IT1234961B - Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi. - Google Patents

Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi.

Info

Publication number
IT1234961B
IT1234961B IT8919917A IT1991789A IT1234961B IT 1234961 B IT1234961 B IT 1234961B IT 8919917 A IT8919917 A IT 8919917A IT 1991789 A IT1991789 A IT 1991789A IT 1234961 B IT1234961 B IT 1234961B
Authority
IT
Italy
Prior art keywords
polypeptides
activities
sequences
nucleic acids
growth factors
Prior art date
Application number
IT8919917A
Other languages
English (en)
Other versions
IT8919917A0 (it
Inventor
Joseph P Brown
Daniel R Twardzik
Hans Marquardt
George J Todaro
A Gregory Bruce
Timothy M Rose
Anthony F Purchio
Shiu Lok Hu
Wen Chang
Suo Win Liu
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of IT8919917A0 publication Critical patent/IT8919917A0/it
Application granted granted Critical
Publication of IT1234961B publication Critical patent/IT1234961B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
IT8919917A 1988-03-24 1989-03-24 Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi. IT1234961B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17265388A 1988-03-24 1988-03-24

Publications (2)

Publication Number Publication Date
IT8919917A0 IT8919917A0 (it) 1989-03-24
IT1234961B true IT1234961B (it) 1992-06-09

Family

ID=22628611

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8919917A IT1234961B (it) 1988-03-24 1989-03-24 Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi.

Country Status (22)

Country Link
JP (1) JPH0279981A (it)
KR (1) KR890014743A (it)
AU (2) AU3169589A (it)
BE (1) BE1004202A5 (it)
CH (1) CH681081A5 (it)
DE (1) DE3910084A1 (it)
DK (1) DK146789A (it)
ES (1) ES2013408A6 (it)
FI (1) FI891308A (it)
FR (1) FR2632321A1 (it)
GB (1) GB2219799B (it)
GR (1) GR1000876B (it)
HU (1) HUT50501A (it)
IE (1) IE890950L (it)
IL (1) IL89673A0 (it)
IT (1) IT1234961B (it)
LU (1) LU87489A1 (it)
NL (1) NL8900724A (it)
NO (1) NO891273D0 (it)
NZ (1) NZ228427A (it)
PT (1) PT90118B (it)
SE (1) SE8901031L (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293785A3 (en) * 1987-05-29 1990-05-02 Oncogen Limited Partnership Cloning and expression of simian transforming growth factor-ss1
EP0444961A1 (en) * 1990-03-02 1991-09-04 Bristol-Myers Squibb Company Her3: A novel EGF receptor homolog
EP0739984A1 (en) * 1995-04-26 1996-10-30 San Tumorforschungs-Gmbh Bivalent polypeptides containing at least two domains
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein
WO1997038002A1 (en) * 1996-04-10 1997-10-16 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108132A1 (en) * 1982-05-06 1984-05-16 Applied Molecular Genetics Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
JPS6028994A (ja) * 1983-07-08 1985-02-14 Wakunaga Seiyaku Kk 〔２１―ロイシン〕ヒトウロガストロン
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
JP2554459B2 (ja) * 1984-07-02 1996-11-13 アース製薬 株式会社 β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体
JPS62501071A (ja) * 1984-10-30 1987-04-30 オンコゲン 成長因子活性を有する新規なポリペプチド及び該ポリペプチドをコ−ドする核酸配列
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
GB2210618B (en) * 1987-10-08 1991-10-16 British Bio Technology Synthetic egf gene
EP0372005A4 (en) * 1987-10-30 1990-06-26 Oncogen EXPRESSION SYSTEMS FOR THE PREPARATION OF POLYPEPTIDES IN PROKARYOTIC CELLS.
EP0314184B1 (en) * 1987-10-30 1995-12-13 Bristol-Myers Squibb Company Expression plasmids

Also Published As

Publication number Publication date
ES2013408A6 (es) 1990-05-01
NO891273D0 (no) 1989-03-22
NL8900724A (nl) 1989-10-16
PT90118B (pt) 1994-07-29
FI891308A0 (fi) 1989-03-20
LU87489A1 (fr) 1989-10-26
HUT50501A (en) 1990-02-28
SE8901031L (sv) 1989-09-25
GB2219799B (en) 1992-10-14
GB8906758D0 (en) 1989-05-10
GR890100185A (en) 1990-01-19
SE8901031D0 (sv) 1989-03-22
DK146789D0 (da) 1989-03-22
NZ228427A (en) 1993-03-26
AU3169589A (en) 1989-09-28
JPH0279981A (ja) 1990-03-20
GB2219799A (en) 1989-12-20
IE890950L (en) 1989-09-24
GR1000876B (el) 1993-03-16
FI891308A (fi) 1989-09-25
IL89673A0 (en) 1989-09-28
DK146789A (da) 1989-09-25
AU2990492A (en) 1993-03-04
CH681081A5 (it) 1993-01-15
IT8919917A0 (it) 1989-03-24
FR2632321A1 (fr) 1989-12-08
BE1004202A5 (fr) 1992-10-13
PT90118A (pt) 1989-11-10
DE3910084A1 (de) 1989-11-16
KR890014743A (ko) 1989-10-25

Similar Documents

Publication Publication Date Title
IT8523408A0 (it) Procedimento per la identificazione di acidi nucleici.
DE69132905D1 (de) Detektion von Nukleinsäuresequenzen
DK216589A (da) Dna sekvenser, rekombinante dna molekyler samt fremgangsmaader til fresmtilling af oploeselige t4-proteiner
DE69333346T2 (de) Neuartiges p- selectin ligandenprotein
DE3676601D1 (de) Mittel zur injektion von aktiviertem vitamin-d3.
DE3855449D1 (de) DNS-Klone von menschlichem Thrombomodulin
IT1238374B (it) Recupero di acidi umici.
DE3883439D1 (de) Bestimmung von Peptidsequenzen.
ITRM910286A0 (it) Procedimento per rivelare sequenze di acidi nucleici e kit per la sua utilizzazione.
IT1234961B (it) Polipeptidi che hanno attivita' di fattori di crescita e sequenze di acidi nucleici che codificano i polipeptidi.
IL98273A0 (en) Dna sequences,proteins having esterase activity coded by them,and use of such proteins
DE68910771T2 (de) Verfahren zur Herstellung von verbessertem Proteinhydrolysat.
RU97103147A (ru) Днк-последовательности, кодирующие человеческие протеины тх и ту, родственные конвергирующему интерлейкин-1-бета ферменту
ZA916431B (en) Nucleotide and amino acid sequences of protein mtp 40 of m.tuberculosis and synthetic peptides derived therefrom
DE69003306D1 (de) Reinigung von Proteinhydrolysaten.
AU6655190A (en) Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides
IT8720291A0 (it) Sintesi di alfa amminoacidi otticamente attivi.
IT1240228B (it) Preparazione di acidi alfa-metilarenacetici.
IT8848169A0 (it) Procedimento per la preparazione di polilattoni di acidi poli [a-idrossi-(acrilici e/o-crotonici)]
NO891274D0 (no) Nye polypeptider med vekstfaktoraktivitet og nukleinsyresekvenser som koder for disse.
SE8803443D0 (sv) Fusion protein possessing enzymatic activity and a nucleotide sequence coding for such fusion protein
ITTO930717A1 (it) Metodo per estrarre acidi nucleici e metodo per rivelare sequenze specificate di acidi nucleici.
ATE193060T1 (de) Enzymatische ligation von 3'-aminosubstituierten oligonukleotiden