DE69922498D1 - Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied - Google Patents
Fluorescierende Cyaninlabels mit einem SulphamidobrückengliedInfo
- Publication number
- DE69922498D1 DE69922498D1 DE1999622498 DE69922498T DE69922498D1 DE 69922498 D1 DE69922498 D1 DE 69922498D1 DE 1999622498 DE1999622498 DE 1999622498 DE 69922498 T DE69922498 T DE 69922498T DE 69922498 D1 DE69922498 D1 DE 69922498D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- group
- indipendently
- alkylensulfonic
- alkylensulfonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99112696A EP1065250B1 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69922498D1 true DE69922498D1 (de) | 2005-01-13 |
DE69922498T2 DE69922498T2 (de) | 2005-12-08 |
Family
ID=8238492
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69922498T Expired - Lifetime DE69922498T2 (de) | 1999-07-02 | 1999-07-02 | Fluorescierende Cyaninlabels mit einem Sulphamidobrückenglied |
DE69941067T Expired - Lifetime DE69941067D1 (de) | 1999-07-02 | 1999-07-02 | Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69941067T Expired - Lifetime DE69941067D1 (de) | 1999-07-02 | 1999-07-02 | Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied |
Country Status (8)
Country | Link |
---|---|
US (1) | US6448008B1 (de) |
EP (2) | EP1491591B1 (de) |
AT (2) | ATE284433T1 (de) |
AU (1) | AU776841B2 (de) |
BR (1) | BR0005843A (de) |
CA (1) | CA2312099C (de) |
DE (2) | DE69922498T2 (de) |
ES (1) | ES2329572T3 (de) |
Families Citing this family (74)
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JP2001288197A (ja) * | 2000-04-10 | 2001-10-16 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド |
US7597878B2 (en) * | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
EP1770129B1 (de) | 2000-09-29 | 2012-07-25 | Life Technologies Corporation | Modifizierte Carbocyaninfarbstoffe und deren Konjugate |
DE60126297T2 (de) | 2000-09-29 | 2007-11-15 | Molecular Probes, Inc., Eugene | Modifizierte carbocyaninfarbstoffe und deren konjugate |
US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
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AU2003237185A1 (en) * | 2002-05-07 | 2003-11-11 | The Research Foundation Of State University Of New York | A method to rapidly prepare and screen formulations and compositions containing same |
US7172907B2 (en) * | 2003-03-21 | 2007-02-06 | Ge Healthcare Bio-Sciences Corp. | Cyanine dye labelling reagents with meso-substitution |
US20080102036A1 (en) * | 2003-06-04 | 2008-05-01 | Poss Kirtland G | Biocompatible Fluorescent Silicon Nanoparticles |
US7282339B2 (en) | 2003-09-17 | 2007-10-16 | Invitrogen Corporation | Competitive immunoassay |
WO2006020947A2 (en) | 2004-08-13 | 2006-02-23 | Epoch Biosciences, Inc. | Phosphonate fluorescent dyes and conjugates |
US7569695B2 (en) * | 2005-05-24 | 2009-08-04 | Enzo Life Sciences, Inc. | Dyes for the detection or quantification of desirable target molecules |
US8357801B2 (en) | 2005-05-24 | 2013-01-22 | Enzo Life Sciences, Inc. | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits |
US7737281B2 (en) * | 2005-05-24 | 2010-06-15 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Purine based fluorescent dyes |
US9574085B2 (en) * | 2005-09-02 | 2017-02-21 | Visen Medical, Inc. | Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels |
US8173819B2 (en) | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
EP1937676B1 (de) * | 2005-09-02 | 2016-11-30 | Visen Medical, Inc. | Biologisch kompatible, fluoreszente mittel zur bilddarstellung |
ES2434491T3 (es) | 2005-10-13 | 2013-12-16 | Funda��O D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud | An�lisis inmunohistoqu�mico multiplex in situ |
ATE500778T1 (de) | 2005-12-22 | 2011-03-15 | Visen Medical Inc | Kombiniertes röntgen- und optisches tomographie- bildgebungssystem |
EP1973575B1 (de) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biokompatibele fluoreszierende metalloxide nanopartikel |
ITSV20060002A1 (it) * | 2006-01-19 | 2007-07-20 | Ferrania Technologies Spa | Colorante fluorescente di tipo cianinico |
WO2007087582A1 (en) | 2006-01-24 | 2007-08-02 | Invitrogen Corporation | Device and methods for quantifying analytes |
DK1987068T3 (en) | 2006-02-10 | 2018-09-03 | Life Technologies Corp | OLIGOSACCHARID MODIFICATION AND LABELING OF PROTEINS |
US8114636B2 (en) | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
US8562802B1 (en) | 2006-02-13 | 2013-10-22 | Life Technologies Corporation | Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems |
MX2008012167A (es) | 2006-03-23 | 2009-01-07 | Absorber Ab | Antigenos de grupo sanguineo de diferentes tipos para aplicaciones de diagnostico y terapeuticas. |
US8623639B2 (en) | 2006-04-20 | 2014-01-07 | Becton, Dickinson And Company | Thermostable proteins and methods of making and using thereof |
EP2118206B9 (de) | 2007-02-09 | 2018-08-29 | Visen Medical, Inc. | Polycyclofarbstoffe und verwendung davon |
US8906354B2 (en) | 2007-02-28 | 2014-12-09 | Bruker Biospin Corporation | Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes |
US8017104B2 (en) | 2007-02-28 | 2011-09-13 | Carestream Health, Inc. | Large stoke shift dye used for optical imaging |
WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
WO2009055095A1 (en) | 2007-10-19 | 2009-04-30 | Visen Medical, Inc. | Imaging systems featuring waveguiding compensation |
EP2244741B1 (de) | 2008-01-18 | 2015-03-25 | VisEn Medical, Inc. | Fluoreszierende bildgebungsmittel |
WO2009114776A2 (en) | 2008-03-14 | 2009-09-17 | Visen Medical, Inc. | Integrin targeting agents and methods of using same |
CN102119223A (zh) | 2008-05-16 | 2011-07-06 | 生命技术公司 | 用于测量细胞增殖的双标记法 |
US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
US20110021908A1 (en) | 2009-05-27 | 2011-01-27 | Lumicell Diagnostics, Inc. | Methods and systems for spatially identifying abnormal cells |
US9155471B2 (en) | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
CA2809798C (en) | 2009-08-28 | 2018-09-18 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
EP2473563B1 (de) | 2009-08-31 | 2019-06-19 | Promega Corporation | Reaktive cyaninverbindungen |
CN102781307B (zh) | 2009-09-22 | 2016-01-20 | 文森医学公司 | 用于漫射性介质虚拟折射率匹配的系统和方法 |
CN101747655B (zh) * | 2009-12-24 | 2013-04-03 | 渤海大学 | 含薁类结构水溶性菁染料及其合成方法 |
WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
US9314304B2 (en) | 2010-12-08 | 2016-04-19 | Lumicell, Inc. | Methods and system for image guided cell ablation with microscopic resolution |
CN110204478A (zh) * | 2011-05-09 | 2019-09-06 | 文森医学公司 | 碳酸酐酶靶向剂及其使用方法 |
US9375493B2 (en) | 2012-03-30 | 2016-06-28 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
JP6370785B2 (ja) | 2012-08-15 | 2018-08-08 | ビセン メディカル, インコーポレイテッド | 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法 |
WO2014062716A1 (en) | 2012-10-15 | 2014-04-24 | Visen Medical, Inc. | Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources |
EP2912459A2 (de) | 2012-10-25 | 2015-09-02 | Life Technologies Corporation | Verfahren und zusammensetzungen zur enzymvermittelten stellenspezifischen radioaktiven markierung von glykoproteinen |
CA2902982C (en) * | 2013-03-08 | 2020-08-04 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
EP2967280A4 (de) | 2013-03-14 | 2016-09-28 | Lumicell Inc | Medizinische bildgebungsvorrichtung und verfahren zur verwendung |
EP2970342B1 (de) | 2013-03-15 | 2024-01-24 | VisEn Medical, Inc. | Substituiertes silaxanthenium-rot für nahinfrarot-fluorchrome zur in-vitro- und in-vivo-bildgebung und -erkennung |
WO2014144702A2 (en) | 2013-03-15 | 2014-09-18 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
KR102501920B1 (ko) | 2013-10-02 | 2023-02-20 | 메디뮨 엘엘씨 | 중화 항-인플루엔자 a 항체 및 이의 용도 |
US10542918B2 (en) | 2013-10-23 | 2020-01-28 | Verily Life Sciences Llc | Modulation of a response signal to distinguish between analyte and background signals |
US9504405B2 (en) | 2013-10-23 | 2016-11-29 | Verily Life Sciences Llc | Spatial modulation of magnetic particles in vasculature by external magnetic field |
JP5824729B2 (ja) * | 2013-12-18 | 2015-11-25 | 東洋インキScホールディングス株式会社 | カラーフィルタ用着色組成物、およびカラーフィルタ |
