DE69841186D1 - Lipoprotein-regulierende Medikamente - Google Patents

Lipoprotein-regulierende Medikamente

Info

Publication number
DE69841186D1
DE69841186D1 DE69841186T DE69841186T DE69841186D1 DE 69841186 D1 DE69841186 D1 DE 69841186D1 DE 69841186 T DE69841186 T DE 69841186T DE 69841186 T DE69841186 T DE 69841186T DE 69841186 D1 DE69841186 D1 DE 69841186D1
Authority
DE
Germany
Prior art keywords
lsr
purified
ffa
isolated
binds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69841186T
Other languages
English (en)
Inventor
Bernard Bihain
Lydie Bougueleret
Frances Yen-Potin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Merck Biodevelopment SAS
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Merck Serono Biodevelopment SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9710088A external-priority patent/FR2767136B1/fr
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Merck Serono Biodevelopment SAS filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Application granted granted Critical
Publication of DE69841186D1 publication Critical patent/DE69841186D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69841186T 1997-08-06 1998-08-06 Lipoprotein-regulierende Medikamente Expired - Lifetime DE69841186D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9710088A FR2767136B1 (fr) 1997-08-06 1997-08-06 Recepteur complexe lsr, activite, clonage, et applications au diagnostic, a la prevention et/ou au traitement de l'obesite et des risques ou complications associes
FR9805032A FR2767135B1 (fr) 1997-08-06 1998-04-22 Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes

Publications (1)

Publication Number Publication Date
DE69841186D1 true DE69841186D1 (de) 2009-11-05

Family

ID=26233732

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69841186T Expired - Lifetime DE69841186D1 (de) 1997-08-06 1998-08-06 Lipoprotein-regulierende Medikamente
DE69838720T Expired - Lifetime DE69838720T2 (de) 1997-08-06 1998-08-06 Lipoprotein-regulierende arzneimittel
DE69820419T Expired - Lifetime DE69820419T2 (de) 1997-08-06 1998-08-06 Klonierung und verwendung des lsr-rezeptors

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69838720T Expired - Lifetime DE69838720T2 (de) 1997-08-06 1998-08-06 Lipoprotein-regulierende arzneimittel
DE69820419T Expired - Lifetime DE69820419T2 (de) 1997-08-06 1998-08-06 Klonierung und verwendung des lsr-rezeptors

Country Status (13)

Country Link
US (8) US6635431B1 (de)
EP (4) EP1903057B1 (de)
JP (3) JP3726969B2 (de)
AT (3) ATE378354T1 (de)
AU (2) AU754942B2 (de)
CA (2) CA2298849A1 (de)
CY (1) CY1107808T1 (de)
DE (3) DE69841186D1 (de)
DK (2) DK1003783T3 (de)
ES (2) ES2210786T3 (de)
FR (1) FR2767135B1 (de)
PT (2) PT964870E (de)
WO (2) WO1999007737A2 (de)

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US20020106728A1 (en) * 2000-06-20 2002-08-08 Genentech, Inc. NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders
AU772243B2 (en) 1998-11-04 2004-04-22 Genset Genomic and complete cDNA sequences of human adipocyte-specific APM1 and biallelic markers thereof
DE60041912D1 (de) 1999-02-10 2009-05-14 Serono Genetics Inst Sa Polymorphe marker des lsr-gens
CA2370609A1 (en) * 1999-04-20 2000-10-26 Zymogenetics, Inc. Adipocyte complement related protein homolog zacrp3
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EP1214351A2 (de) 1999-09-22 2002-06-19 Genset Verfahren zur selektion von verbindungen, die die wechselwirkung zwischen leptin und lsr modulieren, und ihre verwendung für die verhütung und behandlung von fettsuchtverwandten krankheiten
WO2001032868A1 (en) * 1999-11-04 2001-05-10 Genset Apm1 biallelic markers and uses thereof
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US6566332B2 (en) 2000-01-14 2003-05-20 Genset S.A. OBG3 globular head and uses thereof for decreasing body mass
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US20020058617A1 (en) 2000-01-14 2002-05-16 Joachim Fruebis OBG3 globular head and uses thereof for decreasing body mass
MXPA02006834A (es) * 2000-01-14 2005-07-01 Genset Sa Extremo anterior de obg3 globular y usos del mismo para disminuir la masa corporal.
US7338787B2 (en) * 2000-01-14 2008-03-04 Serono Genetics Institute S.A. Nucleic acids encoding OBG3 globular head and uses thereof
WO2001092330A2 (en) * 2000-05-31 2001-12-06 Genset S.A. Use of acrp30 globular head to promote increases in muscle mass and muscle differentiation
IL153927A0 (en) * 2000-07-18 2003-07-31 Genset Sa Genomic maps comprising biallelic markers, new such markers and the use of biallelic markers
MXPA03007672A (es) * 2001-02-26 2004-11-12 Univ Sydney Metodo para mejorar la funcion de crecimiento de un animal.
CA2440144A1 (en) * 2001-03-14 2002-09-19 Oklahoma Medical Research Foundation Methods for reducing fat by administration of adiponectin
JP4547696B2 (ja) * 2001-06-07 2010-09-22 第一三共株式会社 肝硬変予防・治療剤
EP1414483A1 (de) * 2001-07-31 2004-05-06 Serono Genetics Institute S.A. Agonisten und antagonisten von moxifin zur behandlung von stoffwechselerkrankungen
US7276342B2 (en) * 2001-08-02 2007-10-02 Serono Genetics Institute S.A. Xobesin agonists and antagonists for the treatment of metabolic disorders
WO2003041738A1 (en) * 2001-11-15 2003-05-22 Genset S.A. Treatment of metabolic disorders with xitar agonists and antagonists
AU2002339691A1 (en) * 2001-11-29 2003-06-10 Genset Agonists and antagonists of prolixin for the treatment of metabolic disorders
NZ534699A (en) * 2002-01-18 2008-12-24 Protemix Corp Ltd Glycoisoforms of adiponectin and uses thereof
US6852693B2 (en) 2002-02-07 2005-02-08 Blm Group Compositions and methods for promoting lipid mobilization in humans
DE60329000D1 (de) * 2002-05-24 2009-10-08 Japan Science & Tech Agency C-terminale globulardomäne von adiponectin zur behandlung von arteriosklerose
ATE478890T1 (de) * 2002-05-31 2010-09-15 Serono Genetics Inst Sa Homotrimerer, erweiterter globulärer kopf von obg3 und verwendungen davon
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US8147561B2 (en) 2004-02-26 2012-04-03 Endosphere, Inc. Methods and devices to curb appetite and/or reduce food intake
US7931693B2 (en) * 2004-02-26 2011-04-26 Endosphere, Inc. Method and apparatus for reducing obesity
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US20060127468A1 (en) * 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US20060128610A1 (en) * 2004-12-10 2006-06-15 Protemix Corporation Limited Methods of treatment
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US20070054359A1 (en) * 2005-07-11 2007-03-08 Jonathan Zalevsky Rational Chemical Modification of Adiponectin Variants
US20090291091A1 (en) * 2005-07-29 2009-11-26 Laboratoires Serono Sa Use of the globular domain of acrp30 for the preparation of a medicament for the prevention and/or treatment of thrombosis-related diseases
US9060835B2 (en) 2006-05-26 2015-06-23 Endosphere, Inc. Conformationally-stabilized intraluminal device for medical applications
US20110137227A1 (en) 2007-07-16 2011-06-09 Mckinley James T Methods and devices for delivering or delaying lipids within a duodenum
CA2710248A1 (en) * 2007-12-19 2009-07-09 Eli Lilly And Company Methods, systems and computer program products for predicting responsiveness to a pharmaceutical therapy for obesity or evaluating investigational pharmaceutical agents
JP5429736B2 (ja) * 2009-04-13 2014-02-26 国立大学法人神戸大学 タイトジャンクション調節剤
JP2014517685A (ja) * 2011-04-15 2014-07-24 コンピュゲン エルティーディー． 免疫関連疾患およびがんの治療のためのポリペプチドおよびポリヌクレオチドならびにそれらの使用
EP2744830A4 (de) * 2012-06-21 2015-06-17 Compugen Ltd Lsr-antikörper und verwendungen davon zur behandlung von krebs
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US7276342B2 (en) * 2001-08-02 2007-10-02 Serono Genetics Institute S.A. Xobesin agonists and antagonists for the treatment of metabolic disorders
AU2002339691A1 (en) * 2001-11-29 2003-06-10 Genset Agonists and antagonists of prolixin for the treatment of metabolic disorders

Also Published As

Publication number Publication date
EP0964870A2 (de) 1999-12-22
EP1003783A2 (de) 2000-05-31
FR2767135A1 (fr) 1999-02-12
WO1999007736A2 (en) 1999-02-18
WO1999007736A3 (en) 1999-05-20
DK1003783T3 (da) 2008-01-02
EP0964870B1 (de) 2003-12-10
WO1999007737A3 (fr) 1999-06-10
ES2210786T3 (es) 2004-07-01
JP2001512746A (ja) 2001-08-28
ATE443721T1 (de) 2009-10-15
DE69838720D1 (de) 2007-12-27
US20090263847A1 (en) 2009-10-22
US7919091B2 (en) 2011-04-05
EP1903057B1 (de) 2009-09-23
JP2005143508A (ja) 2005-06-09
EP1903057A3 (de) 2008-06-25
DK0964870T3 (da) 2004-03-08
US7291709B2 (en) 2007-11-06
US20040077051A1 (en) 2004-04-22
PT964870E (pt) 2004-02-27
US7220722B2 (en) 2007-05-22
FR2767135B1 (fr) 2002-07-12
AU745607C (en) 2002-08-29
DE69820419T2 (de) 2004-11-25
PT1003783E (pt) 2007-12-06
US6635431B1 (en) 2003-10-21
ES2296339T3 (es) 2008-04-16
DE69820419D1 (de) 2004-01-22
CA2274302A1 (fr) 1999-02-18
DE69838720T2 (de) 2008-10-30
EP1375516A3 (de) 2004-06-09
EP1903057A2 (de) 2008-03-26
US20080249009A1 (en) 2008-10-09
CY1107808T1 (el) 2013-06-19
US6946444B2 (en) 2005-09-20
EP1003783B1 (de) 2007-11-14
US20110165166A1 (en) 2011-07-07
ATE378354T1 (de) 2007-11-15
JP3726969B2 (ja) 2005-12-14
AU754942B2 (en) 2002-11-28
US20020151498A1 (en) 2002-10-17
AU8556398A (en) 1999-03-01
AU745607B2 (en) 2002-03-21
US6344441B1 (en) 2002-02-05
JP2001512492A (ja) 2001-08-21
WO1999007737A2 (fr) 1999-02-18
CA2298849A1 (en) 1999-02-18
AU8556498A (en) 1999-03-01
US20020165154A1 (en) 2002-11-07
ATE256146T1 (de) 2003-12-15
EP1375516A2 (de) 2004-01-02

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