ATE435262T1 - Fluoreszierende cyaninlabels mit einem sulphamidobrückenglied - Google Patents
Fluoreszierende cyaninlabels mit einem sulphamidobrückengliedInfo
- Publication number
- ATE435262T1 ATE435262T1 AT04023147T AT04023147T ATE435262T1 AT E435262 T1 ATE435262 T1 AT E435262T1 AT 04023147 T AT04023147 T AT 04023147T AT 04023147 T AT04023147 T AT 04023147T AT E435262 T1 ATE435262 T1 AT E435262T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- group
- indipendently
- alkylensulfonic
- alkylensulfonate
- Prior art date
Links
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 title abstract 2
- 239000012038 nucleophile Substances 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052755 nonmetal Inorganic materials 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- 238000006862 quantum yield reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99112696A EP1065250B1 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435262T1 true ATE435262T1 (de) | 2009-07-15 |
Family
ID=8238492
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04023147T ATE435262T1 (de) | 1999-07-02 | 1999-07-02 | Fluoreszierende cyaninlabels mit einem sulphamidobrückenglied |
| AT99112696T ATE284433T1 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende cyaninlabels mit einem sulphamidobrückenglied |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99112696T ATE284433T1 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende cyaninlabels mit einem sulphamidobrückenglied |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6448008B1 (de) |
| EP (2) | EP1065250B1 (de) |
| AT (2) | ATE435262T1 (de) |
| AU (1) | AU776841B2 (de) |
| BR (1) | BR0005843A (de) |
| CA (1) | CA2312099C (de) |
| DE (2) | DE69941067D1 (de) |
| ES (1) | ES2329572T3 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001288197A (ja) * | 2000-04-10 | 2001-10-16 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド |
| US7597878B2 (en) * | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
| EP1770129B1 (de) | 2000-09-29 | 2012-07-25 | Life Technologies Corporation | Modifizierte Carbocyaninfarbstoffe und deren Konjugate |
| ATE352586T2 (de) | 2000-09-29 | 2007-02-15 | Molecular Probes Inc | Modifizierte carbocyaninfarbstoffe und deren konjugate |
| US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
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| AU2003237185A1 (en) * | 2002-05-07 | 2003-11-11 | The Research Foundation Of State University Of New York | A method to rapidly prepare and screen formulations and compositions containing same |
| US7172907B2 (en) * | 2003-03-21 | 2007-02-06 | Ge Healthcare Bio-Sciences Corp. | Cyanine dye labelling reagents with meso-substitution |
| US20080102036A1 (en) * | 2003-06-04 | 2008-05-01 | Poss Kirtland G | Biocompatible Fluorescent Silicon Nanoparticles |
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| US7737281B2 (en) * | 2005-05-24 | 2010-06-15 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Purine based fluorescent dyes |
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| USD580285S1 (en) | 2006-01-13 | 2008-11-11 | Invitrogen Corporation | Fluorometer |
| ITSV20060002A1 (it) * | 2006-01-19 | 2007-07-20 | Ferrania Technologies Spa | Colorante fluorescente di tipo cianinico |
| JP2009524832A (ja) | 2006-01-24 | 2009-07-02 | ライフ テクノロジーズ コーポレーション | 検体を定量するためのデバイスおよび方法 |
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| KR20160037834A (ko) | 2013-03-14 | 2016-04-06 | 루미셀, 아이엔씨. | 의료 이미징 장치 및 사용 방법 |
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| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
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| CA3007062A1 (en) * | 2015-12-01 | 2017-06-08 | Dishman Pharmaceuticals And Chemicals Limited | An improved process for the preparation of indocyanine green |
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| RU2637310C1 (ru) * | 2016-06-08 | 2017-12-04 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Флуоресцентно-меченые дезоксиуридинтрифосфаты |
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| BR112019010947A2 (pt) | 2016-11-30 | 2019-10-01 | Memorial Sloan Kettering Cancer Center | nanopartículas ultrapequenas funcionalizadas por inibidores e métodos das mesmas |
| EP3601608A1 (de) | 2017-03-30 | 2020-02-05 | Life Technologies Corporation | Quantifizierung von ngs-dna durch adaptersequenz |
| US11989803B2 (en) | 2018-03-30 | 2024-05-21 | Perkinelmer Health Sciences, Inc. | Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography |
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| EP4015004A1 (de) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglykanspezifische verzweigte peptide |
| WO2024170742A1 (en) | 2023-02-17 | 2024-08-22 | Danmarks Tekniske Universitet | Copolymer-drug conjugate for treatment of tumours |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1287000A (fr) * | 1961-03-07 | 1962-03-09 | Gevaert Photo Prod Nv | Procédé pour la sensibilisation d'émulsions photographiques |
| US5556959A (en) * | 1993-01-22 | 1996-09-17 | Pharmacia P-L Biochemicals Inc. | Indocarbocyanine-linked phosphoramidites |
| US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
| US5714386A (en) * | 1996-01-11 | 1998-02-03 | Board Of Trustees Of The Leland Stanford Junior University | Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays |
-
1999
- 1999-07-02 AT AT04023147T patent/ATE435262T1/de not_active IP Right Cessation
- 1999-07-02 EP EP99112696A patent/EP1065250B1/de not_active Expired - Lifetime
- 1999-07-02 DE DE69941067T patent/DE69941067D1/de not_active Expired - Lifetime
- 1999-07-02 ES ES04023147T patent/ES2329572T3/es not_active Expired - Lifetime
- 1999-07-02 AT AT99112696T patent/ATE284433T1/de not_active IP Right Cessation
- 1999-07-02 DE DE69922498T patent/DE69922498T2/de not_active Expired - Lifetime
- 1999-07-02 EP EP04023147A patent/EP1491591B1/de not_active Expired - Lifetime
-
2000
- 2000-06-21 AU AU42581/00A patent/AU776841B2/en not_active Expired
- 2000-06-22 CA CA002312099A patent/CA2312099C/en not_active Expired - Lifetime
- 2000-06-30 US US09/609,035 patent/US6448008B1/en not_active Expired - Lifetime
- 2000-07-03 BR BR0005843-2A patent/BR0005843A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1491591A1 (de) | 2004-12-29 |
| DE69941067D1 (de) | 2009-08-13 |
| CA2312099C (en) | 2009-05-12 |
| DE69922498T2 (de) | 2005-12-08 |
| CA2312099A1 (en) | 2001-01-02 |
| DE69922498D1 (de) | 2005-01-13 |
| BR0005843A (pt) | 2002-01-02 |
| EP1065250B1 (de) | 2004-12-08 |
| AU4258100A (en) | 2001-01-11 |
| AU776841B2 (en) | 2004-09-23 |
| ES2329572T3 (es) | 2009-11-27 |
| EP1065250A1 (de) | 2001-01-03 |
| US6448008B1 (en) | 2002-09-10 |
| EP1491591B1 (de) | 2009-07-01 |
| ATE284433T1 (de) | 2004-12-15 |
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