KR880013885A - 비사이클 설폰아미드 유도체 및 그의 제조방법 - Google Patents

비사이클 설폰아미드 유도체 및 그의 제조방법 Download PDF

Info

Publication number
KR880013885A
KR880013885A KR1019880005325A KR880005325A KR880013885A KR 880013885 A KR880013885 A KR 880013885A KR 1019880005325 A KR1019880005325 A KR 1019880005325A KR 880005325 A KR880005325 A KR 880005325A KR 880013885 A KR880013885 A KR 880013885A
Authority
KR
South Korea
Prior art keywords
compound
lower alkyl
salt
halogen
phenyl
Prior art date
Application number
KR1019880005325A
Other languages
English (en)
Other versions
KR950004045B1 (ko
Inventor
산지 하기시따
가오루 세노
Original Assignee
요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요시또시 가즈오, 시오노기세이야꾸 가부시끼가이샤 filed Critical 요시또시 가즈오
Publication of KR880013885A publication Critical patent/KR880013885A/ko
Application granted granted Critical
Publication of KR950004045B1 publication Critical patent/KR950004045B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

비사이클 설폰아미드 유도체 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(Ⅰ)의 화합물 또는 그의 염 :
    (식중, R₁은 수소 또는 저급알킬이고 : R₂는 저급알킬, 아르알킬, 또는 저급알킬, 알콕시, 아세톡시, 히드록시, 할로겐, 니트로 또는 페닐로 치환 가능한 아릴이고 : 파선은 R 또는 S배위 또는 그들의 혼합물을 나타낸다).
  2. 제1항에 있어서, R₂가 저급알킬, 알콕시, 아세톡시, 히드록시, 할로겐, 니트로 또는 페닐로치환 가능한 페닐인 화합물.
  3. 제1항에 있어서, 5(Z)-7-[2-벤젠설포아미도-6, 6-디메틸비사이클로[3. 1. 1]헵트-3-일]-5-헵테노산 또는 그의 염인 화합물.
  4. 제1항에 있어서, 5(Z)-7-[6, 6-디메틸-2-(4-토실아미도)비사이클로[3. 1. 1]헵트-3-일]-5-헵테노산 또는 그의 염인 화합물.
  5. 제1항에 있어서, 5(Z)-7-[2-(3-클로로벤젠설포아미도-6, 6-디메틸비사이클로[3. 1. 1]헵트-3-일]-5-헵테노산 또는 그의 염인 화합물.
  6. 제1항에 있어서, 5(Z)-7-[6, 6-디메틸-2-(4-히드록시벤젠설포아미도비사이클로[3. 1. 1]헵트-3-일]-5-헵테노산 또는 그의 염인 화합물.
  7. 하기 일반식(Ⅱ)의 화합물 또는 그의 염을 하기 일반식(Ⅲ)의 화합물과 반응시키고, 필요하다면, 생성된 화합물을 가수분해 및/또는 염 형성 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물 또는 그의 염인 제조방법.
    (식중, R₁은 수소 또는 저급알킬이고 : R₂는 저급알킬, 아르알킬, 또는 저급알킬, 알콕시, 아세톡시, 히드록시, 할로겐, 니트로 또는 페닐로 치환 가능한 아릴이고 : 파선은 R 또는 S배위 또는 그들의 혼합물을 나타내며 : R₁은 저급알킬이고 : Hal을 할로겐이다).
  8. 하기 일반식(Ⅳ)의 화합물 또는 그의 당량체를 하기 일반식(Ⅴ)의 화합물과 반응시키고, 필요하다면, 생성된 화합물을 에스테르화, 가수분해 및/또는 염형성 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물 또는 그의 염의 제조방법.
    (식중, R₁은 수소 또는 저급알킬이고 : R₂는 저급알킬, 아르알킬, 또는 저급알킬, 알콕시, 아세톡시, 히드록시, 할로겐, 니트로 또는 페닐로 치환 가능한 아릴이고 : 파선은 R 또는 S배위 또는 그들의 혼합물을 나타내고 : Ar은 아릴이다).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880005325A 1987-05-08 1988-05-07 비사이클 설폰 아미드 유도체 및 그의 제조방법 KR950004045B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-113086 1987-05-08
JP11308687 1987-05-08
JP113086/87 1987-05-08

Publications (2)

Publication Number Publication Date
KR880013885A true KR880013885A (ko) 1988-12-22
KR950004045B1 KR950004045B1 (ko) 1995-04-22

Family

ID=14603125

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880005325A KR950004045B1 (ko) 1987-05-08 1988-05-07 비사이클 설폰 아미드 유도체 및 그의 제조방법

Country Status (10)

Country Link
US (1) US4904819A (ko)
EP (1) EP0290285B1 (ko)
KR (1) KR950004045B1 (ko)
AT (1) ATE92474T1 (ko)
AU (1) AU599227B2 (ko)
CA (1) CA1294974C (ko)
DE (1) DE3882795T2 (ko)
DK (1) DK248788A (ko)
ES (1) ES2058275T3 (ko)
HK (1) HK1004750A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives
CA1332607C (en) * 1988-07-19 1994-10-18 Masayuki Narisada Alkenyltetrazole derivatives
MX9710256A (es) 1995-06-21 1998-03-31 Shionogi & Co Derivados de amino biciclicos y antagonistas pgd2 que contienen los mismos.
JP4120993B2 (ja) * 1996-12-12 2008-07-16 塩野義製薬株式会社 ヘテロ環縮合ベンゼンカルボン酸アミド誘導体およびそれを含有するｐｇｄ２拮抗剤
ATE223911T1 (de) * 1996-12-13 2002-09-15 Shionogi & Co Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten
AU745129B2 (en) * 1998-03-31 2002-03-14 Shionogi & Co., Ltd. Process for producing 5-hydroxybenzo(b)thiophene-3- carboxylic acid derivatives
US6506789B2 (en) 1998-06-03 2003-01-14 Shionogi & Co., Ltd. Methods for the treatment of itching comprising administering PGD2 receptor antagonist
US20050106576A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Methods of using cleavable solid phases for isolating nucleic acids
US20050106589A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Compositions and methods for releasing nucleic acids from solid phase binding materials
FR2898893A1 (fr) * 2006-03-27 2007-09-28 Ppg Sipsy Soc Par Actions Simp Procede d'alkylation diastereoselective d'ether d'oxime du compose nopinone et nouveaux intermediaires pour la synthese de derives 2-amino-nopinone diastereospecifiques substitues sur le carbone 3

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445783A1 (de) * 1964-10-30 1969-01-23 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
GB1249490A (en) * 1968-12-24 1971-10-13 Leo Pharm Prod Ltd New sulphamyl-benzoic acid derivatives
US3706790A (en) * 1970-02-27 1972-12-19 Merck & Co Inc (mono-and di-substituted sulfamoyl) benzoic acids
AR206507A1 (es) * 1972-10-13 1976-07-30 Ciba Geigy Ag Procedimiento para la obtencion de nuevos 4-eteres de acidos 3-amino-5-sulfamoilbenzoicos
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
EP0044711B1 (en) * 1980-07-22 1984-03-14 Ono Pharmaceutical Co., Ltd. 9,11-methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof
US4654357A (en) * 1985-08-09 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted sulfonamide prostaglandin analogs
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives

Also Published As

Publication number Publication date
AU1534788A (en) 1988-11-10
AU599227B2 (en) 1990-07-12
US4904819A (en) 1990-02-27
ES2058275T3 (es) 1994-11-01
DK248788A (da) 1988-11-09
DK248788D0 (da) 1988-05-06
DE3882795T2 (de) 1993-11-11
EP0290285B1 (en) 1993-08-04
EP0290285A3 (en) 1991-01-30
ATE92474T1 (de) 1993-08-15
DE3882795D1 (de) 1993-09-09
HK1004750A1 (en) 1998-12-04
CA1294974C (en) 1992-01-28
KR950004045B1 (ko) 1995-04-22
EP0290285A2 (en) 1988-11-09

Similar Documents

Publication Publication Date Title
KR870003998A (ko) 퀴나졸린 유도체류의 제조방법
ES2059069T3 (es) Nuevos derivados de 1-alcoxi-(2-acilamino-etil)-naftalenos y su procedimiento de preparacion.
FI820295L (fi) Nya kefemkompositioner och foerfarande foer deras framstaellning
KR860008976A (ko) 2-(4-벤조일-1- 피페리딜)-1- 페닐알칸올 유도체
ES2031569T3 (es) Derivados de acidos quinolinocarboxilicos.
KR880013885A (ko) 비사이클 설폰아미드 유도체 및 그의 제조방법
DE3572170D1 (de) Quinolonecarboxylic acid derivatives
DE3882895D1 (de) Imid-derivate, ihre herstellung und verwendung.
ES2046229T3 (es) Composicion antiulcerosa.
ES2044908T3 (es) Procedimiento para la produccion de derivados de quinazolina.
ES2057777T3 (es) Composicion farmaceutica para inhibir la agregacion plaquetaria.
ES2089097T3 (es) Procedimiento para la fabricacion de derivados de bencilftalacinona y sales de la misma.
SE8901060D0 (sv) New compounds
FI903967A0 (fi) Nya imidazolderivat.
FI883507A0 (fi) Naftotiazepinderivat och deras framstaellning.
KR850004760A (ko) 이미다조 퀴놀린 유도체의 제조방법
KR870008838A (ko) 아릴술폰 화합물 제조방법
KR860003251A (ko) 에르골린 유도체의 제조방법
JPS6452751A (en) Bicyclo-cyclic sulfonamide derivative and production thereof
DK0455899T3 (da) Prostaglandin I-analog
KR880000384A (ko) 안식향산 유도체의 제조방법
KR880011137A (ko) 혈당 감소제로서의 플루오로옥시란 카복실레이트
KR870011142A (ko) 비시클로환계 술폰아미드 유도체의 제조방법
KR930700501A (ko) 신규 설포닐 화합물

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20010223

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee