GR1000876B - Νεα πολυπεπτιδια που δρουν ως παραγοντες αναπτυξης και αλληλουχιες νουκλεινικων οξεων που κωδικοποιοουν τα πολυπεπτιδια - Google Patents
Νεα πολυπεπτιδια που δρουν ως παραγοντες αναπτυξης και αλληλουχιες νουκλεινικων οξεων που κωδικοποιοουν τα πολυπεπτιδιαInfo
- Publication number
- GR1000876B GR1000876B GR890100185A GR890100185A GR1000876B GR 1000876 B GR1000876 B GR 1000876B GR 890100185 A GR890100185 A GR 890100185A GR 890100185 A GR890100185 A GR 890100185A GR 1000876 B GR1000876 B GR 1000876B
- Authority
- GR
- Greece
- Prior art keywords
- polypeptides
- growth factor
- nucleic acid
- acid sequences
- sequences encoding
- Prior art date
Links
- 239000003102 growth factor Substances 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 150000007523 nucleic acids Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000008470 skin growth Effects 0.000 abstract 2
- 102000001301 EGF receptor Human genes 0.000 abstract 1
- 108060006698 EGF receptor Proteins 0.000 abstract 1
- 102000009465 Growth Factor Receptors Human genes 0.000 abstract 1
- 108010009202 Growth Factor Receptors Proteins 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 208000031513 cyst Diseases 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000002297 mitogenic effect Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Abstract
Νέα πολυπεπτίδια ικανά για σύνδεση σε ένα υποδοχέα επιδερμικού παράγοντα ανάπτυξης παρέχονται, όπως επίσης πρόδρομοί τους, όπου τα πολυπεπτίδια που κωδικοποιούνται από ευλογοϊους. Οι ενώσεις έχουν ένα δομικό πλαίσιο που ειδικά περιλαμβάνει έξι κυστείνες που παρέχουν βρόχους ανάλογους με εκείνους που βρίσκονται σε φυσικά απαντώμενους παράγοντες ανάπτυξης που συνδέονται με ένα υποδοχέα παράγοντα επιδερμικής ανάπτυξης. Οι ενώσεις βρίσκουν χρήση ως μιτογόνα, προσθετικά σε μέσα θρεπτικά, σε δοκιμασίες για υποδοχείς EGF, και ως ανταγωνιστές για άλλους παράγοντες ανάπτυξης. Τα συστατικά βρίσκουν επίσης χρήση στην θεραπεία των πληγών. ω
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17265388A | 1988-03-24 | 1988-03-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
GR890100185A GR890100185A (en) | 1990-01-19 |
GR1000876B true GR1000876B (el) | 1993-03-16 |
Family
ID=22628611
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR890100185A GR1000876B (el) | 1988-03-24 | 1989-03-23 | Νεα πολυπεπτιδια που δρουν ως παραγοντες αναπτυξης και αλληλουχιες νουκλεινικων οξεων που κωδικοποιοουν τα πολυπεπτιδια |
Country Status (22)
Country | Link |
---|---|
JP (1) | JPH0279981A (el) |
KR (1) | KR890014743A (el) |
AU (2) | AU3169589A (el) |
BE (1) | BE1004202A5 (el) |
CH (1) | CH681081A5 (el) |
DE (1) | DE3910084A1 (el) |
DK (1) | DK146789A (el) |
ES (1) | ES2013408A6 (el) |
FI (1) | FI891308A (el) |
FR (1) | FR2632321A1 (el) |
GB (1) | GB2219799B (el) |
GR (1) | GR1000876B (el) |
HU (1) | HUT50501A (el) |
IE (1) | IE890950L (el) |
IL (1) | IL89673A0 (el) |
IT (1) | IT1234961B (el) |
LU (1) | LU87489A1 (el) |
NL (1) | NL8900724A (el) |
NO (1) | NO891273D0 (el) |
NZ (1) | NZ228427A (el) |
PT (1) | PT90118B (el) |
SE (1) | SE8901031L (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0293785A3 (en) * | 1987-05-29 | 1990-05-02 | Oncogen Limited Partnership | Cloning and expression of simian transforming growth factor-ss1 |
EP0444961A1 (en) * | 1990-03-02 | 1991-09-04 | Bristol-Myers Squibb Company | Her3: A novel EGF receptor homolog |
EP0739984A1 (en) * | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalent polypeptides containing at least two domains |
US6852506B1 (en) | 1996-04-10 | 2005-02-08 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
AU5549296A (en) * | 1996-04-10 | 1997-10-29 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1983004030A1 (en) * | 1982-05-06 | 1983-11-24 | Applied Molecular Genetics, Inc. | The manufacture and expression of genes for urogastrone and polypeptide analogs thereof |
JPS6028994A (ja) * | 1983-07-08 | 1985-02-14 | Wakunaga Seiyaku Kk | 〔21―ロイシン〕ヒトウロガストロン |
WO1985002198A1 (en) * | 1983-11-01 | 1985-05-23 | Amgen | Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides |
JP2554459B2 (ja) * | 1984-07-02 | 1996-11-13 | アース製薬 株式会社 | β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体 |
WO1986002650A1 (en) * | 1984-10-30 | 1986-05-09 | Oncogen | Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides |
GB8507666D0 (en) * | 1985-03-25 | 1985-05-01 | Wellcome Found | Epidermal growth factor production |
US4743679A (en) * | 1986-02-24 | 1988-05-10 | Creative Biomolecules, Inc. | Process for producing human epidermal growth factor and analogs thereof |
GB2210618B (en) * | 1987-10-08 | 1991-10-16 | British Bio Technology | Synthetic egf gene |
WO1989003886A1 (en) * | 1987-10-30 | 1989-05-05 | Oncogen, A Limited Partnership | Expression systems for preparation of polypeptides in prokaryotic cells |
EP0314184B1 (en) * | 1987-10-30 | 1995-12-13 | Bristol-Myers Squibb Company | Expression plasmids |
-
1989
- 1989-03-20 IL IL89673A patent/IL89673A0/xx unknown
- 1989-03-20 FI FI891308A patent/FI891308A/fi not_active IP Right Cessation
- 1989-03-21 NZ NZ228427A patent/NZ228427A/xx unknown
- 1989-03-22 SE SE8901031A patent/SE8901031L/xx not_active Application Discontinuation
- 1989-03-22 DK DK146789A patent/DK146789A/da not_active Application Discontinuation
- 1989-03-22 NO NO891273A patent/NO891273D0/no unknown
- 1989-03-22 ES ES8901049A patent/ES2013408A6/es not_active Expired - Lifetime
- 1989-03-23 GR GR890100185A patent/GR1000876B/el unknown
- 1989-03-23 GB GB8906758A patent/GB2219799B/en not_active Expired - Fee Related
- 1989-03-23 NL NL8900724A patent/NL8900724A/nl not_active Application Discontinuation
- 1989-03-23 IE IE890950A patent/IE890950L/xx unknown
- 1989-03-23 AU AU31695/89A patent/AU3169589A/en not_active Abandoned
- 1989-03-24 HU HU891515A patent/HUT50501A/hu unknown
- 1989-03-24 IT IT8919917A patent/IT1234961B/it active
- 1989-03-24 LU LU87489A patent/LU87489A1/xx unknown
- 1989-03-24 FR FR8903952A patent/FR2632321A1/fr not_active Withdrawn
- 1989-03-24 JP JP1073723A patent/JPH0279981A/ja active Pending
- 1989-03-24 BE BE8900329A patent/BE1004202A5/fr not_active IP Right Cessation
- 1989-03-24 KR KR1019890003761A patent/KR890014743A/ko not_active Application Discontinuation
- 1989-03-27 PT PT90118A patent/PT90118B/pt active IP Right Grant
- 1989-03-28 CH CH1114/89A patent/CH681081A5/de not_active IP Right Cessation
- 1989-03-28 DE DE3910084A patent/DE3910084A1/de not_active Withdrawn
-
1992
- 1992-12-04 AU AU29904/92A patent/AU2990492A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IE890950L (en) | 1989-09-24 |
AU2990492A (en) | 1993-03-04 |
PT90118B (pt) | 1994-07-29 |
HUT50501A (en) | 1990-02-28 |
SE8901031L (sv) | 1989-09-25 |
JPH0279981A (ja) | 1990-03-20 |
AU3169589A (en) | 1989-09-28 |
BE1004202A5 (fr) | 1992-10-13 |
DE3910084A1 (de) | 1989-11-16 |
GR890100185A (en) | 1990-01-19 |
NL8900724A (nl) | 1989-10-16 |
ES2013408A6 (es) | 1990-05-01 |
FR2632321A1 (fr) | 1989-12-08 |
FI891308A0 (fi) | 1989-03-20 |
DK146789D0 (da) | 1989-03-22 |
KR890014743A (ko) | 1989-10-25 |
IT8919917A0 (it) | 1989-03-24 |
NO891273D0 (no) | 1989-03-22 |
GB2219799A (en) | 1989-12-20 |
NZ228427A (en) | 1993-03-26 |
SE8901031D0 (sv) | 1989-03-22 |
DK146789A (da) | 1989-09-25 |
CH681081A5 (el) | 1993-01-15 |
GB8906758D0 (en) | 1989-05-10 |
IT1234961B (it) | 1992-06-09 |
IL89673A0 (en) | 1989-09-28 |
LU87489A1 (fr) | 1989-10-26 |
PT90118A (pt) | 1989-11-10 |
FI891308A (fi) | 1989-09-25 |
GB2219799B (en) | 1992-10-14 |
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