DE60306768D1 - Prozess für die dehydrogenierung von azaandrostan verbindungen - Google Patents

Prozess für die dehydrogenierung von azaandrostan verbindungen

Info

Publication number
DE60306768D1
DE60306768D1 DE60306768T DE60306768T DE60306768D1 DE 60306768 D1 DE60306768 D1 DE 60306768D1 DE 60306768 T DE60306768 T DE 60306768T DE 60306768 T DE60306768 T DE 60306768T DE 60306768 D1 DE60306768 D1 DE 60306768D1
Authority
DE
Germany
Prior art keywords
compounds
azaandrostan
dehydrogenation
bioconversion
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60306768T
Other languages
English (en)
Other versions
DE60306768T2 (de
Inventor
Istvan Bartho
Monika Herine
Tamas Devenyi
Gabor Hantos
Katalin Olasz
Agnes Pecsne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of DE60306768D1 publication Critical patent/DE60306768D1/de
Publication of DE60306768T2 publication Critical patent/DE60306768T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60306768T 2002-05-10 2003-05-07 Prozess für die dehydrogenierung von azaandrostanverbindungen Expired - Lifetime DE60306768T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0201584 2002-05-10
HU0201584A HU227117B1 (en) 2002-05-10 2002-05-10 Process for dehydrogenation of aza-androstane compounds
PCT/HU2003/000036 WO2003095472A1 (en) 2002-05-10 2003-05-07 Process for dehydrogenation of azaandrostane compounds

Publications (2)

Publication Number Publication Date
DE60306768D1 true DE60306768D1 (de) 2006-08-24
DE60306768T2 DE60306768T2 (de) 2007-08-02

Family

ID=89980420

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60306768T Expired - Lifetime DE60306768T2 (de) 2002-05-10 2003-05-07 Prozess für die dehydrogenierung von azaandrostanverbindungen

Country Status (10)

Country Link
US (1) US6762302B2 (de)
EP (1) EP1504021B1 (de)
AT (1) ATE332912T1 (de)
AU (1) AU2003230042A1 (de)
DE (1) DE60306768T2 (de)
DK (1) DK1504021T3 (de)
ES (1) ES2268356T3 (de)
HU (1) HU227117B1 (de)
PT (1) PT1504021E (de)
WO (1) WO2003095472A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101760496A (zh) * 2008-11-06 2010-06-30 天津金耀集团有限公司 一种甾体药物中间体的生物脱氢制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2902411A (en) 1957-06-28 1959-09-01 Upjohn Co Use of second steroid to accelerate 1-dehydrogenation of substrate steroid
GB1318917A (en) 1970-08-21 1973-05-31 Richter Gedeon Vegyeszet Process for the microbiological c-1,2-dehydrogenation of corti costeroids
HU190784B (en) 1981-09-28 1986-11-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for the intensification of the microbiological transformation of steroid compounds
US4749649A (en) 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
NZ211145A (en) 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
JPS6296084A (ja) 1985-10-21 1987-05-02 Agency Of Ind Science & Technol 酵素の修飾方法
EP0350488B1 (de) 1987-03-12 1993-09-08 The Upjohn Company 1-2-dehydrierung von steroid-21-estern mit a. simplex
NZ225100A (en) 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
JP2778135B2 (ja) 1989-07-18 1998-07-23 味の素株式会社 リパーゼ固定化酵素剤の調製方法
US5021575A (en) 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
US5674718A (en) 1990-02-07 1997-10-07 Roussel Uclaf DNA segments and transformed microorganisms comprising the delta1 -dehydrogenase gene pseudomonas testosteroni, and uses thereof
US5091534A (en) 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
JPH06296084A (ja) 1993-02-12 1994-10-21 Ngk Spark Plug Co Ltd 高熱伝導体及びこれを備えた配線基板とこれらの製造方法
RU2039824C1 (ru) 1993-06-22 1995-07-20 Институт биохимии и физиологии микроорганизмов РАН Способ получения андроста-1,4-диен-3,17-диона
IT1270660B (it) 1994-10-13 1997-05-07 Poli Ind Chimica Spa Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
JP2001352974A (ja) 1996-07-25 2001-12-25 Inst Of Physical & Chemical Res 酵素を熱活性化する方法
JP3709471B2 (ja) 1996-07-25 2005-10-26 独立行政法人理化学研究所 酵素を熱活性化する方法
US6458556B1 (en) 1996-07-25 2002-10-01 The Institute Of Physical & Chemical Research Method for enhancing enzyme activity at elevated temperature
JP3206894B2 (ja) 1996-07-25 2001-09-10 理化学研究所 酵素を熱活性化する方法
CA2271974A1 (en) 1999-05-14 2000-11-14 Bob Macel 2, 2-dibromo-azasteroids and their use in a method for introducing a 1, 2-double bond into azasteroids

Also Published As

Publication number Publication date
HUP0201584A2 (hu) 2004-09-28
WO2003095472A1 (en) 2003-11-20
HU0201584D0 (de) 2002-07-29
DK1504021T3 (da) 2006-11-06
EP1504021A1 (de) 2005-02-09
US6762302B2 (en) 2004-07-13
PT1504021E (pt) 2006-11-30
DE60306768T2 (de) 2007-08-02
ES2268356T3 (es) 2007-03-16
US20030215902A1 (en) 2003-11-20
HU227117B1 (en) 2010-07-28
ATE332912T1 (de) 2006-08-15
AU2003230042A1 (en) 2003-11-11
EP1504021B1 (de) 2006-07-12

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