DE69104842T2 - Zwischenprodukte für chelatbildende wirkstoffe mit vorherbestimmter symmetrie und verfahren zu ihrer herstellung. - Google Patents

Zwischenprodukte für chelatbildende wirkstoffe mit vorherbestimmter symmetrie und verfahren zu ihrer herstellung.

Info

Publication number
DE69104842T2
DE69104842T2 DE69104842T DE69104842T DE69104842T2 DE 69104842 T2 DE69104842 T2 DE 69104842T2 DE 69104842 T DE69104842 T DE 69104842T DE 69104842 T DE69104842 T DE 69104842T DE 69104842 T2 DE69104842 T2 DE 69104842T2
Authority
DE
Germany
Prior art keywords
chelate
production
active substances
intermediate products
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69104842T
Other languages
English (en)
Other versions
DE69104842D1 (de
Inventor
Fulvio Uggeri
Pier Lucio Anelli
Marcella Murru
Mario Virtuani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Application granted granted Critical
Publication of DE69104842D1 publication Critical patent/DE69104842D1/de
Publication of DE69104842T2 publication Critical patent/DE69104842T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69104842T 1990-08-29 1991-08-14 Zwischenprodukte für chelatbildende wirkstoffe mit vorherbestimmter symmetrie und verfahren zu ihrer herstellung. Expired - Fee Related DE69104842T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT02131890A IT1243801B (it) 1990-08-29 1990-08-29 Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
PCT/EP1991/001546 WO1992004336A1 (en) 1990-08-29 1991-08-14 Intermediates for chelating agents with prefixed symmetry and process for their preparation

Publications (2)

Publication Number Publication Date
DE69104842D1 DE69104842D1 (de) 1994-12-01
DE69104842T2 true DE69104842T2 (de) 1995-03-23

Family

ID=11180039

Family Applications (2)

Application Number Title Priority Date Filing Date
DE91914890T Pending DE545983T1 (de) 1990-08-29 1991-08-14 Zwischenprodukten für chelatbildende wirkstoffe mit vorherbestimmten symmetrie und verfahren zu ihrer herstellung.
DE69104842T Expired - Fee Related DE69104842T2 (de) 1990-08-29 1991-08-14 Zwischenprodukte für chelatbildende wirkstoffe mit vorherbestimmter symmetrie und verfahren zu ihrer herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE91914890T Pending DE545983T1 (de) 1990-08-29 1991-08-14 Zwischenprodukten für chelatbildende wirkstoffe mit vorherbestimmten symmetrie und verfahren zu ihrer herstellung.

Country Status (13)

Country Link
US (1) US5424423A (de)
EP (1) EP0545983B1 (de)
JP (1) JP3119872B2 (de)
KR (1) KR930701419A (de)
AT (1) ATE113278T1 (de)
AU (1) AU650903B2 (de)
CA (1) CA2090433A1 (de)
DE (2) DE545983T1 (de)
DK (1) DK0545983T3 (de)
ES (1) ES2041617T3 (de)
GR (1) GR930300084T1 (de)
IT (1) IT1243801B (de)
WO (1) WO1992004336A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5539105A (en) * 1990-08-29 1996-07-23 Dibra S.P.A. Intermediates for chelating agents with prefixed symmetry and process for their preparation
US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
EP0588229A3 (en) * 1992-09-12 1994-06-15 Hoechst Ag Macrocyclic chelating agents for the preparation of technetium or rhenium complexes
EP0702677A1 (de) * 1994-04-08 1996-03-27 BRACCO International B.V. Aromatische amidverbindungen und seine metallchelate
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
FR2725449B1 (fr) * 1994-10-05 1996-12-27 Air Liquide Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes
GB9504910D0 (en) * 1995-03-10 1995-04-26 Nycomed Imaging As Compounds
GB9504922D0 (en) * 1995-03-10 1995-04-26 Nycomed As Process
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979379A (en) * 1975-04-25 1976-09-07 The United States Of America As Represented By The Secretary Of The Army Process for producing 1,3,5,7-tetraalkanoyl-1,3,5,7-octahydrotetrazocines
US4085106A (en) * 1976-01-07 1978-04-18 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic trisaminomethanes
JPS53144593A (en) * 1977-05-19 1978-12-15 Iwao Tabuse Alklycyclum
JPS5672070A (en) * 1979-11-14 1981-06-16 Iwao Tabuse Preparation of uranyl ion trapping agent
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5247077A (en) * 1989-06-23 1993-09-21 Celltech Limited Tri-aza macrocycles and processes for their preparation

Also Published As

Publication number Publication date
ES2041617T3 (es) 1994-12-16
EP0545983A1 (de) 1993-06-16
IT9021318A0 (it) 1990-08-29
IT9021318A1 (it) 1992-02-29
ES2041617T1 (es) 1993-12-01
DE545983T1 (de) 1993-10-14
KR930701419A (ko) 1993-06-11
ATE113278T1 (de) 1994-11-15
AU650903B2 (en) 1994-07-07
AU8412591A (en) 1992-03-30
WO1992004336A1 (en) 1992-03-19
DK0545983T3 (da) 1994-11-28
IT1243801B (it) 1994-06-28
CA2090433A1 (en) 1992-03-01
JP3119872B2 (ja) 2000-12-25
JPH06503303A (ja) 1994-04-14
GR930300084T1 (en) 1993-09-30
EP0545983B1 (de) 1994-10-26
US5424423A (en) 1995-06-13
DE69104842D1 (de) 1994-12-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee