DE69941067D1 - Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied - Google Patents

Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied

Info

Publication number
DE69941067D1
DE69941067D1 DE69941067T DE69941067T DE69941067D1 DE 69941067 D1 DE69941067 D1 DE 69941067D1 DE 69941067 T DE69941067 T DE 69941067T DE 69941067 T DE69941067 T DE 69941067T DE 69941067 D1 DE69941067 D1 DE 69941067D1
Authority
DE
Germany
Prior art keywords
sub
group
indipendently
alkylensulfonic
alkylensulfonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941067T
Other languages
English (en)
Inventor
Giuseppe Caputo
Ciana Leopoldo Della
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Visen Medical Inc
Original Assignee
Visen Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visen Medical Inc filed Critical Visen Medical Inc
Application granted granted Critical
Publication of DE69941067D1 publication Critical patent/DE69941067D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
DE69941067T 1999-07-02 1999-07-02 Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied Expired - Lifetime DE69941067D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99112696A EP1065250B1 (de) 1999-07-02 1999-07-02 Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied

Publications (1)

Publication Number Publication Date
DE69941067D1 true DE69941067D1 (de) 2009-08-13

Family

ID=8238492

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69941067T Expired - Lifetime DE69941067D1 (de) 1999-07-02 1999-07-02 Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied
DE69922498T Expired - Lifetime DE69922498T2 (de) 1999-07-02 1999-07-02 Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69922498T Expired - Lifetime DE69922498T2 (de) 1999-07-02 1999-07-02 Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied

Country Status (8)

Country Link
US (1) US6448008B1 (de)
EP (2) EP1065250B1 (de)
AT (2) ATE284433T1 (de)
AU (1) AU776841B2 (de)
BR (1) BR0005843A (de)
CA (1) CA2312099C (de)
DE (2) DE69941067D1 (de)
ES (1) ES2329572T3 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001288197A (ja) * 2000-04-10 2001-10-16 Fuji Photo Film Co Ltd 蛍光ヌクレオチド
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
EP1801165B1 (de) 2000-09-29 2012-08-01 Life Technologies Corporation Modifizierte Carbocyanin-Farbstoffe und ihre Konjugate
AU2001294859A1 (en) 2000-09-29 2002-04-08 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
AU2003207438A1 (en) 2002-01-02 2003-07-24 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
EP1485716A1 (de) * 2002-03-11 2004-12-15 Visen Medical, Inc. Sonden zur erzeugung von optischen bildern
ATE466281T1 (de) * 2002-05-07 2010-05-15 Univ New York State Res Found ßHIGH THROUGPUTß METHODE, UM BIOMOLEKÜLANLIEFERUNG FORMULIERUNGEN ZU KENNZEICHNEN
US7172907B2 (en) * 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
WO2004108902A2 (en) * 2003-06-04 2004-12-16 Visen Medical, Inc. Biocompatible fluorescent silicon nanoparticles
WO2005050206A2 (en) 2003-09-17 2005-06-02 Molecular Probes, Inc. Competitive immunoassay
ES2461858T3 (es) 2004-08-13 2014-05-21 Epoch Biosciences, Inc. Colorantes fluorescentes de fosfonato y conjugados
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US8357801B2 (en) 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
WO2007028163A1 (en) * 2005-09-02 2007-03-08 Visen Medical, Inc. Biocompatible fluorescent imaging agents
US8173819B2 (en) 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
WO2007028037A1 (en) * 2005-09-02 2007-03-08 Visen Medical, Inc. Biocompatible n, n-disubstituted sulfonamide-containing fluorescent dye labels
WO2007047450A1 (en) 2005-10-13 2007-04-26 Aureon Laboratories, Inc. Multiplex in situ immunohistochemical analysis
ATE500778T1 (de) 2005-12-22 2011-03-15 Visen Medical Inc Kombiniertes röntgen- und optisches tomographie- bildgebungssystem
EP1973575B1 (de) 2005-12-22 2019-07-24 Visen Medical, Inc. Biokompatibele fluoreszierende metalloxide nanopartikel
ITSV20060002A1 (it) * 2006-01-19 2007-07-20 Ferrania Technologies Spa Colorante fluorescente di tipo cianinico
WO2007087582A1 (en) 2006-01-24 2007-08-02 Invitrogen Corporation Device and methods for quantifying analytes
US20070249014A1 (en) 2006-02-10 2007-10-25 Invitrogen Corporation Labeling and detection of post translationally modified proteins
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
SG171598A1 (en) 2006-03-23 2011-06-29 Absorber Ab Blood group antigens of different types for diagnostic and therapeutic applications
WO2007124464A2 (en) 2006-04-20 2007-11-01 Becton, Dickinson And Company Thermostable proteins and methods of making and using thereof
ES2670852T3 (es) 2007-02-09 2018-06-01 Visen Medical, Inc. Colorantes con policiclo y uso de los mismos
US8906354B2 (en) 2007-02-28 2014-12-09 Bruker Biospin Corporation Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes
US8017104B2 (en) 2007-02-28 2011-09-13 Carestream Health, Inc. Large stoke shift dye used for optical imaging
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
US8492734B2 (en) 2007-10-19 2013-07-23 Visen Medical, Inc. Imaging systems featuring waveguiding compensation
EP2732826B1 (de) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluoreszierende Bildgebungsmittel
WO2009114776A2 (en) 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same
CN102119223A (zh) 2008-05-16 2011-07-06 生命技术公司 用于测量细胞增殖的双标记法
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
US20110021908A1 (en) 2009-05-27 2011-01-27 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
AU2010286592B2 (en) 2009-08-28 2015-08-13 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
WO2011026085A2 (en) 2009-08-31 2011-03-03 Promega Corporation Reactive cyanine compounds
AU2010298388B2 (en) 2009-09-22 2015-05-28 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
CN101747655B (zh) * 2009-12-24 2013-04-03 渤海大学 含薁类结构水溶性菁染料及其合成方法
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
JP6122840B2 (ja) 2011-05-09 2017-04-26 ビセン メディカル, インコーポレイテッド 炭酸脱水酵素標的化剤およびそれの使用方法
US9375493B2 (en) 2012-03-30 2016-06-28 Visen Medical, Inc. Bacterial imaging agents and methods of using same
JP6370785B2 (ja) 2012-08-15 2018-08-08 ビセン メディカル, インコーポレイテッド 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法
WO2014062716A1 (en) 2012-10-15 2014-04-24 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
EP2912459A2 (de) 2012-10-25 2015-09-02 Life Technologies Corporation Verfahren und zusammensetzungen zur enzymvermittelten stellenspezifischen radioaktiven markierung von glykoproteinen
CA2902982C (en) * 2013-03-08 2020-08-04 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
KR20160037834A (ko) 2013-03-14 2016-04-06 루미셀, 아이엔씨. 의료 이미징 장치 및 사용 방법
JP6606487B2 (ja) 2013-03-15 2019-11-13 ビセン メディカル, インコーポレイテッド invitroおよびinvivoイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素
WO2014144702A2 (en) 2013-03-15 2014-09-18 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
US10494419B2 (en) 2013-10-02 2019-12-03 Medimmune, Llc Neutralizing anti-influenza A antibodies and uses thereof
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US9504405B2 (en) 2013-10-23 2016-11-29 Verily Life Sciences Llc Spatial modulation of magnetic particles in vasculature by external magnetic field
JP5824729B2 (ja) * 2013-12-18 2015-11-25 東洋インキScホールディングス株式会社 カラーフィルタ用着色組成物、およびカラーフィルタ
EP3089653A1 (de) 2013-12-31 2016-11-09 Memorial Sloan Kettering Cancer Center Systeme, verfahren und vorrichtung für die mehrkanalbildgebung von fluoreszierenden quellen in echtzeit
CN107249647A (zh) 2014-12-15 2017-10-13 纪念斯隆-凯特琳癌症中心 具有增强的神经结合选择性的环状肽、与所述环状肽结合的纳米颗粒和此二者用于实时体内神经组织成像的用途
US9861710B1 (en) 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
US10028659B2 (en) 2015-03-26 2018-07-24 Verily Life Sciences Llc Aptamer-based sensors, implantable devices and detection system
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
JP2018538428A (ja) * 2015-12-01 2018-12-27 ディッシュマン ファーマスーティカルズ アンド ケミカルズ リミテッドDishman Pharmaceuticals and Chemicals Limited インドシアニングリーンの改善された製造方法
JP2019509252A (ja) 2015-12-15 2019-04-04 メモリアル スローン ケタリング キャンサー センター 組織の区別、例えば、手術中の可視化のための、イメージングシステムおよび方法
EP3443126B1 (de) 2016-04-15 2023-11-15 Icahn School of Medicine at Mount Sinai Gewebeprofilierung unter verwendung von multiplexierten immunhistochemischen aufeinanderfolgenden färbungen
RU2637310C1 (ru) * 2016-06-08 2017-12-04 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Флуоресцентно-меченые дезоксиуридинтрифосфаты
EP3496762A1 (de) 2016-08-11 2019-06-19 The U.S.A. as represented by the Secretary, Department of Health and Human Services Durch nahinfrarotlicht spaltbare konjugate und konjugatvorläufer
BR112019010947A2 (pt) 2016-11-30 2019-10-01 Univ Cornell nanopartículas ultrapequenas funcionalizadas por inibidores e métodos das mesmas
WO2018183621A1 (en) 2017-03-30 2018-10-04 Life Technologies Corporation Quantification of ngs dna by adapter sequence
KR20230034333A (ko) 2020-07-02 2023-03-09 라이프 테크놀로지스 코포레이션 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도
EP4015004A1 (de) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglykanspezifische verzweigte peptide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1287000A (fr) * 1961-03-07 1962-03-09 Gevaert Photo Prod Nv Procédé pour la sensibilisation d'émulsions photographiques
US5556959A (en) * 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
US5808044A (en) 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5714386A (en) * 1996-01-11 1998-02-03 Board Of Trustees Of The Leland Stanford Junior University Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays

Also Published As

Publication number Publication date
EP1491591B1 (de) 2009-07-01
ES2329572T3 (es) 2009-11-27
EP1065250B1 (de) 2004-12-08
EP1491591A1 (de) 2004-12-29
AU776841B2 (en) 2004-09-23
CA2312099A1 (en) 2001-01-02
EP1065250A1 (de) 2001-01-03
AU4258100A (en) 2001-01-11
US6448008B1 (en) 2002-09-10
DE69922498T2 (de) 2005-12-08
BR0005843A (pt) 2002-01-02
ATE284433T1 (de) 2004-12-15
ATE435262T1 (de) 2009-07-15
CA2312099C (en) 2009-05-12
DE69922498D1 (de) 2005-01-13

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