ATE490264T1 - Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen - Google Patents

Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen

Info

Publication number
ATE490264T1
ATE490264T1 AT04761605T AT04761605T ATE490264T1 AT E490264 T1 ATE490264 T1 AT E490264T1 AT 04761605 T AT04761605 T AT 04761605T AT 04761605 T AT04761605 T AT 04761605T AT E490264 T1 ATE490264 T1 AT E490264T1
Authority
AT
Austria
Prior art keywords
spaciously
macrocyclic compounds
drug discovery
compounds suitable
defined macrocyclic
Prior art date
Application number
AT04761605T
Other languages
German (de)
English (en)
Inventor
Pierre Deslongchamps
Yves Dory
Mark Peterson
Kamel Benakli
Eric Marsault
Luc Ouellet
Mahesh Ramaseshan
Martin Vezina
Daniel Fortin
Ruoxi Lan
Shigui Li
Gerald Villeneuve
Hamid Hoveyda
Sylvie Beaubien
Graeme Fraser
Original Assignee
Tranzyme Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tranzyme Pharma Inc filed Critical Tranzyme Pharma Inc
Application granted granted Critical
Publication of ATE490264T1 publication Critical patent/ATE490264T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT04761605T 2003-07-31 2004-08-02 Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen ATE490264T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49124803P 2003-07-31 2003-07-31
PCT/CA2004/001439 WO2005012331A1 (fr) 2003-07-31 2004-08-02 Composes macrocycliques definis spatialement utiles pour la decouverte de medicaments

Publications (1)

Publication Number Publication Date
ATE490264T1 true ATE490264T1 (de) 2010-12-15

Family

ID=34115484

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04761605T ATE490264T1 (de) 2003-07-31 2004-08-02 Räumlich definierte makrocyclische verbindungen, die sich für die entdeckung von arzneimittel eignen

Country Status (15)

Country Link
US (3) US7452862B2 (fr)
EP (3) EP1648922B9 (fr)
JP (1) JP4928262B2 (fr)
AT (1) ATE490264T1 (fr)
AU (1) AU2004261329B2 (fr)
CA (1) CA2533818C (fr)
CY (1) CY1111901T1 (fr)
DE (1) DE602004030344D1 (fr)
DK (1) DK1648922T3 (fr)
ES (1) ES2357235T7 (fr)
IL (1) IL173312A0 (fr)
PL (1) PL1648922T3 (fr)
PT (1) PT1648922E (fr)
SI (1) SI1648922T1 (fr)
WO (1) WO2005012331A1 (fr)

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US7491695B2 (en) * 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
USRE42013E1 (en) 2003-06-18 2010-12-28 Tranzyme Pharma Inc. Macrocyclic modulators of the ghrelin receptor
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US8088733B2 (en) 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
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RU2533116C2 (ru) 2009-02-27 2014-11-20 Раквалиа Фарма Инк. Оксииндольные производные, обладающие агонистической активностью в отношении мотилинового рецептора
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MX348131B (es) 2011-02-25 2017-05-26 Merck Sharp & Dohme Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos.
MX2015001500A (es) 2012-08-02 2015-04-08 Merck Sharp & Dohme Compuestos antidiabeticos triciclicos.
CN103113404B (zh) * 2013-02-22 2015-09-23 广州巨元生化有限公司 一种制备4-二烃氧基膦酰基-2-甲基-2-丁烯酸烃基酯的方法
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WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
EP3353341A4 (fr) 2015-09-24 2018-10-31 Cyclenium Pharma Inc. Bibliothèques de composés macrocycliques contenant hétéroaryle et procédés pour leur fabrication et leur utilisation
CR20180232A (es) 2015-10-27 2018-05-31 Hoffmann La Roche Macrociclos peptídicos contra acinetobacter baumannii
WO2017075535A1 (fr) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Méthodes de traitement de troubles neurodégénératifs
JP2019527672A (ja) * 2016-05-16 2019-10-03 サイクルニウム ファーマ インコーポレイテッド 多様な大環状化合物のライブラリならびにその製造方法および使用方法
US20180110824A1 (en) * 2016-10-21 2018-04-26 Ocera Therapeutics, Inc. Macrocyclic Modulators of the Ghrelin Receptor
EP3551176A4 (fr) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. Composés hétérocycliques antidiabétiques
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
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Also Published As

Publication number Publication date
US20090137817A1 (en) 2009-05-28
CY1111901T1 (el) 2015-11-04
AU2004261329B2 (en) 2011-10-27
EP1648922B9 (fr) 2013-04-03
WO2005012331A1 (fr) 2005-02-10
SI1648922T1 (sl) 2011-03-31
EP1648922B3 (fr) 2012-08-15
EP1648922A4 (fr) 2006-08-23
US8022252B2 (en) 2011-09-20
PT1648922E (pt) 2011-01-04
EP2319859B1 (fr) 2013-03-27
ES2357235T8 (es) 2011-06-06
CA2533818C (fr) 2015-03-17
US20050137127A1 (en) 2005-06-23
PL1648922T3 (pl) 2011-05-31
EP2319859A2 (fr) 2011-05-11
JP2007527863A (ja) 2007-10-04
US7452862B2 (en) 2008-11-18
EP2316846B1 (fr) 2019-10-02
EP2319859A3 (fr) 2011-12-21
AU2004261329A1 (en) 2005-02-10
ES2357235T3 (es) 2011-04-20
DE602004030344D1 (de) 2011-01-13
JP4928262B2 (ja) 2012-05-09
EP2316846A3 (fr) 2012-04-04
IL173312A0 (en) 2009-02-11
EP1648922A1 (fr) 2006-04-26
US8440851B2 (en) 2013-05-14
ES2357235T7 (es) 2013-02-14
CA2533818A1 (fr) 2005-02-10
EP2316846A2 (fr) 2011-05-04
DK1648922T3 (da) 2011-03-14
US20110237785A1 (en) 2011-09-29
EP1648922B1 (fr) 2010-12-01

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