ATE443721T1 - Lipoprotein-regulierende medikamente - Google Patents
Lipoprotein-regulierende medikamenteInfo
- Publication number
- ATE443721T1 ATE443721T1 AT07120518T AT07120518T ATE443721T1 AT E443721 T1 ATE443721 T1 AT E443721T1 AT 07120518 T AT07120518 T AT 07120518T AT 07120518 T AT07120518 T AT 07120518T AT E443721 T1 ATE443721 T1 AT E443721T1
- Authority
- AT
- Austria
- Prior art keywords
- lsr
- purified
- ffa
- isolated
- binds
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 108010077695 lipolysis-stimulated receptor Proteins 0.000 abstract 7
- 235000021588 free fatty acids Nutrition 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000016267 Leptin Human genes 0.000 abstract 1
- 108010092277 Leptin Proteins 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 abstract 1
- 229940039781 leptin Drugs 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9710088A FR2767136B1 (fr) | 1997-08-06 | 1997-08-06 | Recepteur complexe lsr, activite, clonage, et applications au diagnostic, a la prevention et/ou au traitement de l'obesite et des risques ou complications associes |
| FR9805032A FR2767135B1 (fr) | 1997-08-06 | 1998-04-22 | Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443721T1 true ATE443721T1 (de) | 2009-10-15 |
Family
ID=26233732
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98936610T ATE378354T1 (de) | 1997-08-06 | 1998-08-06 | Lipoprotein-regulierende arzneimittel |
| AT98936611T ATE256146T1 (de) | 1997-08-06 | 1998-08-06 | Klonierung und verwendung des lsr-rezeptors |
| AT07120518T ATE443721T1 (de) | 1997-08-06 | 1998-08-06 | Lipoprotein-regulierende medikamente |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98936610T ATE378354T1 (de) | 1997-08-06 | 1998-08-06 | Lipoprotein-regulierende arzneimittel |
| AT98936611T ATE256146T1 (de) | 1997-08-06 | 1998-08-06 | Klonierung und verwendung des lsr-rezeptors |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US6635431B1 (de) |
| EP (4) | EP1375516A3 (de) |
| JP (3) | JP2001512746A (de) |
| AT (3) | ATE378354T1 (de) |
| AU (2) | AU745607C (de) |
| CA (2) | CA2298849A1 (de) |
| CY (1) | CY1107808T1 (de) |
| DE (3) | DE69838720T2 (de) |
| DK (2) | DK0964870T3 (de) |
| ES (2) | ES2210786T3 (de) |
| FR (1) | FR2767135B1 (de) |
| PT (2) | PT964870E (de) |
| WO (2) | WO1999007736A2 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6469158B1 (en) * | 1992-05-14 | 2002-10-22 | Ribozyme Pharmaceuticals, Incorporated | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
| US6525174B1 (en) | 1997-06-06 | 2003-02-25 | Human Genome Sciences, Inc. | Precerebellin-like protein |
| FR2767135B1 (fr) * | 1997-08-06 | 2002-07-12 | Genset Sa | Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes |
| US20020106728A1 (en) * | 2000-06-20 | 2002-08-08 | Genentech, Inc. | NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders |
| JP2002528118A (ja) | 1998-11-04 | 2002-09-03 | ジェンセット | ヒト脂肪細胞に特異的なＡＰＭ１のゲノム配列および全ｃＤＮＡ配列ならびにそのバイアレリックマーカー |
| CA2359757A1 (en) * | 1999-02-10 | 2000-08-17 | Genset S.A. | Polymorphic markers of the lsr gene |
| AU4468800A (en) * | 1999-04-20 | 2000-11-02 | Zymogenetics Inc. | Adipocyte complement related protein homolog zacrp3 |
| EP1171599A1 (de) * | 1999-04-20 | 2002-01-16 | ZymoGenetics, Inc. | Zacrp2: homolog des adipozyten komplement verwandten proteins |
| AU782230B2 (en) * | 1999-09-22 | 2005-07-14 | Serono Genetics Institute S.A. | Methods of screening for compounds that modulate the LSR-leptin interaction and their use in the prevention and treatment of obesity-related diseases |
| WO2001032868A1 (en) * | 1999-11-04 | 2001-05-10 | Genset | Apm1 biallelic markers and uses thereof |
| US6566332B2 (en) | 2000-01-14 | 2003-05-20 | Genset S.A. | OBG3 globular head and uses thereof for decreasing body mass |
| US7338787B2 (en) | 2000-01-14 | 2008-03-04 | Serono Genetics Institute S.A. | Nucleic acids encoding OBG3 globular head and uses thereof |
| US6579852B2 (en) | 2000-01-14 | 2003-06-17 | Genset S.A. | OBG3 globular head and uses thereof for decreasing body mass |
| US20020058617A1 (en) * | 2000-01-14 | 2002-05-16 | Joachim Fruebis | OBG3 globular head and uses thereof for decreasing body mass |
| CA2383136C (en) * | 2000-01-14 | 2012-09-18 | Genset S.A. | Obg3 globular head and uses thereof for decreasing body mass |
| US6989367B2 (en) | 2000-01-14 | 2006-01-24 | Genset S.A. | OBG3 globular head and uses thereof |
| ATE464378T1 (de) * | 2000-05-31 | 2010-04-15 | Serono Genetics Inst Sa | Verwendung des globulären kopfes von acrp30 zur verstärkung der zunahme von muskelmasse und - differenzierung |
| WO2002006525A2 (en) * | 2000-07-18 | 2002-01-24 | Genset S.A. | Obesity associated biallelic marker maps |
| US20040170601A1 (en) * | 2001-02-26 | 2004-09-02 | Strom Alan David Greve | Method of improving the growth performance of an animal |
| CA2440144A1 (en) * | 2001-03-14 | 2002-09-19 | Oklahoma Medical Research Foundation | Methods for reducing fat by administration of adiponectin |
| JP4547696B2 (ja) * | 2001-06-07 | 2010-09-22 | 第一三共株式会社 | 肝硬変予防・治療剤 |
| WO2003011324A1 (en) * | 2001-07-31 | 2003-02-13 | Genset S.A. | Agonists and antagonists of moxifin for the treatment of metabolic disorders |
| WO2003011319A1 (en) * | 2001-08-02 | 2003-02-13 | Genset S.A | Xobesin agonists and antagonists for the treatment of metabolic disorders |
| WO2003041738A1 (en) * | 2001-11-15 | 2003-05-22 | Genset S.A. | Treatment of metabolic disorders with xitar agonists and antagonists |
| AU2002339691A1 (en) * | 2001-11-29 | 2003-06-10 | Genset | Agonists and antagonists of prolixin for the treatment of metabolic disorders |
| CA2473781A1 (en) * | 2002-01-18 | 2003-07-31 | Protemix Corporation Limited | Glycoisoforms of adiponectin and uses thereof |
| US6852693B2 (en) | 2002-02-07 | 2005-02-08 | Blm Group | Compositions and methods for promoting lipid mobilization in humans |
| DE60329000D1 (de) * | 2002-05-24 | 2009-10-08 | Japan Science & Tech Agency | C-terminale globulardomäne von adiponectin zur behandlung von arteriosklerose |
| EP1509545B8 (de) | 2002-05-31 | 2010-10-13 | Merck Serono Biodevelopment SAS | Homotrimerer, erweiterter globulärer kopf von obg3 und verwendungen davon |
| WO2004063711A2 (en) * | 2003-01-09 | 2004-07-29 | Beth Israel Deaconess Medical Center, Inc. | Use of adiponectin to diagnose and treat malignancy |
| US8147561B2 (en) * | 2004-02-26 | 2012-04-03 | Endosphere, Inc. | Methods and devices to curb appetite and/or reduce food intake |
| US8585771B2 (en) | 2004-02-26 | 2013-11-19 | Endosphere, Inc. | Methods and devices to curb appetite and/or to reduce food intake |
| US7931693B2 (en) * | 2004-02-26 | 2011-04-26 | Endosphere, Inc. | Method and apparatus for reducing obesity |
| US20060127468A1 (en) * | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| WO2006062422A1 (en) * | 2004-12-10 | 2006-06-15 | Protemix Corporation Limited | Glyponectin (glycosylated adiponectin) for the treatment of diseases and conditions |
| CA2585733A1 (en) * | 2005-01-07 | 2006-07-13 | Arthur J. Chirino | Adiponectin variants |
| US7592423B2 (en) * | 2005-01-07 | 2009-09-22 | Xencor, Inc. | Globular adiponectin variants |
| US7749956B2 (en) * | 2005-01-07 | 2010-07-06 | Xencor, Inc. | Method of treatment using adiponectin variants |
| US7678886B2 (en) * | 2005-01-07 | 2010-03-16 | Xencor, Inc. | Pharmaceutical compositions of adiponectin variants and methods of storage |
| WO2006104964A2 (en) * | 2005-03-28 | 2006-10-05 | University Of Louisville Research Foundation, Inc. | Inhibition of wet type age related macular degeneration (amd) by adiponectin or acrp 30 |
| US20070054359A1 (en) * | 2005-07-11 | 2007-03-08 | Jonathan Zalevsky | Rational Chemical Modification of Adiponectin Variants |
| WO2007014798A2 (en) * | 2005-07-29 | 2007-02-08 | Laboratoires Serono S.A. | Use of the globular domain of acrp30 for the preparation of a medicament for the prevention and/or treatment of thrombosis-related diseases |
| US9060835B2 (en) | 2006-05-26 | 2015-06-23 | Endosphere, Inc. | Conformationally-stabilized intraluminal device for medical applications |
| US20110137227A1 (en) * | 2007-07-16 | 2011-06-09 | Mckinley James T | Methods and devices for delivering or delaying lipids within a duodenum |
| KR101240875B1 (ko) * | 2007-12-19 | 2013-03-08 | 일라이 릴리 앤드 캄파니 | 비만용 제약 요법에 대한 반응성을 예상하는 방법 |
| JP5429736B2 (ja) * | 2009-04-13 | 2014-02-26 | 国立大学法人神戸大学 | タイトジャンクション調節剤 |
| RU2016147206A (ru) | 2011-04-15 | 2018-10-19 | Компуджен Лтд. | Полипептиды и полинуклеотиды и их применение для лечения иммунологических нарушений и рака |
| KR20150023811A (ko) * | 2012-06-21 | 2015-03-05 | 컴퓨젠 엘티디. | 암의 치료를 위한 lsr 항체 및 그의 용도 |
| CN104004066B (zh) * | 2013-02-26 | 2017-05-31 | 上海市第一人民医院 | 预防或抑制炎症反应和血管新生的小分子多肽及其应用 |
| US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
| EP3088001B1 (de) * | 2013-12-27 | 2020-02-12 | National University Corporation Kochi University | Antikörpern gegen lipolysis stimulated liporotein receptor zur behandlung von eierstockkrebs |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US77051A (en) * | 1868-04-21 | peters | ||
| US111500A (en) * | 1871-01-31 | Improvement in repeating fire-arms | ||
| US67881A (en) * | 1867-08-20 | Geobge p | ||
| US5543394A (en) * | 1986-07-01 | 1996-08-06 | Genetics Institute, Inc. | Bone morphogenetic protein 5(BMP-5) compositions |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| NL9100132A (nl) * | 1991-01-25 | 1992-08-17 | Ingeny Bv | Werkwijze voor het detecteren van dna sequentievariatie. |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US5691447A (en) * | 1995-03-24 | 1997-11-25 | Tanox Biosystems, Inc. | GC1q receptor, HIV-1 gp120 region binding thereto, and related peptides and targeting antibodies |
| FR2733762B1 (fr) | 1995-05-02 | 1997-08-01 | Genset Sa | Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm et preparation d'arnm et d'adnc complet |
| US5869330A (en) * | 1995-06-05 | 1999-02-09 | Whitehead Institute For Biomedical Research | DNA encoding a novel serum protein produced exclusively in adipocytes |
| ATE320479T1 (de) | 1996-01-23 | 2006-04-15 | Indevus Pharmaceuticals Inc | Process zur verwendung des obese-gens und seines genprodukts zur stimulierung der entwicklung von haemotopoietischen zellen |
| US6116126A (en) | 1996-07-10 | 2000-09-12 | Van Den Bulcke; Marc | Method and machine for making profile pieces |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| WO1998020165A2 (en) | 1996-11-06 | 1998-05-14 | Whitehead Institute For Biomedical Research | Biallelic markers |
| ES2264207T3 (es) * | 1997-07-18 | 2006-12-16 | Zymogenetics, Inc. | Homonologos proteinicos especificos de adipocitos. |
| FR2767135B1 (fr) | 1997-08-06 | 2002-07-12 | Genset Sa | Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes |
| ATE324443T1 (de) | 1997-08-26 | 2006-05-15 | Zymogenetics Inc | Für adipozyten spezifische protein homologe |
| EP1033134B8 (de) | 1997-10-29 | 2007-09-19 | Otsuka Pharmaceutical Co., Ltd. | Compositions zur inhibierung der proliferation glatter muskulatur und verfahren zur diagnose von arteriosklerose |
| US6579852B2 (en) | 2000-01-14 | 2003-06-17 | Genset S.A. | OBG3 globular head and uses thereof for decreasing body mass |
| US20020058617A1 (en) | 2000-01-14 | 2002-05-16 | Joachim Fruebis | OBG3 globular head and uses thereof for decreasing body mass |
| US6989367B2 (en) | 2000-01-14 | 2006-01-24 | Genset S.A. | OBG3 globular head and uses thereof |
| US6566332B2 (en) | 2000-01-14 | 2003-05-20 | Genset S.A. | OBG3 globular head and uses thereof for decreasing body mass |
| US20030224501A1 (en) | 2000-03-17 | 2003-12-04 | Young Paul E. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
| US20030215836A1 (en) | 2000-03-17 | 2003-11-20 | Young Paul E. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
| US6867189B2 (en) | 2001-07-26 | 2005-03-15 | Genset S.A. | Use of adipsin/complement factor D in the treatment of metabolic related disorders |
| WO2003011324A1 (en) | 2001-07-31 | 2003-02-13 | Genset S.A. | Agonists and antagonists of moxifin for the treatment of metabolic disorders |
| WO2003011319A1 (en) | 2001-08-02 | 2003-02-13 | Genset S.A | Xobesin agonists and antagonists for the treatment of metabolic disorders |
| AU2002339691A1 (en) | 2001-11-29 | 2003-06-10 | Genset | Agonists and antagonists of prolixin for the treatment of metabolic disorders |
-
1998
- 1998-04-22 FR FR9805032A patent/FR2767135B1/fr not_active Expired - Fee Related
- 1998-08-06 ES ES98936611T patent/ES2210786T3/es not_active Expired - Lifetime
- 1998-08-06 WO PCT/IB1998/001256 patent/WO1999007736A2/en active IP Right Grant
- 1998-08-06 EP EP03102647A patent/EP1375516A3/de not_active Withdrawn
- 1998-08-06 JP JP2000506238A patent/JP2001512746A/ja active Pending
- 1998-08-06 CA CA002298849A patent/CA2298849A1/en not_active Abandoned
- 1998-08-06 AT AT98936610T patent/ATE378354T1/de not_active IP Right Cessation
- 1998-08-06 US US09/269,939 patent/US6635431B1/en not_active Expired - Fee Related
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- 1998-08-06 DE DE69838720T patent/DE69838720T2/de not_active Expired - Lifetime
- 1998-08-06 WO PCT/IB1998/001257 patent/WO1999007737A2/fr active IP Right Grant
- 1998-08-06 AU AU85564/98A patent/AU745607C/en not_active Ceased
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- 1998-08-06 EP EP07120518A patent/EP1903057B1/de not_active Expired - Lifetime
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- 1998-08-06 DK DK98936610T patent/DK1003783T3/da active
- 1998-08-06 EP EP98936610A patent/EP1003783B1/de not_active Expired - Lifetime
- 1998-08-06 DE DE69820419T patent/DE69820419T2/de not_active Expired - Lifetime
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2002
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2003
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2004
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2007
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