ES8206511A1 - Procedimiento para la preparacion de derivados de isoquino- leina - Google Patents

Procedimiento para la preparacion de derivados de isoquino- leina

Info

Publication number
ES8206511A1
ES8206511A1 ES505191A ES505191A ES8206511A1 ES 8206511 A1 ES8206511 A1 ES 8206511A1 ES 505191 A ES505191 A ES 505191A ES 505191 A ES505191 A ES 505191A ES 8206511 A1 ES8206511 A1 ES 8206511A1
Authority
ES
Spain
Prior art keywords
preparation
isoquinoline derivatives
processes
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505191A
Other languages
English (en)
Other versions
ES505191A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES505191A0 publication Critical patent/ES505191A0/es
Publication of ES8206511A1 publication Critical patent/ES8206511A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ISOQUINOLEINA Y DE SUS SALES CON ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE M Y N VALEN 1 O 2, R2 ES HIDROGENO O ALOHILO C1-6 Y R1 Y R3 PUEDEN SER VARIOS RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON DOS EQUIVALENTES AL MENOS DE UNA AMINA DE FORMULA (III), EN LAS QUE Y ES HALOGENO, ALCOHILOXI O ALCOHILTIO C1-4, Y LOS DEMAS SIMBOLOS TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE O EN UNA MINA LIQUIDA QUE ACTUA TAMBIEN COMO ACEPTOR DE ACIDO, A UNA TEMPERATURA ENTRE 80 Y 220C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS SOBRE EL SISTEMA NERVIOSO CENTRAL Y SOBRE EL SISTEMA CIRCULATORIO CARDIACO.
ES505191A 1980-09-10 1981-09-04 Procedimiento para la preparacion de derivados de isoquino- leina Expired ES8206511A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803034001 DE3034001A1 (de) 1980-09-10 1980-09-10 Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung

Publications (2)

Publication Number Publication Date
ES505191A0 ES505191A0 (es) 1982-08-16
ES8206511A1 true ES8206511A1 (es) 1982-08-16

Family

ID=6111554

Family Applications (3)

Application Number Title Priority Date Filing Date
ES505191A Expired ES8206511A1 (es) 1980-09-10 1981-09-04 Procedimiento para la preparacion de derivados de isoquino- leina
ES506583A Granted ES506583A0 (es) 1980-09-10 1981-10-27 Procedimiento para la preparacion de derivados de isoquino- leina
ES506584A Expired ES8304563A1 (es) 1980-09-10 1981-10-27 Procedimiento para la preparacion de derivados de isoquino- leina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES506583A Granted ES506583A0 (es) 1980-09-10 1981-10-27 Procedimiento para la preparacion de derivados de isoquino- leina
ES506584A Expired ES8304563A1 (es) 1980-09-10 1981-10-27 Procedimiento para la preparacion de derivados de isoquino- leina

Country Status (20)

Country Link
US (1) US4590273A (es)
EP (1) EP0047923B1 (es)
JP (1) JPS5780372A (es)
KR (1) KR830007622A (es)
AT (1) ATE7389T1 (es)
AU (1) AU541976B2 (es)
CA (1) CA1168232A (es)
DE (2) DE3034001A1 (es)
DK (1) DK400681A (es)
ES (3) ES8206511A1 (es)
FI (1) FI71734C (es)
GR (1) GR74978B (es)
HU (1) HU187357B (es)
IE (1) IE51551B1 (es)
IL (1) IL63765A (es)
NO (1) NO813066L (es)
NZ (1) NZ198308A (es)
PH (1) PH19431A (es)
PT (1) PT73629B (es)
ZA (1) ZA816237B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GR79603B (es) * 1982-07-24 1984-10-31 Pfizer
DE3244594A1 (de) * 1982-12-02 1984-06-07 Hoechst Ag, 6230 Frankfurt 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung
US4544657A (en) * 1983-05-19 1985-10-01 Hoffmann-La Roche Inc. Substituted isoquinolines
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4843077A (en) * 1987-06-09 1989-06-27 Ortho Pharmaceutical Corporation Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
US5332733A (en) * 1990-11-24 1994-07-26 Kali-Chemie Pharma Gmbh Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
US6008352A (en) * 1997-04-03 1999-12-28 Neurogen Corporation 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands
US6313141B1 (en) 1997-06-13 2001-11-06 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine D4 ligands
US5972945A (en) * 1997-06-13 1999-10-26 Neurogen Corporation 2-aminoalkylaminoquinolines; dopamine receptor subtype specific ligands
DE69839887D1 (de) * 1997-10-02 2008-09-25 Eisai R&D Man Co Ltd Kondensierte pyridinderivate
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
CZ299499B6 (cs) * 1997-10-27 2008-08-13 Neurosearch A/S Homopiperazinový derivát, farmaceutická kompoziceho obsahující a jeho použití
US6613901B2 (en) 2000-03-08 2003-09-02 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine D4 ligands
US20100016293A1 (en) * 2006-07-03 2010-01-21 Rogier Adriaan Smits Quinazolines and Related Heterocyclic Compounds, and Their Therapeutic Use
US8623889B2 (en) * 2010-12-17 2014-01-07 Genentech, Inc. Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof
BR112019019555A2 (pt) 2017-03-30 2020-04-22 Hoffmann La Roche composto de fórmula i, composição farmacêutica, método de inibição de hpk1, método para melhorar uma resposta imune, método para tratar um distúrbio e uso do composto
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
GB1244501A (en) * 1968-03-09 1971-09-02 Aspro Nicholas Ltd Heterocyclic amines
DE2030675A1 (en) * 1969-06-23 1971-02-11 Arthur D Little, Inc , Cambridge, Mass (V St A) 3-amino-4-phenyl-isoquinoline derivs
US3932412A (en) * 1970-12-07 1976-01-13 Sandoz, Inc. 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates
DE2420012C3 (de) * 1974-04-25 1980-01-10 Dr. Karl Thomae Gmbh, 7950 Biberach Isochinoline
DE2503961C3 (de) * 1975-01-31 1980-02-28 Dr. Karl Thomae Gmbh, 7950 Biberach Isochinoline
AT342057B (de) * 1974-04-25 1978-03-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen
DE2811312A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln
DE2818403A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
CA1168232A (en) 1984-05-29
DE3163510D1 (en) 1984-06-14
IE51551B1 (en) 1987-01-07
ES505191A0 (es) 1982-08-16
ES8305351A1 (es) 1983-04-01
ATE7389T1 (de) 1984-05-15
KR830007622A (ko) 1983-11-04
ES506584A0 (es) 1983-03-01
DE3034001A1 (de) 1982-04-22
GR74978B (es) 1984-07-12
PT73629A (de) 1981-10-01
EP0047923B1 (de) 1984-05-09
IL63765A (en) 1985-05-31
DK400681A (da) 1982-03-11
JPS5780372A (en) 1982-05-19
AU541976B2 (en) 1985-01-31
ES506583A0 (es) 1983-04-01
FI71734B (fi) 1986-10-31
ZA816237B (en) 1982-08-25
AU7509181A (en) 1982-03-18
US4590273A (en) 1986-05-20
IE812094L (en) 1982-03-10
FI812783L (fi) 1982-03-11
IL63765A0 (en) 1981-12-31
HU187357B (en) 1985-12-28
PT73629B (de) 1983-04-29
NO813066L (no) 1982-03-11
FI71734C (fi) 1987-02-09
ES8304563A1 (es) 1983-03-01
NZ198308A (en) 1984-03-30
PH19431A (en) 1986-04-15
EP0047923A1 (de) 1982-03-24

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