FI104180B1 - Menetelmä polypeptidin vasta-aineen ekä IL-4 välittämien tilojen hoitoon tarkoitetun seoksen valmistamiseksi - Google Patents

Menetelmä polypeptidin vasta-aineen ekä IL-4 välittämien tilojen hoitoon tarkoitetun seoksen valmistamiseksi

Info

Publication number
FI104180B1
FI104180B1 FI922847A FI922847A FI104180B1 FI 104180 B1 FI104180 B1 FI 104180B1 FI 922847 A FI922847 A FI 922847A FI 922847 A FI922847 A FI 922847A FI 104180 B1 FI104180 B1 FI 104180B1
Authority
FI
Finland
Prior art keywords
binding
antibody
antagonists
polypeptide
management
Prior art date
Application number
FI922847A
Other languages
English (en)
Swedish (sv)
Other versions
FI104180B (fi
FI922847A (fi
FI922847A0 (fi
Inventor
Lata Ramanathan
Gail F Seelig
Paul P Trotta
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of FI922847A publication Critical patent/FI922847A/fi
Publication of FI922847A0 publication Critical patent/FI922847A0/fi
Application granted granted Critical
Publication of FI104180B publication Critical patent/FI104180B/fi
Publication of FI104180B1 publication Critical patent/FI104180B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI922847A 1989-12-20 1992-06-18 Menetelmä polypeptidin vasta-aineen ekä IL-4 välittämien tilojen hoitoon tarkoitetun seoksen valmistamiseksi FI104180B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45357089A 1989-12-20 1989-12-20
US45357089 1989-12-20
US9007289 1990-12-18
PCT/US1990/007289 WO1991009059A1 (en) 1989-12-20 1990-12-18 Antibody antagonists of human interleukin-4

Publications (4)

Publication Number Publication Date
FI922847A FI922847A (fi) 1992-06-18
FI922847A0 FI922847A0 (fi) 1992-06-18
FI104180B FI104180B (fi) 1999-11-30
FI104180B1 true FI104180B1 (fi) 1999-11-30

Family

ID=23801108

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922847A FI104180B1 (fi) 1989-12-20 1992-06-18 Menetelmä polypeptidin vasta-aineen ekä IL-4 välittämien tilojen hoitoon tarkoitetun seoksen valmistamiseksi

Country Status (26)

Country Link
US (1) US6358509B1 (fi)
EP (1) EP0506826B1 (fi)
JP (1) JPH0730116B2 (fi)
KR (1) KR960016862B1 (fi)
AT (1) ATE136906T1 (fi)
AU (1) AU639754B2 (fi)
CA (1) CA2071908C (fi)
CZ (1) CZ283050B6 (fi)
DE (1) DE69026627T2 (fi)
DK (1) DK0506826T3 (fi)
ES (1) ES2085983T3 (fi)
FI (1) FI104180B1 (fi)
GR (1) GR3020325T3 (fi)
HU (1) HU215245B (fi)
IE (1) IE74708B1 (fi)
IL (1) IL96714A0 (fi)
MX (1) MX9203401A (fi)
MY (1) MY106507A (fi)
NO (1) NO922457L (fi)
NZ (1) NZ236511A (fi)
OA (1) OA09704A (fi)
PT (1) PT96230B (fi)
SK (1) SK279933B6 (fi)
TW (1) TW221675B (fi)
WO (1) WO1991009059A1 (fi)
ZA (1) ZA9010190B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714146A (en) * 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
KR100398819B1 (ko) 1993-09-02 2004-02-05 트러스티스 오브 다트마우스 칼리지 gp39길항제를포함하는약제조성물
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
HU222041B1 (hu) * 1993-09-07 2003-04-28 Smithkline Beecham Corporation Az IL4 által kőzvetített rendellenességek kezelésére használható rekombináns 1L4 antitestek, eljárás ezek előállítására, alkalmazására és az őket tartalmazó gyógyszerkészítmények
US20020193575A1 (en) 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
CA2252790A1 (en) * 1997-02-28 1998-09-03 Enzo Therapeutics, Inc. Novel processes implementing selective immune down regulation (sidr)
US7553487B2 (en) 1998-12-14 2009-06-30 Genetics Institute, Llc Method and compositions for treating asthma
US7507706B1 (en) 1998-12-14 2009-03-24 Genetics Institute, Llc Cytokine receptor chain
EP1142961B1 (en) * 2000-04-06 2008-08-06 FUJIFILM Corporation Dye complex and optical information recording medium
AU2001272925A1 (en) 2000-05-26 2001-12-11 Immunex Corporation Use of interleukin-4 antagonists and compositions thereof
US20020076409A1 (en) * 2000-07-12 2002-06-20 March Carl J. Method for treating cancer
US20030170258A1 (en) * 2001-05-09 2003-09-11 Enzo Therapeutics, Inc. Novel processes implementing selective immune down regulation (SIDR)
FR2838444B1 (fr) 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
WO2004003156A2 (en) * 2002-07-01 2004-01-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Il-21 as a regulator of immunoglobin production
US20110223168A1 (en) * 2002-12-27 2011-09-15 Greg Winter Ligand that has binding specificity for il-4 and/or il-13
WO2004096849A2 (en) * 2003-04-25 2004-11-11 University Of Manitoba Peptide-based cytokine/chemokine vaccines against allergy
AU2004290017B2 (en) 2003-11-07 2012-05-03 Immunex Corporation Antibodies that bind interleukin-4 receptor
SG10201900535UA (en) 2003-12-23 2019-02-27 Genentech Inc Novel anti-il 13 antibodies and uses thereof
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
AR050044A1 (es) * 2004-08-03 2006-09-20 Novartis Ag Anticuerpo especifico de il-4
AU2009316076B2 (en) * 2008-11-17 2015-11-19 Kobenhavns Universitet IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases
ES2617777T5 (es) 2010-04-23 2022-10-13 Hoffmann La Roche Producción de proteínas heteromultiméricas
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
WO2012106587A1 (en) 2011-02-04 2012-08-09 Genentech, Inc. Fc VARIANTS AND METHODS FOR THEIR PRODUCTION
RU2015141529A (ru) * 2013-04-05 2017-05-15 Дженентек, Инк. Антитела и биспецифические антитела к il-4 и их применение
CA2920686C (en) 2013-09-13 2022-12-06 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
SG11201601823TA (en) 2013-09-13 2016-04-28 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
KR102603417B1 (ko) 2014-05-06 2023-11-20 제넨테크, 인크. 포유동물 세포를 사용한 이종다량체 단백질의 생산
RU2758092C1 (ru) * 2018-02-01 2021-10-26 Бэйцзин Кавин Текнолоджи Шеа-Холдинг Ко., Лтд. АНТИТЕЛО К IL-4Rα И ЕГО ПРИМЕНЕНИЕ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013824A (en) * 1985-11-19 1991-05-07 Schering Corporation Human interleukin-4 peptides and conjugates thereof
IL80678A (en) * 1985-11-19 1999-05-09 Schering Biotech Corp Human interleukin-4
US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
ZA872781B (en) 1986-05-19 1987-10-05 Immunology Ventures B-cell stimulating factor
EP0327283B1 (en) * 1988-02-02 1993-08-18 Schering Biotech Corporation Method of reducing immunoglobulin e responses

