ATE364685T1 - Anlagen und verfahren für zellkulturen auf pharmacokinetischer basis - Google Patents

Anlagen und verfahren für zellkulturen auf pharmacokinetischer basis

Info

Publication number
ATE364685T1
ATE364685T1 AT02793757T AT02793757T ATE364685T1 AT E364685 T1 ATE364685 T1 AT E364685T1 AT 02793757 T AT02793757 T AT 02793757T AT 02793757 T AT02793757 T AT 02793757T AT E364685 T1 ATE364685 T1 AT E364685T1
Authority
AT
Austria
Prior art keywords
cell
pharmacokinetic parameter
pharmacocinetic
installations
methods
Prior art date
Application number
AT02793757T
Other languages
English (en)
Inventor
Michael Shuler
Gregory Baxter
Aaron Sin
Scott Meyers
Robert Andrew Harrison
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Application granted granted Critical
Publication of ATE364685T1 publication Critical patent/ATE364685T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
AT02793757T 2001-04-25 2002-04-25 Anlagen und verfahren für zellkulturen auf pharmacokinetischer basis ATE364685T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28649301P 2001-04-25 2001-04-25

Publications (1)

Publication Number Publication Date
ATE364685T1 true ATE364685T1 (de) 2007-07-15

Family

ID=23098849

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02793757T ATE364685T1 (de) 2001-04-25 2002-04-25 Anlagen und verfahren für zellkulturen auf pharmacokinetischer basis

Country Status (10)

Country Link
US (16) US7288405B2 (de)
EP (1) EP1392814B1 (de)
JP (1) JP4260627B2 (de)
AT (1) ATE364685T1 (de)
AU (1) AU2002359234B2 (de)
CA (1) CA2445458C (de)
DE (1) DE60220671T2 (de)
DK (1) DK1392814T3 (de)
ES (1) ES2287351T3 (de)
WO (1) WO2003027223A2 (de)

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US7326563B2 (en) * 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
US20030077817A1 (en) * 2001-04-10 2003-04-24 Zarur Andrey J. Microfermentor device and cell based screening method
US20040058437A1 (en) * 2001-04-10 2004-03-25 Rodgers Seth T. Materials and reactor systems having humidity and gas control
US20070048727A1 (en) * 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
DK1392814T3 (da) * 2001-04-25 2007-09-24 Cornell Res Foundation Inc Indretninger og fremgangsmåder til farmakokinetisk baseret cellekultursystem
US20070037277A1 (en) * 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
DE10213809C1 (de) * 2002-03-27 2003-12-04 Innovacell Biotechnologie Gmbh Zellträger und Verfahren zu dessen Herstellung
US20050026134A1 (en) * 2002-04-10 2005-02-03 Bioprocessors Corp. Systems and methods for control of pH and other reactor environment conditions
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
US20040171091A1 (en) * 2003-02-27 2004-09-02 Cell Work, Inc. Standardized evaluation of therapeutic efficacy based on cellular biomarkers
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
JP2007501633A (ja) * 2003-05-06 2007-02-01 ベル ブルック ラブズ リミテッド ライアビリティ カンパニー 微小規模の流体ハンドリングシステムにおける三次元細胞培養
EP1628748A2 (de) * 2003-06-05 2006-03-01 Bioprocessors Corporation Reaktor mit speicherkomponente
DE10326749B4 (de) * 2003-06-13 2006-11-16 Gerlach, Jörg, Dr.med. Hybrides Kreislaufsystem
WO2005033263A1 (en) * 2003-10-01 2005-04-14 Athena Capital Partners, Llc Circulating flow device for assays of cell cultures, cellular components and cell products
US20060147903A1 (en) * 2004-01-07 2006-07-06 Li Albert P In vitro organ modeling with cell culture tool
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
JP2008513022A (ja) 2004-09-15 2008-05-01 マイクロチップ バイオテクノロジーズ， インコーポレイテッド マイクロ流体デバイス
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
AU2006206426B2 (en) * 2005-01-20 2012-03-15 The Regents Of The University Of California Cellular microarrays for screening differentiation factors
CN101223268A (zh) * 2005-05-18 2008-07-16 康奈尔研究基金会（有限公司） 具有生物屏障的基于药代动力学的培养系统
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
KR20080056163A (ko) * 2005-08-24 2008-06-20 헤파호프 인코포레이티드 신규의 향상된 인체 조직을 사용한 약물 시험 및 선별 방법
KR20080052597A (ko) * 2005-08-24 2008-06-11 헤파호프 인코포레이티드 약제민감성 시험기
US8603806B2 (en) * 2005-11-02 2013-12-10 The Ohio State Universtiy Research Foundation Materials and methods for cell-based assays
WO2007056355A2 (en) * 2005-11-07 2007-05-18 Athena Capital Partners, Llc Devices and methods for culturing, preserving, transporting, storing, reconstituting and assaying cellular materials
CA2636855C (en) 2006-01-11 2016-09-27 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
WO2008030631A2 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
US20090263849A1 (en) * 2006-04-21 2009-10-22 Drexel University Bioprinting Three-Dimensional Structure Onto Microscale Tissue Analog Devices for Pharmacokinetic Study and Other Uses
EP2047910B1 (de) 2006-05-11 2012-01-11 Raindance Technologies, Inc. Mikrofluidische Vorrichtung und Verfahren
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
US20080064088A1 (en) * 2006-09-08 2008-03-13 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system
US20080138828A1 (en) * 2006-12-08 2008-06-12 Marshall University Research Corporation Microgravity bioreactor systems for production of bioactive compounds and biological macromolecules
KR20100028526A (ko) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US20080221847A1 (en) * 2007-03-09 2008-09-11 Frederique Fenetteau Method of developing a pharmacokinetic profile of a xenobiotic disposition in a mammalian tissue
US8343740B2 (en) * 2007-03-29 2013-01-01 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Micro-organ device
WO2008124104A1 (en) 2007-04-04 2008-10-16 Network Biosystems Inc. Integrated nucleic acid analysis
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009039378A2 (en) * 2007-09-19 2009-03-26 The Charles Stark Draper Laboratory, Inc. Microfluidic structures for biomedical applications
KR100936276B1 (ko) 2007-10-25 2010-01-13 한국과학기술원 미세유체제어기술 기반으로 난관의 물리적 특징 및 생물적특징을 모방한 수정란 및 난자 배양 시스템
CN101939644B (zh) * 2008-01-10 2014-06-11 休雷尔公司 免疫系统模拟装置和方法
US20090253181A1 (en) 2008-01-22 2009-10-08 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
DE102008010436A1 (de) * 2008-02-21 2009-09-03 Berthold Technologies Gmbh & Co. Kg Vorrichtung und Verfahren zur Messung von Lumineszenz und Fluoreszenz von transfizierten Zellen oder Organteilen
WO2009123657A1 (en) * 2008-04-01 2009-10-08 University Of North Carolina At Charlotte Bioreactor assembly and associated methods
US9121847B2 (en) * 2008-04-08 2015-09-01 Massachussetts Institute Of Technology Three-dimensional microfluidic platforms and methods of use thereof
US9921576B2 (en) * 2008-05-05 2018-03-20 Finesse Solutions, Inc. Virtual transmitter for bioreactor automation system
DE102008001969A1 (de) * 2008-05-26 2009-12-03 Hilti Aktiengesellschaft Handgeführtes elektrisch betriebenes Eintreibgerät
EP3778858A1 (de) 2008-07-16 2021-02-17 Children's Medical Center Corporation Vorrichtung mit mikrokanälen sowie verfahren zur verwendung der vorrichtung
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
HUE031849T2 (en) 2008-09-20 2017-08-28 Univ Leland Stanford Junior Non-invasive diagnosis of fetal aneuploidy by sequencing
DE102008058068A1 (de) * 2008-11-18 2010-05-20 Leica Microsystems Cms Gmbh Vorrichtung und ein Verfahren zur Bereitstellung einer vorgebbaren Konzentration mindestens einer Komponente in einem flüssigen Medium
TWI406939B (zh) * 2008-12-11 2013-09-01 Univ Chang Gung A system and method for providing external stimuli for cell samples
WO2010077322A1 (en) 2008-12-31 2010-07-08 Microchip Biotechnologies, Inc. Instrument with microfluidic chip
US10386360B2 (en) 2009-03-13 2019-08-20 University Of Central Florida Research Foundation, Inc. Bio-microelectromechanical system transducer and associated methods
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2010141326A1 (en) 2009-06-02 2010-12-09 Integenx Inc. Fluidic devices with diaphragm valves
EP3586945A3 (de) 2009-06-05 2020-03-04 IntegenX Inc. Universelles probenvorbereitungssystem und verwendung in einem integrierten analysesystem
AU2010257887B2 (en) 2009-06-10 2013-11-07 Kjølby, Mads SorCS1-like agent for use in the treatment of insulin resistance and diseases related thereto
JP2012529908A (ja) 2009-06-15 2012-11-29 ネットバイオ・インコーポレーテッド 法医学的ｄｎａの定量化のための改善された方法
WO2011014674A2 (en) * 2009-07-29 2011-02-03 Cornell University Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof
US10751464B2 (en) 2009-08-25 2020-08-25 Nanoshell Company, Llc Therapeutic retrieval of targets in biological fluids
US11285494B2 (en) 2009-08-25 2022-03-29 Nanoshell Company, Llc Method and apparatus for continuous removal of sub-micron sized particles in a closed loop liquid flow system
US20110136162A1 (en) * 2009-08-31 2011-06-09 Drexel University Compositions and Methods for Functionalized Patterning of Tissue Engineering Substrates Including Bioprinting Cell-Laden Constructs for Multicompartment Tissue Chambers
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US8481303B2 (en) 2009-10-12 2013-07-09 Corning Incorporated Microfluidic device for cell culture
US9404140B1 (en) 2009-11-03 2016-08-02 The University Of Central Florida Research Foundation, Inc. Patterned cardiomyocyte culture on microelectrode array
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
US8239030B1 (en) 2010-01-06 2012-08-07 DJ Technologies Transcranial stimulation device and method based on electrophysiological testing
WO2011083768A1 (ja) * 2010-01-08 2011-07-14 住友ベークライト株式会社 細胞凝集塊形成用培養容器
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2534267B1 (de) 2010-02-12 2018-04-11 Raindance Technologies, Inc. Digitale analyse von analyten
JP5881621B2 (ja) 2010-03-02 2016-03-09 ユニヴェルシテ テクノロジエ デ コンピエーニュ−ユテセ 動的細胞培養のマルチリアクタボックス
CN102234612B (zh) * 2010-05-06 2014-01-29 同济大学 一种生物工程体外循环系统
KR101270094B1 (ko) * 2010-05-25 2013-05-31 고려대학교 산학협력단 Ｃｍｏｓ 기반 세포 이미징 분석 시스템
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US10023832B2 (en) 2013-07-16 2018-07-17 Vanderbilt University Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same
WO2012048275A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
DE102011009854A1 (de) * 2011-02-01 2012-08-02 Erwin Quarder Systemtechnik Gmbh Sensoreinrichtung zur Messung von Eigenschaften von Analyten
EP2673614B1 (de) 2011-02-11 2018-08-01 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
EP2675819B1 (de) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
JP6122388B2 (ja) 2011-02-28 2017-04-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞培養システム
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20140248698A1 (en) * 2011-10-21 2014-09-04 Arkray, Inc. Method for culturing pluripotency-maintained singly dispersed cells by means of laminar flow
WO2013086329A1 (en) 2011-12-08 2013-06-13 Research Triangle Institute Human emulated response with microfluidic enhanced systems
WO2013086486A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
WO2013116729A1 (en) * 2012-02-02 2013-08-08 The Trustees Of The University Of Pennsylvania Microfabricated 3d cell culture system
DE102012101240A1 (de) 2012-02-16 2013-08-22 Technische Universität Ilmenau Verfahren zur bestimmung der ansiedelbarkeit von biologischen zellen auf strukturen aus einem polymer sowie verfahren zur herstellung solcher strukturen
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN104350142A (zh) 2012-04-18 2015-02-11 海莫希尔有限责任公司 病理或生理性病况的体外模型
US9528082B2 (en) 2012-07-25 2016-12-27 The Charles Stark Draper Laboratory, Inc. Modular platform for multi-tissue integrated cell culture
WO2014028940A1 (en) * 2012-08-17 2014-02-20 University Of Central Florida Research Foundation, Inc. Methods, systems and compositions for functional in vitro cellular models of mammalian systems
PT2712918E (pt) * 2012-09-28 2015-02-17 Tissuse Gmbh Chip-multi-órgãos com melhor tempo de vida e homeostase
CA2886247C (en) * 2012-09-29 2023-01-03 Nortis, Inc. Microfluidic system for reproducing functional units of tissues and organs in vitro
US9518977B2 (en) 2012-10-19 2016-12-13 University Of Washington Through Its Center For Commercialization Microfluidic assay apparatus and methods of use
GB201223495D0 (en) 2012-12-30 2013-02-13 Plummer Simon M A Bioreactor
US9249387B2 (en) 2013-01-29 2016-02-02 The Charles Stark Draper Laboratory, Inc. Modular platform for multi-tissue integrated cell culture
EP2951281B1 (de) 2013-01-30 2018-06-27 University of Central Florida Research Foundation, Inc. System und verfahren zur nachahmung der herzfunktion
WO2014127250A1 (en) * 2013-02-14 2014-08-21 Cfd Research Corporation Cell culture device with an array of microfluidic networks
US20140274796A1 (en) * 2013-03-15 2014-09-18 University Of Central Florida Research Foundation, Inc. Methods, Systems, and Compositions for In Vitro Concentric Cell Culture Analog Systems
DE102013011768B4 (de) * 2013-07-10 2015-07-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Zirkulationssystem sowie Verfahren zur Vitalversorgung von Zellkulturen in einem mikrofluidischen Netzwerk
US9389231B2 (en) 2013-07-22 2016-07-12 Sandia Corporation Apparatus comprising magnetically actuated valves and uses thereof
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
EP3060654B1 (de) 2013-10-21 2023-03-15 Hemoshear, LLC In-vitro-modell für eine tumormikroumgebung
US10633625B2 (en) 2013-11-16 2020-04-28 Terumo Bct, Inc. Expanding cells in a bioreactor
CN114471756B (zh) 2013-11-18 2024-04-16 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9957554B1 (en) 2013-12-19 2018-05-01 National Technology & Engineering Solutions Of Sandia, Llc Microfluidic platform for multiplexed detection in single cells and methods thereof
JP2017504320A (ja) 2013-12-20 2017-02-09 プレジデント アンド フェローズ オブ ハーバード カレッジ 低剪断マイクロ流体デバイスならびにその使用および製造の方法
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
JP2015169722A (ja) * 2014-03-05 2015-09-28 ソニー株式会社 撮像装置
US9631167B2 (en) * 2014-03-21 2017-04-25 Iontox, Llc Dynamic multi organ plate
EP3122866B1 (de) 2014-03-25 2019-11-20 Terumo BCT, Inc. Passives ersetzen von medien
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
AU2015289999B2 (en) 2014-07-14 2020-09-10 President And Fellows Of Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
US9995411B1 (en) 2014-07-16 2018-06-12 National Technology & Engineering Solutions Of Sandia, Llc High-temperature, adhesive-based microvalves and uses thereof
US10175219B2 (en) * 2014-07-28 2019-01-08 The Board Of Trustees Of The Leland Stanford Junior University Method to sort cells on the basis of radionuclide uptake
US10935541B2 (en) 2014-08-07 2021-03-02 University Of Central Florida Research Foundation, Inc. Devices and methods comprising neuromuscular junctions
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
US20170307595A1 (en) * 2014-10-22 2017-10-26 The General Hospital Corporation Methods and devices to study metabolism
CN113092563A (zh) 2014-10-22 2021-07-09 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
WO2016090237A1 (en) * 2014-12-04 2016-06-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Systems for dissociation of biological tissues
JP2018516065A (ja) 2015-02-04 2018-06-21 ザ チャールズ スターク ドレイパー ラボラトリー インク マイクロ流体装置用の作動バルブまたはポンプ
DK3279310T3 (da) * 2015-04-03 2021-08-02 Aist Celledyrkningsapparat og fremgangsmåde til celledyrkning
US20180291325A1 (en) * 2015-05-14 2018-10-11 Merck Sharp & Dohme Corp. In vitro pharmacokinetic-pharmacodynamic device
WO2017004169A1 (en) * 2015-06-29 2017-01-05 Northeastern University Dendritic cell generator
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
GB201512600D0 (en) * 2015-07-17 2015-08-26 Koniku Ltd Cell culture, transport and investigation
US10202569B2 (en) 2015-07-24 2019-02-12 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10988723B1 (en) 2015-09-23 2021-04-27 National Technology & Engineering Solutions Of Sandia, Llc Modular assemblies and systems for cell cultures and methods thereof
JP6995369B2 (ja) * 2015-11-18 2022-01-14 スライブ バイオサイエンス， インコーポレイテッド 器具リソーススケジューリング
EP3190172A3 (de) * 2016-01-07 2017-08-30 Vanderbilt University Verbindungen mehrerer manipulierter perfundierter gewebekonstrukte und mikrobioreaktoren, multi-mikroformulator und anwendungen dafür
WO2017181258A1 (en) * 2016-04-21 2017-10-26 Duane Hewitt Continuous flow system
EP3464565A4 (de) 2016-05-25 2020-01-01 Terumo BCT, Inc. Zellexpansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
SG10201606627QA (en) * 2016-08-10 2018-03-28 Agency Science Tech & Res Microfluidic chip
US11022605B2 (en) 2016-08-26 2021-06-01 University Of Central Florida Research Foundation, Inc. Multi-component in vitro system to deduce cell signaling pathways by electronic stimulation patterns
US11884905B2 (en) 2017-02-09 2024-01-30 University Public Corporation Osaka Fluidic chip for cell culture use, culture vessel, and culture method
WO2018208332A2 (en) 2017-02-17 2018-11-15 Koniku, Inc. Systems for detection
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
EP3624943A1 (de) * 2017-05-16 2020-03-25 Cairn Biosciences, Inc. Mikrofluidisch aktivierte zellkulturvorrichtungen mit mehreren kavitäten und systeme zur präzisionskultur, kontrolle und überwachung lebender zellen
WO2019043130A1 (en) * 2017-08-31 2019-03-07 Philip Morris Products S.A. CELL CULTURE PLATE, IN VITRO EXPOSURE DEVICES AND METHODS
WO2019191685A1 (en) * 2018-03-30 2019-10-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Workstation for automated control of an in vitro system
CN110713921B (zh) * 2018-07-13 2022-12-20 复旦大学 一套体外动态的药物代谢孵育系统
CN108918451B (zh) * 2018-09-13 2024-02-13 上海健康医学院 一种细胞代谢实时检测及动态干预装置及测试干预方法
US20220025308A1 (en) * 2018-10-17 2022-01-27 Northwestern University Tissue culture platform having multiple well chambers fluidically coupled via microfluidic channels and selector valves
US10647954B1 (en) 2018-11-15 2020-05-12 Flaskworks, Llc Dendritic cell generating apparatus and method
US20210403853A1 (en) * 2018-11-16 2021-12-30 Cairn Biosciences, Inc. Methods for dynamic evolution and monitoring of characteristics in living cells using a microfluidic-enabled multi-well cell culture devices and systems
WO2020148238A1 (en) * 2019-01-15 2020-07-23 Philip Morris Products S.A. Perforated structure
US11661332B2 (en) * 2019-02-20 2023-05-30 Invensense, Inc. Stiction reduction system and method thereof
WO2020252225A1 (en) 2019-06-14 2020-12-17 University Of Connecticut Multigel tumor-on-a-chip system
WO2021018365A1 (en) * 2019-07-26 2021-02-04 Swiss Medical Union Sa Micro-bioreactor comprising an organ layer
US11566217B2 (en) 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
AU2020369940A1 (en) 2019-10-21 2022-05-26 Flaskworks, Llc Systems and methods for cell culturing
JP2021153533A (ja) * 2020-03-30 2021-10-07 株式会社安川電機 細胞製造装置、細胞製造方法、細胞製造装置用プログラム、および、細胞製造システム
US20210301238A1 (en) * 2020-03-30 2021-09-30 Javelin Biotech, Inc. Microfluidic devices and methods of designing and using microfluidic devices
US20220373462A1 (en) * 2021-05-14 2022-11-24 MBD Co., Ltd. Measuring method of cell migration using the rate of cell invasion
WO2024013100A1 (en) * 2022-07-15 2024-01-18 Philip Morris Products S.A. Distal airway and alveoli model
CN116103152B (zh) * 2023-04-13 2023-06-13 零壹人工智能科技研究院(南京)有限公司 一种用于药物测试的类器官芯片模型

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941662A (en) 1971-06-09 1976-03-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Apparatus for culturing cells
US3948732A (en) 1973-05-31 1976-04-06 Instrumentation Laboratory, Inc. Cell culture assembly
US4436824A (en) * 1981-06-09 1984-03-13 Ortho Diagnostic Systems, Inc. Leukocyte migration through antigen containing agaroses for immunocompetence testing
US5043260A (en) * 1987-11-02 1991-08-27 Rhode Island Hospital Perfusion device with hepatocytes
DE68922390T2 (de) 1988-10-21 1995-10-05 Molecular Devices Corp Verfahren und apparat zur messung der effekte von zellwirksamen mitteln auf lebende zellen.
AU6513790A (en) 1989-09-18 1991-04-18 Biostar Medical Products, Inc. Apparatus for detection of an immobilized analyte
AU646045B2 (en) 1990-05-16 1994-02-03 Baylor College Of Medicine A permanent human hepatocyte cell line and its use in a liver assist device (LAD)
JPH04152885A (ja) 1990-10-15 1992-05-26 Fujitsu Ltd 細胞の培養方法および装置
EP0620939A4 (en) * 1991-11-25 1996-05-29 Cornell Res Foundation Inc Automated multicompartmental cell culture system.
US5612188A (en) 1991-11-25 1997-03-18 Cornell Research Foundation, Inc. Automated, multicompartmental cell culture system
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
WO1993022058A1 (en) 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Polynucleotide amplification analysis using a microfabricated device
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5900160A (en) 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
US7008634B2 (en) * 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
US5820769A (en) 1995-05-24 1998-10-13 Regents Of The University Of Minnesota Method for making magnetic storage having discrete elements with quantized magnetic moments
CN1183121A (zh) 1996-01-24 1998-05-27 松下电器产业株式会社 测定组织或细胞物理化学特性的方法、检测药品的方法及其装置
US6054277A (en) 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
CA2217266A1 (en) * 1997-05-14 1998-11-14 The General Hospital Corporation Co-cultivation of cells in a micropatterned configuration
DE69903800T2 (de) 1998-03-18 2003-10-02 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
AT407047B (de) * 1998-08-03 2000-11-27 Pfaller Walter Dr Zellkulturvorrichtung
FR2786783B1 (fr) * 1998-12-04 2002-12-06 Rtm Rech S Et Tech Modernes Poche comportant un textile poreux biocompatible pour l'expansion tridimensionnelle in vitro de cellules notamment a usage therapeutique
US6562616B1 (en) * 1999-06-21 2003-05-13 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
US6653124B1 (en) * 2000-11-10 2003-11-25 Cytoplex Biosciences Inc. Array-based microenvironment for cell culturing, cell monitoring and drug-target validation
US20070037277A1 (en) * 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
DK1392814T3 (da) * 2001-04-25 2007-09-24 Cornell Res Foundation Inc Indretninger og fremgangsmåder til farmakokinetisk baseret cellekultursystem
US20070048727A1 (en) * 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
US7704728B2 (en) * 2001-07-18 2010-04-27 The University Of Michigan Microfluidic gravity pump with constant flow rate
US6630801B2 (en) 2001-10-22 2003-10-07 Lümileds USA Method and apparatus for sensing the color point of an RGB LED white luminary using photodiodes
US6948732B2 (en) * 2002-11-25 2005-09-27 Joseph Amacker Convertible cargo rack
US20080064088A1 (en) * 2006-09-08 2008-03-13 Michael Shuler Devices and methods for pharmacokinetic-based cell culture system

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