KR930701419A - 예정된 대칭성을 갖는 킬레이트제 제조를 위한 중간체 및 그의 제조 방법 - Google Patents
예정된 대칭성을 갖는 킬레이트제 제조를 위한 중간체 및 그의 제조 방법Info
- Publication number
- KR930701419A KR930701419A KR1019930700568A KR930700568A KR930701419A KR 930701419 A KR930701419 A KR 930701419A KR 1019930700568 A KR1019930700568 A KR 1019930700568A KR 930700568 A KR930700568 A KR 930700568A KR 930701419 A KR930701419 A KR 930701419A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- formula
- compound
- substituted
- alkyl
- Prior art date
Links
- 239000002738 chelating agent Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- -1 1,7-disubstituted 1,4,7,10- tetraazacyclododecane Chemical class 0.000 claims 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000004036 acetal group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
하기 일반식(Ⅰ) (식중, R 및 R1은 특허 청구 범위 제1항에 정의한 바와 같음)의 화합물을 제조하는 방법이 제공되며, 이 화합물(Ⅰ)은 킬레이트제 제조에 이용되는 중간체이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 하기 일반식(Ⅰ)의 1,7-이치환 1,4,7,10-테트라아자시클로도데칸.
-
- 상기 식중, R은 포르밀기 또는 그의 유도체이고, R1은 a) 단백질과 결합할 수 있는 기 (예를 들면, OH, NH2, COOH, CHO, SH 등) 또는 그의 전구체 (예를 들면, NO2, NO, CN, COOR 등)에 의해 치환되거나 또는 치환 되지 않는 직쇄 또는 분지쇄 C1-C20알킬기, b) 아릴 부분이 1종 이상의 C1-C4알킬, C1-C4알콕시 또는 할로겐기 또는 단백질과 결합할 수 있는 (예를 들면, OH, NH2, COOH, CHO, SH등) 또는 그의 전구체 (예를 들면, NO2, NO, CN, COOR등)에 의해 치환되거나 또는 치환되지 않은 C7-C19아릴알킬기, c) C1-C4알콕시카르보닐메틸 또는 2-[C1-C4알콕시카르보닐]에틸기, d) 식-(CH2)n-R2(여기서, n은 1내지 4이고, R2는 유리 또는 보호된 포르밀기 (예를 들면, 아세탈기)임)의 기 또는그의 전구체이다.
- 제1항에 있어서 R1이 C6-C18알킬, 벤질, 트리페닐메틸, t-부톡시카르보닐메틸 또는 식-(CH2)n-R2(여기서, n은 1 내지 2이고, R2는 -CH(OCH|3)2, -CH(OC2H5)2또는 1,3-디옥솔-2-일기임)의 기인 일반식(Ⅰ)의 1,7-이치환 1,4,7,10-테트라아자시클로도데칸.
- 하기 반응식에 따라서 일반식(Ⅱ)의 R1-치환 테트라아자시클로도테칸을 일반식(Ⅲ)의 N,N-디알킬포름아미드의 디알킬아세탈과 반응시키거나 또는 일반식(Ⅴ)의 화합물을 R1-X 화합물로 알킬화시켜서 얻어지는 일반식(Ⅳ)의 대응 유도체를 가수분해시키는 것으로 이루어지는 제1항 또는 2항에 기재된 화합물의 제조 방법.
-
- 상기 식중, R1은 상기 정의한 바와 같고, X는 이탈기 (바람직하게는 염소 또는 브롬)이고, R3및 R4는 서로 동일 또는 상이한 것으로서, C1-C4알킬, 바람직하게는 에틸 또는 메틸이다.
- 제1항 또는 2항에 기재된 일반식(Ⅰ)의 화합물을 제조하는데 유용한 하기 일반식(Ⅳ)의 화합물.