Also Published As

Publication number Publication date
SK635290A3 (en) 1999-06-11
HUT64568A (en) 1994-01-28
NZ236511A (en) 1993-02-25
DE69026627D1 (de) 1996-05-23
HU9202073D0 (en) 1992-09-28
CA2071908C (en) 2002-04-30
FI104180B (fi) 1999-11-30
NO922457D0 (no) 1992-06-19
FI922847A (fi) 1992-06-18
AU7176291A (en) 1991-07-18
ATE136906T1 (de) 1996-05-15
ZA9010190B (en) 1991-08-28
KR920703642A (ko) 1992-12-18
NO922457L (no) 1992-06-19
OA09704A (en) 1993-08-30
MX9203401A (es) 1992-07-01
US6358509B1 (en) 2002-03-19
ES2085983T3 (es) 1996-06-16
IE904589A1 (en) 1991-07-03
IL96714A0 (en) 1991-09-16
CZ283050B6 (cs) 1997-12-17
IE74708B1 (en) 1997-07-30
MY106507A (en) 1995-06-30
SK279933B6 (sk) 1999-06-11
HU215245B (hu) 1998-11-30
KR960016862B1 (ko) 1996-12-23
FI922847A0 (fi) 1992-06-18
TW221675B (fi) 1994-03-11
AU639754B2 (en) 1993-08-05
GR3020325T3 (en) 1996-09-30
JPH0730116B2 (ja) 1995-04-05
EP0506826A1 (en) 1992-10-07
PT96230B (pt) 1998-06-30
DE69026627T2 (de) 1996-08-22
DK0506826T3 (da) 1996-05-13
WO1991009059A1 (en) 1991-06-27
PT96230A (pt) 1991-10-15
CZ635290A3 (en) 1997-08-13
CA2071908A1 (en) 1991-06-21
EP0506826B1 (en) 1996-04-17
JPH04506359A (ja) 1992-11-05

Similar Documents

Publication Publication Date Title
FI104180B1 (fi) Menetelmä polypeptidin vasta-aineen ekä IL-4 välittämien tilojen hoitoon tarkoitetun seoksen valmistamiseksi
DK0760857T3 (da) Receptor for onkostatin M
DK0931092T3 (da) Varianter af vækstfaktor for vaskulære endotelceller med antagonistiske egenskaber
ATE117375T1 (de) Transduktionsveränderte fibroblasten und ihre anwendung.
DE69434538D1 (de) Vaskularer endothelialer wachstumsfaktor 2
DE69232952D1 (de) Antikörper der Rezeptoren von pluripotenten hämatopoetischen Stammzellen flk-1
LU91116I2 (en) cetuximab
DE68918867D1 (de) Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen.
IL100343A0 (en) G protein coupled glutamate receptors
ATE272116T1 (de) Polypeptide mit der möglichkeit rhesus d antigenspezifische bindungsstrukturen aus zu bilden, dafür kodierende dna und deren prozess der herstellung und anwendung
DE69115917D1 (de) Humane gammainterferonantagonisten
DE3867537D1 (de) Mischung von monoklonalen antikoerpern zur bestimmung der creatinkinaseaktivitaet.
ES2192199T3 (es) Ligandos de la familia eph biologicamente activos.
GR1000876B (el) Νεα πολυπεπτιδια που δρουν ως παραγοντες αναπτυξης και αλληλουχιες νουκλεινικων οξεων που κωδικοποιοουν τα πολυπεπτιδια