CA2583345A1 - Antagonistes macrocycliques du recepteur de la ghreline et agonistes inverses et procedes d'utilisation de ceux-ci - Google Patents
Antagonistes macrocycliques du recepteur de la ghreline et agonistes inverses et procedes d'utilisation de ceux-ci Download PDFInfo
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- CA2583345A1 CA2583345A1 CA002583345A CA2583345A CA2583345A1 CA 2583345 A1 CA2583345 A1 CA 2583345A1 CA 002583345 A CA002583345 A CA 002583345A CA 2583345 A CA2583345 A CA 2583345A CA 2583345 A1 CA2583345 A1 CA 2583345A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2005/020887 WO2006046977A1 (fr) | 2004-10-26 | 2005-06-13 | Antagonistes macrocycliques du recepteur de la ghreline et procedes d'utilisation |
USPCT/US2005/020887 | 2005-06-13 | ||
PCT/US2006/015698 WO2006137974A2 (fr) | 2005-06-13 | 2006-04-26 | Antagonistes macrocycliques du recepteur de la ghreline et agonistes inverses et procedes d'utilisation de ceux-ci |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2583345A1 true CA2583345A1 (fr) | 2006-12-28 |
Family
ID=37570927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002583345A Abandoned CA2583345A1 (fr) | 2005-06-13 | 2006-04-26 | Antagonistes macrocycliques du recepteur de la ghreline et agonistes inverses et procedes d'utilisation de ceux-ci |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1891090A2 (fr) |
JP (1) | JP5122446B2 (fr) |
CA (1) | CA2583345A1 (fr) |
WO (1) | WO2006137974A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2054429B1 (fr) | 2006-09-11 | 2013-11-06 | Tranzyme Pharma, Inc. | Antagonistes macrocycliques du récepteur de la motiline pour le traitement de troubles de dysmotilité gastro-intestinale |
DK2118123T3 (en) | 2007-01-31 | 2016-01-25 | Dana Farber Cancer Inst Inc | Stabilized p53 peptides and uses thereof |
EA200901077A1 (ru) * | 2007-02-09 | 2010-04-30 | Транзим Фарма, Инк. | Макроциклические модуляторы грелинового рецептора и их применение |
ES2610531T3 (es) | 2007-03-28 | 2017-04-28 | President And Fellows Of Harvard College | Polipéptidos cosidos |
US20110105389A1 (en) * | 2009-10-30 | 2011-05-05 | Hoveyda Hamid R | Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same |
ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
RU2639523C2 (ru) | 2011-10-18 | 2017-12-21 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы и их применение |
MX362492B (es) | 2012-02-15 | 2019-01-21 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos. |
JP6450192B2 (ja) | 2012-02-15 | 2019-01-09 | エイルロン セラピューティクス,インコーポレイテッド | トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物 |
AU2013337388B2 (en) | 2012-11-01 | 2018-08-02 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
SG11201702175YA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof |
EP3294318A4 (fr) | 2015-03-20 | 2019-04-03 | Aileron Therapeutics, Inc. | Macrocycles peptidomimétiques et leurs utilisations |
JP2018528217A (ja) | 2015-09-10 | 2018-09-27 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | Mcl−1のモジュレーターとしてのペプチド模倣大環状分子 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2284459C (fr) * | 1999-10-04 | 2012-12-11 | Neokimia Inc. | Synthese combinatoire de bibliotheques de composes macrocycliques utiles pour la decouverte de medicaments |
US7491695B2 (en) * | 2003-06-18 | 2009-02-17 | Tranzyme Pharma Inc. | Methods of using macrocyclic modulators of the ghrelin receptor |
EP1633774B1 (fr) * | 2003-06-18 | 2010-02-17 | Tranzyme Pharma Inc. | Antagonistes macrocycliques du recepteur de motiline |
US7476653B2 (en) * | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
DE602004018782D1 (de) * | 2003-07-31 | 2009-02-12 | Tranzyme Pharma Inc | Räumlich definierte makrocyclen, die peptidbindungssurrogate enthalten |
SI1648922T1 (sl) * | 2003-07-31 | 2011-03-31 | Tranzyme Pharma Inc | Prostorsko opredeljene makrocikliäśne spojine uporabne za odkrivanje zdravil |
WO2006046977A1 (fr) * | 2004-10-26 | 2006-05-04 | Tranzyme Pharma, Inc. | Antagonistes macrocycliques du recepteur de la ghreline et procedes d'utilisation |
-
2006
- 2006-04-26 CA CA002583345A patent/CA2583345A1/fr not_active Abandoned
- 2006-04-26 JP JP2008515697A patent/JP5122446B2/ja not_active Expired - Fee Related
- 2006-04-26 WO PCT/US2006/015698 patent/WO2006137974A2/fr active Application Filing
- 2006-04-26 EP EP06751414A patent/EP1891090A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP5122446B2 (ja) | 2013-01-16 |
WO2006137974A2 (fr) | 2006-12-28 |
EP1891090A2 (fr) | 2008-02-27 |
WO2006137974A3 (fr) | 2007-04-12 |
JP2009508805A (ja) | 2009-03-05 |
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