herstellung von escitalopram |
CN101001823A (zh) | 2004-08-05 | 2007-07-18 | 住友化学株式会社 | 制造卤素取代的苯二甲醇的方法 |
CN102190641A (zh) * | 2011-03-23 | 2011-09-21 | 四川科伦药物研究有限公司 | 一种制备西酞普兰和艾司西酞普兰关键中间体的方法 |
CN104478690A (zh) * | 2014-11-18 | 2015-04-01 | 四川大学 | 一种4,4’-二羧基二苯甲酮的制备方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4604A (en) * | 1846-06-27 | Apparatus for generating gas | ||
US60640A (en) * | 1866-12-18 | peters | ||
US114692A (en) * | 1871-05-09 | Improvement in chemical electric telegraphs | ||
US134895A (en) * | 1873-01-14 | Improvement in folding-cribs | ||
US109577A (en) * | 1870-11-29 | Improvement in machines for | ||
US40153A (en) * | 1863-10-06 | Improvement in bullets for fire-arms | ||
US83508A (en) * | 1868-10-27 | Improved car-brake | ||
GB1219609A (en) * | 1968-07-19 | 1971-01-20 | Koninklijke Pharma Fab Nv | Diphenylmethoxyethylamino derivatives |
US3642997A (en) | 1969-06-25 | 1972-02-15 | Merck & Co Inc | Tricyclic carboxylic acids in the treatment of inflammation |
US3835167A (en) | 1972-12-18 | 1974-09-10 | Syntex Inc | Anthrone carboxylic acids and derivatives |
US3959475A (en) * | 1973-12-12 | 1976-05-25 | American Hoechst Corporation | Substituted 1,3-dihydrospiro(isobenzofuran)s |
GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
ES8700647A1 (es) | 1984-10-11 | 1986-11-16 | Raychem Corp | Procedimiento para la preparacion de un compuesto carbonilo aromatico |
US4940822A (en) * | 1988-11-04 | 1990-07-10 | Warner-Lambert Company | Substituted benzenemethanol compounds, intermediates thereof, and preparation thereof |
US5061810A (en) | 1989-11-28 | 1991-10-29 | Ethyl Corporation | Substituted benzophenone dicarboxylic acids |
EP0467435A3 (en) * | 1990-07-19 | 1992-04-01 | Akzo N.V. | Benzhydryl derivatives having calmodulin inhibitor properties |
US5198594A (en) * | 1991-11-27 | 1993-03-30 | Amoco Corporation | Alkylation of alkylaromatics promoted by sonicated alkali metal |
US5210313A (en) | 1992-01-10 | 1993-05-11 | Maxdem Incorporated | Preparation of 2,5-dichlorobenzophenones |
UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
DE69935331T2 (de) * | 1998-07-13 | 2007-10-31 | NPS Pharmaceuticals, Inc., Salt Lake City | Verfahren und verbindungen zur behandlung der depression |
TR200102957T2 (tr) | 1999-04-14 | 2004-12-21 | H. Lundbeck A/S | Sitalopram hazırlanması için metod. |
US6310222B1 (en) * | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
FR2805812A1 (fr) * | 2000-02-24 | 2001-09-07 | Lundbeck & Co As H | Procede de preparation du citalopram |
IES20010143A2 (en) * | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
WO2001068632A1 (en) | 2000-03-16 | 2001-09-20 | H. Lundbeck A/S | Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
US20030109577A1 (en) | 2000-10-27 | 2003-06-12 | Ken Liljegren | Pharmaceutical composition containing citalopram |
-
2000
- 2000-09-05 US US09/654,768 patent/US6433196B1/en not_active Expired - Fee Related
- 2000-09-06 SI SI200030487T patent/SI1125907T1/xx unknown
- 2000-09-06 PT PT00119222T patent/PT1125907E/pt unknown
- 2000-09-06 EP EP04006759A patent/EP1428813A1/de not_active Withdrawn
- 2000-09-06 AT AT00119222T patent/ATE271025T1/de not_active IP Right Cessation
- 2000-09-06 EP EP00119222A patent/EP1125907B1/de not_active Expired - Lifetime
- 2000-09-06 DE DE60012131T patent/DE60012131T2/de not_active Expired - Fee Related
- 2000-09-06 DK DK00119222T patent/DK1125907T3/da active
- 2000-09-06 ES ES00119222T patent/ES2220308T3/es not_active Expired - Lifetime
- 2000-09-07 AU AU56560/00A patent/AU777193B2/en not_active Ceased
- 2000-09-13 CA CA002318701A patent/CA2318701A1/en not_active Abandoned
-
2001
- 2001-11-28 US US09/996,134 patent/US6458975B1/en not_active Expired - Fee Related
-
2002
- 2002-02-28 US US10/086,076 patent/US7119215B2/en not_active Expired - Fee Related
-
2003
- 2003-12-23 US US10/744,734 patent/US6946564B2/en not_active Expired - Fee Related
-
2004
- 2004-06-14 US US10/867,350 patent/US20040230066A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1125907A2 (de) | 2001-08-22 |
EP1125907A3 (de) | 2002-05-02 |
US6458975B1 (en) | 2002-10-01 |
US20040138497A1 (en) | 2004-07-15 |
CA2318701A1 (en) | 2001-08-17 |
AU777193B2 (en) | 2004-10-07 |
PT1125907E (pt) | 2004-10-29 |
US6433196B1 (en) | 2002-08-13 |
US20020062040A1 (en) | 2002-05-23 |
US6946564B2 (en) | 2005-09-20 |
US20040230066A1 (en) | 2004-11-18 |
AU5656000A (en) | 2001-08-23 |
EP1428813A1 (de) | 2004-06-16 |
US7119215B2 (en) | 2006-10-10 |
ES2220308T3 (es) | 2004-12-16 |
US20020095051A1 (en) | 2002-07-18 |
DE60012131D1 (de) | 2004-08-19 |
DK1125907T3 (da) | 2004-10-18 |
EP1125907B1 (de) | 2004-07-14 |
DE60012131T2 (de) | 2005-08-11 |
SI1125907T1 (en) | 2004-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEIH | Change in the person of patent owner | ||
UEP | Publication of translation of european patent specification |
Ref document number: 1125907 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |