DE60232904D1 - Antikörperkomplexe sowie immunmarkierungsverfahren - Google Patents
Antikörperkomplexe sowie immunmarkierungsverfahrenInfo
- Publication number
- DE60232904D1 DE60232904D1 DE60232904T DE60232904T DE60232904D1 DE 60232904 D1 DE60232904 D1 DE 60232904D1 DE 60232904 T DE60232904 T DE 60232904T DE 60232904 T DE60232904 T DE 60232904T DE 60232904 D1 DE60232904 D1 DE 60232904D1
- Authority
- DE
- Germany
- Prior art keywords
- labeling
- target
- immuno
- antibody
- binding antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Biophysics (AREA)
- Mathematical Physics (AREA)
- Composite Materials (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Theoretical Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32906801P | 2001-10-12 | 2001-10-12 | |
US36941802P | 2002-04-01 | 2002-04-01 | |
US10/118,204 US8323903B2 (en) | 2001-10-12 | 2002-04-05 | Antibody complexes and methods for immunolabeling |
PCT/US2002/031416 WO2003030817A2 (en) | 2001-10-12 | 2002-10-02 | Antibody complexes and methods for immunolabeling |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60232904D1 true DE60232904D1 (de) | 2009-08-20 |
Family
ID=27382120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60232904T Expired - Lifetime DE60232904D1 (de) | 2001-10-12 | 2002-10-02 | Antikörperkomplexe sowie immunmarkierungsverfahren |
Country Status (8)
Country | Link |
---|---|
US (2) | US8323903B2 (de) |
EP (3) | EP1442302B1 (de) |
JP (2) | JP2006513398A (de) |
AT (1) | ATE436022T1 (de) |
CA (1) | CA2462280C (de) |
DE (1) | DE60232904D1 (de) |
GB (1) | GB2397302B (de) |
WO (1) | WO2003030817A2 (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE46351E1 (en) | 2001-05-10 | 2017-03-28 | Battelle Energy Alliance, Llc | Antibody profiling sensitivity through increased reporter antibody layering |
US6989276B2 (en) | 2001-05-10 | 2006-01-24 | Battelle Energy Alliance, Llc | Rapid classification of biological components |
US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
US7282339B2 (en) | 2003-09-17 | 2007-10-16 | Invitrogen Corporation | Competitive immunoassay |
US7642341B2 (en) * | 2003-12-18 | 2010-01-05 | Merck Serono S.A. | Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer |
US20050214882A1 (en) * | 2004-03-25 | 2005-09-29 | Ez Bio Inc. | Reagents, methods and kits for the universal rapid immuno-detection |
WO2006005465A1 (en) * | 2004-07-08 | 2006-01-19 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Antigen binding proteins directed against scavenger receptor b1 that inhibit hcv replication |
WO2006058287A2 (en) * | 2004-11-26 | 2006-06-01 | The Texas A & M University System | Immunologic assay for detection of autoantibodies to folate binding protein |
EP1832875A4 (de) * | 2004-12-28 | 2008-02-13 | Inst Molekulyarnoi Biolog Im V | Biologischer mikrochip für parallelen mehrfachimmuntest von verbindungen und immuntestverfahren unter verwendung des mikrochips |
WO2008020823A2 (en) * | 2005-05-23 | 2008-02-21 | University Of Hawaii | Cooperative reporter systems, components, and methods for analyte detection |
WO2007030521A1 (en) * | 2005-09-06 | 2007-03-15 | Invitrogen Corporation | Control of chemical modification |
PT1934607E (pt) * | 2005-10-13 | 2013-11-13 | Fundacao D Anna Sommer Champalimaud E Dr Carlos Montez Champalimaud | Análise imuno-histoquímica in situ multiplex |
WO2008029281A2 (en) * | 2006-02-10 | 2008-03-13 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
CA2663243A1 (en) * | 2006-09-28 | 2008-04-03 | Merck Serono S.A. | Junctional adhesion molecule-c (jam-c) binding compounds and methods of their use |
US7741045B2 (en) * | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
US9201063B2 (en) * | 2006-11-16 | 2015-12-01 | General Electric Company | Sequential analysis of biological samples |
US8305579B2 (en) * | 2006-11-16 | 2012-11-06 | Thomas Pirrie Treynor | Sequential analysis of biological samples |
US7629125B2 (en) * | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
JP5553615B2 (ja) * | 2007-03-01 | 2014-07-16 | アボット・ラボラトリーズ | プロゾーン現象の低減を示すイムノアッセイ |
US20080233660A1 (en) * | 2007-03-23 | 2008-09-25 | Mu Bioteknik Ab | Solid phase labeling method |
US20080286881A1 (en) * | 2007-05-14 | 2008-11-20 | Apel William A | Compositions and methods for combining report antibodies |
KR101553723B1 (ko) * | 2007-07-13 | 2015-09-16 | 네스텍 소시에테아노님 | 항체기반 어레이를 사용한 폐 암 치료를 위한 약물 선별법 |
US20090035216A1 (en) * | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
JPWO2009044650A1 (ja) * | 2007-10-05 | 2011-02-03 | 株式会社カネカ | 免疫グロブリンおよび/または免疫グロブリン複合体に結合活性を有する、標識されたペプチド、および上記ペプチドを用いた免疫グロブリンの検出方法または測定方法 |
WO2009097425A2 (en) * | 2008-01-29 | 2009-08-06 | Spring Bioscience Corporation | Method for detecting truncated molecules |
ES2545760T3 (es) | 2008-02-25 | 2015-09-15 | Nestec S.A. | Selección de fármacos para terapia del cáncer de mama utilizando matrices de anticuerpos |
WO2009131643A1 (en) * | 2008-04-21 | 2009-10-29 | Monabio, Inc. | Immunoassay for specific determination of s-adenosymethionine and analogs thereof in biological samples |
JP5120889B2 (ja) * | 2008-06-12 | 2013-01-16 | 独立行政法人産業技術総合研究所 | ボロンジピロロメタン誘導体及びそれを用いた過酸化脂質測定試薬 |
US20110269147A1 (en) * | 2008-07-18 | 2011-11-03 | Bayer Healthcare Llc | Methods, Devices, and Systems for Glycated Hemoglobin Analysis |
US9528988B2 (en) * | 2009-04-07 | 2016-12-27 | National Institute Of Transplantation Foundation | Methods and kits for screening transplant recipients and candidates |
AU2010273319B2 (en) | 2009-07-15 | 2015-01-22 | Nestec S.A. | Drug selection for gastric cancer therapy using antibody-based arrays |
US8969009B2 (en) * | 2009-09-17 | 2015-03-03 | Vicki S. Thompson | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual |
US9410965B2 (en) * | 2009-09-17 | 2016-08-09 | Battelle Energy Alliance, Llc | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual |
US9677125B2 (en) * | 2009-10-21 | 2017-06-13 | General Electric Company | Detection of plurality of targets in biological samples |
US10822396B2 (en) * | 2009-12-15 | 2020-11-03 | MuHyeon CHOE | Repeat-chain for the production of dimer, multimer, multimer complex and super-complex |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
CZ304250B6 (cs) * | 2010-08-27 | 2014-01-29 | Ústav molekulární genetiky AV ČR, v.v.i. | Soubor vzájemně rozlišitelných nanočástic, způsob jejich přípravy a jejich použití pro vícenásobné ultrastrukturální značení |
WO2012058638A2 (en) | 2010-10-29 | 2012-05-03 | President And Fellows Of Harvard College | Nucleic acid nanostructure barcode probes |
US10010616B2 (en) * | 2011-01-28 | 2018-07-03 | Purdue Research Foundation | Immunogenic compositions and reagents for preparing |
US9719995B2 (en) | 2011-02-03 | 2017-08-01 | Pierian Holdings, Inc. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
WO2012135440A1 (en) | 2011-03-30 | 2012-10-04 | Arizona Board Of Regents, For And On Behalf Of, Arizona State University | Auristatin tyramine phosphate salts and auristatin aminoquinoline derivatives and prodrugs thereof |
WO2013033623A1 (en) | 2011-09-02 | 2013-03-07 | Nestec S.A. | Profiling of signal pathway proteins to determine therapeutic efficacy |
WO2013035688A1 (ja) * | 2011-09-09 | 2013-03-14 | コニカミノルタエムジー株式会社 | 組織染色方法 |
ES2678211T3 (es) | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
WO2014039119A1 (en) * | 2012-05-09 | 2014-03-13 | Life Technologies Corporation | Systems and method for fluorescence imaging |
EP2932244A4 (de) * | 2012-12-11 | 2016-09-28 | Univ Toronto | Auf drahtloser kommunikationsvorrichtung basiertes detektionssystem |
EP3696277B1 (de) | 2013-07-30 | 2023-01-25 | President and Fellows of Harvard College | Quantitative dna-basierte bildgebung und hochauflösende bildgebung |
JP6190534B2 (ja) | 2013-08-22 | 2017-08-30 | ソニー株式会社 | 水溶性蛍光染料又は有色染料及びその使用方法 |
CA2932943C (en) | 2014-03-11 | 2023-09-26 | President And Fellows Of Harvard College | High-throughput and highly multiplexed imaging with programmable nucleic acid probes |
WO2015184144A1 (en) * | 2014-05-28 | 2015-12-03 | Siemens Healthcare Diagnostics Inc. | Rare molecule signal amplification |
US10352933B2 (en) | 2014-12-18 | 2019-07-16 | Rhode Island Hospital | Visualization of bacterial colonization and biofilm formation on orthopaedic trauma explants |
US11084932B2 (en) | 2015-02-26 | 2021-08-10 | Sony Group Corporation | Phenylethynylnaphthalene dyes and methods for their use |
WO2016138461A1 (en) | 2015-02-26 | 2016-09-01 | Sony Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
WO2016178083A2 (en) | 2015-05-01 | 2016-11-10 | Diagnostear, Ltd. | Method for measuring tear constitutents in a tear sample |
WO2016183185A1 (en) | 2015-05-11 | 2016-11-17 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
AT517379B1 (de) * | 2015-06-26 | 2017-03-15 | Technische Universität Graz | Fusionsprotein |
KR102557419B1 (ko) | 2015-08-07 | 2023-07-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 단백질-단백질 상호작용의 초해상도 영상화 |
US10845305B1 (en) | 2015-11-20 | 2020-11-24 | Verily Life Sciences Llc | Method for increasing sensor resolution by spectrally stacking responsive dyes |
EP3402385A4 (de) * | 2016-01-14 | 2019-06-12 | DiagnosTear, Ltd. | Verfahren zur messung der tränenbestandteile in einer tränenprobe |
CN105784657A (zh) * | 2016-03-25 | 2016-07-20 | 鲁延军 | 利用tr-fret高效筛选单克隆抗体阳性克隆的方法 |
CN108139406B (zh) * | 2016-03-31 | 2020-11-10 | 株式会社艾索罗技 | 一种利用光致氧化扩增效应的生物标记物高灵敏定量方法 |
KR102525252B1 (ko) | 2016-04-01 | 2023-04-26 | 소니그룹주식회사 | 강성 공간군을 갖는 매우 밝은 이량체성 또는 중합체성 염료 |
AU2017240154B2 (en) | 2016-04-01 | 2021-08-12 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
EP3440136A2 (de) | 2016-04-06 | 2019-02-13 | Sony Corporation | Ultrahelle dimere oder polymere farbstoffe mit abstandslinkergruppen |
JP7068192B2 (ja) | 2016-05-10 | 2022-05-16 | ソニーグループ株式会社 | ポリマー染料およびシクロデキストリンを含む組成物、ならびにその使用 |
EP3455238A1 (de) | 2016-05-10 | 2019-03-20 | Sony Corporation | Ultrahelle polymere farbstoffe mit peptidgerüst |
US11685835B2 (en) | 2016-05-11 | 2023-06-27 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
GB201609235D0 (en) * | 2016-05-25 | 2016-07-06 | Univ Cape Town | Production of a horseradish peroxidase-IGG fusion protein |
WO2017210387A1 (en) * | 2016-06-02 | 2017-12-07 | Ultivue, Inc. | Compositions and methods to expedite antibody-based exchange imaging |
WO2017214165A1 (en) | 2016-06-06 | 2017-12-14 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
EP3551765A4 (de) | 2016-12-09 | 2020-11-11 | Ultivue, Inc. | Verbesserte verfahren für multiplex-bildgebung unter verwendung von markierten nukleinsäurekontrastmitteln |
US20200064341A1 (en) | 2017-03-14 | 2020-02-27 | Nanotag Biotechnologies Gmbh | Target detection using a monovalent antibody |
CN111315415A (zh) | 2017-10-05 | 2020-06-19 | 索尼公司 | 可编程的聚合药物 |
KR20200083605A (ko) | 2017-11-16 | 2020-07-08 | 소니 주식회사 | 프로그램가능한 중합체성 약물 |
KR102047978B1 (ko) * | 2017-11-22 | 2019-11-22 | 바디텍메드(주) | 측방유동 면역 분석 기반의 항ccp 항체 및 류마티스인자를 이용한 류마티스 관절염 진단 방법 |
WO2019130503A1 (ja) * | 2017-12-27 | 2019-07-04 | コニカミノルタ株式会社 | 情報取得方法 |
US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
EP3768689A1 (de) | 2018-03-21 | 2021-01-27 | Sony Corporation | Polymere tandemfarbstoffe mit linkergruppen |
GB2573323A (en) * | 2018-05-03 | 2019-11-06 | Mursia Ltd | Biosensor method and system |
EP3861074A2 (de) | 2019-09-26 | 2021-08-11 | Sony Group Corporation | Polymere tandemfarbstoffe mit linkergruppen |
WO2023044574A1 (en) * | 2021-09-24 | 2023-03-30 | Enveric Biosciences Canada Inc. | Phosphorylated and sulfonated mescaline derivatives and methods of using |
CN114002438A (zh) * | 2021-11-04 | 2022-02-01 | 河南赛诺特生物技术有限公司 | 一种小鼠一抗-小鼠组织同种属免疫组化染色方法 |
CN116004221B (zh) * | 2022-12-15 | 2023-12-19 | 湖南卓润生物科技有限公司 | 环肽的新应用、吖啶标记复合物与制备方法、检测试剂盒 |
Family Cites Families (162)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5896A (en) * | 1848-10-31 | Shoe-pegging machine | ||
US4199559A (en) * | 1974-08-12 | 1980-04-22 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US3996345A (en) * | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4174384A (en) * | 1975-06-30 | 1979-11-13 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
US4235869A (en) * | 1978-05-16 | 1980-11-25 | Syva Company | Assay employing a labeled Fab-fragment ligand complex |
US4261968A (en) * | 1979-05-10 | 1981-04-14 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
JPS6033479B2 (ja) | 1980-07-30 | 1985-08-02 | 協和醗酵工業株式会社 | 過酸化水素の定量方法 |
US4481298A (en) * | 1981-04-13 | 1984-11-06 | Amf Incorporated | Pre-precipitated double antibody immunoassay method |
US4520110A (en) | 1981-10-06 | 1985-05-28 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor |
US4859582A (en) | 1981-10-06 | 1989-08-22 | The Board Of Trustees Of The Leland Stanford Jr. University | Fluorescent conjugates for analysis of molecules and cells |
US5055556A (en) | 1981-10-06 | 1991-10-08 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Fluorescent conjugates for analysis of molecules and cells |
EP0088994B1 (de) * | 1982-03-15 | 1991-06-19 | Schering Corporation | Hybride DNS, damit hergestellte Bindungszusammensetzung und Verfahren dafür |
US4469787A (en) | 1982-05-14 | 1984-09-04 | Mallinckrodt Inc. | Immunoassay involving soluble complex of second antibody and labeled binding protein |
US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
US4542104A (en) | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
JPS6082966A (ja) * | 1983-10-14 | 1985-05-11 | Amano Pharmaceut Co Ltd | 抗原の定量法 |
NL193545C (nl) * | 1983-12-29 | 2000-01-04 | Mitsubishi Electric Corp | Constante stroom opwekkende schakeling. |
EP0150905A3 (de) | 1984-01-05 | 1987-01-14 | Ortho Diagnostic Systems Inc. | Anti-Idiotyptest unter Verwendung fluoreszierender Energieübertragung |
US4661444A (en) * | 1984-03-29 | 1987-04-28 | Ortho Diagnostic Systems Inc. | Homogeneous immunoassays employing double antibody conjugates comprising anti-idiotype antibody |
US5011771A (en) * | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
US4603209A (en) * | 1984-09-07 | 1986-07-29 | The Regents Of The University Of California | Fluorescent indicator dyes for calcium ions |
US4665024A (en) | 1984-10-01 | 1987-05-12 | Becton, Dickinson And Company | Fluorescent gram stain |
US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
ZA858371B (en) * | 1984-11-02 | 1987-03-25 | Oncogen | Monoclonal antibodies for human non-small cell lung carcinomas |
US5422266A (en) | 1984-12-31 | 1995-06-06 | University Of Georgia Research Foundation, Inc. | Recombinant DNA vectors capable of expressing apoaequorin |
US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
NL8501219A (nl) | 1985-04-29 | 1986-11-17 | Stichting Vrienden Van De Stic | Immunologisch complex, de bereiding en toepassing daarvan. |
NZ212437A (en) * | 1985-06-17 | 1992-06-25 | Mark Philip Best | Site-directed antibody conjugates, and their preparation |
US4735210A (en) * | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US4714763A (en) * | 1985-07-11 | 1987-12-22 | Viomedics Inc. | Novel oxazine-ureas and thiazine urea chromophors as fluorescent labels |
US4812409A (en) * | 1986-01-31 | 1989-03-14 | Eastman Kodak Company | Hydrolyzable fluorescent substrates and analytical determinations using same |
US5569587A (en) * | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
US5627027A (en) * | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
CA1340806C (en) * | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
US5151507A (en) * | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
EP0273928B1 (de) * | 1986-07-18 | 1997-01-08 | The University Of Melbourne | Aktives protein in humoraler hyperkalzemia, durch bösartigkeit verursacht |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4959306A (en) | 1986-11-28 | 1990-09-25 | Sclavo, Inc. | Labeling design for a binding assay reagent |
US4810636A (en) * | 1986-12-09 | 1989-03-07 | Miles Inc. | Chromogenic acridinone enzyme substrates |
US5360895A (en) * | 1987-04-22 | 1994-11-01 | Associated Universities, Inc. | Derivatized gold clusters and antibody-gold cluster conjugates |
DE3800048A1 (de) | 1987-05-14 | 1988-11-24 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung eines antikoerpers in menschlichen koerperfluessigkeiten |
DE3717401A1 (de) | 1987-05-23 | 1988-12-08 | Behringwerke Ag | Einschritt-immuntest zur bestimmung von antigen-spezifischen antikoerpern aus einer der immunglobulin-klassen a, m, d oder e und dazu geeignetes mittel |
US4774339A (en) * | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
US4945171A (en) * | 1987-08-10 | 1990-07-31 | Molecular Probes, Inc. | Xanthene dyes having a fused (C) benzo ring |
US4814433A (en) | 1987-09-16 | 1989-03-21 | Miles Inc. | Method for obtaining a papain-free antibody fragment preparation |
DK546988A (da) | 1987-10-02 | 1989-04-03 | Du Pont | Immunobestemmelse og reagenssaet til anvendesle herved |
JPH01131458A (ja) * | 1987-11-17 | 1989-05-24 | Nippon Zenyaku Kogyo Kk | 簡易迅速免疫測定試薬 |
