ATE436022T1 - Antikörperkomplexe sowie immunmarkierungsverfahren - Google Patents

Antikörperkomplexe sowie immunmarkierungsverfahren

Info

Publication number
ATE436022T1
ATE436022T1 AT02768949T AT02768949T ATE436022T1 AT E436022 T1 ATE436022 T1 AT E436022T1 AT 02768949 T AT02768949 T AT 02768949T AT 02768949 T AT02768949 T AT 02768949T AT E436022 T1 ATE436022 T1 AT E436022T1
Authority
AT
Austria
Prior art keywords
labeling
target
antibody
immuno
binding antibody
Prior art date
Application number
AT02768949T
Other languages
English (en)
Inventor
Robert Archer
Joseph Beechem
David Hagen
Richard Haugland
Rosaria Haugland
Original Assignee
Molecular Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Probes Inc filed Critical Molecular Probes Inc
Application granted granted Critical
Publication of ATE436022T1 publication Critical patent/ATE436022T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Mathematical Physics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02768949T 2001-10-12 2002-10-02 Antikörperkomplexe sowie immunmarkierungsverfahren ATE436022T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32906801P 2001-10-12 2001-10-12
US36941802P 2002-04-01 2002-04-01
US10/118,204 US8323903B2 (en) 2001-10-12 2002-04-05 Antibody complexes and methods for immunolabeling
PCT/US2002/031416 WO2003030817A2 (en) 2001-10-12 2002-10-02 Antibody complexes and methods for immunolabeling

Publications (1)

Publication Number Publication Date
ATE436022T1 true ATE436022T1 (de) 2009-07-15

Family

ID=27382120

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02768949T ATE436022T1 (de) 2001-10-12 2002-10-02 Antikörperkomplexe sowie immunmarkierungsverfahren

Country Status (8)

Country Link
US (2) US8323903B2 (de)
EP (3) EP1442302B1 (de)
JP (2) JP2006513398A (de)
AT (1) ATE436022T1 (de)
CA (1) CA2462280C (de)
DE (1) DE60232904D1 (de)
GB (1) GB2397302B (de)
WO (1) WO2003030817A2 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989276B2 (en) 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
WO2005050206A2 (en) 2003-09-17 2005-06-02 Molecular Probes, Inc. Competitive immunoassay
US7642341B2 (en) * 2003-12-18 2010-01-05 Merck Serono S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
US20050214882A1 (en) * 2004-03-25 2005-09-29 Ez Bio Inc. Reagents, methods and kits for the universal rapid immuno-detection
US7928193B2 (en) * 2004-07-08 2011-04-19 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Antigen binding proteins directed against scavenger receptor B1 that inhibit HCV replication
EP1815249A4 (de) * 2004-11-26 2009-06-24 Texas A & M Univ Sys Immunologischer test für den nachweis von autoantikörpern gegen folatbindendes protein
EP1832875A4 (de) * 2004-12-28 2008-02-13 Inst Molekulyarnoi Biolog Im V Biologischer mikrochip für parallelen mehrfachimmuntest von verbindungen und immuntestverfahren unter verwendung des mikrochips
US7741128B2 (en) * 2005-05-23 2010-06-22 University Of Hawaii Cooperative reporter systems, components, and methods for analyte detection
WO2007030521A1 (en) * 2005-09-06 2007-03-15 Invitrogen Corporation Control of chemical modification
WO2007047450A1 (en) 2005-10-13 2007-04-26 Aureon Laboratories, Inc. Multiplex in situ immunohistochemical analysis
WO2008029281A2 (en) 2006-02-10 2008-03-13 Invitrogen Corporation Labeling and detection of post translationally modified proteins
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
US8007797B2 (en) * 2006-09-28 2011-08-30 Merck Serono S.A. Junctional adhesion molecule-C (JAM-C) binding compounds and methods of their use
US8305579B2 (en) 2006-11-16 2012-11-06 Thomas Pirrie Treynor Sequential analysis of biological samples
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
JP5553615B2 (ja) * 2007-03-01 2014-07-16 アボット・ラボラトリーズ プロゾーン現象の低減を示すイムノアッセイ
US20080233660A1 (en) * 2007-03-23 2008-09-25 Mu Bioteknik Ab Solid phase labeling method
US20080286881A1 (en) * 2007-05-14 2008-11-20 Apel William A Compositions and methods for combining report antibodies
ES2526211T3 (es) * 2007-07-13 2015-01-08 Nestec S.A. Selección de fármacos para la terapia del cáncer de pulmón utilizando matrices basadas en anticuerpos
US20090035216A1 (en) * 2007-08-03 2009-02-05 Biomonitor Aps Method for determining in vivo biopharmaceutical concentration or bioavailability
WO2009044650A1 (ja) * 2007-10-05 2009-04-09 Kaneka Corporation 免疫グロブリンおよび／または免疫グロブリン複合体に結合活性を有する、標識されたペプチド、および上記ペプチドを用いた免疫グロブリンの検出方法または測定方法
WO2009097425A2 (en) * 2008-01-29 2009-08-06 Spring Bioscience Corporation Method for detecting truncated molecules
NZ617520A (en) 2008-02-25 2015-05-29 Nestec Sa Drug selection for breast cancer therapy using antibody-based arrays
US8344115B2 (en) * 2008-04-21 2013-01-01 Chan-Sui Pang, legal representative Immunoassay for specific determination of S-adenosylmethionine and analogs thereof in biological samples
JP5120889B2 (ja) * 2008-06-12 2013-01-16 独立行政法人産業技術総合研究所 ボロンジピロロメタン誘導体及びそれを用いた過酸化脂質測定試薬
WO2010009459A1 (en) * 2008-07-18 2010-01-21 Bayer Healthcare Llc Methods, devices, and systems for glycated hemoglobin analysis
US9528988B2 (en) * 2009-04-07 2016-12-27 National Institute Of Transplantation Foundation Methods and kits for screening transplant recipients and candidates
JP5795311B2 (ja) 2009-07-15 2015-10-14 ネステク ソシエテ アノニム 抗体ベースのアレイを使用する胃癌療法のための薬物選択
US9410965B2 (en) * 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US8969009B2 (en) * 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
US10822396B2 (en) * 2009-12-15 2020-11-03 MuHyeon CHOE Repeat-chain for the production of dimer, multimer, multimer complex and super-complex
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
CZ304250B6 (cs) * 2010-08-27 2014-01-29 Ústav molekulární genetiky AV ČR, v.v.i. Soubor vzájemně rozlišitelných nanočástic, způsob jejich přípravy a jejich použití pro vícenásobné ultrastrukturální značení
US10024796B2 (en) 2010-10-29 2018-07-17 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
WO2012103444A2 (en) * 2011-01-28 2012-08-02 Purdue Research Foundation Immunogenic compositions and reagents for preparing
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
WO2012135440A1 (en) 2011-03-30 2012-10-04 Arizona Board Of Regents, For And On Behalf Of, Arizona State University Auristatin tyramine phosphate salts and auristatin aminoquinoline derivatives and prodrugs thereof
KR101851425B1 (ko) 2011-09-02 2018-04-23 네스텍 소시에테아노님 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링
EP2755026B1 (de) * 2011-09-09 2021-10-27 Konica Minolta, Inc. Verfahren zum färben von geweben
WO2013148498A1 (en) 2012-03-27 2013-10-03 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
EP2893323A1 (de) * 2012-05-09 2015-07-15 Life Technologies Corporation Systeme und verfahren zur fluoreszenzabbildung
CN105378460A (zh) * 2012-12-11 2016-03-02 多伦多大学理事会 基于无线通信设备的检测系统
EP3027773B1 (de) 2013-07-30 2020-03-25 President and Fellows of Harvard College Quantitative bildgebung auf dna-basis und hochauflösende bildgebung
EP3019559A4 (de) 2013-08-22 2017-04-05 Sony Corporation Wasserlösliche fluoreszierende oder gefärbte farbstoffe und verfahren zu verwendung
KR102313982B1 (ko) 2014-03-11 2021-10-18 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 프로그램가능한 핵산 프로브를 이용한 고처리량 고도 다중 영상화
WO2015184144A1 (en) * 2014-05-28 2015-12-03 Siemens Healthcare Diagnostics Inc. Rare molecule signal amplification
EP3234681B1 (de) 2014-12-18 2020-02-26 Rhode Island Hospital Visualisierung von bakterieller kolonisation und biofilmbildung auf orthopädischen traumaexplantaten
WO2016138461A1 (en) 2015-02-26 2016-09-01 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
WO2016138457A1 (en) 2015-02-26 2016-09-01 Sony Corporation Phenylethynylnaphthalene dyes and methods for their use
CA2984469A1 (en) 2015-05-01 2016-11-10 Diagnostear, Ltd. Method for measuring tear constituents in a tear sample
CN107709470B (zh) 2015-05-11 2021-01-29 索尼公司 超亮二聚或多聚染料
AT517379B1 (de) * 2015-06-26 2017-03-15 Technische Universität Graz Fusionsprotein
JP6858744B2 (ja) 2015-08-07 2021-04-14 プレジデント アンド フェローズ オブ ハーバード カレッジ タンパク質−タンパク質相互作用の超分解能イメージング
US10845305B1 (en) * 2015-11-20 2020-11-24 Verily Life Sciences Llc Method for increasing sensor resolution by spectrally stacking responsive dyes
US20190302028A1 (en) * 2016-01-14 2019-10-03 Diagnos Tear, Ltd. Method for Measuring Tear Constituents in a Tear Sample
CN105784657A (zh) * 2016-03-25 2016-07-20 鲁延军 利用tr-fret高效筛选单克隆抗体阳性克隆的方法
JP6603419B2 (ja) * 2016-03-31 2019-11-06 インテックバイオ カンパニー リミテッド 光酸化増幅を用いた高感度バイオマーカー定量方法
EP3436529A1 (de) 2016-04-01 2019-02-06 Sony Corporation Ultrahelle dimere oder polymere farbstoffe
KR102525252B1 (ko) 2016-04-01 2023-04-26 소니그룹주식회사 강성 공간군을 갖는 매우 밝은 이량체성 또는 중합체성 염료
US9851359B2 (en) 2016-04-06 2017-12-26 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
EP3455238A1 (de) 2016-05-10 2019-03-20 Sony Corporation Ultrahelle polymere farbstoffe mit peptidgerüst
WO2017197144A1 (en) 2016-05-11 2017-11-16 Sony Corporation Ultra bright dimeric or polymeric dyes
GB201609235D0 (en) * 2016-05-25 2016-07-06 Univ Cape Town Production of a horseradish peroxidase-IGG fusion protein
EP3465162A4 (de) * 2016-06-02 2020-03-25 Ultivue, Inc. Zusammensetzungen und verfahren zur beschleunigung von austauschbildgebung auf antikörperbasis
US11377563B2 (en) 2016-06-06 2022-07-05 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
KR20230166141A (ko) 2016-12-09 2023-12-06 얼티뷰, 인크. 표지된 핵산 조영제를 사용한 다중 이미지형성을 위한 개선된 방법
WO2018167141A2 (en) * 2017-03-14 2018-09-20 Nanotag Biotechnologies Gmbh Target detection using a monovalent antibody
CN111315415A (zh) 2017-10-05 2020-06-19 索尼公司 可编程的聚合药物
KR20200083605A (ko) 2017-11-16 2020-07-08 소니 주식회사 프로그램가능한 중합체성 약물
KR102047978B1 (ko) * 2017-11-22 2019-11-22 바디텍메드(주) 측방유동 면역 분석 기반의 항ccp 항체 및 류마티스인자를 이용한 류마티스 관절염 진단 방법
WO2019130503A1 (ja) * 2017-12-27 2019-07-04 コニカミノルタ株式会社 情報取得方法
US11874280B2 (en) 2018-03-19 2024-01-16 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
US20210032474A1 (en) 2018-03-21 2021-02-04 Sony Corporation Polymeric tandem dyes with linker groups
GB2573323A (en) 2018-05-03 2019-11-06 Mursia Ltd Biosensor method and system
KR20230012097A (ko) 2019-09-26 2023-01-25 소니그룹주식회사 링커 그룹을 갖는 중합체성 탠덤 염료
WO2023044574A1 (en) * 2021-09-24 2023-03-30 Enveric Biosciences Canada Inc. Phosphorylated and sulfonated mescaline derivatives and methods of using
CN114002438A (zh) * 2021-11-04 2022-02-01 河南赛诺特生物技术有限公司 一种小鼠一抗-小鼠组织同种属免疫组化染色方法
CN116004221B (zh) * 2022-12-15 2023-12-19 湖南卓润生物科技有限公司 环肽的新应用、吖啶标记复合物与制备方法、检测试剂盒

