ATE354792T1 - Band-durchflusszytometrie und zellsortierung - Google Patents

Band-durchflusszytometrie und zellsortierung

Info

Publication number
ATE354792T1
ATE354792T1 AT03744624T AT03744624T ATE354792T1 AT E354792 T1 ATE354792 T1 AT E354792T1 AT 03744624 T AT03744624 T AT 03744624T AT 03744624 T AT03744624 T AT 03744624T AT E354792 T1 ATE354792 T1 AT E354792T1
Authority
AT
Austria
Prior art keywords
channel
microfluidic
microfluidic junction
outlet channel
junction
Prior art date
Application number
AT03744624T
Other languages
English (en)
Inventor
Bernhard H Weigl
Ronald L Bardell
Jon W Hayenga
Christopher J Morris
Original Assignee
Micronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micronics Inc filed Critical Micronics Inc
Application granted granted Critical
Publication of ATE354792T1 publication Critical patent/ATE354792T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0636Focussing flows, e.g. to laminate flows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/117497Automated chemical analysis with a continuously flowing sample or carrier stream
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/117497Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Measuring Cells (AREA)
  • Optical Integrated Circuits (AREA)
AT03744624T 2002-03-14 2003-03-10 Band-durchflusszytometrie und zellsortierung ATE354792T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36434302P 2002-03-14 2002-03-14

Publications (1)

Publication Number Publication Date
ATE354792T1 true ATE354792T1 (de) 2007-03-15

Family

ID=28041902

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03716414T ATE370787T1 (de) 2002-03-14 2003-03-10 Vorrichtung mit einem netzwerk von mikroflüssigkeitskanälen
AT03744624T ATE354792T1 (de) 2002-03-14 2003-03-10 Band-durchflusszytometrie und zellsortierung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03716414T ATE370787T1 (de) 2002-03-14 2003-03-10 Vorrichtung mit einem netzwerk von mikroflüssigkeitskanälen

Country Status (7)

Country Link
US (1) US7223371B2 (de)
EP (2) EP1483564B1 (de)
JP (2) JP2005519751A (de)
AT (2) ATE370787T1 (de)
AU (1) AU2003220121A1 (de)
DE (2) DE60311968T2 (de)
WO (2) WO2003078065A1 (de)

Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4323571B2 (ja) 1997-01-31 2009-09-02 エックスワイ, インコーポレイテッド 光学装置
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
AU2002220018A1 (en) 2000-11-29 2002-06-11 Colorado State University System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US20040109793A1 (en) * 2002-02-07 2004-06-10 Mcneely Michael R Three-dimensional microfluidics incorporating passive fluid control structures
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
WO2004012837A2 (en) 2002-08-01 2004-02-12 Xy, Inc. Low pressure sperm cell separation system
WO2004017041A2 (en) 2002-08-15 2004-02-26 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
WO2004029221A2 (en) 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
DK2305172T3 (en) 2003-03-28 2016-08-22 Inguran Llc DEVICE AND PROCEDURES TO PROVIDE SEXUAL ANIMAL SEED
DE10320870A1 (de) * 2003-05-09 2004-12-09 Evotec Technologies Gmbh Partikelinjektor für einen Zellsortierer
ES2541121T3 (es) 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
US20050047967A1 (en) * 2003-09-03 2005-03-03 Industrial Technology Research Institute Microfluidic component providing multi-directional fluid movement
KR20060134942A (ko) 2003-10-30 2006-12-28 사이토놈, 인크. 다중 층의 유체 역학적 쉬스 유동 구조
US20070151855A1 (en) * 2004-02-04 2007-07-05 Evotec Technologies Gmbh Microfluidic system and associated operational method
BRPI0509485A (pt) 2004-03-29 2007-09-11 Monsanto Technology Llc suspensões de esperma para uso em inseminação
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
MX2007000888A (es) 2004-07-22 2007-04-02 Monsanto Technology Llc Procedimiento para enriquecer una poblacion de celulas de esperma.
JP4279754B2 (ja) * 2004-09-13 2009-06-17 アルプス電気株式会社 プレート及び前記プレートを用いた検査方法
DE102004047953A1 (de) * 2004-10-01 2006-04-20 Rudolf Rigler Selektion von Partikeln im laminaren Fluss
EP1859330B1 (de) * 2005-01-28 2012-07-04 Duke University Vorrichtungen und verfahren zur manipulation von tropfen auf einer leiterplatte
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US7740804B2 (en) * 2005-04-12 2010-06-22 Chromedx Inc. Spectroscopic sample holder
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
DE112005003572T5 (de) * 2005-05-13 2008-03-27 Agilent Technologies Inc., Santa Clara Flusszelle mit Hüllfluss
TWI253435B (en) * 2005-06-13 2006-04-21 Univ Chung Yuan Christian Loop micro fluid system
EP1902298B1 (de) * 2005-07-01 2012-01-18 Honeywell International Inc. Geformte kassette mit dreidimensionaler hydrodynamischer fokussierung
WO2007008609A2 (en) 2005-07-07 2007-01-18 The Regents Of The University Of California Methods and apparatus for cell culture array
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US8257964B2 (en) * 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7731910B2 (en) * 2005-08-05 2010-06-08 Hewlett-Packard Development Company, L.P. Microfluidic mixing assembly
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
WO2009126257A1 (en) 2008-04-07 2009-10-15 E.I. Spectra, Llc Method for manufactiring a microfluidic sensor
US20110189714A1 (en) * 2010-02-03 2011-08-04 Ayliffe Harold E Microfluidic cell sorter and method
US8072603B2 (en) 2006-02-02 2011-12-06 E I Spectra, LLC Fluorescence-activated cell detector
US9452429B2 (en) 2006-02-02 2016-09-27 E. I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
US8616048B2 (en) * 2006-02-02 2013-12-31 E I Spectra, LLC Reusable thin film particle sensor
US9293311B1 (en) 2006-02-02 2016-03-22 E. I. Spectra, Llc Microfluidic interrogation device
JP2007225438A (ja) * 2006-02-23 2007-09-06 Konica Minolta Medical & Graphic Inc マイクロ流体チップ
WO2007106580A2 (en) 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
US7569789B2 (en) * 2006-03-16 2009-08-04 Visiongate, Inc. Cantilevered coaxial flow injector apparatus and method for sorting particles
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2587007T3 (es) 2006-03-24 2016-10-20 Handylab, Inc. Sistema integrado para procesar muestras microfluídicas, y métodos de uso del mismo
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
EP2041573B1 (de) * 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Verfahren und vorrichtung für mikrofluidische point-of-care-immunoassays
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
EP2091647A2 (de) 2006-11-14 2009-08-26 Handylab, Inc. Mikrofluidisches system für parallele amplifikation und erkennung von polynukleotiden
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008076406A2 (en) 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
US8262900B2 (en) * 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US20090042241A1 (en) 2007-04-06 2009-02-12 California Institute Of Technology Microfluidic device
JP4911514B2 (ja) * 2007-05-14 2012-04-04 独立行政法人産業技術総合研究所 マイクロチップ、液体分注方法
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
JP5852781B2 (ja) * 2007-07-31 2016-02-03 マイクロニクス, インコーポレイテッド 衛生的スワブ採取システム、マイクロ流体アッセイデバイスおよび診断アッセイのための方法
US8268246B2 (en) 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
WO2009045343A1 (en) * 2007-09-29 2009-04-09 El Spectra, Llc Instrumented pipette tip
WO2009049268A1 (en) 2007-10-12 2009-04-16 Rheonix, Inc. Integrated microfluidic device and methods
JP5542060B2 (ja) * 2007-11-27 2014-07-09 イーアイ・スペクトラ・エルエルシー 蛍光ベースのピペット器具
EP2245453B1 (de) 2008-01-03 2016-10-05 EMD Millipore Corporation Mikrofluidisches zellkulturmatrixsystem für automatisierte tests sowie bedienungsverfahren dafür
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
JP2010169701A (ja) * 2008-05-13 2010-08-05 Sony Corp マイクロチップ
JP4661942B2 (ja) * 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
ES2620294T3 (es) 2008-09-20 2017-06-28 The Board Of Trustees Of The Leland Stanford Junior University Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
US8546128B2 (en) * 2008-10-22 2013-10-01 Life Technologies Corporation Fluidics system for sequential delivery of reagents
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US11951474B2 (en) 2008-10-22 2024-04-09 Life Technologies Corporation Fluidics systems for sequential delivery of reagents
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
WO2012109612A2 (en) * 2011-02-11 2012-08-16 Code Footwear, Llc Reconfigurable apparel manufacture and business processes
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
CA2786569C (en) 2010-01-29 2019-04-09 Micronics, Inc. Sample-to-answer microfluidic cartridge
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US9371598B2 (en) 2010-04-05 2016-06-21 Prognosys Biosciences, Inc. Spatially encoded biological assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
CN106932456B (zh) 2010-06-30 2020-02-21 生命科技公司 用于测试isfet阵列的方法和装置
US8415176B2 (en) 2010-06-30 2013-04-09 Life Technologies Corporation One-transistor pixel array
CN103154718B (zh) 2010-06-30 2015-09-23 生命科技公司 感测离子的电荷堆积电路和方法
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
US8653567B2 (en) 2010-07-03 2014-02-18 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
EP2609476B1 (de) 2010-08-23 2022-04-20 Life Technologies Corporation Temperatursteuerung eines chemischen erkennungssystems
WO2012036679A1 (en) 2010-09-15 2012-03-22 Life Technologies Corporation Methods and apparatus for measuring analytes
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
ES2617599T3 (es) 2011-04-15 2017-06-19 Becton, Dickinson And Company Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración
DE102011076051A1 (de) * 2011-05-18 2012-11-22 Siemens Aktiengesellschaft Magnetophoretische Analytselektion und -anreicherung
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
WO2013082612A1 (en) 2011-12-03 2013-06-06 Emd Millipore Corporation Micro-incubation systems for microfluidic cell culture and methods
CN104136123B (zh) 2012-01-09 2017-03-01 精密公司 微流体反应器系统
JP6262152B2 (ja) 2012-02-03 2018-01-17 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 分子診断試験の分布及び試験間のコンパチビリティ判断のための外部ファイル
US8804105B2 (en) 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
EP3511423B2 (de) 2012-10-17 2024-05-29 Spatial Transcriptomics AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
EP3919174A3 (de) 2012-10-24 2022-03-09 Genmark Diagnostics Inc. Integrierte multiplex-zielanalyse
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
JP6298474B2 (ja) 2012-12-17 2018-03-20 レウコドゥックス,リミテッド 生物学的状態を検出するシステムおよび方法
US10610861B2 (en) * 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
CN104919191B (zh) 2012-12-21 2019-07-09 精密公司 流体回路及相关的制造方法
US20150346097A1 (en) 2012-12-21 2015-12-03 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
CN104994957B (zh) 2012-12-21 2017-11-28 精密公司 用于微流体用途的低弹性膜
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
CN103191791B (zh) * 2013-03-01 2014-09-10 东南大学 生物微粒高通量分选和计数检测的集成芯片系统及应用
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
NZ743491A (en) 2013-03-14 2020-03-27 Cytonome St Llc Hydrodynamic focusing apparatus and methods
CN105051525B (zh) 2013-03-15 2019-07-26 生命科技公司 具有薄导电元件的化学设备
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
EP2972280B1 (de) 2013-03-15 2021-09-29 Life Technologies Corporation Chemischer sensor mit stetigen sensoroberflächen
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス, インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
EP2994750B1 (de) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Mikrofluidische vorrichtungen und verfahren zur durchführung von serumtrennung und blutkreuzproben
AU2014262710B2 (en) 2013-05-07 2019-09-12 Revvity Health Sciences, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
CN105189784B (zh) 2013-05-07 2020-06-30 珀金埃尔默健康科学有限公司 用于制备和分析核酸的装置
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
LT3013983T (lt) 2013-06-25 2023-05-10 Prognosys Biosciences, Inc. Erdviniai koduoti biologiniai tyrimai, naudojant mikrofluidinį įrenginį
JP6205055B2 (ja) * 2013-07-16 2017-09-27 プレミアム ジェネティクス (ユーケー) リミテッド マイクロ流体チップ
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US20160161343A1 (en) * 2013-07-19 2016-06-09 Advanced Liquid Logic, Inc. Methods of On-Actuator Temperature Measurement
GB2516669B (en) * 2013-07-29 2015-09-09 Atlas Genetics Ltd A method for processing a liquid sample in a fluidic cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
EP4354131A3 (de) 2014-12-18 2024-06-26 Life Technologies Corporation Integrierte schaltung mit hoher datenrate und mit transmitterkonfiguration
SG11201707515SA (en) 2015-04-10 2017-10-30 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US9700891B2 (en) * 2015-11-13 2017-07-11 International Business Machines Corporation Integrated nanofluidic arrays for high capacity colloid separation
CN106378216B (zh) * 2016-11-09 2019-05-21 杭州电子科技大学 一种基于负磁泳技术的微粒子分选器
EP4241888B1 (de) 2017-06-08 2025-08-27 Becton, Dickinson and Company Vorrichtung zum trennen einer biologischen flüssigkeit
USD878622S1 (en) * 2018-04-07 2020-03-17 Precision Nanosystems Inc. Microfluidic chip
BR112020023607A2 (pt) 2018-05-23 2021-02-17 Abs Global, Inc. sistemas e métodos para focalização de partículas em microcanais
CN117413819A (zh) 2019-04-18 2024-01-19 艾步思国际有限责任公司 用于连续添加冷冻保护剂的系统和工艺
CN109975265B (zh) * 2019-04-22 2020-06-16 中国矿业大学 一种多向诱导Dean流的三维缩扩微流控器件及方法
US12157124B2 (en) 2019-11-06 2024-12-03 10X Genomics, Inc. Imaging system hardware
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
USD989342S1 (en) * 2020-02-04 2023-06-13 Ut-Battelle, Llc Microfluidic polymer chip interface bracket
USD993443S1 (en) * 2020-02-04 2023-07-25 Ut-Battelle, Llc Microfluidic glass chip interface bracket
US11856947B2 (en) 2020-02-17 2024-01-02 Cook Medical Technologies Llc System for automated permeation of a biological material and method of using same
EP4153984A1 (de) 2020-05-19 2023-03-29 10X Genomics, Inc. Elektrophoresekassetten und -instrumentierung
ES2989052T3 (es) 2020-05-22 2024-11-25 10X Genomics Inc Medición espacio-temporal simultánea de la expresión génica y la actividad celular
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
ES2993269T3 (en) 2020-09-18 2024-12-26 10X Genomics Inc Sample handling apparatus and image registration methods
CN116368237A (zh) 2020-10-21 2023-06-30 Abs全球股份有限公司 用于处理遗传样本以确定特性或检测污染的方法及系统
WO2022108840A1 (en) 2020-11-23 2022-05-27 Abs Global, Inc. Modular flow cytometry systems and methods of processing samples
EP4421491A3 (de) 2021-02-19 2024-11-27 10X Genomics, Inc. Verfahren zur verwendung einer modularen testträgervorrichtung
USD1064308S1 (en) 2021-09-17 2025-02-25 10X Genomics, Inc. Sample handling device
WO2023122033A1 (en) 2021-12-20 2023-06-29 10X Genomics, Inc. Self-test for pathology/histology slide imaging device
WO2025064694A1 (en) * 2023-09-21 2025-03-27 Deepcell, Inc. Apparatus and method for control of fluid flow

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE48477T1 (de) * 1984-09-11 1989-12-15 Partec Ag Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln.
GB9008044D0 (en) 1990-04-09 1990-06-06 Hatfield Polytechnic Higher Ed Microfabricated device for biological cell sorting
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
JPH07232056A (ja) * 1994-02-23 1995-09-05 Hitachi Ltd 微量反応装置
US5811062A (en) * 1994-07-29 1998-09-22 Battelle Memorial Institute Microcomponent chemical process sheet architecture
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
DE19520298A1 (de) * 1995-06-02 1996-12-05 Bayer Ag Sortiervorrichtung für biologische Zellen oder Viren
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
AU6541596A (en) 1995-06-16 1997-01-15 University Of Washington Microfabricated differential extraction device and method
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
WO1998010267A1 (en) * 1996-09-04 1998-03-12 Technical University Of Denmark A micro flow system for particle separation and analysis
GB9707096D0 (en) * 1997-04-08 1997-05-28 Smithkline Beecham Plc Novel device
EP0988529B1 (de) * 1997-04-25 2013-06-12 Caliper Life Sciences, Inc. Mikrofluidische geräte mit verbesserten kanalgeometrien
JP3654481B2 (ja) * 1997-06-05 2005-06-02 独立行政法人理化学研究所 生化学反応用マイクロリアクタ
AU3771599A (en) 1998-05-18 1999-12-06 University Of Washington Liquid analysis cartridge
JP2002528699A (ja) * 1998-05-22 2002-09-03 カリフォルニア インスティチュート オブ テクノロジー 微細製作細胞分類器
DE19847952C2 (de) * 1998-09-01 2000-10-05 Inst Physikalische Hochtech Ev Fluidstromschalter
JP2000246092A (ja) * 1999-03-04 2000-09-12 Kawamura Inst Of Chem Res マイクロケミカルデバイスの製造方法
US6270641B1 (en) * 1999-04-26 2001-08-07 Sandia Corporation Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems
US6524456B1 (en) * 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
JP2001137693A (ja) * 1999-11-11 2001-05-22 Kawamura Inst Of Chem Res 分液機構を有する微小ケミカルデバイス
US6408884B1 (en) * 1999-12-15 2002-06-25 University Of Washington Magnetically actuated fluid handling devices for microfluidic applications
SE9904858D0 (sv) * 1999-12-30 1999-12-30 Acreo Ab Flow controlling device and method
JP2001194373A (ja) * 2000-01-06 2001-07-19 Olympus Optical Co Ltd 超小型化学操作装置
AU2001232805A1 (en) * 2000-01-12 2001-07-24 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US6358387B1 (en) * 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
JP3418727B2 (ja) * 2000-04-27 2003-06-23 独立行政法人産業技術総合研究所 マイクロバルブ装置及びその製作方法
US20010048900A1 (en) * 2000-05-24 2001-12-06 Bardell Ronald L. Jet vortex mixer
US6597438B1 (en) * 2000-08-02 2003-07-22 Honeywell International Inc. Portable flow cytometry
DE10031028B4 (de) * 2000-06-26 2008-09-04 Gnothis Holding Sa Verfahren zur Selektion von Partikeln
WO2002011888A2 (en) 2000-08-07 2002-02-14 Nanostream, Inc. Fluidic mixer in microfluidic system

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US7223371B2 (en) 2007-05-29
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EP1483564A1 (de) 2004-12-08
ATE370787T1 (de) 2007-09-15
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US20030175990A1 (en) 2003-09-18
AU2003220121A1 (en) 2003-09-29
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WO2003078972A1 (en) 2003-09-25

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