US5084398A (en) * | 1987-11-20 | 1992-01-28 | Creative Biomolecules | Selective removal of immune complexes |
US4891313A (en) | 1988-01-21 | 1990-01-02 | Boehringer Manheim Corporation | Method for determination of a component of a sample |
US5229302A (en) * | 1988-03-29 | 1993-07-20 | Matsushita Electric Industrial Co., Ltd. | Fluorescence immunoassay method utilizing pseudo-antigens combined with fluorescent quenchers |
US4849362A (en) * | 1988-05-19 | 1989-07-18 | Smithkline Beckman Corporation | Fluorescent intracellular calcium indicators |
JPH0276600A (ja) * | 1988-09-10 | 1990-03-15 | Akad Wissenschaften Ddr | 標識を付した分子プローブ、その製造及び利用 |
DE3836348A1 (de) | 1988-10-25 | 1990-04-26 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von fuer ein antigen klassenspezifischen antikoerpern und dazu geeignetes reagenz |
EP0368674A3 (de) | 1988-11-11 | 1991-10-09 | SANYO CHEMICAL INDUSTRIES, Ltd. | Immunoessay und dafür geeignete Testsätze |
CA2013006A1 (en) * | 1989-03-24 | 1990-09-24 | Marc E. Key | Reagent complex for immunoassay |
US5196306A (en) | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
GB8910263D0 (en) | 1989-05-04 | 1989-06-21 | Ciba Geigy Ag | Monoclonal antibodies specific for an immunoglobulin isotype |
US4981977A (en) * | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
US5089419A (en) * | 1989-08-07 | 1992-02-18 | International Canine Genetics | Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals |
CA2065362A1 (en) * | 1989-08-24 | 1991-02-25 | Fook-Thean Lee | Radio-labelled antibodies for imaging |
US5132432A (en) * | 1989-09-22 | 1992-07-21 | Molecular Probes, Inc. | Chemically reactive pyrenyloxy sulfonic acid dyes |
US6274324B1 (en) | 1989-12-01 | 2001-08-14 | Unilever Patent Holdings B.V. | Specific binding reagent comprising a variable domain protein linked to a support or tracer |
US5292658A (en) | 1989-12-29 | 1994-03-08 | University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center | Cloning and expressions of Renilla luciferase |
US5227487A (en) * | 1990-04-16 | 1993-07-13 | Molecular Probes, Inc. | Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes |
US5501980A (en) * | 1994-05-20 | 1996-03-26 | Molecular Probes, Inc. | Benzazolylcoumarin-based ion indicators |
US5274113A (en) * | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
US5433896A (en) | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
US5459276A (en) * | 1994-05-20 | 1995-10-17 | Molecular Probes, Inc. | Benzazolylcoumarin-based ion indicators for heavy metals |
US5789157A (en) * | 1990-06-11 | 1998-08-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: tissue selex |
US5602240A (en) * | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
US5187085A (en) * | 1990-09-28 | 1993-02-16 | Applied Biosystems, Inc. | Nucleic acid sequence analysis with nucleoside-5'-o-(1-thiotriphosphates) |
US5208148A (en) | 1990-12-07 | 1993-05-04 | Molecular Probes, Inc. | Lipophilic fluorescent glycosidase substrates |
US5248782A (en) * | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
DE4129849A1 (de) * | 1991-02-14 | 1992-08-27 | Boehringer Mannheim Gmbh | Monoklonale antikoerper gegen humane pankreas-inselzellen |
GR920100123A (el) * | 1991-04-12 | 1993-03-16 | Ortho Diagnostic Systems Inc | Αντιδραστήριο πολυχρωματικής κηλίδωσης και μέ?οδος ανάλυσης. |
US5451343A (en) * | 1991-05-20 | 1995-09-19 | Spectra Group Limited, Inc. | Fluorone and pyronin y derivatives |
US5187288A (en) * | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
US6352830B1 (en) | 1991-08-22 | 2002-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | NF-AT polypeptides and polynucleotides and screening methods for immunosuppressive agents |
ATE180018T1 (de) | 1991-08-23 | 1999-05-15 | Molecular Probes Inc | Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen |
US5576424A (en) | 1991-08-23 | 1996-11-19 | Molecular Probes, Inc. | Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells |
US5316906A (en) | 1991-08-23 | 1994-05-31 | Molecular Probes, Inc. | Enzymatic analysis using substrates that yield fluorescent precipitates |
US5242805A (en) | 1991-08-23 | 1993-09-07 | Molecular Probes, Inc. | Long wavelength lipophilic fluorogenic glycosidase substrates |
US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
CA2093494A1 (en) | 1992-04-17 | 1993-10-18 | Keisuke Iwata | Method for the elimination of non-specific reactions in immuno-assays |
US5195303A (en) | 1992-05-29 | 1993-03-23 | Philip Morris Incorporated | Apparatus for automatic bagging of compressed tobacco |
US6030773A (en) | 1992-07-08 | 2000-02-29 | Agnello; Vincent | Chemiluminescent assay for DSDNA antibodies |
US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
DK0599803T3 (da) | 1992-11-23 | 2000-07-03 | Sanochemia Pharmazeutica Aktie | Fremgangsmåde til påvisning af antistoffer og antigener |
ES2051651B1 (es) * | 1992-12-10 | 1995-01-01 | Univ Salamanca | Procedimiento para la cuantificacion simultanea, en una sola medicion, de los principales tipos de linfocitos humanos y sus subpoblaciones. |
US5808044A (en) * | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
US6482655B1 (en) * | 1993-07-23 | 2002-11-19 | University Of Utah Research Foundation | Immunoassay procedure utilizing fluorogenic tracer antigens |
CA2125639A1 (en) | 1993-06-16 | 1994-12-17 | Shinjirou Imai | Immunoassay for quantitatively determining antigens |
US5585243A (en) * | 1993-09-15 | 1996-12-17 | The Blood Center Of Southeastern Wisconsin, Inc. | Method of detecting cytopenia that is mediated by drug-dependent antibody binding to blood cells |
US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
US5561045A (en) | 1994-01-04 | 1996-10-01 | Intracel Corporation | Detection reagent, article, and immunoassay method |
US5630924A (en) * | 1995-04-20 | 1997-05-20 | Perseptive Biosystems, Inc. | Compositions, methods and apparatus for ultrafast electroseparation analysis |
US6127134A (en) * | 1995-04-20 | 2000-10-03 | Carnegie Mellon University | Difference gel electrophoresis using matched multiple dyes |
US5679519A (en) * | 1995-05-09 | 1997-10-21 | Oprandy; John J. | Multi-label complex for enhanced sensitivity in electrochemiluminescence assay |
US6008373A (en) * | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
US5798276A (en) * | 1995-06-07 | 1998-08-25 | Molecular Probes, Inc. | Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability |
US5869274A (en) | 1995-08-09 | 1999-02-09 | Zymed Laboratories, Inc. | Immuno-histochemical method that reduces background staining |
US5736330A (en) | 1995-10-11 | 1998-04-07 | Luminex Corporation | Method and compositions for flow cytometric determination of DNA sequences |
US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
US5969135A (en) * | 1995-11-02 | 1999-10-19 | Icn Pharmaceuticals, Inc. | Oligonucleotide analogs with an amino acid or a modified amino alcohol residue |
AU7723096A (en) * | 1995-11-08 | 1997-05-29 | Pharmaceutical Discovery Corporation | Method for fluorescent labeling of antibody |
US6004536A (en) * | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
US5994143A (en) * | 1996-02-01 | 1999-11-30 | Abbott Laboratories | Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment |
GB9602265D0 (en) * | 1996-02-05 | 1996-04-03 | Amersham Int Plc | Benzophenoxazine dyes |
US5723294A (en) | 1996-03-05 | 1998-03-03 | Gull Laboratories | Methods for detection and discrimination of multiple analytes using fluorescent technology |
US5637258A (en) * | 1996-03-18 | 1997-06-10 | Nanocrystals Technology L.P. | Method for producing rare earth activited metal oxide nanocrystals |
US6162931A (en) * | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
WO1997040104A1 (en) | 1996-04-19 | 1997-10-30 | Amersham Pharmacia Biotech Uk Limited | Squarate dyes and their use in fluorescent sequencing method |
GB9712818D0 (en) | 1996-07-08 | 1997-08-20 | Cambridge Antibody Tech | Labelling and selection of specific binding molecules |
US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
US5846737A (en) * | 1996-07-26 | 1998-12-08 | Molecular Probes, Inc. | Conjugates of sulforhodamine fluorophores with enhanced fluorescence |
US5696157A (en) | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
US5830912A (en) | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
ZA9710262B (en) | 1996-11-19 | 1999-05-13 | Lilly Co Eli | Process for the synthesis of benzothiophenes |
US5945294A (en) | 1996-11-26 | 1999-08-31 | Heska Corporation | Method to detect IgE |
US5948386A (en) * | 1997-03-14 | 1999-09-07 | The Curators Of The University Of Missouri | Conjugate and method for forming aminomethyl phosphorus conjugates |
US5877310A (en) * | 1997-04-25 | 1999-03-02 | Carnegie Mellon University | Glycoconjugated fluorescent labeling reagents |
US5773236A (en) | 1997-04-25 | 1998-06-30 | Molecule Probes, Inc. | Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules |
US5891741A (en) | 1997-05-16 | 1999-04-06 | Coulter International Corp. | Antibody-aminodextran-phycobiliprotein conjugates |
US5994089A (en) * | 1997-05-16 | 1999-11-30 | Coulter International Corp. | Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry |
US6146836A (en) * | 1997-05-19 | 2000-11-14 | Bayer Corporation | Immunoassays using anti-allotypic monoclonal antibodies |
US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
JPH11153599A (ja) | 1997-11-21 | 1999-06-08 | Dai Ichi Pure Chem Co Ltd | 免疫学的測定方法 |
US6133445A (en) * | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
US6080868A (en) | 1998-01-23 | 2000-06-27 | The Perkin-Elmer Corporation | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds |
EP1078023B1 (de) | 1998-04-08 | 2011-01-05 | Corporation Luminex | Lumineszierende verbindungen |
CA2293677C (en) | 1998-04-14 | 2009-01-27 | Otsuka Pharmaceutical Co., Ltd. | Method for assay of antibodies and antibody assay device |
US6002003A (en) * | 1998-04-14 | 1999-12-14 | Beckman Instruments, Inc. | Cyanine dye activating group with improved coupling selectivity |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6150123A (en) | 1998-09-03 | 2000-11-21 | Centre Integre De Recherches Biocliniques Sur Le Sida (Cirbs) | Affinity biotinylation |
US6306610B1 (en) * | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
DE69905832T2 (de) * | 1998-09-18 | 2004-02-05 | Massachusetts Institute Of Technology, Cambridge | Biologische Verwendungen von halbleitenden Nanokristallen |
US6326144B1 (en) * | 1998-09-18 | 2001-12-04 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
US6114038A (en) * | 1998-11-10 | 2000-09-05 | Biocrystal Ltd. | Functionalized nanocrystals and their use in detection systems |
US6221602B1 (en) * | 1998-11-10 | 2001-04-24 | Bio-Pixels Ltd. | Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination |
US6261779B1 (en) * | 1998-11-10 | 2001-07-17 | Bio-Pixels Ltd. | Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system |
US6787638B1 (en) * | 1998-12-02 | 2004-09-07 | Applied Molecular Evolution, Inc. | Tumor specific human monoclonal antibodies and methods of use |
JP3983404B2 (ja) * | 1999-01-13 | 2007-09-26 | 本田技研工業株式会社 | レーダ搭載車両用ゲート |
JP2000214165A (ja) | 1999-01-22 | 2000-08-04 | Fuji Photo Film Co Ltd | 均一系酵素免疫分析方法 |
DE19915532B4 (de) * | 1999-04-07 | 2009-05-20 | Schaeffler Kg | Schaltbares Ventiltriebsglied |
US6399392B1 (en) * | 1999-04-23 | 2002-06-04 | Molecular Probes, Inc. | Xanthene dyes and their application as luminescence quenching compounds |
JP2000310638A (ja) | 1999-04-28 | 2000-11-07 | Fuji Photo Film Co Ltd | 均一系酵素免疫分析方法 |
US6664047B1 (en) | 1999-04-30 | 2003-12-16 | Molecular Probes, Inc. | Aza-benzazolium containing cyanine dyes |
EP1491591B1 (de) | 1999-07-02 | 2009-07-01 | Visen Medical, Inc. | Fluoreszierende Cyaninlabels mit einem Sulphamidobrückenglied |
JP2001059845A (ja) | 1999-08-24 | 2001-03-06 | Fuji Photo Film Co Ltd | 乾式分析方法及び乾式分析要素 |
EP1219626B1 (de) | 1999-09-20 | 2005-06-01 | Fuji Photo Film Co., Ltd. | Verbindungen zur floureszenz-kennzeichnung |
US6179912B1 (en) * | 1999-12-20 | 2001-01-30 | Biocrystal Ltd. | Continuous flow process for production of semiconductor nanocrystals |
US20020081635A1 (en) | 2000-05-11 | 2002-06-27 | Thomas Terry E. | Novel antibody compositions for preparing enriched T cell preparations |
US7524628B2 (en) | 2000-07-25 | 2009-04-28 | The Trustees Of The University Of Pennsylvania | Method for detecting molecules expressing a selected epitope via fluorescent dyes |
DE60136719D1 (de) | 2000-08-04 | 2009-01-08 | Molecular Probes Inc | Kondensierte ringe enthaltende 1,2-dihydro-7-hydroxychinolinderivate |
EP2325263B1 (de) * | 2000-09-29 | 2013-01-23 | Life Technologies Corporation | Modifizierte Carbocyaninfarbstoffe und deren Konjugate |
US20020132254A1 (en) * | 2000-11-30 | 2002-09-19 | Twu Jesse J. | Molecular labeling and assay systems using poly (amino acid)-metal ion complexes as linkers |
US20050069962A1 (en) * | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
US6972326B2 (en) * | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
-
2002
- 2002-04-05 US US10/118,204 patent/US8323903B2/en not_active Expired - Lifetime
- 2002-10-02 DE DE60232904T patent/DE60232904D1/de not_active Expired - Lifetime
- 2002-10-02 CA CA002462280A patent/CA2462280C/en not_active Expired - Lifetime
- 2002-10-02 JP JP2003533851A patent/JP2006513398A/ja active Pending
- 2002-10-02 AT AT02768949T patent/ATE436022T1/de not_active IP Right Cessation
- 2002-10-02 EP EP02768949A patent/EP1442302B1/de not_active Expired - Lifetime
- 2002-10-02 EP EP09163588A patent/EP2113773B1/de not_active Expired - Lifetime
- 2002-10-02 WO PCT/US2002/031416 patent/WO2003030817A2/en active Search and Examination
- 2002-10-02 EP EP10181177A patent/EP2259067B1/de not_active Expired - Lifetime
- 2002-10-02 GB GB0410515A patent/GB2397302B/en not_active Expired - Lifetime
-
2003
- 2003-09-17 US US10/666,291 patent/US20070269902A1/en not_active Abandoned
-
2007
- 2007-03-27 JP JP2007083130A patent/JP4977512B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2003030817B1 (en) | 2003-11-06 |
CA2462280A1 (en) | 2003-04-17 |
EP2259067A3 (de) | 2011-03-09 |
GB2397302A (en) | 2004-07-21 |
WO2003030817A3 (en) | 2003-09-18 |
GB0410515D0 (en) | 2004-06-16 |
JP4977512B2 (ja) | 2012-07-18 |
EP1442302A4 (de) | 2007-03-28 |
GB2397302B (en) | 2005-06-08 |
JP2007183291A (ja) | 2007-07-19 |
EP2113773A3 (de) | 2010-02-17 |
EP1442302B1 (de) | 2009-07-08 |
CA2462280C (en) | 2008-03-11 |
US8323903B2 (en) | 2012-12-04 |
US20030073149A1 (en) | 2003-04-17 |
EP2113773B1 (de) | 2012-06-27 |
WO2003030817A2 (en) | 2003-04-17 |
EP2259067B1 (de) | 2012-06-27 |
EP1442302A2 (de) | 2004-08-04 |
US20070269902A1 (en) | 2007-11-22 |
EP2259067A2 (de) | 2010-12-08 |
ATE436022T1 (de) | 2009-07-15 |
JP2006513398A (ja) | 2006-04-20 |
EP2113773A2 (de) | 2009-11-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60232904D1 (de) | Antikörperkomplexe sowie immunmarkierungsverfahren | |
JP5675597B2 (ja) | 大麻の使用の検出 | |
US20090088332A1 (en) | Multiplex Digital Immuno-Sensing Using a Library of Photocleavable Mass Tags | |
AU2003210662A1 (en) | Rapid lateral flow assay for determining exposure to mycobacterium tuberculosis and other mycobacteria | |
CA2573749A1 (en) | Immunological test element with improved control zone | |
DE60136034D1 (de) | Molekular-Modifikations-Assays | |
CA2503509A1 (en) | Non-competitive immunoassay for small analytes | |
WO2004042349A3 (en) | Method for evaluating the immunization status of a patient | |
EP1314982A4 (de) | Gut reproduzierbares agglutinations-immunoassayverfahren und reagenzien | |
ATE395598T1 (de) | Verfahren und vorrichtung zum nachweis von antikörpern | |
JPH05504481A (ja) | 改良された抗体―酵素直接接合体及びその製造方法 | |
Müller et al. | Covalently modified carboxyl side chains on cell surface leads to a novel method toward topology analysis of transmembrane proteins | |
CN105353131A (zh) | 基于双编码和单分子计数的细胞因子多重检测方法 | |
WO2001073443A3 (en) | Methods and compositions for the simultaneous detection of multiple analytes | |
DE3781643D1 (de) | Verfahren und testtraeger zur bestimmung eines analyten. | |
WO2005050206A3 (en) | Competitive immunoassay | |
DE69428998T2 (de) | Reagenzien und verfahren zur detektion und quantitativen bestimmung von testosteron in flüssigen proben | |
KR960024367A (ko) | N-펩티드의 샌드위치 면역학적 측정법 | |
RU2373540C1 (ru) | Способ одновременного определения двух аналитов биолюминесцентным молекулярным микроанализом | |
CN108593909A (zh) | 一种定点标记免疫试剂的方法、标记免疫试剂及应用 | |
Wu et al. | Time-resolved immunofluorometry of serum hTSH with enhanced sensitivity | |
EP3465204B1 (de) | Verfahren zur herstellung einer biologischen probe zur verwendung in einem immunmarkierungsverfahren | |
EP0368674A3 (de) | Immunoessay und dafür geeignete Testsätze | |
KR910021586A (ko) | 리간드의 면역학적 검출방법 | |
CN117706082A (zh) | 一种蛋白质-dna-分子复合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |