KR830007622A - 이소퀴놀린 유도체의 제조방법 - Google Patents

이소퀴놀린 유도체의 제조방법 Download PDF

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Publication number
KR830007622A
KR830007622A KR1019810003356A KR810003356A KR830007622A KR 830007622 A KR830007622 A KR 830007622A KR 1019810003356 A KR1019810003356 A KR 1019810003356A KR 810003356 A KR810003356 A KR 810003356A KR 830007622 A KR830007622 A KR 830007622A
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KR
South Korea
Prior art keywords
formula
alkyl
compound
halogen
alkoxy
Prior art date
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KR1019810003356A
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English (en)
Inventor
콘쯔 엘마
호크 프란쯔
카이저 요아힘
예르크 크루제 한스
Original Assignee
하인리히 베커, 베른하르트 벡크
훽스트 아크티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 하인리히 베커, 베른하르트 벡크, 훽스트 아크티엔 게젤샤프트 filed Critical 하인리히 베커, 베른하르트 벡크
Publication of KR830007622A publication Critical patent/KR830007622A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

내용 없음

Description

이소퀴놀린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (a) 다음 구조식(Ⅱ)의 화합물을 구조식(Ⅲ)의 화합물과 반응시키거나,
    상기 구조식에서
    Y는 할로겐, 또는 알콕시 또는 알킬티오(각각 알킬부위에 1 내지 4개의 탄소함유)이고
    R1, R2, R3, m 및 n은 하기 구조식(Ⅰ)에서와 같고
    (b) 구조식(Ⅳ)의 화합물을 구조식(Ⅴ)의 화합물과 반응시키거나, 또는
    상기 구조식에서
    R2, R3및 m은 하기 구조식(Ⅰ)에서와 같고
    Hal은 할로겐을 나타내며,
    R5는 수소, C1∼C6-알킬 또는 구조식(Ⅰ)에서 R1(c) 또는 R1(e)로 표시한 기와 같고,
    (c) 구조식(Ⅰa)의 화합물을 구조식 Z-R6(Z는 요드, 염소 또는 브롬이며 R6는 구조식(Ⅰ)의 R1(b)에서의 알킬을 나타냄)의 알킬화제 또는 구조식 Cl-CO2(C1-C6)-알킬의 클로로포름산 에스테르 또는 구조식 Cl-(CH2)q-COR4(R5, q는 구조식(Ⅰ)의 R1(f)에서와 같음)의 화합물과 반응시켜,
    다음 구조식(Ⅰ)이 이소퀴놀린 유도체 및 이들의 생리적으로 무독한 염을 제조하는 방법.
    상기 구조식에서
    m은 1 또는 2이고
    n은 1 또는 2이며
    R1은 (a) 수소, (b) 하이드록실로 임의로 치환된 직쇄 또는 측쇄 C1∼C6알킬, C1∼C4알콕시 또는 C3∼C6-사이클로알킬, (c) 티에닐, 푸릴, 피리딜 또는 피리미딜, (d) 포밀 또는 C1∼C6-알콕시카보닐, (e) C1∼C6-알킬, C1∼C6알콕시, 메틸렌디옥시, 하이드록실, 니트로, 아미노, 트리플루오로메틸 또는 할로겐 등에 의해 일치환, 이치환 또는 삼치환될 수 있는 페닐, (f)-(CH2)q-COR4(q는 0,1,2,3 또는 4이며 R4는 티에틸, 푸릴, 피리딜 또는 상기 (e)항의 페닐에서와 같이 임의로 치환된 페닐기) 및 (g)
    를 나타내며(Hal은 할로겐)
    R2는 수소 또는 C1∼C6-알킬이고
    R3는 수소, 할로겐, 하이드록실, C1∼C6알킬, C1∼C6알콕시, 벤질옥시, 메틸렌디옥시, 에틸렌디옥시, 니트로 또는 아미노를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810003356A 1980-09-10 1981-09-08 이소퀴놀린 유도체의 제조방법 KR830007622A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803034001 DE3034001A1 (de) 1980-09-10 1980-09-10 Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung
DE3034001.3 1980-09-10

Publications (1)

Publication Number Publication Date
KR830007622A true KR830007622A (ko) 1983-11-04

Family

ID=6111554

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003356A KR830007622A (ko) 1980-09-10 1981-09-08 이소퀴놀린 유도체의 제조방법

Country Status (20)