-
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02131890A IT1243801B (it) | 1990-08-29 | 1990-08-29 | Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione |
| IT21318A/90 | 1990-08-29 | ||
| PCT/EP1991/001546 WO1992004336A1 (en) | 1990-08-29 | 1991-08-14 | Intermediates for chelating agents with prefixed symmetry and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930701419A true KR930701419A (ko) | 1993-06-11 |
Family
ID=11180039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930700568A KR930701419A (ko) | 1990-08-29 | 1991-08-14 | 예정된 대칭성을 갖는 킬레이트제 제조를 위한 중간체 및 그의 제조 방법 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5424423A (ko) |
| EP (1) | EP0545983B1 (ko) |
| JP (1) | JP3119872B2 (ko) |
| KR (1) | KR930701419A (ko) |
| AT (1) | ATE113278T1 (ko) |
| AU (1) | AU650903B2 (ko) |
| CA (1) | CA2090433A1 (ko) |
| DE (2) | DE69104842T2 (ko) |
| DK (1) | DK0545983T3 (ko) |
| ES (1) | ES2041617T3 (ko) |
| GR (1) | GR930300084T1 (ko) |
| IT (1) | IT1243801B (ko) |
| WO (1) | WO1992004336A1 (ko) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5539105A (en) * | 1990-08-29 | 1996-07-23 | Dibra S.P.A. | Intermediates for chelating agents with prefixed symmetry and process for their preparation |
| US6875864B2 (en) | 1991-08-01 | 2005-04-05 | Bracco International B.V. | Aminocarboxylate ligands having substituted aromatic amide moieties |
| US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
| DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
| DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
| EP0588229A3 (en) * | 1992-09-12 | 1994-06-15 | Hoechst Ag | Macrocyclic chelating agents for the preparation of technetium or rhenium complexes |
| EP0702677A1 (en) * | 1994-04-08 | 1996-03-27 | BRACCO International B.V. | Aromatic amide compounds and metal chelates thereof |
| US6693190B1 (en) | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
| FR2725449B1 (fr) * | 1994-10-05 | 1996-12-27 | Air Liquide | Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes |
| GB9504910D0 (en) * | 1995-03-10 | 1995-04-26 | Nycomed Imaging As | Compounds |
| GB9504922D0 (en) * | 1995-03-10 | 1995-04-26 | Nycomed As | Process |
| IT1292130B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3979379A (en) * | 1975-04-25 | 1976-09-07 | The United States Of America As Represented By The Secretary Of The Army | Process for producing 1,3,5,7-tetraalkanoyl-1,3,5,7-octahydrotetrazocines |
| US4085106A (en) * | 1976-01-07 | 1978-04-18 | E. I. Du Pont De Nemours And Company | Bicyclic and tricyclic trisaminomethanes |
| JPS53144593A (en) * | 1977-05-19 | 1978-12-15 | Iwao Tabuse | Alklycyclum |
| JPS5672070A (en) * | 1979-11-14 | 1981-06-16 | Iwao Tabuse | Preparation of uranyl ion trapping agent |
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US5247077A (en) * | 1989-06-23 | 1993-09-21 | Celltech Limited | Tri-aza macrocycles and processes for their preparation |
-
1990
- 1990-08-29 IT IT02131890A patent/IT1243801B/it active IP Right Grant
-
1991
- 1991-08-14 AT AT91914890T patent/ATE113278T1/de active
- 1991-08-14 DK DK91914890.8T patent/DK0545983T3/da active
- 1991-08-14 DE DE69104842T patent/DE69104842T2/de not_active Expired - Fee Related
- 1991-08-14 CA CA002090433A patent/CA2090433A1/en not_active Abandoned
- 1991-08-14 US US08/030,007 patent/US5424423A/en not_active Expired - Fee Related
- 1991-08-14 DE DE91914890T patent/DE545983T1/de active Pending
- 1991-08-14 EP EP91914890A patent/EP0545983B1/en not_active Expired - Lifetime
- 1991-08-14 KR KR1019930700568A patent/KR930701419A/ko not_active Application Discontinuation
- 1991-08-14 AU AU84125/91A patent/AU650903B2/en not_active Ceased
- 1991-08-14 WO PCT/EP1991/001546 patent/WO1992004336A1/en active IP Right Grant
- 1991-08-14 ES ES91914890T patent/ES2041617T3/es not_active Expired - Lifetime
- 1991-08-14 JP JP03513884A patent/JP3119872B2/ja not_active Expired - Fee Related
-
1993
- 1993-09-30 GR GR930300084T patent/GR930300084T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0545983B1 (en) | 1994-10-26 |
| CA2090433A1 (en) | 1992-03-01 |
| IT9021318A0 (it) | 1990-08-29 |
| ES2041617T1 (es) | 1993-12-01 |
| JPH06503303A (ja) | 1994-04-14 |
| DE69104842T2 (de) | 1995-03-23 |
| US5424423A (en) | 1995-06-13 |
| ES2041617T3 (es) | 1994-12-16 |
| IT1243801B (it) | 1994-06-28 |
| DK0545983T3 (da) | 1994-11-28 |
| IT9021318A1 (it) | 1992-02-29 |
| AU650903B2 (en) | 1994-07-07 |
| GR930300084T1 (en) | 1993-09-30 |
| WO1992004336A1 (en) | 1992-03-19 |
| JP3119872B2 (ja) | 2000-12-25 |
| DE545983T1 (de) | 1993-10-14 |
| ATE113278T1 (de) | 1994-11-15 |
| DE69104842D1 (de) | 1994-12-01 |
| AU8412591A (en) | 1992-03-30 |
| EP0545983A1 (en) | 1993-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |