ATE378354T1 - Lipoprotein-regulierende arzneimittel - Google Patents

Lipoprotein-regulierende arzneimittel

Info

Publication number
ATE378354T1
ATE378354T1 AT98936610T AT98936610T ATE378354T1 AT E378354 T1 ATE378354 T1 AT E378354T1 AT 98936610 T AT98936610 T AT 98936610T AT 98936610 T AT98936610 T AT 98936610T AT E378354 T1 ATE378354 T1 AT E378354T1
Authority
AT
Austria
Prior art keywords
lsr
purified
ffa
isolated
binds
Prior art date
Application number
AT98936610T
Other languages
English (en)
Inventor
Bernard Bihain
Lydie Bougueleret
Frances Yen-Potin
Original Assignee
Serono Genetics Inst Sa
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9710088A external-priority patent/FR2767136B1/fr
Application filed by Serono Genetics Inst Sa, Inst Nat Sante Rech Med filed Critical Serono Genetics Inst Sa
Application granted granted Critical
Publication of ATE378354T1 publication Critical patent/ATE378354T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98936610T 1997-08-06 1998-08-06 Lipoprotein-regulierende arzneimittel ATE378354T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9710088A FR2767136B1 (fr) 1997-08-06 1997-08-06 Recepteur complexe lsr, activite, clonage, et applications au diagnostic, a la prevention et/ou au traitement de l'obesite et des risques ou complications associes
FR9805032A FR2767135B1 (fr) 1997-08-06 1998-04-22 Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes

Publications (1)

Publication Number Publication Date
ATE378354T1 true ATE378354T1 (de) 2007-11-15

Family

ID=26233732

Family Applications (3)

Application Number Title Priority Date Filing Date
AT07120518T ATE443721T1 (de) 1997-08-06 1998-08-06 Lipoprotein-regulierende medikamente
AT98936610T ATE378354T1 (de) 1997-08-06 1998-08-06 Lipoprotein-regulierende arzneimittel
AT98936611T ATE256146T1 (de) 1997-08-06 1998-08-06 Klonierung und verwendung des lsr-rezeptors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07120518T ATE443721T1 (de) 1997-08-06 1998-08-06 Lipoprotein-regulierende medikamente

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98936611T ATE256146T1 (de) 1997-08-06 1998-08-06 Klonierung und verwendung des lsr-rezeptors

Country Status (13)

Country Link
US (8) US6635431B1 (de)
EP (4) EP1375516A3 (de)
JP (3) JP3726969B2 (de)
AT (3) ATE443721T1 (de)
AU (2) AU754942B2 (de)
CA (2) CA2298849A1 (de)
CY (1) CY1107808T1 (de)
DE (3) DE69841186D1 (de)
DK (2) DK0964870T3 (de)
ES (2) ES2296339T3 (de)
FR (1) FR2767135B1 (de)
PT (2) PT1003783E (de)
WO (2) WO1999007736A2 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6469158B1 (en) * 1992-05-14 2002-10-22 Ribozyme Pharmaceuticals, Incorporated Synthesis, deprotection, analysis and purification of RNA and ribozymes
US6525174B1 (en) 1997-06-06 2003-02-25 Human Genome Sciences, Inc. Precerebellin-like protein
FR2767135B1 (fr) * 1997-08-06 2002-07-12 Genset Sa Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes
US20020106728A1 (en) * 2000-06-20 2002-08-08 Genentech, Inc. NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders
CA2348828C (en) * 1998-11-04 2009-09-15 Genset S.A. Genomic and complete cdna sequences of apm1 and biallelic markers thereof
CA2359757A1 (en) * 1999-02-10 2000-08-17 Genset S.A. Polymorphic markers of the lsr gene
MXPA01010540A (es) * 1999-04-20 2002-06-04 Zymogenetics Inc Proteina homologa zacrp2 relacionada al complemento de adipocitos.
JP3754299B2 (ja) * 1999-04-20 2006-03-08 ザイモジェネティクス，インコーポレイティド 脂肪細胞補体関連タンパク質同族体ｚａｃｒｐ３
CA2388417A1 (en) * 1999-09-22 2001-03-29 Genset Methods of screening for compounds that modulate the lsr-leptin interaction and their use in the prevention and treatment of obesity-related diseases
WO2001032868A1 (en) * 1999-11-04 2001-05-10 Genset Apm1 biallelic markers and uses thereof
US6579852B2 (en) 2000-01-14 2003-06-17 Genset S.A. OBG3 globular head and uses thereof for decreasing body mass
US7338787B2 (en) * 2000-01-14 2008-03-04 Serono Genetics Institute S.A. Nucleic acids encoding OBG3 globular head and uses thereof
US6566332B2 (en) 2000-01-14 2003-05-20 Genset S.A. OBG3 globular head and uses thereof for decreasing body mass
US6989367B2 (en) 2000-01-14 2006-01-24 Genset S.A. OBG3 globular head and uses thereof
PT1248849E (pt) * 2000-01-14 2008-09-08 Serono Genetics Inst Sa Cabeça globular obg3 e suas utilizações para reduzir a massa corporal
US20020058617A1 (en) 2000-01-14 2002-05-16 Joachim Fruebis OBG3 globular head and uses thereof for decreasing body mass
US7405193B2 (en) * 2000-05-31 2008-07-29 Serono Genetics Institute S.A. Use of Acrp30 globular head to promote increases in muscle mass and muscle differentiation
JP2004504037A (ja) * 2000-07-18 2004-02-12 ジェンセット　ソシエテ　アノニム 肥満関連の二対立遺伝子マーカー地図
CA2439116A1 (en) * 2001-02-26 2002-09-06 The University Of Sydney Method of improving the growth performance of an animal
EP1372726A4 (de) * 2001-03-14 2004-04-21 Oklahoma Med Res Found Verfahren zur reduzierung von fett durch verabreichung von adiponectin
JP4547696B2 (ja) * 2001-06-07 2010-09-22 第一三共株式会社 肝硬変予防・治療剤
US20050054565A1 (en) * 2001-07-31 2005-03-10 John Lucas Agonists and antagonists of moxifin for the treatment of metabolic disorders
US7276342B2 (en) * 2001-08-02 2007-10-02 Serono Genetics Institute S.A. Xobesin agonists and antagonists for the treatment of metabolic disorders
WO2003041738A1 (en) * 2001-11-15 2003-05-22 Genset S.A. Treatment of metabolic disorders with xitar agonists and antagonists
AU2002339691A1 (en) * 2001-11-29 2003-06-10 Genset Agonists and antagonists of prolixin for the treatment of metabolic disorders
EP1474445A4 (de) * 2002-01-18 2007-02-21 Protemix Corp Ltd Glykoisoformen vom adiponektin und deren verwendung
US6852693B2 (en) 2002-02-07 2005-02-08 Blm Group Compositions and methods for promoting lipid mobilization in humans
JP4147220B2 (ja) * 2002-05-24 2008-09-10 独立行政法人科学技術振興機構 動脈硬化症予防治療薬
ES2350573T3 (es) 2002-05-31 2011-01-25 Merck Serono Biodevelopment Sas Cabeza globular de obg3 ensanchada, homotrimérica y sus usos.
EP1585987B1 (de) * 2003-01-09 2009-08-19 Beth Israel Deaconess Medical Center, Inc. Verwendung von adiponectin zur diagnose von krebs
US7931693B2 (en) * 2004-02-26 2011-04-26 Endosphere, Inc. Method and apparatus for reducing obesity
US8585771B2 (en) 2004-02-26 2013-11-19 Endosphere, Inc. Methods and devices to curb appetite and/or to reduce food intake
US8147561B2 (en) * 2004-02-26 2012-04-03 Endosphere, Inc. Methods and devices to curb appetite and/or reduce food intake
US20060127468A1 (en) * 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
JP2008523057A (ja) * 2004-12-10 2008-07-03 プロテミックス コーポレイション リミティド 疾患および状態の治療のためのグリポネクチン（グリコシル化アディポネクチン）
US7749956B2 (en) * 2005-01-07 2010-07-06 Xencor, Inc. Method of treatment using adiponectin variants
CA2585733A1 (en) * 2005-01-07 2006-07-13 Arthur J. Chirino Adiponectin variants
US7592423B2 (en) * 2005-01-07 2009-09-22 Xencor, Inc. Globular adiponectin variants
US7678886B2 (en) * 2005-01-07 2010-03-16 Xencor, Inc. Pharmaceutical compositions of adiponectin variants and methods of storage
US7964557B2 (en) * 2005-03-28 2011-06-21 University Of Louisville Research Foundation, Inc. Inhibition of wet type age related macular degeneration (AMD) by adiponectin or acrp 30
US20070054359A1 (en) * 2005-07-11 2007-03-08 Jonathan Zalevsky Rational Chemical Modification of Adiponectin Variants
US20090291091A1 (en) * 2005-07-29 2009-11-26 Laboratoires Serono Sa Use of the globular domain of acrp30 for the preparation of a medicament for the prevention and/or treatment of thrombosis-related diseases
US9060835B2 (en) 2006-05-26 2015-06-23 Endosphere, Inc. Conformationally-stabilized intraluminal device for medical applications
US20110137227A1 (en) 2007-07-16 2011-06-09 Mckinley James T Methods and devices for delivering or delaying lipids within a duodenum
CA2710248A1 (en) * 2007-12-19 2009-07-09 Eli Lilly And Company Methods, systems and computer program products for predicting responsiveness to a pharmaceutical therapy for obesity or evaluating investigational pharmaceutical agents
JP5429736B2 (ja) * 2009-04-13 2014-02-26 国立大学法人神戸大学 タイトジャンクション調節剤
CN103596974B (zh) * 2011-04-15 2016-08-31 卡姆普根有限公司 多肽和多核苷酸及其用于治疗免疫相关失调和癌症的用途
MX2014015830A (es) * 2012-06-21 2015-03-05 Compugen Ltd Anticuerpos lsr y usos de los mismos para el tratamiento de cancer.
CN104004066B (zh) * 2013-02-26 2017-05-31 上海市第一人民医院 预防或抑制炎症反应和血管新生的小分子多肽及其应用
US9682123B2 (en) 2013-12-20 2017-06-20 The Trustees Of Columbia University In The City Of New York Methods of treating metabolic disease
JP6372930B2 (ja) 2013-12-27 2018-08-15 国立大学法人高知大学 悪性腫瘍の治療薬

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US67881A (en) * 1867-08-20 Geobge p
US77051A (en) * 1868-04-21 peters
US111500A (en) * 1871-01-31 Improvement in repeating fire-arms
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
NL9100132A (nl) * 1991-01-25 1992-08-17 Ingeny Bv Werkwijze voor het detecteren van dna sequentievariatie.
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5691447A (en) * 1995-03-24 1997-11-25 Tanox Biosystems, Inc. GC1q receptor, HIV-1 gp120 region binding thereto, and related peptides and targeting antibodies
FR2733762B1 (fr) 1995-05-02 1997-08-01 Genset Sa Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm et preparation d'arnm et d'adnc complet
US5869330A (en) 1995-06-05 1999-02-09 Whitehead Institute For Biomedical Research DNA encoding a novel serum protein produced exclusively in adipocytes
EP1731164A1 (de) * 1996-01-23 2006-12-13 Indevus Pharmaceuticals, Inc. Anwendungen des Obese-Gens und des Genprodukts zur Stimulierung der Haematopoietischen Entwicklung
US6116126A (en) 1996-07-10 2000-09-12 Van Den Bulcke; Marc Method and machine for making profile pieces
US6126939A (en) * 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
WO1998020165A2 (en) 1996-11-06 1998-05-14 Whitehead Institute For Biomedical Research Biallelic markers
KR100385868B1 (ko) * 1997-07-18 2003-06-02 지모제넥틱스, 인코포레이티드 함지방세포-특이적 단백질 상동체
FR2767135B1 (fr) * 1997-08-06 2002-07-12 Genset Sa Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes
DE69834334T2 (de) 1997-08-26 2007-04-26 Zymogenetics, Inc., Seattle Für adipozyten spezifische protein homologe
PT1033134E (pt) * 1997-10-29 2007-07-11 Otsuka Pharma Co Ltd Composições que inibem a proliferação de músculo liso e processo de diagonóstico da arteriosclerose
US6989367B2 (en) 2000-01-14 2006-01-24 Genset S.A. OBG3 globular head and uses thereof
US6566332B2 (en) * 2000-01-14 2003-05-20 Genset S.A. OBG3 globular head and uses thereof for decreasing body mass
US20020058617A1 (en) 2000-01-14 2002-05-16 Joachim Fruebis OBG3 globular head and uses thereof for decreasing body mass
US6579852B2 (en) * 2000-01-14 2003-06-17 Genset S.A. OBG3 globular head and uses thereof for decreasing body mass
US20030215836A1 (en) * 2000-03-17 2003-11-20 Young Paul E. Bone morphogenic protein polynucleotides, polypeptides, and antibodies
US20030224501A1 (en) * 2000-03-17 2003-12-04 Young Paul E. Bone morphogenic protein polynucleotides, polypeptides, and antibodies
US6867189B2 (en) * 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders
US20050054565A1 (en) * 2001-07-31 2005-03-10 John Lucas Agonists and antagonists of moxifin for the treatment of metabolic disorders
US7276342B2 (en) * 2001-08-02 2007-10-02 Serono Genetics Institute S.A. Xobesin agonists and antagonists for the treatment of metabolic disorders
AU2002339691A1 (en) * 2001-11-29 2003-06-10 Genset Agonists and antagonists of prolixin for the treatment of metabolic disorders

Also Published As

Publication number Publication date
EP1375516A3 (de) 2004-06-09
FR2767135B1 (fr) 2002-07-12
AU8556398A (en) 1999-03-01
ATE256146T1 (de) 2003-12-15
DE69838720D1 (de) 2007-12-27
DE69841186D1 (de) 2009-11-05
DE69820419T2 (de) 2004-11-25
EP1903057A2 (de) 2008-03-26
ES2210786T3 (es) 2004-07-01
US20020151498A1 (en) 2002-10-17
US6344441B1 (en) 2002-02-05
EP1903057A3 (de) 2008-06-25
US20090263847A1 (en) 2009-10-22
EP1003783A2 (de) 2000-05-31
US20020165154A1 (en) 2002-11-07
ATE443721T1 (de) 2009-10-15
EP0964870B1 (de) 2003-12-10
EP1003783B1 (de) 2007-11-14
US20110165166A1 (en) 2011-07-07
WO1999007737A2 (fr) 1999-02-18
US7291709B2 (en) 2007-11-06
US6635431B1 (en) 2003-10-21
AU745607C (en) 2002-08-29
US7919091B2 (en) 2011-04-05
ES2296339T3 (es) 2008-04-16
DK1003783T3 (da) 2008-01-02
CY1107808T1 (el) 2013-06-19
PT1003783E (pt) 2007-12-06
DE69838720T2 (de) 2008-10-30
AU745607B2 (en) 2002-03-21
CA2274302A1 (fr) 1999-02-18
AU8556498A (en) 1999-03-01
EP1375516A2 (de) 2004-01-02
JP3726969B2 (ja) 2005-12-14
AU754942B2 (en) 2002-11-28
EP0964870A2 (de) 1999-12-22
US7220722B2 (en) 2007-05-22
JP2001512746A (ja) 2001-08-28
JP2005143508A (ja) 2005-06-09
WO1999007736A3 (en) 1999-05-20
CA2298849A1 (en) 1999-02-18
FR2767135A1 (fr) 1999-02-12
US20040077051A1 (en) 2004-04-22
JP2001512492A (ja) 2001-08-21
US20080249009A1 (en) 2008-10-09
PT964870E (pt) 2004-02-27
US6946444B2 (en) 2005-09-20
WO1999007737A3 (fr) 1999-06-10
DK0964870T3 (da) 2004-03-08
WO1999007736A2 (en) 1999-02-18
EP1903057B1 (de) 2009-09-23
DE69820419D1 (de) 2004-01-22

Similar Documents

Publication Publication Date Title
ATE378354T1 (de) Lipoprotein-regulierende arzneimittel
ATE444361T1 (de) Il-17 und il-17r homologe polypeptide und deren therapeutische verwendungen
DE69738432D1 (de) Targeting von adenoviren mit hilfe von konformationsbeschränkten peptidmotiven
FI104180B1 (fi) Menetelmä polypeptidin vasta-aineen ekä IL-4 välittämien tilojen hoitoon tarkoitetun seoksen valmistamiseksi
DK1860187T3 (da) Apo-2-receptor
BR9713294A (pt) "anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano"
NO964650L (no) LAG-3 proteinopploselige polypeptidfraksjoner, fremgangsmate for fremstilling, terapeutisk preparat og anti-idiotype antistoff
NO864139D0 (no) Polypeptid virksomt ved dannelse av aids-antistoff.
DK230683A (da) Rekombinante dna-klonende vektorer til udtrykkelse af endogent protein
ATE269901T1 (de) Cytokinähnlicher faktor-7 aus säugetieren
DK1017715T3 (da) Kimært polypeptid der omfatter fragment B af shiga-toksin og peptider af terapeutisk interesse
NO944887L (no) Monoklonale antistoffer mot glykoprotein
ATE426028T1 (de) Zellvolumenregulierte humane kinase h-sgk
ATE323764T1 (de) Kappa/mu ähnliche proteintyrosinphosphatase, proteintyrosinphosphatase lambda
DK0901526T3 (da) Cortistatin: neuropeptider, sammensætninger og metoder
CY1111763T1 (el) ΑΝΤΙΣΩΜΑΤΑ ΕΝΑΝΤΙΟΝ ΤΗΣ ΠΡΩΤΕΪΝΗΣ p51
DK0990703T3 (da) Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf
ATE309270T1 (de) ßSMOOTHENEDß PROTEINE AUS WIRBELTIEREN
Chuba Susceptibility of Monoclonal IGG Paraproteins to Plasmic Cleavage Using Glycerin Stabilized Human Plasmin
DK0487229T3 (da) DNA, der koder for et protein, som binder til enhanceren for alfa-føtoproteingenet
DE69032096D1 (de) Antikörper gegen das carboxy-terminale Peptid des Somatotropin-Bindungsproteins der Ratte
DE50113411D1 (de) Neue humane Androgenrezeptor-Varianten
DE69932644D1 (de) Menschliches Protein mit in vitro antiproliferativer Aktivität.
DK1249491T3 (da) Nucleinsyre, der opformeres i humane tumorer samt beslægtede materialer og fremgangsmåder

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1003783

Country of ref document: EP

REN Ceased due to non-payment of the annual fee