Family Cites Families (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5896A (en) * 1848-10-31 Shoe-pegging machine
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4199559A (en) * 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4174384A (en) * 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4235869A (en) * 1978-05-16 1980-11-25 Syva Company Assay employing a labeled Fab-fragment ligand complex
US4261968A (en) * 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
JPS6033479B2 (ja) 1980-07-30 1985-08-02 協和醗酵工業株式会社 過酸化水素の定量方法
US4481298A (en) * 1981-04-13 1984-11-06 Amf Incorporated Pre-precipitated double antibody immunoassay method
US4859582A (en) 1981-10-06 1989-08-22 The Board Of Trustees Of The Leland Stanford Jr. University Fluorescent conjugates for analysis of molecules and cells
US4520110A (en) 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
US5055556A (en) 1981-10-06 1991-10-08 The Board Of Trustees Of The Leland Stanford Jr. Univ. Fluorescent conjugates for analysis of molecules and cells
DE3382317D1 (de) * 1982-03-15 1991-07-25 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
US4469787A (en) 1982-05-14 1984-09-04 Mallinckrodt Inc. Immunoassay involving soluble complex of second antibody and labeled binding protein
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4542104A (en) 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
JPS6082966A (ja) * 1983-10-14 1985-05-11 Amano Pharmaceut Co Ltd 抗原の定量法
NL193545C (nl) * 1983-12-29 2000-01-04 Mitsubishi Electric Corp Constante stroom opwekkende schakeling.
EP0150905A3 (de) 1984-01-05 1987-01-14 Ortho Diagnostic Systems Inc. Anti-Idiotyptest unter Verwendung fluoreszierender Energieübertragung
US4661444A (en) * 1984-03-29 1987-04-28 Ortho Diagnostic Systems Inc. Homogeneous immunoassays employing double antibody conjugates comprising anti-idiotype antibody
US5011771A (en) * 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4603209A (en) * 1984-09-07 1986-07-29 The Regents Of The University Of California Fluorescent indicator dyes for calcium ions
US4665024A (en) 1984-10-01 1987-05-12 Becton, Dickinson And Company Fluorescent gram stain
US4659839A (en) 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
ZA858371B (en) * 1984-11-02 1987-03-25 Oncogen Monoclonal antibodies for human non-small cell lung carcinomas
US5422266A (en) 1984-12-31 1995-06-06 University Of Georgia Research Foundation, Inc. Recombinant DNA vectors capable of expressing apoaequorin
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
NL8501219A (nl) 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
NZ212437A (en) * 1985-06-17 1992-06-25 Mark Philip Best Site-directed antibody conjugates, and their preparation
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4714763A (en) * 1985-07-11 1987-12-22 Viomedics Inc. Novel oxazine-ureas and thiazine urea chromophors as fluorescent labels
US4812409A (en) * 1986-01-31 1989-03-14 Eastman Kodak Company Hydrolyzable fluorescent substrates and analytical determinations using same
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5569587A (en) * 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US5627027A (en) * 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5151507A (en) * 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
EP0273928B1 (de) * 1986-07-18 1997-01-08 The University Of Melbourne Aktives protein in humoraler hyperkalzemia, durch bösartigkeit verursacht
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4959306A (en) 1986-11-28 1990-09-25 Sclavo, Inc. Labeling design for a binding assay reagent
US4810636A (en) * 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US5360895A (en) * 1987-04-22 1994-11-01 Associated Universities, Inc. Derivatized gold clusters and antibody-gold cluster conjugates
DE3800048A1 (de) 1987-05-14 1988-11-24 Boehringer Mannheim Gmbh Verfahren zur bestimmung eines antikoerpers in menschlichen koerperfluessigkeiten
DE3717401A1 (de) 1987-05-23 1988-12-08 Behringwerke Ag Einschritt-immuntest zur bestimmung von antigen-spezifischen antikoerpern aus einer der immunglobulin-klassen a, m, d oder e und dazu geeignetes mittel
US4945171A (en) * 1987-08-10 1990-07-31 Molecular Probes, Inc. Xanthene dyes having a fused (C) benzo ring
US4774339A (en) * 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US4814433A (en) 1987-09-16 1989-03-21 Miles Inc. Method for obtaining a papain-free antibody fragment preparation
NO884368L (no) 1987-10-02 1989-04-03 Du Pont Immunanalyse ved anvendelse av igg-innfangelsesantistoff og multippel, monoklonalt antistoffpaavisningssystem.
JPH01131458A (ja) * 1987-11-17 1989-05-24 Nippon Zenyaku Kogyo Kk 簡易迅速免疫測定試薬
US5084398A (en) * 1987-11-20 1992-01-28 Creative Biomolecules Selective removal of immune complexes
US4891313A (en) 1988-01-21 1990-01-02 Boehringer Manheim Corporation Method for determination of a component of a sample
US5229302A (en) * 1988-03-29 1993-07-20 Matsushita Electric Industrial Co., Ltd. Fluorescence immunoassay method utilizing pseudo-antigens combined with fluorescent quenchers
US4849362A (en) * 1988-05-19 1989-07-18 Smithkline Beckman Corporation Fluorescent intracellular calcium indicators
JPH0276600A (ja) * 1988-09-10 1990-03-15 Akad Wissenschaften Ddr 標識を付した分子プローブ、その製造及び利用
DE3836348A1 (de) 1988-10-25 1990-04-26 Boehringer Mannheim Gmbh Verfahren zur bestimmung von fuer ein antigen klassenspezifischen antikoerpern und dazu geeignetes reagenz
EP0368674A3 (de) 1988-11-11 1991-10-09 SANYO CHEMICAL INDUSTRIES, Ltd. Immunoessay und dafür geeignete Testsätze
EP0389301A3 (de) * 1989-03-24 1991-06-05 Biogenex Laboratories Reagenzkomplex für Immunoessay
US5196306A (en) 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
GB8910263D0 (en) 1989-05-04 1989-06-21 Ciba Geigy Ag Monoclonal antibodies specific for an immunoglobulin isotype
US4981977A (en) * 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
US5089419A (en) * 1989-08-07 1992-02-18 International Canine Genetics Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
WO1991002547A1 (en) * 1989-08-24 1991-03-07 Australian Nuclear Science & Technology Organisation Radio-labelled antibodies for imaging
US5132432A (en) * 1989-09-22 1992-07-21 Molecular Probes, Inc. Chemically reactive pyrenyloxy sulfonic acid dyes
US6274324B1 (en) 1989-12-01 2001-08-14 Unilever Patent Holdings B.V. Specific binding reagent comprising a variable domain protein linked to a support or tracer
US5292658A (en) 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
US5227487A (en) * 1990-04-16 1993-07-13 Molecular Probes, Inc. Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes
US5501980A (en) * 1994-05-20 1996-03-26 Molecular Probes, Inc. Benzazolylcoumarin-based ion indicators
US5459276A (en) * 1994-05-20 1995-10-17 Molecular Probes, Inc. Benzazolylcoumarin-based ion indicators for heavy metals
US5274113A (en) * 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5789157A (en) * 1990-06-11 1998-08-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US5602240A (en) * 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5187085A (en) * 1990-09-28 1993-02-16 Applied Biosystems, Inc. Nucleic acid sequence analysis with nucleoside-5'-o-(1-thiotriphosphates)
US5208148A (en) 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
US5248782A (en) * 1990-12-18 1993-09-28 Molecular Probes, Inc. Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes
DE4129849A1 (de) * 1991-02-14 1992-08-27 Boehringer Mannheim Gmbh Monoklonale antikoerper gegen humane pankreas-inselzellen
GR920100123A (el) * 1991-04-12 1993-03-16 Ortho Diagnostic Systems Inc Αντιδραστήριο πολυχρωματικής κηλίδωσης και μέ?οδος ανάλυσης.
US5451343A (en) * 1991-05-20 1995-09-19 Spectra Group Limited, Inc. Fluorone and pyronin y derivatives
US5187288A (en) * 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
US6352830B1 (en) 1991-08-22 2002-03-05 The Board Of Trustees Of The Leland Stanford Junior University NF-AT polypeptides and polynucleotides and screening methods for immunosuppressive agents
US5316906A (en) 1991-08-23 1994-05-31 Molecular Probes, Inc. Enzymatic analysis using substrates that yield fluorescent precipitates
US5576424A (en) 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
US5242805A (en) 1991-08-23 1993-09-07 Molecular Probes, Inc. Long wavelength lipophilic fluorogenic glycosidase substrates
WO1993004192A1 (en) 1991-08-23 1993-03-04 Molecular Probes, Inc. Use of haloalkyl derivatives of reporter molecules to analyze metabolic activity in cells
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
CA2093494A1 (en) 1992-04-17 1993-10-18 Keisuke Iwata Method for the elimination of non-specific reactions in immuno-assays
US5195303A (en) 1992-05-29 1993-03-23 Philip Morris Incorporated Apparatus for automatic bagging of compressed tobacco
US6030773A (en) 1992-07-08 2000-02-29 Agnello; Vincent Chemiluminescent assay for DSDNA antibodies
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5736137A (en) * 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
EP0599803B1 (de) 1992-11-23 2000-04-05 Sanochemia Pharmazeutika AG Verfahren zum Nachweisen von Antikörpern und Antigenen
ES2051651B1 (es) * 1992-12-10 1995-01-01 Univ Salamanca Procedimiento para la cuantificacion simultanea, en una sola medicion, de los principales tipos de linfocitos humanos y sus subpoblaciones.
US5808044A (en) * 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US6482655B1 (en) * 1993-07-23 2002-11-19 University Of Utah Research Foundation Immunoassay procedure utilizing fluorogenic tracer antigens
CA2125639A1 (en) 1993-06-16 1994-12-17 Shinjirou Imai Immunoassay for quantitatively determining antigens
US5585243A (en) * 1993-09-15 1996-12-17 The Blood Center Of Southeastern Wisconsin, Inc. Method of detecting cytopenia that is mediated by drug-dependent antibody binding to blood cells
US5443953A (en) * 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
US5561045A (en) 1994-01-04 1996-10-01 Intracel Corporation Detection reagent, article, and immunoassay method
US5630924A (en) * 1995-04-20 1997-05-20 Perseptive Biosystems, Inc. Compositions, methods and apparatus for ultrafast electroseparation analysis
US6127134A (en) * 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US5679519A (en) * 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US5798276A (en) * 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
US6008373A (en) * 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US5869274A (en) 1995-08-09 1999-02-09 Zymed Laboratories, Inc. Immuno-histochemical method that reduces background staining
US5736330A (en) 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US5969135A (en) * 1995-11-02 1999-10-19 Icn Pharmaceuticals, Inc. Oligonucleotide analogs with an amino acid or a modified amino alcohol residue
WO1997017610A1 (en) * 1995-11-08 1997-05-15 Pharmaceutical Discovery Corporation Method for fluorescent labeling of antibody
US6004536A (en) * 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
US5994143A (en) * 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
GB9602265D0 (en) * 1996-02-05 1996-04-03 Amersham Int Plc Benzophenoxazine dyes
US5723294A (en) 1996-03-05 1998-03-03 Gull Laboratories Methods for detection and discrimination of multiple analytes using fluorescent technology
US5637258A (en) * 1996-03-18 1997-06-10 Nanocrystals Technology L.P. Method for producing rare earth activited metal oxide nanocrystals
US6162931A (en) * 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
CA2251985A1 (en) 1996-04-19 1997-10-30 Alan Lewis Hamilton Squarate dyes and their use in fluorescent sequencing method
GB9712818D0 (en) 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
US5846737A (en) * 1996-07-26 1998-12-08 Molecular Probes, Inc. Conjugates of sulforhodamine fluorophores with enhanced fluorescence
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US5830912A (en) 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
ZA9710262B (en) 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