CN106455979A (zh) | 2013-12-31 | 2017-02-22 | 纪念斯隆-凯特琳癌症中心 | 用于荧光源实时多通道成像的系统、方法和设备 |
KR20170094268A (ko) | 2014-12-15 | 2017-08-17 | 메모리얼 슬로안-케터링 캔서 센터 | 향상된 신경-결합 선택성을 갖는 고리형 펩티드, 상기 고리형 펩티드와 결합된 나노입자, 및 실시간 생체내 신경 조직 영상화를 위한 이들의 용도 |
US9861710B1 (en) | 2015-01-16 | 2018-01-09 | Verily Life Sciences Llc | Composite particles, methods, and in vivo diagnostic system |
US10028659B2 (en) | 2015-03-26 | 2018-07-24 | Verily Life Sciences Llc | Aptamer-based sensors, implantable devices and detection system |
GB201516987D0 (en) | 2015-09-25 | 2015-11-11 | Illumina Cambridge Ltd | Polymethine compounds and their use as fluorescent labels |
AU2016362673A1 (en) * | 2015-12-01 | 2018-06-28 | Dishman Carbogen Amcis Limited | An improved process for the preparation of indocyanine green |
EP3389726A1 (de) | 2015-12-15 | 2018-10-24 | Memorial Sloan Kettering Cancer Center | Bildgebungssysteme und -verfahren zur differenzierung von gewebe, z.b. zur intraoperativen visualisierung |
EP3443126B1 (de) | 2016-04-15 | 2023-11-15 | Icahn School of Medicine at Mount Sinai | Gewebeprofilierung unter verwendung von multiplexierten immunhistochemischen aufeinanderfolgenden färbungen |
RU2637310C1 (ru) * | 2016-06-08 | 2017-12-04 | Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) | Флуоресцентно-меченые дезоксиуридинтрифосфаты |
WO2018031448A1 (en) | 2016-08-11 | 2018-02-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near-ir light-cleavable conjugates and conjugate precursors |
CN110167601A (zh) | 2016-11-30 | 2019-08-23 | 纪念斯隆凯特琳癌症中心 | 抑制剂-功能化超微小纳米粒子和其方法 |
CN110546273A (zh) | 2017-03-30 | 2019-12-06 | 生命技术公司 | 通过衔接子序列定量ngs dna |
US20220002716A1 (en) | 2020-07-02 | 2022-01-06 | Life Technologies Corporation | Trinucleotide cap analogs, preparation and uses thereof |
EP4015004A1 (de) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglykanspezifische verzweigte peptide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1287000A (fr) * | 1961-03-07 | 1962-03-09 | Gevaert Photo Prod Nv | Procédé pour la sensibilisation d'émulsions photographiques |
US5556959A (en) * | 1993-01-22 | 1996-09-17 | Pharmacia P-L Biochemicals Inc. | Indocarbocyanine-linked phosphoramidites |
US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
US5714386A (en) * | 1996-01-11 | 1998-02-03 | Board Of Trustees Of The Leland Stanford Junior University | Cy7-allophycocyanin conjugates for use in multiplex fluorescence detection assays |
-
1999
- 1999-07-02 ES ES04023147T patent/ES2329572T3/es not_active Expired - Lifetime
- 1999-07-02 AT AT99112696T patent/ATE284433T1/de not_active IP Right Cessation
- 1999-07-02 AT AT04023147T patent/ATE435262T1/de not_active IP Right Cessation
- 1999-07-02 EP EP04023147A patent/EP1491591B1/de not_active Expired - Lifetime
- 1999-07-02 EP EP99112696A patent/EP1065250B1/de not_active Expired - Lifetime
- 1999-07-02 DE DE69922498T patent/DE69922498T2/de not_active Expired - Lifetime
- 1999-07-02 DE DE69941067T patent/DE69941067D1/de not_active Expired - Lifetime
-
2000
- 2000-06-21 AU AU42581/00A patent/AU776841B2/en not_active Expired
- 2000-06-22 CA CA002312099A patent/CA2312099C/en not_active Expired - Lifetime
- 2000-06-30 US US09/609,035 patent/US6448008B1/en not_active Expired - Lifetime
- 2000-07-03 BR BR0005843-2A patent/BR0005843A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE435262T1 (de) | 2009-07-15 |
EP1065250A1 (de) | 2001-01-03 |
DE69922498T2 (de) | 2005-12-08 |
EP1491591A1 (de) | 2004-12-29 |
ES2329572T3 (es) | 2009-11-27 |
ATE284433T1 (de) | 2004-12-15 |
DE69941067D1 (de) | 2009-08-13 |
EP1065250B1 (de) | 2004-12-08 |
CA2312099A1 (en) | 2001-01-02 |
AU4258100A (en) | 2001-01-11 |
BR0005843A (pt) | 2002-01-02 |
AU776841B2 (en) | 2004-09-23 |
CA2312099C (en) | 2009-05-12 |
US6448008B1 (en) | 2002-09-10 |
EP1491591B1 (de) | 2009-07-01 |
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Legal Events
Date | Code | Title | Description |
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8364 | No opposition during term of opposition |