TW221675B - - Google Patents

Info

Publication number
TW221675B
TW221675B TW079110658A TW79110658A TW221675B TW 221675 B TW221675 B TW 221675B TW 079110658 A TW079110658 A TW 079110658A TW 79110658 A TW79110658 A TW 79110658A TW 221675 B TW221675 B TW 221675B
Authority
TW
Taiwan
Prior art keywords
binding
antagonists
receptors
cellular receptors
antibody
Prior art date
Application number
TW079110658A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of TW221675B publication Critical patent/TW221675B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW079110658A 1989-12-20 1990-12-19 TW221675B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45357089A 1989-12-20 1989-12-20

Publications (1)

Publication Number Publication Date
TW221675B true TW221675B (zh) 1994-03-11

Family

ID=23801108

Family Applications (1)

Application Number Title Priority Date Filing Date
TW079110658A TW221675B (zh) 1989-12-20 1990-12-19

Country Status (26)

Country Link
US (1) US6358509B1 (zh)
EP (1) EP0506826B1 (zh)
JP (1) JPH0730116B2 (zh)
KR (1) KR960016862B1 (zh)
AT (1) ATE136906T1 (zh)
AU (1) AU639754B2 (zh)
CA (1) CA2071908C (zh)
CZ (1) CZ283050B6 (zh)
DE (1) DE69026627T2 (zh)
DK (1) DK0506826T3 (zh)
ES (1) ES2085983T3 (zh)
FI (1) FI104180B (zh)
GR (1) GR3020325T3 (zh)
HU (1) HU215245B (zh)
IE (1) IE74708B1 (zh)
IL (1) IL96714A0 (zh)
MX (1) MX9203401A (zh)
MY (1) MY106507A (zh)
NO (1) NO922457D0 (zh)
NZ (1) NZ236511A (zh)
OA (1) OA09704A (zh)
PT (1) PT96230B (zh)
SK (1) SK279933B6 (zh)
TW (1) TW221675B (zh)
WO (1) WO1991009059A1 (zh)
ZA (1) ZA9010190B (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714146A (en) * 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
KR100398819B1 (ko) 1993-09-02 2004-02-05 트러스티스 오브 다트마우스 칼리지 gp39길항제를포함하는약제조성물
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
CN1473854A (zh) * 1993-09-07 2004-02-11 ʷ��˿�������ȳ�ķ���޹�˾ 用于治疗il4介导疾病的重组il4抗体
US20020193575A1 (en) 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
EP2301567A1 (en) * 1997-02-28 2011-03-30 Enzo Therapeutics, Inc. Selective immune down regulation (SIDR) for transplantation
US7553487B2 (en) 1998-12-14 2009-06-30 Genetics Institute, Llc Method and compositions for treating asthma
DE69933696T2 (de) 1998-12-14 2007-08-23 Genetics Institute, LLC, Cambridge Cytokinrezeptor-kette
US6506539B2 (en) * 2000-04-06 2003-01-14 Fuji Photo Film Co., Ltd. Dye complex and optical information recording medium
WO2001092340A2 (en) 2000-05-26 2001-12-06 Immunex Corporation Use of interleukin-4 antagonists and compositions thereof
WO2002004009A2 (en) * 2000-07-12 2002-01-17 Immunex Corporation Method for treating cancer using an interleukin- 4 antagonist
US20030170258A1 (en) * 2001-05-09 2003-09-11 Enzo Therapeutics, Inc. Novel processes implementing selective immune down regulation (SIDR)
FR2838444B1 (fr) 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
AU2003251633A1 (en) * 2002-07-01 2004-01-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Il-21 as a regulator of immunoglobin production
US20110223168A1 (en) * 2002-12-27 2011-09-15 Greg Winter Ligand that has binding specificity for il-4 and/or il-13
WO2004096849A2 (en) * 2003-04-25 2004-11-11 University Of Manitoba Peptide-based cytokine/chemokine vaccines against allergy
AU2004290017B2 (en) 2003-11-07 2012-05-03 Immunex Corporation Antibodies that bind interleukin-4 receptor
FI3718564T3 (fi) 2003-12-23 2023-12-15 Genentech Inc Uusia anti-IL 13 -vasta-aineita ja niiden käyttöjä
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
AR050044A1 (es) * 2004-08-03 2006-09-20 Novartis Ag Anticuerpo especifico de il-4
BRPI0921717A2 (pt) * 2008-11-17 2018-10-09 Kobenhavns Univ composto, sequência de peptídeo isolada, composição farmacêutica, uso de um composto, anticorpo, e, método de tratamento
WO2011133886A2 (en) 2010-04-23 2011-10-27 Genentech, Inc. Production of heteromultimeric proteins
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
CN103649117B (zh) 2011-02-04 2016-09-14 霍夫曼-拉罗奇有限公司 Fc变体及其生成方法
RU2015141529A (ru) * 2013-04-05 2017-05-15 Дженентек, Инк. Антитела и биспецифические антитела к il-4 и их применение
WO2015038884A2 (en) 2013-09-13 2015-03-19 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
EP4331605A3 (en) 2013-09-13 2024-05-22 F. Hoffmann-La Roche AG Methods and compositions comprising purified recombinant polypeptides
MX2016014409A (es) 2014-05-06 2017-01-20 Genentech Inc Produccion de proteinas heteromultimericas usando celulas de mamifero.
WO2019148405A1 (zh) * 2018-02-01 2019-08-08 北京凯因科技股份有限公司 IL-4Rα抗体及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013824A (en) * 1985-11-19 1991-05-07 Schering Corporation Human interleukin-4 peptides and conjugates thereof
US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
IL80678A (en) * 1985-11-19 1999-05-09 Schering Biotech Corp Human interleukin-4
ZA872781B (en) 1986-05-19 1987-10-05 Immunology Ventures B-cell stimulating factor
HU211059B (en) * 1988-02-02 1995-10-30 Schering Biotech Corp Method for producing pharmaceutical compositions usable for reducing immunglobulin e responses, containing human il-4 antibodies