US5945294A (en) 1996-11-26 1999-08-31 Heska Corporation Method to detect IgE
US5948386A (en) * 1997-03-14 1999-09-07 The Curators Of The University Of Missouri Conjugate and method for forming aminomethyl phosphorus conjugates
US5877310A (en) * 1997-04-25 1999-03-02 Carnegie Mellon University Glycoconjugated fluorescent labeling reagents
US5773236A (en) 1997-04-25 1998-06-30 Molecule Probes, Inc. Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules
US5994089A (en) * 1997-05-16 1999-11-30 Coulter International Corp. Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry
US5891741A (en) 1997-05-16 1999-04-06 Coulter International Corp. Antibody-aminodextran-phycobiliprotein conjugates
US6146836A (en) * 1997-05-19 2000-11-14 Bayer Corporation Immunoassays using anti-allotypic monoclonal antibodies
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
JPH11153599A (ja) 1997-11-21 1999-06-08 Dai Ichi Pure Chem Co Ltd 免疫学的測定方法
US6133445A (en) * 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
US6080868A (en) * 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
WO1999051702A1 (en) 1998-04-08 1999-10-14 Terpetschnig Ewald A Luminescent compounds
US6002003A (en) * 1998-04-14 1999-12-14 Beckman Instruments, Inc. Cyanine dye activating group with improved coupling selectivity
WO1999053318A1 (fr) 1998-04-14 1999-10-21 Otsuka Pharmaceutical Co., Ltd. Procedes de detection d'anticorps et dispositif de detection d'anticorps
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6150123A (en) 1998-09-03 2000-11-21 Centre Integre De Recherches Biocliniques Sur Le Sida (Cirbs) Affinity biotinylation
US6326144B1 (en) * 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
US6306610B1 (en) * 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
EP1271154A3 (de) * 1998-09-18 2005-08-17 Massachusetts Institute Of Technology Biologische Verwendung von Halbleiter-Nanokristallen
US6221602B1 (en) * 1998-11-10 2001-04-24 Bio-Pixels Ltd. Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
US6261779B1 (en) * 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
US6787638B1 (en) * 1998-12-02 2004-09-07 Applied Molecular Evolution, Inc. Tumor specific human monoclonal antibodies and methods of use
JP3983404B2 (ja) * 1999-01-13 2007-09-26 本田技研工業株式会社 レーダ搭載車両用ゲート
JP2000214165A (ja) 1999-01-22 2000-08-04 Fuji Photo Film Co Ltd 均一系酵素免疫分析方法
DE19915532B4 (de) * 1999-04-07 2009-05-20 Schaeffler Kg Schaltbares Ventiltriebsglied
DE60001531T2 (de) * 1999-04-23 2003-10-02 Molecular Probes Inc Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen
JP2000310638A (ja) 1999-04-28 2000-11-07 Fuji Photo Film Co Ltd 均一系酵素免疫分析方法
US6664047B1 (en) 1999-04-30 2003-12-16 Molecular Probes, Inc. Aza-benzazolium containing cyanine dyes
ATE435262T1 (de) 1999-07-02 2009-07-15 Visen Medical Inc Fluoreszierende cyaninlabels mit einem sulphamidobrückenglied
JP2001059845A (ja) 1999-08-24 2001-03-06 Fuji Photo Film Co Ltd 乾式分析方法及び乾式分析要素
US6794509B1 (en) 1999-09-20 2004-09-21 Fuji Photo Film Co., Ltd. Compounds for fluorescence labeling
US6179912B1 (en) * 1999-12-20 2001-01-30 Biocrystal Ltd. Continuous flow process for production of semiconductor nanocrystals
US20020081635A1 (en) 2000-05-11 2002-06-27 Thomas Terry E. Novel antibody compositions for preparing enriched T cell preparations
US7524628B2 (en) 2000-07-25 2009-04-28 The Trustees Of The University Of Pennsylvania Method for detecting molecules expressing a selected epitope via fluorescent dyes
AU2001279185B2 (en) 2000-08-04 2005-07-07 Molecular Probes, Inc. Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
EP1322710B2 (de) * 2000-09-29 2015-02-18 Life Technologies Corporation Modifizierte carbocyaninfarbstoffe und deren konjugate
EP1215501A1 (de) * 2000-11-30 2002-06-19 Molecular Devices Corporation Verwendung von poly aminosäure-metalion-komplexen um einen Marker mit einem Substanz zu verbinden
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US6972326B2 (en) * 2001-12-03 2005-12-06 Molecular Probes, Inc. Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes

Also Published As

Publication number Publication date
EP2113773A2 (de) 2009-11-04
EP1442302B1 (de) 2009-07-08
EP2113773A3 (de) 2010-02-17
WO2003030817A2 (en) 2003-04-17
JP4977512B2 (ja) 2012-07-18
EP2259067A3 (de) 2011-03-09
GB2397302B (en) 2005-06-08
US8323903B2 (en) 2012-12-04
JP2007183291A (ja) 2007-07-19
GB0410515D0 (en) 2004-06-16
EP1442302A4 (de) 2007-03-28
JP2006513398A (ja) 2006-04-20
GB2397302A (en) 2004-07-21
DE60232904D1 (de) 2009-08-20
EP2259067A2 (de) 2010-12-08
WO2003030817B1 (en) 2003-11-06
EP2113773B1 (de) 2012-06-27
CA2462280A1 (en) 2003-04-17
EP1442302A2 (de) 2004-08-04
EP2259067B1 (de) 2012-06-27
WO2003030817A3 (en) 2003-09-18
CA2462280C (en) 2008-03-11
US20030073149A1 (en) 2003-04-17
US20070269902A1 (en) 2007-11-22

Similar Documents

Publication Publication Date Title
ATE436022T1 (de) Antikörperkomplexe sowie immunmarkierungsverfahren
US8518653B2 (en) Detection of cannabis use
US20090088332A1 (en) Multiplex Digital Immuno-Sensing Using a Library of Photocleavable Mass Tags
AU2003210662A1 (en) Rapid lateral flow assay for determining exposure to mycobacterium tuberculosis and other mycobacteria
JP6713478B2 (ja) Ｐｉｖｋａ−ｉｉの測定方法、及びｐｉｖｋａ−ｉｉ免疫測定試薬又はキットの製造方法
CA2573749A1 (en) Immunological test element with improved control zone
CA2503509A1 (en) Non-competitive immunoassay for small analytes
SI1232392T1 (en) Improved method for the detection of acid resistant bacteria of the genus helicobacter in stool
WO2004042349A3 (en) Method for evaluating the immunization status of a patient
JP2001506749A (ja) 抗原特異的ＩｇＭ検出
DE69938701D1 (de) Verfahren und vorrichtung zum nachweis von antikörpern
JPH05504481A (ja) 改良された抗体―酵素直接接合体及びその製造方法
Müller et al. Covalently modified carboxyl side chains on cell surface leads to a novel method toward topology analysis of transmembrane proteins
WO2001073443A3 (en) Methods and compositions for the simultaneous detection of multiple analytes
CN105353131A (zh) 基于双编码和单分子计数的细胞因子多重检测方法
WO2005050206A3 (en) Competitive immunoassay
EP0095089A1 (de) Homogene Bindungstestverfahren und Reagenzsystem, Testsatz und Testgerät dafür
CN109804081A (zh) 一种复合靶标-肿瘤血清核酸配基检测方法及试剂盒
KR960024367A (ko) N-펩티드의 샌드위치 면역학적 측정법
Cho et al. Minimum-step immuno-analysis based on continuous recycling of the capture antibody
RU2373540C1 (ru) Способ одновременного определения двух аналитов биолюминесцентным молекулярным микроанализом
CN108593909A (zh) 一种定点标记免疫试剂的方法、标记免疫试剂及应用
Tanaka et al. Novel and sensitive noncompetitive enzyme immunoassay to measure peptides by biotinylation
CN117706082A (zh) 一种蛋白质-dna-分子复合物及其制备方法
EP0368674A3 (de) Immunoessay und dafür geeignete Testsätze

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties