ATE377751T1 - Verfahren zur parallelen bestimmung mehrerer analyten mittels evaneszent angeregter lumineszenz - Google Patents

Verfahren zur parallelen bestimmung mehrerer analyten mittels evaneszent angeregter lumineszenz

Info

Publication number
ATE377751T1
ATE377751T1 AT96914164T AT96914164T ATE377751T1 AT E377751 T1 ATE377751 T1 AT E377751T1 AT 96914164 T AT96914164 T AT 96914164T AT 96914164 T AT96914164 T AT 96914164T AT E377751 T1 ATE377751 T1 AT E377751T1
Authority
AT
Austria
Prior art keywords
sensor platform
luminescence
parallel determination
several analytes
excited luminescence
Prior art date
Application number
AT96914164T
Other languages
English (en)
Inventor
Dieter Neuschaefer
Gert Duveneck
Michael Pawlak
Uwe Pieles
Wolfgang Budach
Original Assignee
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh
Application granted granted Critical
Publication of ATE377751T1 publication Critical patent/ATE377751T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7793—Sensor comprising plural indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT96914164T 1995-05-12 1996-05-02 Verfahren zur parallelen bestimmung mehrerer analyten mittels evaneszent angeregter lumineszenz ATE377751T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH139695 1995-05-12

Publications (1)

Publication Number Publication Date
ATE377751T1 true ATE377751T1 (de) 2007-11-15

Family

ID=4209454

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96914164T ATE377751T1 (de) 1995-05-12 1996-05-02 Verfahren zur parallelen bestimmung mehrerer analyten mittels evaneszent angeregter lumineszenz

Country Status (15)

Country Link
US (2) US6078705A (de)
EP (2) EP1890130A3 (de)
JP (2) JPH11505610A (de)
KR (1) KR19990014709A (de)
AT (1) ATE377751T1 (de)
AU (1) AU5763296A (de)
BR (1) BR9608503A (de)
CA (1) CA2219769A1 (de)
DE (1) DE69637315T2 (de)
IL (1) IL118217A0 (de)
MX (1) MX9708698A (de)
PL (1) PL323257A1 (de)
TW (1) TW302435B (de)
WO (1) WO1996035940A1 (de)
ZA (1) ZA963731B (de)

Families Citing this family (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6327031B1 (en) 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
US6331275B1 (en) 1996-07-08 2001-12-18 Burstein Technologies, Inc. Spatially addressable, cleavable reflective signal elements, assay device and method
WO1998001533A1 (en) 1996-07-08 1998-01-15 Burstein Laboratories, Inc. Cleavable signal element device and method
EP0922214A1 (de) * 1996-08-29 1999-06-16 Novartis AG Optischer chemischer/biochemischer fühler
EP0843172A1 (de) * 1996-11-18 1998-05-20 Novartis AG Flusszelle sowie Vorrichtung zur Erzeugung evaneszent angeregter Strahlung
DE59712460D1 (de) 1996-11-18 2005-12-01 Novartis Ag Messvorrichtung mit einem planaren optischen wellenleiter
BR9808653A (pt) * 1997-02-28 2001-07-31 Burstein Lab Inc Laboratório em um disco
EP0886141A1 (de) * 1997-06-23 1998-12-23 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Optische Sensorvorrichtung und Verfahren zur hochempfindlichen Detektion von chemischen oder biochemischen Analyten
EP0887645A1 (de) * 1997-06-23 1998-12-30 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Verfahren und Gerät zur hochempfindlichen Detektion von Prionen, Prion-Liganden und anderen Biomolekülen
US6200814B1 (en) 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
EP2112501A1 (de) 1998-02-05 2009-10-28 Novartis Ag Verfahren und Vorrichtung zur Lumineszenzmessung
WO1999040415A1 (de) 1998-02-05 1999-08-12 Novartis Ag Verfahren und vorrichtung zur lumineszenzmessung
GB9805935D0 (en) * 1998-03-19 1998-05-13 Ciba Geigy Ag Organic compounds
DE19815109A1 (de) * 1998-04-03 1999-10-07 Bodenseewerk Perkin Elmer Co Vorrichtung zum Nachweis eines Fluoreszenzfarbstoffs
AU3491299A (en) * 1998-04-14 1999-11-01 Lumenal Technologies, L.P. Test cartridge with a single inlet port
FR2778986B1 (fr) * 1998-05-22 2000-07-21 Suisse Electronique Microtech Capteur optique utilisant une reaction immunologique et un marqueur fluorescent
US6346376B1 (en) * 1998-06-03 2002-02-12 Centre Suisse D'electronique Et De Mictotechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
FR2783179B1 (fr) * 1998-09-16 2000-10-06 Commissariat Energie Atomique Dispositif d'analyse chimique ou biologique comprenant une pluralite de sites d'analyse sur un support, et son procede de fabrication
US7014815B1 (en) 1998-10-30 2006-03-21 Burstein Technologies, Inc. Trackable optical discs with concurrently readable nonoperational features
DE19964220C2 (de) 1998-11-23 2003-07-03 Friz Biochem Gmbh Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche
DE19856041A1 (de) * 1998-12-04 2000-07-13 Inst Chemo Biosensorik Verfahren und Vorrichtung zur Durchführung von quantitativen Fluoreszenz markierten Affinitätstests
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
AU772719B2 (en) * 1999-01-08 2004-05-06 Applera Corporation Fiber array for contacting chemical species and methods for using and making same
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
DE19901761A1 (de) * 1999-01-18 1999-07-01 Gerhard Dr Hartwich Verfahren zur elektrochemischen Detektion von Nukleinsäure-Oligomer-Hybridisierungsereignissen
EP1031828B1 (de) 1999-02-25 2006-09-13 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Integrierter optischer Sensor und Verfahren zum integrierten optischen Nachweis einer Substanz
SE9901306D0 (sv) * 1999-04-09 1999-04-09 Amersham Pharm Biotech Ab Improved TIRF chamber
US6192168B1 (en) * 1999-04-09 2001-02-20 The United States Of America As Represented By The Secretary Of The Navy Reflectively coated optical waveguide and fluidics cell integration
WO2000075644A1 (de) * 1999-06-05 2000-12-14 Zeptosens Ag Sensorplatform und verfahren zur multianalytbestimmung
US6771376B2 (en) 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
HK1046438B (en) * 1999-07-05 2007-05-04 Novartis Ag Process of using a sensor platform
AU6834700A (en) 1999-08-13 2001-03-13 Zeptosens Ag Device and method for determining multiple analytes
ES2245947T3 (es) † 1999-08-20 2006-02-01 Stiftung Fur Diagnostische Forschung Procedimiento para determinar sustancias mediante el metodo de campo evanescente.
EP1218727A1 (de) * 1999-10-01 2002-07-03 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Verfahren und einrichtung zur bestimmung von substanzen, wie z.b. dna-sequenzen, in einer probe
DE19947616C2 (de) * 1999-10-01 2003-05-28 Fraunhofer Ges Forschung Verfahren zur Bestimmung von Substanzen, wie z.B. DNA-Sequenzen, in einer Probe und Vorrichtung zur Durchführung des Verfahrens
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
JP4599019B2 (ja) 1999-12-17 2010-12-15 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング フローセル配列及び多重分析対象物測定のためのその利用
DE19962668C1 (de) * 1999-12-23 2000-12-07 Siemens Ag Optische Meßeinrichtung für ein elektrisches Gerät mit einem in eine Nut gepreßten Leiter
DE10002566A1 (de) * 2000-01-21 2001-08-02 Fraunhofer Ges Forschung Verfahren und Einrichtung zur Bestimmung des Schmelzpunktes und/oder der Bindungskonstante von Substanzen, wie z. B. DNA-Sequenzen, in einer Probe
DE10012793C2 (de) * 2000-03-13 2002-01-24 Fraunhofer Ges Forschung Sensorelement zur optischen Detektion von chemischen oder biochemischen Analyten
US6368558B1 (en) * 2000-03-21 2002-04-09 The Board Of Trustees Of The University Of Illinois Colorimetric artificial nose having an array of dyes and method for artificial olfaction
BR0109432A (pt) * 2000-03-21 2004-06-22 Univ Illinois Nariz artificial tendo um arranjo de corantes e método para olfação artificial
US7058245B2 (en) * 2000-04-04 2006-06-06 Waveguide Solutions, Inc. Integrated optical circuits
EP1287360A2 (de) * 2000-06-02 2003-03-05 Zeptosens AG Kit und verfahren zur multianalytbestimmung
US7555333B2 (en) 2000-06-19 2009-06-30 University Of Washington Integrated optical scanning image acquisition and display
EP1311824A4 (de) * 2000-06-25 2010-12-08 Affymetrix Inc Optisch aktive substrate
DE10036457A1 (de) * 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
FR2812942B1 (fr) * 2000-08-08 2002-10-31 Commissariat Energie Atomique Dispositif d'imagerie de fluorescence en lumiere polarisee
US6785433B2 (en) * 2000-08-09 2004-08-31 Artificial Sensing Instruments Asi Ag Waveguide grid array and optical measurement arrangement
WO2002021110A1 (de) * 2000-09-04 2002-03-14 Zeptosens Ag System und verfahren zur multianalytbestimmung
US7517546B2 (en) * 2000-09-05 2009-04-14 Bayer Technology Services Gmbh Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof
US6358748B1 (en) * 2000-09-28 2002-03-19 The United States Of America As Represented By The U.S. Department Of Energy Microbend fiber-optic chemical sensor
EP1334361A2 (de) * 2000-11-17 2003-08-13 Zeptosens AG Kit und verfahren zur multianalytbestimmung, mit vorkehrungen zur referenzierung der dichte immobilisierter erkennungselemente
JP2002221485A (ja) * 2000-11-22 2002-08-09 Minolta Co Ltd マイクロチップ
ATE508363T1 (de) 2000-12-06 2011-05-15 Ecole Polytech Verfahren zur herstellung eines bioanalytischen reagenzes, nachweisverfahren beruhend auf der verwendung des bioanalytischen reagenz, sowie dessen verwendung
DE10108483A1 (de) 2001-02-22 2002-09-05 Bayer Ag Phosphorhaltige Polymere für optischen Signalwandler
US6577780B2 (en) * 2001-03-08 2003-06-10 Veridian Systems Cell designs for optical biosensors
JP2002365211A (ja) * 2001-04-02 2002-12-18 Fuji Photo Film Co Ltd 測定装置
JP2002365210A (ja) * 2001-06-11 2002-12-18 Hitachi Ltd 生体分子検出方法
EP2169383A1 (de) * 2001-06-15 2010-03-31 Bayer Technology Services GmbH Körper für Durchflussküvetten und deren Verwendung
GB0117230D0 (en) * 2001-07-14 2001-09-05 Marconi Applied Technologies Detecting analytes
DE10133844B4 (de) * 2001-07-18 2006-08-17 Micronas Gmbh Verfahren und Vorrichtung zur Detektion von Analyten
US6782013B2 (en) * 2001-07-25 2004-08-24 Jds Uniphase Corporation Waveguide wavelength locker
WO2003014711A1 (en) * 2001-08-07 2003-02-20 Mitsubishi Chemical Corporation Surface plasmon resonance sensor chip, and sample analysis method and analysis apparatus using the same
WO2003020966A2 (de) * 2001-08-27 2003-03-13 Zeptosens Ag Oberfläche zur immobilisierung von nukleinsäuren
US6791677B2 (en) * 2001-08-28 2004-09-14 Tosoh Corporation Information measuring apparatus using a fine channel device
US6767733B1 (en) * 2001-10-10 2004-07-27 Pritest, Inc. Portable biosensor apparatus with controlled flow
FI115343B (fi) * 2001-10-22 2005-04-15 Filtronic Lk Oy Sisäinen monikaista-antenni
US6903815B2 (en) * 2001-11-22 2005-06-07 Kabushiki Kaisha Toshiba Optical waveguide sensor, device, system and method for glucose measurement
AU2003209372B2 (en) 2002-01-31 2009-02-19 Burstein Technologies, Inc. Method for triggering through disc grooves and related optical analysis discs and system
US7179654B2 (en) * 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
EP1348757A1 (de) * 2002-03-27 2003-10-01 Micronas GmbH Vorrichtung und Verfahren zur Detektion von zellulären Vorgängen mittels Lumineszenzmessungen
JP2003308714A (ja) * 2002-04-17 2003-10-31 Fuji Photo Film Co Ltd 導光フィルム
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
US20030232427A1 (en) * 2002-06-18 2003-12-18 Montagu Jean I. Optically active substrates for examination of biological materials
WO2004001392A1 (en) * 2002-06-19 2003-12-31 Biosensor Applications Sweden Ab (Publ) System, device and method for detection of several individual analytes in a solution, and a disposible flow cell for use therein
US7154598B2 (en) * 2002-07-12 2006-12-26 Decision Biomarkers, Inc. Excitation and imaging of fluorescent arrays
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
ATE520027T1 (de) 2002-09-03 2011-08-15 Bayer Technology Services Gmbh Analytische plattform und nachweisverfahren mit gegebenenfalls nach fraktionierung in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
WO2004023142A1 (de) * 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
DE10248209A1 (de) * 2002-10-16 2004-05-06 Kist-Europe Forschungsgesellschaft Mbh Verfahren und Vorrichtung zur Messung einer Vielzahl von parallel durchgeführten Reaktionen
US20040081384A1 (en) * 2002-10-25 2004-04-29 Datesman Aaron M. Multiple-mode planar-waveguide sensor, fabrication materials and techniques
AU2003295481A1 (en) * 2002-11-13 2004-06-03 Tracey L. Baas Waveguide system for detection of fluorescently labeled nucleic acid sequences
WO2005050757A2 (en) * 2002-12-09 2005-06-02 Rensselaer Polytechnic Institute Nanotube-organic photoelectric conversion devices and methods of making same
WO2004053546A1 (en) * 2002-12-10 2004-06-24 Rensselaer Polytechnic Institute Nanotube based non-linear optics and methods of making same
US6861251B2 (en) 2003-02-24 2005-03-01 Pritest, Inc. Translucent solid matrix assay device for microarray analysis
JP2004279196A (ja) * 2003-03-14 2004-10-07 Dainippon Printing Co Ltd バイオマイクロアレイ用基板およびバイオマイクロアレイ
US7162124B1 (en) * 2003-03-14 2007-01-09 Luxtera, Inc. Fiber to chip coupler
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
US20050084909A1 (en) * 2003-08-29 2005-04-21 Kenichi Uchiyama Antigen measuring device and method thereof, an antibody chip package and a pallet
US8501098B1 (en) * 2003-09-18 2013-08-06 The Research Foundation Of State University Of New York Temporally addressable detection array
US20050074784A1 (en) * 2003-10-07 2005-04-07 Tuan Vo-Dinh Integrated biochip with continuous sampling and processing (CSP) system
EP1691666B1 (de) 2003-12-12 2012-05-30 University of Washington Katheterskop-3d-führung und schnittstellensystem
US8008094B2 (en) 2003-12-25 2011-08-30 National Institute Of Advanced Industrial Science And Technology Methods for analyzing interactions between proteins and sugar chains
US7773836B2 (en) 2005-12-14 2010-08-10 Luxtera, Inc. Integrated transceiver with lightpipe coupler
KR100590548B1 (ko) * 2004-03-03 2006-06-19 삼성전자주식회사 광검출 장치
EP1730530A1 (de) * 2004-03-03 2006-12-13 Bayer Technology Services GmbH Analytische plattform und verfahren zur bildung von proteinexpressionsprofilen aus zellpopulationen
US7682567B2 (en) * 2004-10-29 2010-03-23 Canon Kabushiki Kaisha Sensor for analyzing or identifying property of object, sensing apparatus using same, and sensing method
US7901632B2 (en) * 2004-11-16 2011-03-08 Chi Yung Fu Ultrasensitive olfactory system fabrication with doped aerogels
JP2006153497A (ja) * 2004-11-25 2006-06-15 Toshiba Corp グルコースセンシング膜用塗布液の調製方法および光学式グルコースセンサチップの製造方法
US7530948B2 (en) 2005-02-28 2009-05-12 University Of Washington Tethered capsule endoscope for Barrett's Esophagus screening
CN101208599B (zh) 2005-04-26 2014-12-10 拜耳知识产权有限责任公司 用于涂覆通过亲和力-测定法用于被分析物检测的底物基质的新的设备和方法
US7738086B2 (en) * 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US20070097364A1 (en) * 2005-05-09 2007-05-03 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
DE102005026839A1 (de) * 2005-06-10 2006-12-21 Universität Tübingen Verfahren und Vorrichtung zur quantitativen Bestimmung von Analyten in flüssigen Proben
EP3257949A1 (de) * 2005-06-15 2017-12-20 Complete Genomics Inc. Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten
US20090264299A1 (en) 2006-02-24 2009-10-22 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
JP4565237B2 (ja) * 2005-06-23 2010-10-20 独立行政法人産業技術総合研究所 糖鎖あるいは複合糖質の解析装置
US8597576B2 (en) 2005-06-23 2013-12-03 National Institute Of Advanced Industrial Science And Technology Analyzer for glycan or complex carbohydrate
EP1910809A1 (de) * 2005-07-21 2008-04-16 Koninklijke Philips Electronics N.V. Vorrichtung zur erkennung von erregung mithilfe einer multiplen punktanordnung
NZ564642A (en) * 2005-08-11 2010-05-28 Sru Biosystems Inc Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
US7790406B2 (en) * 2005-08-11 2010-09-07 Sru Biosystems, Inc Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
CN101726462B (zh) * 2005-09-29 2013-01-23 株式会社东芝 光波导型生物化学传感器芯片及其制造方法
EP2546360A1 (de) 2005-10-07 2013-01-16 Callida Genomics, Inc. Selbstangeordnete einzelne Molekülarrays und Verwendungen davon
US7960104B2 (en) 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
US7955837B2 (en) 2005-10-29 2011-06-07 Bayer Technology Services Gmbh Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
EP1954193B1 (de) * 2005-11-23 2013-03-06 University of Washington Scanning-strahl mit variablem sequentiellem framing unter verwendung von unterbrochener scanning-resonanz
WO2007091280A1 (en) * 2006-02-06 2007-08-16 Stmicroelectronics S.R.L. Optical apparatus and method for the inspection of nucleic acid probes by polarized radiation
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
EP2495337A1 (de) 2006-02-24 2012-09-05 Callida Genomics, Inc. Genomsequenzierung auf DNA-Arrays mit hohem Durchsatz
WO2007106075A2 (en) 2006-03-03 2007-09-20 University Of Washington Multi-cladding optical fiber scanner
JP4365832B2 (ja) 2006-03-07 2009-11-18 株式会社日立製作所 生化学分析用セル、生化学分析用キット及び生化学分析装置
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
JP2008060445A (ja) * 2006-09-01 2008-03-13 Nec Corp 発光素子
WO2008070352A2 (en) 2006-10-27 2008-06-12 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20090111706A1 (en) 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by amplification
WO2008075578A1 (ja) * 2006-12-19 2008-06-26 Omron Corporation 表面プラズモンセンサ
US7943908B2 (en) * 2007-01-22 2011-05-17 University Of Maryland Sensor system with surface-plasmon-polariton (SPP) enhanced selective fluorescence excitation and method
US8840566B2 (en) 2007-04-02 2014-09-23 University Of Washington Catheter with imaging capability acts as guidewire for cannula tools
US7952718B2 (en) 2007-05-03 2011-05-31 University Of Washington High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor
WO2008136812A2 (en) * 2007-05-07 2008-11-13 The Board Of Trustees Of The University Of Illinois Fluorescence detection enhancement using photonic crystal extraction
US8404450B2 (en) 2007-06-04 2013-03-26 University Of Maryland, Baltimore County Fluorescence microscope in a microwave cavity
US8411274B2 (en) * 2007-06-28 2013-04-02 Koninklijke Philips Electronics N.V. Microelectronic sensor device for optical examinations on a wetted surface
DE102007033124B4 (de) * 2007-07-16 2012-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur optischen Detektion von Substanzen in einem flüssigen oder gasförmigen Medium
US8298496B2 (en) 2007-07-23 2012-10-30 Flir Systems, Inc. Fluidic configuration for flow injection analysis
DK2215209T3 (en) 2007-10-30 2018-09-03 Complete Genomics Inc DEVICE FOR HIGH-THROUGHPUT SEQUENCE OF NUCLEIC ACIDS
JP2009133836A (ja) * 2007-11-06 2009-06-18 Toshiba Corp 光学式センサ
AU2008323984A1 (en) * 2007-11-07 2009-05-14 Siemens Heathcare Diagnostics Inc. A method and apparatus for increasing the sensitivity of a biosensor used in a planar waveguide
DE102008011013B4 (de) * 2008-02-25 2014-11-13 Mevitec Gmbh Verfahren und Einrichtung zur komplexen Stoffwechselanalyse
AT506177B1 (de) * 2008-03-26 2009-07-15 Univ Graz Tech Optischer sensor
CN102037345B (zh) * 2008-04-04 2015-04-22 纳米识别技术股份公司 模块化的吸收测量系统
EP2110694B1 (de) 2008-04-18 2013-08-14 Sony DADC Austria AG Verfahren zur Herstellung eines optischen Wellenleiters, optischer Wellenleiter und Sensoranordnung
DE102008019928A1 (de) 2008-04-21 2009-12-31 Siemens Healthcare Diagnostics Gmbh Polyelektrolyt-Monoschichten mit kovalenten Bindungsstellen für optische Signalwandler
US20090270273A1 (en) * 2008-04-21 2009-10-29 Complete Genomics, Inc. Array structures for nucleic acid detection
EP2338051B1 (de) 2008-07-17 2013-11-20 IKFE Institut für klinische Forschung und Entwicklung GmbH Biomarker für kardiodiabetes
ES2433691T3 (es) 2008-07-17 2013-12-12 Ikfe Institut Für Klinische Forschung Und Entwicklung Gmbh Biomarcadores para la insulinorresistencia y disfunción de células beta
CA2732996A1 (en) * 2008-08-07 2010-05-14 University Of Massachusetts Spectroscopic sensors
DE102008052223A1 (de) * 2008-10-17 2010-04-22 Albert-Ludwigs-Universität Freiburg Lumineszenzscanner sowie Verfahren zur Detektion von Lumineszenz in Halbleiterbauteilen
US20100256196A1 (en) 2008-12-04 2010-10-07 Ikfe Biomarkers for Atherosclerosis
US20110118134A1 (en) 2008-12-11 2011-05-19 Ikfe Gmbh Biomarkers for insulin sensitizer drug response
WO2010076655A1 (en) 2008-12-30 2010-07-08 Ikfe Gmbh Biomarkers for adipose tissue activity
EP2382475A2 (de) 2009-01-07 2011-11-02 IKFE GmbH Biomarker für appetitregulierung
DE102009016712A1 (de) 2009-04-09 2010-10-14 Bayer Technology Services Gmbh Einweg-Mikrofluidik-Testkassette zur Bioassay von Analyten
DE102009025072A1 (de) * 2009-06-16 2010-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Erzeugen eines Bereiches mit erhöhtem Brechungsindex und ein Substrat mit örtlich variablem Brechungsindex
EP2375242A1 (de) 2010-04-06 2011-10-12 FOM Institute for Atomic and Moleculair Physics Integrierte Vorrichtung zum Abtasten von Plasmonennanokavitäten
CN103228796B (zh) 2010-08-11 2016-06-01 赛路拉公司 基因分型dna
US8305577B2 (en) * 2010-11-04 2012-11-06 Nokia Corporation Method and apparatus for spectrometry
WO2012138915A1 (en) 2011-04-05 2012-10-11 Integrated Plasmonics Corporation Integrated plasmonic sensing device and apparatus
RU2476861C2 (ru) * 2011-05-19 2013-02-27 Игорь Иванович Смыслов Лазерноспектрокомпьютерный концентратомер люминесцентов, частиц и их запахов и способ его использования
WO2013079619A1 (en) * 2011-12-01 2013-06-06 Biosurfit, S.A. Photometric device and method
TW201416061A (zh) * 2012-10-19 2014-05-01 Nat Univ Chung Cheng 雙面光柵波導生物感測器
US20150077756A1 (en) * 2013-06-13 2015-03-19 Lumense, Inc. System and method for continuous real-time monitoring of water at contaminated sites
WO2015131056A2 (en) * 2014-02-28 2015-09-03 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US9618693B2 (en) * 2014-06-13 2017-04-11 Infineon Technologies Ag Liquid sensing systems and methods using a ring resonator sensor
US9702813B2 (en) * 2014-07-23 2017-07-11 Infineon Technologies Ag Sensing systems and methods using a coupling structure
WO2016023011A1 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Integrated device with external light source for probing, detecting, and analyzing molecules
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9851290B2 (en) 2015-06-22 2017-12-26 Sharp Laboratories Of America, Inc. Particle detector for particulate matter accumulated on a surface
JP6731815B2 (ja) * 2016-09-08 2020-07-29 株式会社日立ハイテク 自動分析装置
US20210190772A1 (en) * 2017-01-23 2021-06-24 University Of Louisville Research Foundation, Inc. Electrically-modulated surface waves and an electrode interface comprising a metallic bilayer
DE102017127671A1 (de) * 2017-11-23 2019-05-23 Osram Opto Semiconductors Gmbh Photonischer Gassensor und Verfahren zur Herstellung eines photonischen Gassensors
EP3492909B1 (de) 2017-12-01 2023-11-01 ams AG Chemische erfassungsvorrichtung mit fluoreszierendem sensormaterial
RU2737056C1 (ru) * 2018-03-29 2020-11-24 Иллюмина, Инк. Освещение для флуоресцентной визуализации с помощью линзы объектива
JP7179549B2 (ja) * 2018-09-19 2022-11-29 旭化成エレクトロニクス株式会社 光導波路、光学式濃度測定装置、および製造方法
AU2020289796A1 (en) * 2019-06-28 2021-01-28 Illumina Cambridge Limited Flowcells with linear waveguides
CN115279921A (zh) 2019-11-19 2022-11-01 萨摩尔股份有限公司 检测sars-cov-2的方法和设备
US12006535B2 (en) 2019-11-19 2024-06-11 Sarmal, Inc. Methods and devices for detecting SARS-COV-2
KR102378269B1 (ko) * 2020-02-17 2022-03-24 가톨릭대학교산학협력단 회전식의 방사형 다중 진단키트
KR102378277B1 (ko) * 2020-02-17 2022-03-24 가톨릭대학교산학협력단 비회전식의 방사형 다중 진단키트
US12498328B2 (en) 2020-05-07 2025-12-16 Hand Held Products, Inc. Apparatuses, systems, and methods for sample testing
US11740177B2 (en) 2020-09-18 2023-08-29 Salvus, Llc Interferometric detection and quantification system and methods of use in aquatics
US20220091031A1 (en) * 2020-09-18 2022-03-24 Salvus, Llc Interferometric Detection and Quantification System and Methods of Use in Chemical Processing
US12399172B2 (en) 2020-09-18 2025-08-26 Salvus, Llc Interferometric detection and quantification system and methods of use in healthcare
US11994504B2 (en) 2020-09-18 2024-05-28 Salvus, Llc Interferometric detection and quantification system and methods of use in food processing and food supply chain
JP2024509688A (ja) * 2021-01-29 2024-03-05 オルト－クリニカル ダイアグノスティックス インコーポレイテッド 診断フォトニックバイオセンサの方法、装置、及びシステム
EP4306940A1 (de) * 2022-07-15 2024-01-17 lino Biotech AG Vorrichtung zur verwendung bei der detektion von bindungsaffinitäten
DE102022213412A1 (de) 2022-12-12 2024-06-13 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung und Verfahren zur dynamischen Fluoreszenzanalyse, insbesondere für die Molekulardiagnostik
WO2024249362A1 (en) * 2023-06-01 2024-12-05 The Regents Of The University Of California Rare antibody phage isolation and discrimination (rapid) biological panning
EP4621387A3 (de) * 2024-03-20 2025-11-12 Hand Held Products, Inc. Verfahren zur funktionalisierung eines probenkanals in einem wellenleiter

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5163118A (en) * 1986-11-10 1992-11-10 The United States Of America As Represented By The Secretary Of The Air Force Lattice mismatched hetrostructure optical waveguide
US5165005A (en) * 1988-01-29 1992-11-17 Fiberchem Inc. Planar and other waveguide refractive index sensors using metal cladding
GB8807486D0 (en) * 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Waveguide sensor
US5082629A (en) * 1989-12-29 1992-01-21 The Board Of The University Of Washington Thin-film spectroscopic sensor
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
GB9314991D0 (en) * 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
CA2190362A1 (en) * 1994-05-27 1995-12-07 Gert L. Duveneck Process for detecting evanescently excited luminescence

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WO1996035940A1 (en) 1996-11-14
US6289144B1 (en) 2001-09-11
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AU5763296A (en) 1996-11-29
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IL118217A0 (en) 1996-09-12

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