Also Published As

Publication number Publication date
FI104180B1 (fi) 1999-11-30
JPH04506359A (ja) 1992-11-05
NO922457L (no) 1992-06-19
CZ635290A3 (en) 1997-08-13
HU215245B (hu) 1998-11-30
EP0506826A1 (en) 1992-10-07
FI922847A0 (fi) 1992-06-18
HU9202073D0 (en) 1992-09-28
CZ283050B6 (cs) 1997-12-17
AU7176291A (en) 1991-07-18
US6358509B1 (en) 2002-03-19
FI104180B (fi) 1999-11-30
OA09704A (en) 1993-08-30
NO922457D0 (no) 1992-06-19
DE69026627D1 (de) 1996-05-23
KR960016862B1 (ko) 1996-12-23
AU639754B2 (en) 1993-08-05
HUT64568A (en) 1994-01-28
IL96714A0 (en) 1991-09-16
ES2085983T3 (es) 1996-06-16
CA2071908C (en) 2002-04-30
DK0506826T3 (da) 1996-05-13
NZ236511A (en) 1993-02-25
EP0506826B1 (en) 1996-04-17
KR920703642A (ko) 1992-12-18
SK635290A3 (en) 1999-06-11
IE904589A1 (en) 1991-07-03
PT96230B (pt) 1998-06-30
ATE136906T1 (de) 1996-05-15
FI922847A (fi) 1992-06-18
ZA9010190B (en) 1991-08-28
MX9203401A (es) 1992-07-01
IE74708B1 (en) 1997-07-30
PT96230A (pt) 1991-10-15
GR3020325T3 (en) 1996-09-30
CA2071908A1 (en) 1991-06-21
WO1991009059A1 (en) 1991-06-27
JPH0730116B2 (ja) 1995-04-05
DE69026627T2 (de) 1996-08-22
MY106507A (en) 1995-06-30
SK279933B6 (sk) 1999-06-11

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