ATE253645T1 - Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien - Google Patents
Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzienInfo
- Publication number
- ATE253645T1 ATE253645T1 AT93909210T AT93909210T ATE253645T1 AT E253645 T1 ATE253645 T1 AT E253645T1 AT 93909210 T AT93909210 T AT 93909210T AT 93909210 T AT93909210 T AT 93909210T AT E253645 T1 ATE253645 T1 AT E253645T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acids
- stool samples
- reagents required
- required therefor
- mammal nucleic
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86191092A | 1992-04-01 | 1992-04-01 | |
| PCT/US1993/002960 WO1993020235A1 (en) | 1992-04-01 | 1993-03-31 | Methods of detecting mammalian nucleic acids isolated from stool specimen and reagents therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253645T1 true ATE253645T1 (de) | 2003-11-15 |
Family
ID=25337083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93909210T ATE253645T1 (de) | 1992-04-01 | 1993-03-31 | Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5910407A (de) |
| EP (1) | EP0672181B1 (de) |
| JP (1) | JP3633932B2 (de) |
| AT (1) | ATE253645T1 (de) |
| CA (1) | CA2132874C (de) |
| DE (1) | DE69333289T2 (de) |
| ES (1) | ES2210239T3 (de) |
| WO (1) | WO1993020235A1 (de) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5561041A (en) * | 1993-11-12 | 1996-10-01 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection by analysis of sputum |
| US6235470B1 (en) | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| ATE247176T1 (de) * | 1994-12-29 | 2003-08-15 | Eiken Chemical | Verfahren zur zellerkennung |
| DE19530132C2 (de) * | 1995-08-16 | 1998-07-16 | Max Planck Gesellschaft | Verfahren zur Reinigung, Stabilisierung oder Isolierung von Nukleinsäuren aus biologischen Materialien |
| GB9518156D0 (en) * | 1995-09-06 | 1995-11-08 | Medical Res Council | Method of isolating cells |
| NO954667D0 (no) | 1995-11-17 | 1995-11-17 | Dagfinn Oegreid | Fremgangsmåte til deteksjon av Ki-ras mutasjoner |
| US6448002B1 (en) * | 1996-08-26 | 2002-09-10 | Invitek Gmbh | Method to detect clinically relevant mutations of the DNA sequence of ki-ras oncogene, its use and a testkit for early diagnosis of tumors |
| US6406857B1 (en) | 1997-06-16 | 2002-06-18 | Exact Sciences Corporation | Methods for stool sample preparation |
| US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
| EP0939118A1 (de) * | 1998-02-20 | 1999-09-01 | Universiteit Maastricht | Verfahren zur Isolierung von DNA und RNA aus Stuhlproben |
| US6280947B1 (en) | 1999-08-11 | 2001-08-28 | Exact Sciences Corporation | Methods for detecting nucleotide insertion or deletion using primer extension |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| EP1155147B1 (de) * | 1999-02-25 | 2006-06-14 | EXACT Sciences Corporation | Verfahren zur erhaltung der dns-integrität |
| JP4794052B2 (ja) | 1999-04-09 | 2011-10-12 | ジェンザイム・コーポレーション | 癌の指標である核酸を検出するための方法 |
| JP2003530817A (ja) | 1999-06-01 | 2003-10-21 | ベイラー カレッジ オブ メディスン | 聴覚障害、変形性関節症および細胞の異常増殖に関するatonal関連配列の治療用途のための組成物および方法 |
| US6849403B1 (en) | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
| US6586177B1 (en) | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| CA2669753C (en) | 1999-09-30 | 2012-06-26 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
| US7368233B2 (en) | 1999-12-07 | 2008-05-06 | Exact Sciences Corporation | Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm |
| US6919174B1 (en) | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
| DE50113146D1 (de) | 2000-02-04 | 2007-11-29 | Qiagen Gmbh | Nukleinsäure-isolierung aus stuhlproben und anderen biologischen materialien, die reich an inhibitoren sind |
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| AU758744B2 (en) * | 2000-10-31 | 2003-03-27 | F. Hoffmann-La Roche Ag | Methods for the analysis of non-proteinaceous components using a protease from a bacillus strain |
| US20060073530A1 (en) * | 2001-08-15 | 2006-04-06 | Olaf Schneewind | Methods and compositions involving sortase B |
| US20030165940A1 (en) | 2001-12-06 | 2003-09-04 | The Johns Hopkins University | Disease detection by digital protein truncation assays |
| EP1572902B1 (de) | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HOCHWIRKSAME siRNAS ZUR REDUZIERUNG DER EXPRESSION VON ZIELGENEN |
| WO2003064625A2 (en) | 2002-02-01 | 2003-08-07 | Sequitur, Inc. | Oligonucleotide compositions with enhanced efficiency |
| US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| US20060258856A1 (en) * | 2002-02-13 | 2006-11-16 | Medimolecular Pty. Ltd. | Method of isolating nucleic acids from stool samples |
| WO2003071252A2 (en) | 2002-02-15 | 2003-08-28 | Exact Sciences Corporation | Methods for analysis of molecular events |
| US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
| EP2269618A1 (de) | 2002-08-12 | 2011-01-05 | Jennerex Biotherapeutics ULC | Ein onkolytisches Vaccinia-Virus zur Verwendung in Kombination mit Chemotherapie zur Behandlung von Krebs |
| US20090305294A1 (en) * | 2003-02-13 | 2009-12-10 | Medimolecular Pty Ltd | Method of isolating nucleic acids from stool samples |
| US20040259101A1 (en) * | 2003-06-20 | 2004-12-23 | Shuber Anthony P. | Methods for disease screening |
| US7189068B2 (en) * | 2003-09-19 | 2007-03-13 | Gast Manufacturing, Inc. | Sound reduced rotary vane compressor |
| WO2005111244A2 (en) * | 2004-05-10 | 2005-11-24 | Exact Sciences Corporation | Methods for detecting a mutant nucleic acid |
| WO2005113769A1 (en) * | 2004-05-14 | 2005-12-01 | Exact Sciences Corporation | Method for stabilizing biological samples for nucleic acid analysis |
| US7981607B2 (en) * | 2004-08-27 | 2011-07-19 | Esoterix Genetic Laboratories LLC | Method for detecting recombinant event |
| EP1802775B1 (de) | 2004-09-14 | 2010-05-26 | The Regents of the University of Colorado | Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol |
| WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
| US20090197249A1 (en) | 2004-11-01 | 2009-08-06 | George Mason University | Compositions and methods for diagnosing colon disorders |
| JP2006166711A (ja) * | 2004-12-13 | 2006-06-29 | Okayama Univ | 糞便由来遺伝子の簡便増幅方法 |
| WO2007044071A2 (en) | 2005-04-21 | 2007-04-19 | Exact Sciences Corporation | Analysis of heterogeneous nucleic acid samples |
| AU2006261671A1 (en) * | 2005-06-27 | 2007-01-04 | John Wayne Cancer Institute | Molecular/genetic aberrations in surgical margins of resected pancreatic cancer represents neoplastic disease that correlates with disease outcome |
| US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
| EP1933857A2 (de) * | 2005-09-07 | 2008-06-25 | Jennerex Biotherapeutics ULC | Systemische behandlung von metastasierten und/oder systemisch dissemierten tumoren mit gm-csf-exprimierenden pockenviren |
| CA2921063C (en) | 2006-09-15 | 2020-01-28 | Ottawa Hospital Research Institute | Oncolytic rhabdovirus |
| US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| JP2010533714A (ja) * | 2007-07-16 | 2010-10-28 | ポニアード ファーマシューティカルズ, インコーポレイテッド | ピコプラチンのための経口製剤 |
| AU2009210656A1 (en) * | 2008-02-08 | 2009-08-13 | Poniard Pharmaceuticals, Inc. | Use of picoplatin and cetuximab to treat colorectal cancer |
| CN102105583A (zh) * | 2008-07-23 | 2011-06-22 | 奥林巴斯株式会社 | 从粪便试样中回收核酸的方法、核酸分析方法以及粪便试样处理装置 |
| EP2789689B1 (de) | 2009-06-29 | 2016-04-27 | Luminex Corporation | Chimäre Primer mit Haarnadel-Konformationen und Verfahren zur Verwendung davon |
| US9409983B2 (en) | 2009-07-23 | 2016-08-09 | The Board Of Trustess Of The University Of Illinois | Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases |
| US9512481B2 (en) | 2009-09-11 | 2016-12-06 | The Regents Of The University Of Colorado, A Body Corporate | Polymorphisms in the PDE3A gene |
| WO2011032180A1 (en) | 2009-09-14 | 2011-03-17 | Jennerex, Inc. | Oncolytic vaccinia virus combination cancer therapy |
| US9045729B2 (en) | 2009-12-10 | 2015-06-02 | Ottawa Hospital Research Institute | Oncolytic rhabdovirus |
| US20130131161A1 (en) | 2009-12-23 | 2013-05-23 | Michael R. Bristow | Methods and compositions for cardiovascular diseases and conditions |
| EP2661278B1 (de) | 2011-01-04 | 2019-06-19 | SillaJen Biotherapeutics, Inc. | Tumorspezifischen komplementabhängigen zytotoxizität (cdc) antikörper erzeugert durch verabreichung von onkolytischen vacciniaviren, zur behandlung von krebs |
| MX2013009863A (es) | 2011-02-28 | 2013-12-06 | Univ Iowa Res Found | Cambios de la hormona anti-mulleriana en el embarazo y prediccion de sexo y de resultados adversos en el embarazo. |
| AU2012226530B2 (en) | 2011-03-08 | 2016-12-01 | King Abdullah University Of Science And Technology | Molecular biomarker set for early detection of ovarian cancer |
| GB201107466D0 (en) | 2011-05-05 | 2011-06-15 | Loktionov Alexandre | Device and method for non-invasive collection of colorectal mucocellular layer and disease detection |
| WO2012167382A1 (en) | 2011-06-08 | 2012-12-13 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Compositions and methods for glioblastoma treatment |
| AU2012273121B2 (en) | 2011-06-19 | 2016-08-25 | Abogen, Inc. | Devices, solutions and methods for sample collection |
| WO2013036799A2 (en) | 2011-09-09 | 2013-03-14 | Fred Hutchinson Cancer Research Center | Methods and compositions involving nkg2d inhibitors and cancer |
| US10125373B2 (en) | 2013-01-22 | 2018-11-13 | Arizona Board Of Regents On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
| WO2014127478A1 (en) | 2013-02-21 | 2014-08-28 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Vaccine composition |
| MX2016004283A (es) | 2013-10-03 | 2016-10-12 | Oklahoma Med Res Found | Biomarcadores para la actividad, e intesidad y arrebato de la enfermedad lupus eritematoso sistemico. |
| SG11201607364RA (en) | 2014-03-07 | 2016-10-28 | Dna Genotek Inc | Composition and method for stabilizing nucleic acids in biological samples |
| US20180057839A1 (en) | 2014-11-26 | 2018-03-01 | The Regents Of The University Of California | Therapeutic compositions comprising transcription factors and methods of making and using the same |
| AU2018213315A1 (en) | 2017-01-26 | 2019-07-25 | Oklahoma Medical Research Foundation | Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare |
| US12140592B2 (en) | 2017-06-16 | 2024-11-12 | Oklahoma Medical Research Foundation | Biomarkers for assessing risk of transitioning to systemic lupus erythematosus classification and disease pathogenesis |
| EP3810182A4 (de) | 2018-06-19 | 2022-08-24 | BioNTech US Inc. | Neoantigene und ihre verwendungen |
| US12510539B2 (en) | 2018-10-18 | 2025-12-30 | Progentec Diagnostics, Inc. | Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity |
| EP3867645B1 (de) | 2018-10-18 | 2024-06-05 | Oklahoma Medical Research Foundation | Biomarker für krankheitsaktivitätimmunindex von systemischem lupus erythematodes (sle) zur charakterisierung der krankheitsaktivität |
| EP3874273B1 (de) | 2018-10-31 | 2024-03-27 | Arizona Board of Regents on behalf of the University of Arizona | Biomarker und verfahren zur verwendung bei strahlungsinduzierter lungenverletzung |
| JP2022547627A (ja) | 2019-09-16 | 2022-11-14 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | Swi-snf変異型腫瘍の処置のための組成物および方法 |
| CN113186185B (zh) * | 2020-01-14 | 2023-05-26 | 东北林业大学 | 一种从哺乳动物粪便中高效富集宿主dna的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4358535A (en) | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| US5482834A (en) * | 1982-05-17 | 1996-01-09 | Hahnemann University | Evaluation of nucleic acids in a biological sample hybridization in a solution of chaotrophic salt solubilized cells |
| US5037959A (en) * | 1984-05-29 | 1991-08-06 | Lubrizol Genetics, Inc. | Self incompatibility protein |
| FR2567541B1 (fr) | 1984-07-13 | 1987-02-06 | Pasteur Institut | Sonde d'adn et procede pour la detection de " shigelles " et des souches entero-invasives de escherichia coli |
| US4800159A (en) * | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5053331A (en) * | 1986-04-21 | 1991-10-01 | Lubrizol Genetics, Inc. | Self-incompatibility gene |
| US4935342A (en) * | 1986-12-01 | 1990-06-19 | Syngene, Inc. | Method of isolating and purifying nucleic acids from biological samples |
| US5024934A (en) | 1988-03-14 | 1991-06-18 | The Board Of Regents, The University Of Texas System | Detection of minimal numbers of neoplastic cells carrying DNA translocations by DNA sequence amplification |
| US5362623A (en) * | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| AU7224591A (en) | 1990-01-24 | 1991-08-21 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | A rapid and sensitive test for detecting hepatitis a virus |
| US5352775A (en) * | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| US5330892A (en) * | 1991-03-13 | 1994-07-19 | The Johns Hopkins University | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
| US5670325A (en) * | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| US5612473A (en) * | 1996-01-16 | 1997-03-18 | Gull Laboratories | Methods, kits and solutions for preparing sample material for nucleic acid amplification |
-
1993
- 1993-03-31 EP EP93909210A patent/EP0672181B1/de not_active Expired - Lifetime
- 1993-03-31 AT AT93909210T patent/ATE253645T1/de not_active IP Right Cessation
- 1993-03-31 ES ES93909210T patent/ES2210239T3/es not_active Expired - Lifetime
- 1993-03-31 DE DE69333289T patent/DE69333289T2/de not_active Expired - Lifetime
- 1993-03-31 CA CA002132874A patent/CA2132874C/en not_active Expired - Lifetime
- 1993-03-31 WO PCT/US1993/002960 patent/WO1993020235A1/en not_active Ceased
- 1993-03-31 JP JP51762893A patent/JP3633932B2/ja not_active Expired - Fee Related
-
1994
- 1994-08-26 US US08/297,265 patent/US5910407A/en not_active Expired - Lifetime
-
1999
- 1999-06-08 US US09/328,114 patent/US6177251B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08504081A (ja) | 1996-05-07 |
| US5910407A (en) | 1999-06-08 |
| DE69333289T2 (de) | 2004-08-26 |
| US6177251B1 (en) | 2001-01-23 |
| EP0672181B1 (de) | 2003-11-05 |
| EP0672181A4 (de) | 1997-03-26 |
| EP0672181A1 (de) | 1995-09-20 |
| JP3633932B2 (ja) | 2005-03-30 |
| CA2132874A1 (en) | 1993-10-14 |
| WO1993020235A1 (en) | 1993-10-14 |
| CA2132874C (en) | 2003-08-19 |
| DE69333289D1 (de) | 2003-12-11 |
| ES2210239T3 (es) | 2004-07-01 |
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