ATE386126T1 - Verbesserte expressionsvektoren - Google Patents
Verbesserte expressionsvektorenInfo
- Publication number
- ATE386126T1 ATE386126T1 AT97947444T AT97947444T ATE386126T1 AT E386126 T1 ATE386126 T1 AT E386126T1 AT 97947444 T AT97947444 T AT 97947444T AT 97947444 T AT97947444 T AT 97947444T AT E386126 T1 ATE386126 T1 AT E386126T1
- Authority
- AT
- Austria
- Prior art keywords
- expression vectors
- improved expression
- nucleic acid
- constructs
- encodes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Image Generation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2954596P | 1996-11-08 | 1996-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE386126T1 true ATE386126T1 (de) | 2008-03-15 |
Family
ID=21849585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97947444T ATE386126T1 (de) | 1996-11-08 | 1997-11-07 | Verbesserte expressionsvektoren |
Country Status (13)
Country | Link |
---|---|
US (1) | US6117651A (de) |
EP (1) | EP0946711B1 (de) |
JP (1) | JP2001503274A (de) |
KR (1) | KR20000068934A (de) |
CN (1) | CN1244214A (de) |
AT (1) | ATE386126T1 (de) |
AU (1) | AU718382B2 (de) |
CA (1) | CA2271230A1 (de) |
DE (1) | DE69738514D1 (de) |
HU (1) | HUP0001650A3 (de) |
IL (1) | IL129843A0 (de) |
NZ (1) | NZ335628A (de) |
WO (1) | WO1998020111A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7129343B2 (en) * | 2001-02-13 | 2006-10-31 | University Of Florida | Bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes |
US7172865B2 (en) * | 2001-08-13 | 2007-02-06 | Saint Louis University | Rapid and sensitive assay for the detection and quantification of coregulators of nucleic acid binding factors |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
CN1314810C (zh) * | 2002-01-31 | 2007-05-09 | 圣路易大学 | 一种用来检测和定量核酸结合因子辅调节物的快速灵敏测定法 |
DE60336555D1 (de) | 2002-06-21 | 2011-05-12 | Novo Nordisk Healthcare Ag | Pegylierte glykoformen von faktor vii |
DE60325611D1 (de) * | 2002-07-03 | 2009-02-12 | Dow Global Technologies Inc | Benzoat- und antranilatinduzierbare promotoren |
DE60336826D1 (de) | 2002-07-23 | 2011-06-01 | Biogenerix Ag | Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen |
ES2420581T3 (es) | 2003-03-14 | 2013-08-26 | Biogenerix Gmbh | Polímeros solubles en agua ramificados y sus conjugados |
EP2338333B1 (de) | 2003-04-09 | 2017-09-06 | ratiopharm GmbH | Glycopegylierungsverfahren und durch die Verfahren hergestellte Proteine/Peptide |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
ATE540055T1 (de) | 2003-05-09 | 2012-01-15 | Biogenerix Ag | Zusammensetzungen und verfahren zur herstellung von glykosylierungsmutanten des menschlichen wachstumshormons |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
WO2005040388A2 (en) * | 2003-08-22 | 2005-05-06 | Nucleonics Inc. | Eukariotic expression systems for expression of inhibitory rna in multiple intracellular compartments |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
EP1694351A2 (de) * | 2003-12-03 | 2006-08-30 | Neose Technologies, Inc. | Glycopegyliertes follikel-stimulierendes hormon |
US8361961B2 (en) | 2004-01-08 | 2013-01-29 | Biogenerix Ag | O-linked glycosylation of peptides |
US20080058245A1 (en) * | 2004-01-09 | 2008-03-06 | Johnson Karl F | Vectors for Recombinant Protein Expression in E. Coli |
EP2484759B1 (de) | 2004-02-04 | 2014-06-25 | ratiopharm GmbH | Verfahren zur Neufaltung von Säuger-Glykosyltransferasen |
EP1771066A2 (de) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Remodellierung von verzweigtem peg und klykolysierung von glucagonähnlichem peptide-1 glp-1 |
EP2169072A1 (de) | 2004-08-23 | 2010-03-31 | Alnylam Pharmaceuticals, Inc | Expressionskonstrukte mit mehreren RNA-Polymerase-III-Promotoren |
US8268967B2 (en) | 2004-09-10 | 2012-09-18 | Novo Nordisk A/S | Glycopegylated interferon α |
SI2586456T1 (sl) | 2004-10-29 | 2016-05-31 | Ratiopharm Gmbh | Preoblikovanje in glikopegliacija fibroblastnega rastnega faktorja (FGF) |
EP1858543B1 (de) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylierten Granulocyten-Kolonie-stimulierender Faktor |
EP2386571B1 (de) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Zusammensetzungen und Verfahren zur Herstellung von Glycosylierungsmutanten eines Proteaseresistenten menschlichen Wachstumshormons |
EP2975135A1 (de) * | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glykopegylierter Faktor IX |
EP1888098A2 (de) | 2005-05-25 | 2008-02-20 | Neose Technologies, Inc. | Glykopegylierte erythropoetin-formulierungen |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
US8198045B2 (en) | 2006-04-19 | 2012-06-12 | Biogenerix Ag | Expression of O-glycosylated therapeutic proteins in prokaryotic microorganisms |
EP2049144B8 (de) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen |
EP2054521A4 (de) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Verfahren zur reinigung von polypeptid-konjugate |
EP2144923B1 (de) | 2007-04-03 | 2013-02-13 | BioGeneriX AG | Behandlungsverfahren mit glycopegyliertem g-csf |
MX2009011851A (es) | 2007-05-02 | 2010-03-04 | Merial Ltd | Plasmidos de dna que tienen expresion y estabilidad mejoradas. |
EP2170919B8 (de) | 2007-06-12 | 2016-01-20 | ratiopharm GmbH | Verbessertes verfahren zur herstellung von nukleotidzuckern |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
JP5619630B2 (ja) | 2008-02-27 | 2014-11-05 | ノボ・ノルデイスク・エー/エス | 結合型第viii因子分子 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
EP3938518A4 (de) | 2019-03-12 | 2023-01-11 | Terra Bioworks, Inc. | Expressionsvektor |
US20240018529A1 (en) * | 2022-04-19 | 2024-01-18 | Worcester Polytechnic Institute | Inducible promoters |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4565785A (en) * | 1978-06-08 | 1986-01-21 | The President And Fellows Of Harvard College | Recombinant DNA molecule |
US4673641A (en) * | 1982-12-16 | 1987-06-16 | Molecular Genetics Research And Development Limited Partnership | Co-aggregate purification of proteins |
US4710473A (en) * | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
US4795706A (en) * | 1985-01-31 | 1989-01-03 | Eli Lilly And Company | Novel expression control sequences |
US5304472A (en) * | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
US5342763A (en) * | 1992-11-23 | 1994-08-30 | Genentech, Inc. | Method for producing polypeptide via bacterial fermentation |
US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
-
1997
- 1997-11-07 DE DE69738514T patent/DE69738514D1/de not_active Expired - Lifetime
- 1997-11-07 CA CA002271230A patent/CA2271230A1/en not_active Abandoned
- 1997-11-07 AU AU52524/98A patent/AU718382B2/en not_active Ceased
- 1997-11-07 EP EP97947444A patent/EP0946711B1/de not_active Expired - Lifetime
- 1997-11-07 US US08/965,850 patent/US6117651A/en not_active Expired - Lifetime
- 1997-11-07 JP JP52185798A patent/JP2001503274A/ja not_active Ceased
- 1997-11-07 KR KR1019997004107A patent/KR20000068934A/ko active IP Right Grant
- 1997-11-07 AT AT97947444T patent/ATE386126T1/de not_active IP Right Cessation
- 1997-11-07 CN CN97180609A patent/CN1244214A/zh active Pending
- 1997-11-07 IL IL12984397A patent/IL129843A0/xx unknown
- 1997-11-07 WO PCT/US1997/020528 patent/WO1998020111A1/en active IP Right Grant
- 1997-11-07 NZ NZ335628A patent/NZ335628A/xx unknown
- 1997-11-07 HU HU0001650A patent/HUP0001650A3/hu unknown
Also Published As
Publication number | Publication date |
---|---|
KR20000068934A (ko) | 2000-11-25 |
US6117651A (en) | 2000-09-12 |
EP0946711B1 (de) | 2008-02-13 |
EP0946711A1 (de) | 1999-10-06 |
CN1244214A (zh) | 2000-02-09 |
JP2001503274A (ja) | 2001-03-13 |
HUP0001650A3 (en) | 2001-09-28 |
CA2271230A1 (en) | 1998-05-14 |
EP0946711A4 (de) | 2004-10-27 |
IL129843A0 (en) | 2000-02-29 |
HUP0001650A2 (hu) | 2000-09-28 |
NZ335628A (en) | 2000-10-27 |
WO1998020111A1 (en) | 1998-05-14 |
AU5252498A (en) | 1998-05-29 |
AU718382B2 (en) | 2000-04-13 |
DE69738514D1 (de) | 2008-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |