DE69737071D1 - Integrierte mikrofluidische vorrichtungen - Google Patents

Integrierte mikrofluidische vorrichtungen

Info

Publication number
DE69737071D1
DE69737071D1 DE69737071T DE69737071T DE69737071D1 DE 69737071 D1 DE69737071 D1 DE 69737071D1 DE 69737071 T DE69737071 T DE 69737071T DE 69737071 T DE69737071 T DE 69737071T DE 69737071 D1 DE69737071 D1 DE 69737071D1
Authority
DE
Germany
Prior art keywords
electrophoretic
microfluidic devices
integrated
integrated microfluidic
flowpath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69737071T
Other languages
English (en)
Other versions
DE69737071T2 (de
Inventor
Robert J Nelson
Herbert H Hooper
Alan K Hauser
Alexander P Sassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Aclara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences Inc filed Critical Aclara Biosciences Inc
Publication of DE69737071D1 publication Critical patent/DE69737071D1/de
Application granted granted Critical
Publication of DE69737071T2 publication Critical patent/DE69737071T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
DE69737071T 1996-07-30 1997-07-30 Integrierte mikrofluidische vorrichtungen Expired - Lifetime DE69737071T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/690,307 US5770029A (en) 1996-07-30 1996-07-30 Integrated electrophoretic microdevices
US690307 1996-07-30
PCT/US1997/013503 WO1998004909A1 (en) 1996-07-30 1997-07-30 Integrated microfluidic devices

Publications (2)

Publication Number Publication Date
DE69737071D1 true DE69737071D1 (de) 2007-01-18
DE69737071T2 DE69737071T2 (de) 2007-07-05

Family

ID=24771959

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737071T Expired - Lifetime DE69737071T2 (de) 1996-07-30 1997-07-30 Integrierte mikrofluidische vorrichtungen

Country Status (8)

Country Link
US (2) US5770029A (de)
EP (1) EP1007953B1 (de)
JP (1) JP3989964B2 (de)
AT (1) ATE347692T1 (de)
AU (1) AU744264B2 (de)
CA (1) CA2261869C (de)
DE (1) DE69737071T2 (de)
WO (1) WO1998004909A1 (de)

Families Citing this family (385)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6309602B1 (en) * 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US6319472B1 (en) * 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US7857957B2 (en) 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
NZ333346A (en) * 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6447727B1 (en) * 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
WO1998049344A1 (en) * 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US6632619B1 (en) * 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
EP0981408B1 (de) * 1997-05-16 2004-04-21 Alberta Research Council Mikrofluidisches system und verfahren zu dessen betrieb
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US6440725B1 (en) 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
WO1999014368A2 (en) * 1997-09-15 1999-03-25 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6106779A (en) * 1997-10-02 2000-08-22 Biosite Diagnostics, Inc. Lysis chamber for use in an assay device
CA2320296A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
US6306590B1 (en) * 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
EP1084391A4 (de) * 1998-06-08 2006-06-14 Caliper Life Sciences Inc Mikrofluidische geräte, systeme und verfahren zur durchführung integrierter reaktionen und trennungen
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
DE19826020C2 (de) * 1998-06-10 2000-11-02 Max Planck Gesellschaft Vorrichtung und Verfahren zur miniaturisierten, hochparallelen elektrophoretischen Trennung
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US6761816B1 (en) * 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
JP3662850B2 (ja) * 1998-06-24 2005-06-22 イルミナ インコーポレイテッド 微小球を有するアレイセンサーのデコード
WO1999067639A1 (en) * 1998-06-25 1999-12-29 Caliper Technologies Corporation High throughput methods, systems and apparatus for performing cell based screening assays
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6447724B1 (en) 1998-08-11 2002-09-10 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
US6716394B2 (en) 1998-08-11 2004-04-06 Caliper Technologies Corp. DNA sequencing using multiple fluorescent labels being distinguishable by their decay times
JP2002523741A (ja) * 1998-08-19 2002-07-30 イェーノプティク アクチエンゲゼルシャフト 極少量の液体を搬送する装置およびその製造方法
DE19846958C2 (de) * 1998-08-19 2001-06-13 Fraunhofer Ges Forschung Verfahren zur Herstellung einer Einrichtung zum Transport von kleinsten Flüssigkeitsmengen
US6846668B1 (en) 1998-10-08 2005-01-25 Astrazeneca Ab Microfabricated cell injector
US7914994B2 (en) * 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
WO2000046595A1 (en) * 1999-02-03 2000-08-10 Aclara Biosciences, Inc. Multichannel control in microfluidics
EP1163052B1 (de) * 1999-02-23 2010-06-02 Caliper Life Sciences, Inc. Manipulation von mikroteilchen in mikrofluiden systemen
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
US6605475B1 (en) * 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
CA2370749A1 (en) 1999-04-20 2000-10-26 Target Discovery, Inc. Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US9073053B2 (en) * 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
ATE278771T1 (de) * 1999-05-28 2004-10-15 Cepheid Vorrichtung und verfahren zur analyse flüssiger proben
US8815521B2 (en) * 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
DE19927535B4 (de) * 1999-06-16 2004-06-17 Merck Patent Gmbh Miniaturisiertes Analysensystem mit Vorrichtung zum Ausschleusen von Substanzen
US6878540B2 (en) * 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms
AU6068300A (en) * 1999-07-06 2001-01-22 Caliper Technologies Corporation Microfluidic systems and methods for determining modulator kinetics
US6381025B1 (en) 1999-08-19 2002-04-30 Texas Tech University Interferometric detection system and method
US6613581B1 (en) * 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US6676819B1 (en) * 1999-09-14 2004-01-13 Yaoqing Diana Liu Methods and apparatus for automatic on-line multi-dimensional electrophoresis
US6210986B1 (en) * 1999-09-23 2001-04-03 Sandia Corporation Microfluidic channel fabrication method
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
DE10004853C1 (de) * 2000-02-03 2001-04-26 Fraunhofer Ges Forschung Verfahren zum dauerhaften Verbinden von Polymerbauteilen mit Bauteilen aus gleichartigem oder andersartigem Material
US6728429B1 (en) 2000-02-16 2004-04-27 Biotell, Inc. Optical detection
US6824669B1 (en) * 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
KR20020089357A (ko) * 2000-02-23 2002-11-29 자이오믹스, 인코포레이티드 높은 샘플 표면을 구비하는 칩
JP2001242137A (ja) * 2000-02-29 2001-09-07 Hitachi Chem Co Ltd マイクロチップ電気泳動装置
US6537433B1 (en) * 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
US20010035351A1 (en) * 2000-03-10 2001-11-01 Simpson Peter C. Cross channel device for serial sample injection
US20020012971A1 (en) * 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US7306924B2 (en) * 2000-04-17 2007-12-11 Purdue Research Foundation Biosensor and related method
AU2001252973A1 (en) * 2000-04-17 2001-10-30 Purdue Research Foundation Biosensor and related method
US7435579B2 (en) * 2000-04-17 2008-10-14 Purdue Research Foundation Biosensor and related method
DE10023423B4 (de) * 2000-05-12 2009-03-05 Gnothis Holding Sa Direkter Nachweis von Einzelmolekülen
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
CA2314398A1 (en) * 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US6860980B2 (en) * 2000-09-15 2005-03-01 The United States Of America As Represented By The Secretary Of Commerce Polyelectrolyte derivatization of microfluidic devices
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US6459581B1 (en) 2000-12-19 2002-10-01 Harris Corporation Electronic device using evaporative micro-cooling and associated methods
US6783992B2 (en) 2001-01-03 2004-08-31 Agilent Technologies, Inc. Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples
WO2002059579A1 (en) 2001-01-25 2002-08-01 Texas Tech University Universal detector for biological and chemical separations or assays using plastic microfluidic devices
JP4809983B2 (ja) * 2001-02-14 2011-11-09 明彦 谷岡 生体高分子とリガンドとの相互作用を検出する装置及びその方法
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20040121313A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in organs for transplantation
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20020127740A1 (en) * 2001-03-06 2002-09-12 Ho Winston Z. Quantitative microfluidic biochip and method of use
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7192557B2 (en) * 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6418968B1 (en) 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
ATE367205T1 (de) * 2001-05-02 2007-08-15 Applera Corp Konzentration und reinigung von analyten mit elektrischen feldern
AU2002311885A1 (en) * 2001-05-03 2002-11-18 Colorado School Of Mines Devices employing colloidal-sized particles
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US7214300B2 (en) * 2001-06-04 2007-05-08 Epocal Inc. Integrated electrokinetic devices and methods of manufacture
US20020187557A1 (en) * 2001-06-07 2002-12-12 Hobbs Steven E. Systems and methods for introducing samples into microfluidic devices
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US20030077570A1 (en) * 2001-09-20 2003-04-24 Coventor, Inc. Small molecule substrate based enzyme activity assays
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
EP1418997B1 (de) * 2001-08-13 2010-04-28 The Board Of Trustees Of The Leland Stanford Junior University Photopolymerisierte sol-gel-säule mit gebundener phase und zugehörige verfahren
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
EP1442131A4 (de) * 2001-10-19 2006-06-07 Univ West Virginia Mikrofluidsystem für die proteomanalyse
US20030124592A1 (en) * 2001-10-24 2003-07-03 Bioprofile, Llc Methods for detecting genetic haplotypes by interaction with probes
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
US7157049B2 (en) * 2001-11-20 2007-01-02 Nagaoka & Co., Ltd. Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
US7163612B2 (en) * 2001-11-26 2007-01-16 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
US20040231987A1 (en) * 2001-11-26 2004-11-25 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
US20030098661A1 (en) * 2001-11-29 2003-05-29 Ken Stewart-Smith Control system for vehicle seats
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US7192560B2 (en) * 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
KR100408871B1 (ko) * 2001-12-20 2003-12-11 삼성전자주식회사 바이오칩 상에서 탄소나노튜브를 이용한 시료의 분리 또는여과 방법
US7347976B2 (en) * 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7018849B2 (en) * 2002-01-15 2006-03-28 Piasio Roger N Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout
US7318902B2 (en) * 2002-02-04 2008-01-15 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
WO2003068402A1 (en) 2002-02-13 2003-08-21 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US20050277195A1 (en) * 2002-04-30 2005-12-15 Gyros Ab Integrated microfluidic device (ea)
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US7338459B2 (en) * 2002-05-31 2008-03-04 Swidler Steven A Impact table system and method
US20060134157A1 (en) * 2002-06-06 2006-06-22 Rutgers, The State University Co-continuous phase composite polymer blends for in-vivo and in-vitro biomedical applications
US7867193B2 (en) * 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US20050238506A1 (en) * 2002-06-21 2005-10-27 The Charles Stark Draper Laboratory, Inc. Electromagnetically-actuated microfluidic flow regulators and related applications
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7517440B2 (en) 2002-07-17 2009-04-14 Eksigent Technologies Llc Electrokinetic delivery systems, devices and methods
US7364647B2 (en) * 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
US20040011650A1 (en) * 2002-07-22 2004-01-22 Frederic Zenhausern Method and apparatus for manipulating polarizable analytes via dielectrophoresis
AU2003269954A1 (en) * 2002-08-07 2004-02-25 National Institutes Of Health Measurement systems and methods
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
EP2298448A3 (de) 2002-09-25 2012-05-30 California Institute of Technology Hochintegriertes mikrofluidisches Netzwerk
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
JP2006501449A (ja) 2002-09-27 2006-01-12 ザ ジェネラル ホスピタル コーポレーション 細胞分離のためのマイクロ流体デバイスおよびその使用
WO2004040001A2 (en) * 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
GB0223984D0 (en) * 2002-10-15 2002-11-20 Novartis Forschungsstiftung Methods for detecting teneurin signalling and related screening methods
US7010964B2 (en) 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
US20060211055A1 (en) * 2002-11-12 2006-09-21 Caliper Life Sciences, Inc. Capture and release assay system and method
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
WO2004061085A2 (en) 2002-12-30 2004-07-22 The Regents Of The University Of California Methods and apparatus for pathogen detection and analysis
WO2004065000A1 (en) * 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
WO2004077017A2 (en) * 2003-02-21 2004-09-10 West Virginia University Research Corporation Apparatus and method for on-chip concentration using a microfluidic device with an integrated ultrafiltration membrane structure
US7655477B1 (en) * 2003-02-26 2010-02-02 Science Applications International Corporation System and method for the separation of analytes
US7147764B2 (en) * 2003-03-28 2006-12-12 Applera Corporation Dual electrode injection of analyte into a capillary electrophoretic device
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20040195099A1 (en) * 2003-04-04 2004-10-07 Jacobson Stephen C. Sample filtration, concentration and separation on microfluidic devices
US7981600B2 (en) 2003-04-17 2011-07-19 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US7074327B2 (en) 2003-05-08 2006-07-11 Nanostream, Inc. Sample preparation for parallel chromatography
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7405083B2 (en) * 2003-05-13 2008-07-29 Becton, Dickinson And Company Method and apparatus for purifying and desalting biological samples
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7402398B2 (en) 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
EP2402089A1 (de) 2003-07-31 2012-01-04 Handylab, Inc. Verarbeitung partikelhaltiger Proben
US20090088982A1 (en) * 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
EP1673399B1 (de) 2003-08-11 2017-04-05 Monogram BioSciences, Inc. Nachweis und erstellung des profils eines molekularen komplexes
US7956175B2 (en) 2003-09-11 2011-06-07 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US7235163B2 (en) * 2003-09-12 2007-06-26 Applera Corporation Loading features for channel array
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US20050082168A1 (en) * 2003-10-17 2005-04-21 Kang Jing X. Apparatus of electrophoresis
US7767468B2 (en) * 2003-11-05 2010-08-03 Exact Sciences Corporation Repetitive affinity separation and uses therefor
EP1706735B1 (de) * 2003-11-07 2017-01-04 Princeton Biochemicals, Inc. Mehrdimensionale elektrophoresevorrichtung
US8007724B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having at least one auxiliary buffer passage
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7727710B2 (en) 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
US20050148064A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
EP1729122A1 (de) * 2004-03-01 2006-12-06 Matsushita Electric Industries Co. Ltd. Biosensor, biosensorchip und biosensoreinrichtung
US8119336B2 (en) * 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
US7559356B2 (en) * 2004-04-19 2009-07-14 Eksident Technologies, Inc. Electrokinetic pump driven heat transfer system
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2553097T3 (es) 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
JP2007538236A (ja) 2004-05-21 2007-12-27 アトノミックス アクティーゼルスカブ ヒドロゲルを含む表面弾性波センサ
CA2567839C (en) 2004-05-24 2011-06-28 Isis Pharmaceuticals, Inc. Mass spectrometry with selective ion filtration by digital thresholding
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7799553B2 (en) * 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US7211184B2 (en) * 2004-08-04 2007-05-01 Ast Management Inc. Capillary electrophoresis devices
JP4735119B2 (ja) * 2004-08-09 2011-07-27 日本精工株式会社 反応器及びその製造方法
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
EP1805500A4 (de) * 2004-09-28 2008-05-07 Singulex Inc System und verfahren zur spektroskopischen analyse einzelner partikel
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
WO2006042734A1 (de) * 2004-10-15 2006-04-27 Siemens Aktiengesellschaft Verfahren zur durchführung einer elektrochemischen messung an einer flüssigen messprobe in einer über leitungen zugänglichen messkammer und zugehörige anordnung
JPWO2006046433A1 (ja) * 2004-10-27 2008-05-22 コニカミノルタエムジー株式会社 遺伝子検査用マイクロリアクタ
US20060205061A1 (en) * 2004-11-24 2006-09-14 California Institute Of Technology Biosensors based upon actuated desorption
CN101031802B (zh) * 2005-01-07 2012-11-07 积水化学工业株式会社 使用盒的检测装置
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US8182992B2 (en) 2005-03-03 2012-05-22 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8206974B2 (en) * 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
US20070017808A1 (en) * 2005-05-27 2007-01-25 Intel Corporation Linear valve-coupled two-dimensional separation device and separation matrix and method
US20070014699A1 (en) * 2005-06-23 2007-01-18 Beckman Coulter, Inc, Methods and apparatus for improving the sensitivity of capillary zone electrophoresis
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
AU2006272776B2 (en) 2005-07-21 2012-01-19 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP2537657A3 (de) 2005-08-09 2016-05-04 The University of North Carolina At Chapel Hill Verfahren und Materialien zur Herstellung mikrofluidischer Vorrichtungen
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
CN101317086B (zh) * 2005-10-04 2013-08-14 海德威技术公司 分析物的微观流体检测
US7828948B1 (en) * 2005-10-06 2010-11-09 Sandia Corporation Preconcentration and separation of analytes in microchannels
US20070178133A1 (en) * 2005-11-09 2007-08-02 Liquidia Technologies, Inc. Medical device, materials, and methods
EP1957793B1 (de) 2005-11-23 2013-01-16 Eksigent Technologies, LLC Elektrokinetische pumpenausführungen und arzneimittelabgabesysteme
US20070140918A1 (en) * 2005-12-19 2007-06-21 Hongfeng Yin Fluidic separation devices and methods with reduced sample broadening
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
EP1979079A4 (de) 2006-02-03 2012-11-28 Integenx Inc Mikrofluidische vorrichtungen
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
EP2001990B1 (de) 2006-03-24 2016-06-29 Handylab, Inc. Integriertes system zur verarbeitung von mikrofluidischen proben und verwendungsverfahren
EP3156799B1 (de) 2006-04-04 2024-01-24 Novilux, LLC Analysator und verfahren zur hochempfindlichen detektion von analyten
US7838250B1 (en) * 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP3168618B1 (de) 2006-04-04 2018-11-21 Singulex, Inc. Hochempfindliche verfahren zur troponinanalyse
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20070292889A1 (en) * 2006-06-16 2007-12-20 The Regents Of The University Of California Immunoassay magnetic trapping device
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
US20100311186A1 (en) * 2006-07-28 2010-12-09 Biosite Incorporated Devices and methods for performing receptor binding assays using magnetic particles
EP2064332B1 (de) 2006-09-14 2012-07-18 Ibis Biosciences, Inc. Gezielte gesamtgenomamplifizierung zur identifizierung von krankheitserregern
US7807454B2 (en) 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
US8841116B2 (en) * 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
EP1944078B1 (de) * 2007-01-10 2011-03-02 F. Hoffmann-La Roche AG Vorrichtung zum Bestimmen eines Analyts in einer Flüssigkeit und Verfahren
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
WO2008094672A2 (en) * 2007-01-31 2008-08-07 Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
WO2008115626A2 (en) 2007-02-05 2008-09-25 Microchip Biotechnologies, Inc. Microfluidic and nanofluidic devices, systems, and applications
WO2008104002A2 (en) 2007-02-23 2008-08-28 Ibis Biosciences, Inc. Methods for rapid forensic dna analysis
AU2008236691B2 (en) * 2007-04-04 2014-08-07 Ande Corporation Integrated nucleic acid analysis
US20080302732A1 (en) * 2007-05-24 2008-12-11 Hyongsok Soh Integrated fluidics devices with magnetic sorting
US20080296158A1 (en) 2007-05-31 2008-12-04 Sharp Kabushiki Kaisha Device for electrophoresis, device for transfer, device for electrophoresis and transfer, chip for electrophoresis and transfer, and method for electrophoresis, method for transfer, and method for electrophoresis and transfer
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
WO2009015296A1 (en) 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
US20090053799A1 (en) * 2007-08-23 2009-02-26 Cynvenio Biosystems, Llc Trapping magnetic sorting system for target species
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
EP2201374B1 (de) 2007-08-30 2015-10-07 Trustees Of Tufts College Verfahren zur bestimmung der konzentration eines analyten in lösung
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
WO2009039466A1 (en) 2007-09-20 2009-03-26 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US8381169B2 (en) * 2007-10-30 2013-02-19 International Business Machines Corporation Extending unified process and method content to include dynamic and collaborative content
WO2009076134A1 (en) 2007-12-11 2009-06-18 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
JP2011508219A (ja) 2007-12-19 2011-03-10 シンギュレックス・インコーポレイテッド 単一分子検出走査分析器およびその使用方法
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
JP2011513753A (ja) * 2008-03-05 2011-04-28 シンギュレックス・インコーポレイテッド 分子の高感度検出の方法および組成物
US20110127222A1 (en) * 2008-03-19 2011-06-02 Cynvenio Biosystems, Inc. Trapping magnetic cell sorting system
US20110137018A1 (en) * 2008-04-16 2011-06-09 Cynvenio Biosystems, Inc. Magnetic separation system with pre and post processing modules
FR2931141B1 (fr) * 2008-05-13 2011-07-01 Commissariat Energie Atomique Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8753868B2 (en) * 2008-08-04 2014-06-17 General Electric Company Method and system for selective isolation of target biological molecules in a general purpose system
EP2163305A1 (de) * 2008-09-05 2010-03-17 INSTITUT FÜR MIKROTECHNIK MAINZ GmbH Vorrichtung und Verfahren zur schnellen Isolierung einer Verbindung in einer Probe
EP2347254A2 (de) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Probenverarbeitungseinheiten, -systeme und damit verbundene verfahren
EP2344893B1 (de) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Mikroplatten-handhabungssysteme und verfahren
EP2349549B1 (de) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mischpatronen, mischstationen und verwandte ausrüstungen, und system
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
EP2952589B1 (de) 2008-09-20 2018-02-14 The Board of Trustees of The Leland Stanford Junior University Nicht invasive diagnose von fötaler aneuploidie durch sequenzierung
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US8053239B2 (en) * 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
WO2010040227A1 (en) 2008-10-10 2010-04-15 The Governing Council Of The University Of Toronto Hybrid digital and channel microfluidic devices and methods of use thereof
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
WO2010077322A1 (en) 2008-12-31 2010-07-08 Microchip Biotechnologies, Inc. Instrument with microfluidic chip
CA2751455C (en) 2009-02-03 2019-03-12 Netbio, Inc. Nucleic acid purification
US20100267092A1 (en) * 2009-02-09 2010-10-21 Frederic Zenhausern Components
EP2396803A4 (de) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ionisationssondenanordnungen
RU2549443C2 (ru) 2009-04-14 2015-04-27 Биокартис Нв Индуцированная высокоинтенсивным фокусированным ультразвуком кавитация с уменьшенным порогом мощности
AU2010237532B2 (en) 2009-04-15 2014-11-20 Biocartis Nv Optical detection system for monitoring rtPCR reaction
ES2677010T3 (es) 2009-04-15 2018-07-27 Biocartis Nv Protección de cámaras de muestras bioanalíticas
WO2010127464A1 (en) 2009-05-06 2010-11-11 Biocartis Sa Device for cutting a sample carrier
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
EP2437887B1 (de) 2009-06-04 2016-05-11 Lockheed Martin Corporation Mikrofluidischer chip für dna analyse von mehrfachen proben
KR20120031218A (ko) 2009-06-05 2012-03-30 인터젠엑스 인크. 만능 샘플 제조 시스템 및 집적 분석 시스템에서의 사용
WO2010144358A1 (en) 2009-06-08 2010-12-16 Singulex, Inc. Highly sensitive biomarker panels
CN102713640B (zh) * 2009-06-10 2015-09-16 辛温尼奥生物系统公司 鞘流装置和方法
JP2012529908A (ja) 2009-06-15 2012-11-29 ネットバイオ・インコーポレーテッド 法医学的ｄｎａの定量化のための改善された方法
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
EP3225695A1 (de) 2009-10-15 2017-10-04 Ibis Biosciences, Inc. Multiple-displacement-amplifikation
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
CN103026232B (zh) 2010-03-01 2015-02-04 匡特里克斯公司 扩大用于检测分子或颗粒的测定法中的动态范围的方法和系统
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
EP2567213B1 (de) 2010-05-05 2018-01-24 The Governing Council of the Universtiy of Toronto Verfahren zur verarbeitung getrockneter proben mithilfe einer digitalen mikrofluidischen vorrichtung
CA2798149A1 (en) 2010-05-06 2011-11-10 Singulex, Inc Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
US9188593B2 (en) 2010-07-16 2015-11-17 The University Of British Columbia Methods for assaying cellular binding interactions
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
EP2606154B1 (de) 2010-08-20 2019-09-25 Integenx Inc. Integriertes analysesystem
AU2011315951B2 (en) 2010-10-15 2015-03-19 Lockheed Martin Corporation Micro fluidic optic design
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
JP6162047B2 (ja) 2011-02-02 2017-07-12 ザ チャールズ スターク ドレイパー ラボラトリー インク 薬物送達装置
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
BR112013026451B1 (pt) 2011-04-15 2021-02-09 Becton, Dickinson And Company sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação
CN103813814A (zh) 2011-05-05 2014-05-21 艾克西根特技术有限公司 用于电动输送系统的凝胶联接
EP2709760B1 (de) 2011-05-18 2019-06-05 DiaSorin S.p.A. Systeme und verfahren zur ventilmanipulation auf einer probenverarbeitungsvorrichtung
CN103547370A (zh) 2011-05-18 2014-01-29 3M创新有限公司 用于样品处理装置上体积计量的系统和方法
ES2870874T3 (es) 2011-05-18 2021-10-27 Diasorin S P A Sistemas y métodos para detectar la presencia de un volumen seleccionado de material en un dispositivo de procesamiento de muestra
WO2013025527A1 (en) 2011-08-12 2013-02-21 Life Technologies Corporation Apparatuses, methods, computer program products, and kits for hi-throughput glycan analysis
EP2761305B1 (de) 2011-09-30 2017-08-16 Becton, Dickinson and Company Vereinheitlichter reagenzienstreifen
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
JP6100472B2 (ja) * 2012-03-30 2017-03-22 シャープ株式会社 測定装置、透析終了条件判定装置、および透析経過提示装置
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
NL2009517C2 (en) * 2012-09-25 2014-03-27 Micronit Microfluidics Bv Device and method for activating a capillary-stop valve of a device.
US20150323495A1 (en) * 2012-12-20 2015-11-12 University Of Notre Dame Du Lac Non-aqueous microchip electrophoresis for characterization of lipid biomarkers
EP2939018B1 (de) * 2012-12-31 2022-04-20 Eprep Pty Ltd. Spritzenbaugruppe
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US9994839B2 (en) 2013-01-16 2018-06-12 The Regents Of The University Of California Microfluidic devices to extract, concentrate and isolate molecules
WO2014113614A1 (en) * 2013-01-16 2014-07-24 The Regents Of The University Of California Label free molecular detection methods, systems and devices
CN110560187B (zh) 2013-11-18 2022-01-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US10151753B2 (en) * 2013-12-17 2018-12-11 The General Hospital Corporation Microfluidic devices for isolating particles
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
EP3552690A1 (de) 2014-10-22 2019-10-16 IntegenX Inc. Systeme und verfahren zur automatisierten vorbereitung, verarbeitung und analyse von proben
EP3214426B1 (de) * 2014-10-27 2024-03-27 Universidade de Aveiro Ausrüstung zur chromatischen diskriminierung und zählung von organismen
EP3247988A4 (de) 2015-01-23 2018-12-19 Vanderbilt University Robustes interferometer und verfahren zur verwendung davon
US9606082B2 (en) 2015-05-11 2017-03-28 The University Of North Carolina At Chapel Hill Pressure driven microfluidic injection for chemical separations
US10734216B2 (en) 2015-05-11 2020-08-04 The University Of North Carolina At Chapel Hill Pressure driven fluidic injection for chemical separations by electrophoresis
US10464067B2 (en) 2015-06-05 2019-11-05 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
CN208562324U (zh) 2015-06-05 2019-03-01 米罗库鲁斯公司 空气基质数字微流控(dmf)装置
US9728387B2 (en) 2015-10-20 2017-08-08 The University Of North Carolina At Chapel Hill Solid phase extraction with capillary electrophoresis
WO2017132483A1 (en) 2016-01-29 2017-08-03 Vanderbilt University Free-solution response function interferometry
CA3034064A1 (en) 2016-08-22 2018-03-01 Miroculus Inc. Feedback system for parallel droplet control in a digital microfluidic device
JP2020515815A (ja) 2016-12-28 2020-05-28 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスおよび方法
WO2018187476A1 (en) 2017-04-04 2018-10-11 Miroculus Inc. Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets
CN107225006B (zh) * 2017-07-03 2018-04-03 南京岚煜生物科技有限公司 基于主动控制液体流动的多通量微流控芯片
WO2019023133A1 (en) 2017-07-24 2019-01-31 Miroculus Inc. DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE
CA3073058A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. Digital microfluidics devices and methods of using them
EP3859324A4 (de) * 2018-10-26 2021-11-24 TERUMO Kabushiki Kaisha Verfahren zur trennung einer zielsubstanz und quantifizierungsverfahren
EP3953041A4 (de) 2019-04-08 2023-01-25 Miroculus Inc. Digitale mikrofluidikvorrichtungen mit mehreren patronen und verfahren zur verwendung
WO2021016614A1 (en) 2019-07-25 2021-01-28 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US11857961B2 (en) 2022-01-12 2024-01-02 Miroculus Inc. Sequencing by synthesis using mechanical compression

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714680B1 (en) * 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US5202010A (en) * 1987-11-25 1993-04-13 Princeton Biochemicals, Inc. Automated capillary electrophoresis apparatus
US5114768A (en) * 1988-06-02 1992-05-19 Hewlett-Packard Company Surfaces with reduced protein interactions
US4931328A (en) * 1988-08-19 1990-06-05 Hewlett-Packard Company Capillary tube with reduced protein interactions and controllable electroosmotic flow
WO1989012225A1 (en) * 1988-06-02 1989-12-14 Hewlett-Packard Company Halogenated surface with reduced protein interaction
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5132012A (en) * 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
EP0356160A3 (de) * 1988-08-24 1991-09-11 The Board Of Trustees Of The Leland Stanford Junior University Kapillarvorrichtung
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
US5110514A (en) * 1989-05-01 1992-05-05 Soane Technologies, Inc. Controlled casting of a shrinkable material
US5110745A (en) * 1989-06-01 1992-05-05 The Trustees Of The University Of Pennsylvania Methods of detecting glycated proteins
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5246577A (en) * 1990-05-29 1993-09-21 Millipore Corporation Apparatus for effecting capillary electrophoresis
US5085756A (en) * 1990-08-21 1992-02-04 Hewlett-Packard Company Column separation system for electrophoresis with sample pretreatment
EP0497077B1 (de) * 1991-01-28 1996-07-17 Ciba-Geigy Ag Vorrichtung zur Vorbereitung von Proben insbesondere für Analysezwecke
US5340452A (en) * 1991-02-01 1994-08-23 Beckman Instruments, Inc. On-column preconcentration of samples in capillary electrophoresis
US5646001A (en) * 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
US5294534A (en) * 1991-08-13 1994-03-15 Miles, Inc. Amplification method for polynucleotide assays
DE59108591D1 (de) * 1991-12-06 1997-04-10 Ciba Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
JP3063344B2 (ja) * 1991-12-18 2000-07-12 株式会社島津製作所 オンライン前処理可能なキャピラリ電気泳動方法及び装置
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
ATE174813T1 (de) * 1992-05-01 1999-01-15 Univ Pennsylvania Polynukleotide amplifikationsanalyse mit einer mikrofabrizierten vorrichtung
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method
DE59410283D1 (de) * 1993-11-11 2003-06-18 Aclara Biosciences Inc Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US5423966A (en) * 1994-01-25 1995-06-13 Perkin-Elmer Corporation On line ion contaminant removal apparatus and method for capillary electrophoresis
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5645702A (en) * 1995-06-07 1997-07-08 Hewlett-Packard Company Low voltage miniaturized column analytical apparatus and method
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5500071A (en) * 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5658413A (en) * 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5641400A (en) * 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5985119A (en) * 1994-11-10 1999-11-16 Sarnoff Corporation Electrokinetic pumping
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5632876A (en) * 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
WO1996015576A1 (en) * 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. Liquid distribution system
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
ATE340254T1 (de) * 1995-04-06 2006-10-15 Miltenyi Biotec Inc Verfahren zur freisetzung von magnetischen teilchen, die an zelloberflächen gebunden sind
DE69528387T2 (de) * 1995-06-06 2003-02-13 Orchid Biosciences Inc Herstellung elektrischer leitungen durch löcher
US5646048A (en) * 1995-07-24 1997-07-08 Hewlett-Packard Company Microcolumnar analytical apparatus with microcolumnar flow gating interface and method of using the apparatus
EP0862647A1 (de) * 1995-11-03 1998-09-09 Sarnoff Corporation Testsystem und verfahren zur ausführung von testverfahren
KR19990067263A (ko) * 1995-11-03 1999-08-16 윌리암 제이. 버크 마그네트
EP0869921A4 (de) * 1995-11-09 1999-03-31 Sarnoff David Res Center Schweiben mit hilfe eines magnetisches feld
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
JP2000508961A (ja) * 1996-04-09 2000-07-18 サーノッフ コーポレイション 反応システム用プレート
NZ333346A (en) * 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
EP0909385B1 (de) * 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Verfahren zum Transport von Fluidproben durch einen mikrofluidischen Kanal
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5699157A (en) * 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
AU4607197A (en) * 1996-09-26 1998-04-17 Sarnoff Corporation Massively parallel detection

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JP3989964B2 (ja) 2007-10-10
ATE347692T1 (de) 2006-12-15
CA2261869A1 (en) 1998-02-05
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US5770029A (en) 1998-06-23
DE69737071T2 (de) 2007-07-05
JP2000515978A (ja) 2000-11-28
EP1007953A4 (de) 2004-06-09
EP1007953B1 (de) 2006-12-06
AU3968097A (en) 1998-02-20
WO1998004909A1 (en) 1998-02-05
AU744264B2 (en) 2002-02-21
CA2261869C (en) 2007-06-19

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