ES8504183A1 - Un nuevo procedimiento para la preparacion de nuevos cromanos y cromenos. - Google Patents

Un nuevo procedimiento para la preparacion de nuevos cromanos y cromenos.

Info

Publication number
ES8504183A1
ES8504183A1 ES526516A ES526516A ES8504183A1 ES 8504183 A1 ES8504183 A1 ES 8504183A1 ES 526516 A ES526516 A ES 526516A ES 526516 A ES526516 A ES 526516A ES 8504183 A1 ES8504183 A1 ES 8504183A1
Authority
ES
Spain
Prior art keywords
chromenes
chromans
novel
solvate
pharmaceuticals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526516A
Other languages
English (en)
Other versions
ES526516A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838313677A external-priority patent/GB8313677D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8504183A1 publication Critical patent/ES8504183A1/es
Publication of ES526516A0 publication Critical patent/ES526516A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS CROMANOS Y CROMENOS.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN ANION DE FORMULA (III) PARA OBTENER NUEVOS CROMANOS Y CROMENOS DE FORMULA (I) Y POSTERIORMENTE ALQUILAR O ACILAR, DESHIDRATAR, REDUCIR, SOMETER A TIACION EL GRUPO CARBONILO DEL ANILLO DE LACTAMA DEL COMPUESTO DE FORMULA (I), DONDE R1 O R2 SON H, (ALQUIL C 1 A 6) CARBONILO Y OTROS; R3 O R4 SON H, ALQUILO C 1 A 4 O POLIMETILENO C 2 A 5; R5 ES H, HIDROXI, ALCOXI C 1 A 6; Q ES O O S; R6 ES H; M ES 0 A 2; N ES 0 A 2; X ES O O S O N-R7; R7 ES H, ALQUILO C 1 A 9 Y OTROS.TIENEN APLICACION POR SU ACTIVIDAD ANTI-HIPERTENSIVA.
ES526516A 1982-10-19 1983-10-17 Un nuevo procedimiento para la preparacion de nuevos cromanos y cromenos. Granted ES526516A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8229789 1982-10-19
GB838313677A GB8313677D0 (en) 1983-05-18 1983-05-18 Active compounds

Publications (2)

Publication Number Publication Date
ES8504183A1 true ES8504183A1 (es) 1985-04-16
ES526516A0 ES526516A0 (es) 1985-04-16

Family

ID=26284168

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526516A Granted ES526516A0 (es) 1982-10-19 1983-10-17 Un nuevo procedimiento para la preparacion de nuevos cromanos y cromenos.

Country Status (10)

Country Link
US (1) US4496565A (es)
EP (1) EP0107423B1 (es)
JP (1) JPS5993076A (es)
AU (1) AU567893B2 (es)
CA (1) CA1212946A (es)
DE (1) DE3364734D1 (es)
ES (1) ES526516A0 (es)
GR (1) GR78699B (es)
IE (1) IE56150B1 (es)
NZ (1) NZ205987A (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3475786D1 (de) * 1983-09-01 1989-02-02 Beecham Group Plc Chromanol derivatives
DE3579390D1 (de) * 1984-06-22 1990-10-04 Beecham Group Plc Wirksame benzopyranverbindungen.
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
DE3682331D1 (de) * 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
ES2058148T3 (es) * 1987-02-04 1994-11-01 Hoechst Ag N-benzopiranil-lactamas sustituidas con alquilo, procedimiento para su preparacion, su empleo, asi como preparados farmaceuticos a base de estos compuestos.
CH674984A5 (es) * 1987-05-16 1990-08-15 Sandoz Ag
IL86798A (en) * 1987-06-23 1992-12-01 Sanofi Sa 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
FR2625744B1 (fr) * 1988-01-12 1990-07-06 Sanofi Sa Derives du dimethyl-2,2 chromannol-3 procede d'obtention et compositions pharmaceutiques en contenant
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
AU628331B2 (en) * 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
DE3818245A1 (de) * 1988-05-28 1989-12-07 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
DE3824446A1 (de) * 1988-07-19 1990-01-25 Hoechst Ag Verwendung substituierter 3,4-dihydro-2h-benzopyrane als heilmittel gegen obstruktive funktionsstoerungen der lunge und/oder stoerungen der ableitenden harnwege
DE3827532A1 (de) * 1988-08-13 1990-03-01 Hoechst Ag 6-aroyl-substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
DE3901720A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Substituierte benzo(b)pyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
US5254555A (en) * 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
HUT72741A (en) * 1992-12-19 1996-05-28 Alkaloida Vegyeszeti Gyar Method for producing benzopyrane derivatives and pharmaceutical compositions containing them
AU6264294A (en) * 1993-03-22 1994-10-11 Nippon Kayaku Kabushiki Kaisha Chroman derivative and use thereof
WO2000067754A1 (en) 1999-05-12 2000-11-16 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548221A (en) * 1976-01-27 1979-07-04 Beecham Group Ltd Trans-4-heterocycyl-3,4-dihydro-2h-benzo pyran-3-ol esters
GB1511187A (en) * 1976-04-02 1978-05-17 Beecham Group Ltd Chromans
DE2965739D1 (en) * 1978-10-04 1983-07-28 Beecham Group Plc Chromanol derivatives, a process for their preparation and pharmaceutical compositions comprising them
EP0028449B1 (en) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0028064B1 (en) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3170604D1 (en) * 1980-08-21 1985-06-27 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds

Also Published As

Publication number Publication date
NZ205987A (en) 1987-01-23
US4496565A (en) 1985-01-29
CA1212946A (en) 1986-10-21
JPH0561274B2 (es) 1993-09-06
EP0107423A1 (en) 1984-05-02
AU2023383A (en) 1984-05-03
IE56150B1 (en) 1991-05-08
ES526516A0 (es) 1985-04-16
DE3364734D1 (en) 1986-08-28
GR78699B (es) 1984-09-27
IE832436L (en) 1984-04-19
AU567893B2 (en) 1987-12-10
JPS5993076A (ja) 1984-05-29
EP0107423B1 (en) 1986-07-23

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