Country Link
US (1) US4590273A (ko)
EP (1) EP0047923B1 (ko)
JP (1) JPS5780372A (ko)
KR (1) KR830007622A (ko)
AT (1) ATE7389T1 (ko)
AU (1) AU541976B2 (ko)
CA (1) CA1168232A (ko)
DE (2) DE3034001A1 (ko)
DK (1) DK400681A (ko)
ES (3) ES8206511A1 (ko)
FI (1) FI71734C (ko)
GR (1) GR74978B (ko)
HU (1) HU187357B (ko)
IE (1) IE51551B1 (ko)
IL (1) IL63765A (ko)
NO (1) NO813066L (ko)
NZ (1) NZ198308A (ko)
PH (1) PH19431A (ko)
PT (1) PT73629B (ko)
ZA (1) ZA816237B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4656174A (en) * 1982-07-24 1987-04-07 Pfizer Inc. Quinoline therapeutic agents
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
US4544657A (en) * 1983-05-19 1985-10-01 Hoffmann-La Roche Inc. Substituted isoquinolines
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4843077A (en) * 1987-06-09 1989-06-27 Ortho Pharmaceutical Corporation Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
US5332733A (en) * 1990-11-24 1994-07-26 Kali-Chemie Pharma Gmbh Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
US6008352A (en) * 1997-04-03 1999-12-28 Neurogen Corporation 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands
US6313141B1 (en) 1997-06-13 2001-11-06 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine D4 ligands
US5972945A (en) * 1997-06-13 1999-10-26 Neurogen Corporation 2-aminoalkylaminoquinolines; dopamine receptor subtype specific ligands
EP1020445B1 (en) * 1997-10-02 2008-08-13 Eisai R&D Management Co., Ltd. Fused pyridine derivatives
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
DE69826883T2 (de) * 1997-10-27 2005-02-03 Neurosearch A/S Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren
US6613901B2 (en) 2000-03-08 2003-09-02 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine D4 ligands
CA2657702A1 (en) * 2006-07-03 2008-01-10 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek E N Patieentenzorg Quinazolines and related heterocyclic comp0unds, and their therapeutic use
MX2013006101A (es) * 2010-12-17 2013-07-02 Hoffmann La Roche Compuestos heterociclicos nitrogenados sustituidos fusionados en posicion 6,6 y usos de los mismos.
TW201843139A (zh) 2017-03-30 2018-12-16 瑞士商赫孚孟拉羅股份公司 作為ｈｐｋ１之抑制劑的異喹啉
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof

Family Cites Families (10)

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US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
GB1244501A (en) * 1968-03-09 1971-09-02 Aspro Nicholas Ltd Heterocyclic amines
DE2030675A1 (en) * 1969-06-23 1971-02-11 Arthur D Little, Inc , Cambridge, Mass (V St A) 3-amino-4-phenyl-isoquinoline derivs
US3932412A (en) * 1970-12-07 1976-01-13 Sandoz, Inc. 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates
DE2420012C3 (de) * 1974-04-25 1980-01-10 Dr. Karl Thomae Gmbh, 7950 Biberach Isochinoline
AT342057B (de) * 1974-04-25 1978-03-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen
DE2503961C3 (de) * 1975-01-31 1980-02-28 Dr. Karl Thomae Gmbh, 7950 Biberach Isochinoline
DE2811312A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln
DE2818403A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI812783L (fi) 1982-03-11
ES505191A0 (es) 1982-08-16
DK400681A (da) 1982-03-11
US4590273A (en) 1986-05-20
PH19431A (en) 1986-04-15
IE51551B1 (en) 1987-01-07
ES8305351A1 (es) 1983-04-01
AU7509181A (en) 1982-03-18
ES8206511A1 (es) 1982-08-16
JPS5780372A (en) 1982-05-19
HU187357B (en) 1985-12-28
PT73629A (de) 1981-10-01
AU541976B2 (en) 1985-01-31
GR74978B (ko) 1984-07-12
IL63765A (en) 1985-05-31
IL63765A0 (en) 1981-12-31
ATE7389T1 (de) 1984-05-15
DE3163510D1 (en) 1984-06-14
IE812094L (en) 1982-03-10
ES506584A0 (es) 1983-03-01
EP0047923B1 (de) 1984-05-09
DE3034001A1 (de) 1982-04-22
ES8304563A1 (es) 1983-03-01
NO813066L (no) 1982-03-11
ZA816237B (en) 1982-08-25
FI71734B (fi) 1986-10-31
ES506583A0 (es) 1983-04-01
PT73629B (de) 1983-04-29
EP0047923A1 (de) 1982-03-24
CA1168232A (en) 1984-05-29
FI71734C (fi) 1987-02-09
NZ198308A (en) 1984-03-30

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