DE3853254D1 - Ausrüstungssatz und Verfahren für Analysen von biologischen Proben. - Google Patents

Ausrüstungssatz und Verfahren für Analysen von biologischen Proben.

Info

Publication number
DE3853254D1
DE3853254D1 DE3853254T DE3853254T DE3853254D1 DE 3853254 D1 DE3853254 D1 DE 3853254D1 DE 3853254 T DE3853254 T DE 3853254T DE 3853254 T DE3853254 T DE 3853254T DE 3853254 D1 DE3853254 D1 DE 3853254D1
Authority
DE
Germany
Prior art keywords
analysis
biological samples
equipment set
equipment
biological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3853254T
Other languages
English (en)
Other versions
DE3853254T2 (de
Inventor
James William Bacus
Peter Simon Oud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Analysis Systems Inc
Original Assignee
Cell Analysis Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Analysis Systems Inc filed Critical Cell Analysis Systems Inc
Publication of DE3853254D1 publication Critical patent/DE3853254D1/de
Application granted granted Critical
Publication of DE3853254T2 publication Critical patent/DE3853254T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B01L1/52—Transportable laboratories; Field kits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Multimedia (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Signal Processing (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
DE3853254T 1987-09-21 1988-09-21 Ausrüstungssatz und Verfahren für Analysen von biologischen Proben. Expired - Lifetime DE3853254T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/099,141 US5109429A (en) 1985-11-04 1987-09-21 Apparatus and method for analyses of biological specimens

Publications (2)

Publication Number Publication Date
DE3853254D1 true DE3853254D1 (de) 1995-04-13
DE3853254T2 DE3853254T2 (de) 1995-06-29

Family

ID=22273039

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3853254T Expired - Lifetime DE3853254T2 (de) 1987-09-21 1988-09-21 Ausrüstungssatz und Verfahren für Analysen von biologischen Proben.

Country Status (4)

Country Link
US (1) US5109429A (de)
EP (1) EP0314293B1 (de)
JP (1) JPH01127956A (de)
DE (1) DE3853254T2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5485527A (en) * 1985-11-04 1996-01-16 Becton Dickinson And Company Apparatus and method for analyses of biological specimens
US5546323A (en) * 1990-10-10 1996-08-13 Cell Analysis Systems, Inc. Methods and apparatus for measuring tissue section thickness
DE69130795T2 (de) * 1990-10-26 1999-07-08 Sangtec Medical Ab Verfahren zur bewertung der tauglichkeit von klinischen proben für hybridisierungstests und ein dafür angepastes kit
US6026174A (en) * 1992-10-14 2000-02-15 Accumed International, Inc. System and method for automatically detecting malignant cells and cells having malignancy-associated changes
US5942410A (en) * 1997-07-07 1999-08-24 Oncometrics Imaging Corp. Composition and method for staining cellular DNA, comprising thiazine derivative metabisulfite and methanol or ethanol
US5995645A (en) * 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5352613A (en) * 1993-10-07 1994-10-04 Tafas Triantafillos P Cytological screening method
US6136540A (en) * 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
DE69527465T2 (de) * 1994-04-21 2003-05-08 Hitachi Ltd Überwachungsverfahren einer Färbelösung für Partikelanalysen und Kalibrierungsverfahren von Partikelanalysen
US5846749A (en) * 1994-10-12 1998-12-08 The Regents Of The University Of California Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination
US5732150A (en) * 1995-09-19 1998-03-24 Ihc Health Services, Inc. Method and system for multiple wavelength microscopy image analysis
DE19838429C2 (de) * 1998-08-24 2001-07-26 Fraunhofer Ges Forschung Anordnung zum schnellen Nachweis von mikrobiologischen oder biochemischen Stoffen
US7011940B1 (en) 1999-04-14 2006-03-14 Medical Discovery Partners Llc Quality control for cytochemical assays
US6661501B1 (en) 1999-10-29 2003-12-09 Cytyc Corporation Cytological stain composition including verification characteristic
US6348325B1 (en) 1999-10-29 2002-02-19 Cytyc Corporation Cytological stain composition
US6593102B2 (en) 1999-10-29 2003-07-15 Cytyc Corporation Cytological stain composition
US6665060B1 (en) 1999-10-29 2003-12-16 Cytyc Corporation Cytological imaging system and method
WO2001051928A1 (en) 2000-01-12 2001-07-19 Ventana Medical Systems, Inc. Method for quantitating a protein by image analysis
DE10063112A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Erhöhung der klinischen Spezifität bei der Detektion von Tumoren und ihren Vorstufen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern
DE10063179A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern
US6956695B2 (en) * 2001-03-19 2005-10-18 Ikonisys, Inc. System and method for increasing the contrast of an image produced by an epifluorescence microscope
US7065236B2 (en) * 2001-09-19 2006-06-20 Tripath Imaging, Inc. Method for quantitative video-microscopy and associated system and computer software program product
US7139415B2 (en) * 2001-12-05 2006-11-21 The Regents Of The University Of California Robotic microscopy systems
US7133547B2 (en) * 2002-01-24 2006-11-07 Tripath Imaging, Inc. Method for quantitative video-microscopy and associated system and computer software program product
US20060199243A1 (en) * 2005-03-03 2006-09-07 Garner David M Cytological stain composition and methods of use
US8101368B2 (en) * 2006-02-13 2012-01-24 Dvs Sciences Inc. Quantitation of cellular DNA and cell numbers using element labeling
CN104122191B (zh) 2007-10-29 2020-02-18 希森美康株式会社 细胞分析仪及细胞分析方法
EP2721391B1 (de) 2011-06-17 2022-04-06 Roche Diagnostics Hematology, Inc. Lösung und verfahren für histologische behandlung biologischer proben
JP5918988B2 (ja) * 2011-12-14 2016-05-18 公益財団法人ヒューマンサイエンス振興財団 染色キット及び染色方法
JP6273276B2 (ja) 2012-07-25 2018-01-31 セラノス， インコーポレイテッドＴｈｅｒａｎｏｓ， Ｉｎｃ． 生物学的サンプルの画像分析および測定
JP6373864B2 (ja) 2012-12-14 2018-08-15 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ 自動ロボット顕微鏡検査システム
GB2522231B (en) * 2014-01-17 2019-11-06 Leeds Teaching Hospitals Nhs Trust Method of forming a stain assessment target
US10768105B1 (en) 2016-07-29 2020-09-08 Labrador Diagnostics Llc Image analysis and measurement of biological samples

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3297869A (en) * 1963-02-13 1967-01-10 Hitachi Ltd Specimen heating device for an electron microscope specimen holder made of a single piece of material
US3481659A (en) * 1965-10-20 1969-12-02 Harold James Rosenberg Microscope slide
US3532412A (en) * 1969-01-17 1970-10-06 Ibm Package for and method of packaging pathology specimens
DE2019778B2 (de) * 1970-04-23 1973-02-08 Institutul Pentru Controlul de Sta ta al Medicamentului si Cercetan Far maceutice, Bukarest Verfahren zur bestimmung der intrazellulaeren verteilung von ribonukleinsaeuren
US3773425A (en) * 1971-10-26 1973-11-20 R Bentley Visual comparator system
US3847486A (en) * 1972-06-07 1974-11-12 W Mccabe Automated spectrophotometer apparatus and computer system for simulataneous measurement of a plurality of kinetic reactions
US4125828A (en) * 1972-08-04 1978-11-14 Med-El Inc. Method and apparatus for automated classification and analysis of cells
US4207554A (en) * 1972-08-04 1980-06-10 Med-El Inc. Method and apparatus for automated classification and analysis of cells
US3907437A (en) * 1973-04-26 1975-09-23 Block Engineering Cell classification system
DE2434246B2 (de) * 1974-02-15 1976-01-22 Ausscheidung aus: 24 07 270 Fa. Carl Zeiss, 7920 Heidenheim Mikroskopisches verfahren zur erkennung und deutung von objekten
US4045772A (en) * 1974-04-29 1977-08-30 Geometric Data Corporation Automatic focusing system
US4174178A (en) * 1974-05-07 1979-11-13 Olympus Optical Co., Ltd. Blood serum bearing film with position indicating mark
US4017192A (en) * 1975-02-06 1977-04-12 Neotec Corporation Optical analysis of biomedical specimens
US4000417A (en) * 1975-08-25 1976-12-28 Honeywell Inc. Scanning microscope system with automatic cell find and autofocus
US4152410A (en) * 1975-09-03 1979-05-01 Eisai Co., Ltd. Diagnosis reagent for neoplasm and method for diagnosis of neoplasm
US4048616A (en) * 1975-12-03 1977-09-13 Geometric Data Corporation Pattern recognition system with keyboard entry for adaptive sensitivity
US4132767A (en) * 1976-04-05 1979-01-02 Eisai Co., Ltd. Preparation of α-L antibody, purification of α-L antigen and reagent for detection of α-L antibody and α-L antigen
US4160817A (en) * 1976-09-29 1979-07-10 Research Corporation Application of protein-protein interaction as an assay for the detection of cancer
US4129854A (en) * 1976-10-25 1978-12-12 Hitachi, Ltd. Cell classification method
US4097845A (en) * 1976-11-01 1978-06-27 Rush-Presbyterian-St. Luke's Medical Center Method of and an apparatus for automatic classification of red blood cells
US4307376A (en) * 1976-12-09 1981-12-22 Geometric Data Corporation Pattern recognition system for generating hematology profile
JPS53135697A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Automatic cell diagnosis apparatus
US4175860A (en) * 1977-05-31 1979-11-27 Rush-Presbyterian-St. Luke's Medical Center Dual resolution method and apparatus for use in automated classification of pap smear and other samples
DE2741638C3 (de) * 1977-09-15 1980-03-27 Ernst Dipl.-Phys. Dr. 8000 Muenchen Remy Präparattrager mit Elektrodenanordnung fur die Zelluntersuchung, sowie seine Herstellung
US4213036A (en) * 1977-12-27 1980-07-15 Grumman Aerospace Corporation Method for classifying biological cells
US4199743A (en) * 1978-02-06 1980-04-22 Westinghouse Electric Corp. Encapsulated current transformer
US4219440A (en) * 1979-06-06 1980-08-26 Coulter Electronics, Inc. Multiple analysis hematology reference control reagent and method of making the same
US4232001A (en) * 1978-09-22 1980-11-04 University Patents, Inc. Methods and materials for detection of estrophilin
DE2903855A1 (de) * 1979-02-01 1980-08-14 Bloss Werner H Prof Dr Ing Verfahren zum automatischen markieren von zellen und bestimmung der merkmale von zellen aus zytologischen abstrichpraeparaten
US4227814A (en) * 1979-02-01 1980-10-14 Baxter Travenol Laboratories, Inc. Optical density detector
JPS5661650A (en) * 1979-10-24 1981-05-27 Omron Tateisi Electronics Co Analyzing device of cell
JPS5672845A (en) * 1979-11-19 1981-06-17 Hitachi Ltd Detecting apparatus of examination position of sample
US4257709A (en) * 1979-12-26 1981-03-24 Helena Laboratories Corporation Automatic blanking circuit
JPS56104646A (en) * 1980-01-25 1981-08-20 Minolta Camera Kk Optical analyzer for forming ratio of element contained in organism
US4453266A (en) * 1980-04-21 1984-06-05 Rush-Presbyterian-St. Luke's Medical Center Method and apparatus for measuring mean cell volume of red blood cells
US4345027A (en) * 1980-12-12 1982-08-17 The United States Of America As Represented By The United States Department Of Energy Fluorometric method of quantitative cell mutagenesis
US4389669A (en) * 1981-02-27 1983-06-21 Ilc Data Device Corporation Opto-video inspection system
US4435027A (en) * 1981-03-25 1984-03-06 Edson Tool & Manufacturing Co., Inc. Self-locking hinged door cabinet and latch for the same
US4408231A (en) * 1981-07-31 1983-10-04 International Business Machines Corporation Method and apparatus for calibrating a linear array scanning system
HU184903B (en) * 1981-11-20 1984-11-28 Reanal Finomvegyszergyar Paint composition for biopsy examinations
JPS58154064A (ja) * 1982-03-08 1983-09-13 Mitsubishi Rayon Co Ltd リンパ球ｔ細胞百分率測定方法
US4513438A (en) * 1982-04-15 1985-04-23 Coulter Electronics, Inc. Automated microscopy system and method for locating and re-locating objects in an image
JPS5988716A (ja) * 1982-11-15 1984-05-22 Toshiba Corp 自動焦点用プレパラ−ト
US4592089A (en) * 1983-08-15 1986-05-27 Bio Image Corporation Electrophoretogram analytical image processing system
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US4812412A (en) * 1987-02-26 1989-03-14 Health Research Inc. Standard specimen and method of making and using same

Also Published As

Publication number Publication date
JPH01127956A (ja) 1989-05-19
EP0314293B1 (de) 1995-03-08
EP0314293A3 (en) 1990-05-09
US5109429A (en) 1992-04-28
EP0314293A2 (de) 1989-05-03
DE3853254T2 (de) 1995-06-29

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Legal Events

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8364 No opposition during term of opposition